(5 nodes) Mannosylation network (Streptomyces coelicolor)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCO1752	2SCI34.05, possible integral membrane protein, len: 396 aa; similar to TR:Q9L0K6 (EMBL:AL161691) Streptomyces coelicolor putative integral membrane protein SCD40A.03c, 434 aa; fasta scores: opt: 678 Z-score: 715.1 E(): 3.4e-32; 37.530% identity in 413 aa overlap. Contains possible hydrophobic membrane spanning regions. (396 aa)
	SCO3154	SCE87.05, possible integral membrane protein, len: 591 aa. Similar to several of undefined function e.g. Mycobacterium tuberculosis TR: O05586 (EMBL: Z94752) hypothetical 55.5 KD protein (503 aa), fasta scores opt: 666 z-score: 775.7 E(): 0 39.0% identity in 544 aa overlap and Aeropyrum pernix TR:BAA79111 (EMBL:AP000058) 418aa long hypothetical protein (418 aa), fasta scores opt: 201 z-score: 235.2 E(): 9.9e-06 30.4% identity in 299 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. (591 aa)
	SCO4023	2SC10A7.27, possible integral membrane protein, len: 733 aa; similar to TR:O34575 (EMBL:Z99110) Bacillus subtilis YkcB protein, 716 aa; fasta scores: opt: 768 z-score: 610.1 E(): 1.8e-26; 29.8% identity in 742 aa overlap. Contains possible hydrophobic membrane spanning regions. (733 aa)
	SCO4657	SCD40A.03c, possible integral membrane protein, len: 434 aa; similar to TR:Q9EWX4 (EMBL:AL445403) Streptomyces coelicolor putative integral membrane protein 2SCI34.05, 396 aa; fasta scores: opt: 678 Z-score: 732.5 E(): 3.6e-33; 37.923% identity in 414 aa overlap. Contains possible hydrophobic membrane spanning regions. (434 aa)
	SCO1423	Putative glycosyl transferase; SC6D7.16, possible glycosyl transferase, len: 302 aa. Similar to many eukaryotic dolichol-phosphate-mannose synthases e.g. Mus musculus (Mouse) TR:O70152 (EMBL:AB004789) (260 aa), fasta scores opt: 474 z-score: 560.2 E(): 7.9e-24 37.9% identity in 227 aa overlap. Also similar to a number of Prokaryotic proteins of undefined function e.g. Mycobacterium leprae TR:O32929 (EMBL:Z98604) hypothetical 30.1 KD protein (277 aa), fasta scores opt: 917 z-score: 1076.0 E():0 52.0% identity in 281 aa overlap. Contains a Pfam match to entry PF00535 Glycos_transf_2, Gly [...] (302 aa)

Your Current Organism:

Streptomyces coelicolor

NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SCO1423	SCO3154	gene:17759009	gene:17760771	Putative glycosyl transferase; SC6D7.16, possible glycosyl transferase, len: 302 aa. Similar to many eukaryotic dolichol-phosphate-mannose synthases e.g. Mus musculus (Mouse) TR:O70152 (EMBL:AB004789) (260 aa), fasta scores opt: 474 z-score: 560.2 E(): 7.9e-24 37.9% identity in 227 aa overlap. Also similar to a number of Prokaryotic proteins of undefined function e.g. Mycobacterium leprae TR:O32929 (EMBL:Z98604) hypothetical 30.1 KD protein (277 aa), fasta scores opt: 917 z-score: 1076.0 E():0 52.0% identity in 281 aa overlap. Contains a Pfam match to entry PF00535 Glycos_transf_2, Gly [...]	SCE87.05, possible integral membrane protein, len: 591 aa. Similar to several of undefined function e.g. Mycobacterium tuberculosis TR: O05586 (EMBL: Z94752) hypothetical 55.5 KD protein (503 aa), fasta scores opt: 666 z-score: 775.7 E(): 0 39.0% identity in 544 aa overlap and Aeropyrum pernix TR:BAA79111 (EMBL:AP000058) 418aa long hypothetical protein (418 aa), fasta scores opt: 201 z-score: 235.2 E(): 9.9e-06 30.4% identity in 299 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.	0.887
SCO1423	SCO4023	gene:17759009	gene:17761653	Putative glycosyl transferase; SC6D7.16, possible glycosyl transferase, len: 302 aa. Similar to many eukaryotic dolichol-phosphate-mannose synthases e.g. Mus musculus (Mouse) TR:O70152 (EMBL:AB004789) (260 aa), fasta scores opt: 474 z-score: 560.2 E(): 7.9e-24 37.9% identity in 227 aa overlap. Also similar to a number of Prokaryotic proteins of undefined function e.g. Mycobacterium leprae TR:O32929 (EMBL:Z98604) hypothetical 30.1 KD protein (277 aa), fasta scores opt: 917 z-score: 1076.0 E():0 52.0% identity in 281 aa overlap. Contains a Pfam match to entry PF00535 Glycos_transf_2, Gly [...]	2SC10A7.27, possible integral membrane protein, len: 733 aa; similar to TR:O34575 (EMBL:Z99110) Bacillus subtilis YkcB protein, 716 aa; fasta scores: opt: 768 z-score: 610.1 E(): 1.8e-26; 29.8% identity in 742 aa overlap. Contains possible hydrophobic membrane spanning regions.	0.515
SCO3154	SCO1423	gene:17760771	gene:17759009	SCE87.05, possible integral membrane protein, len: 591 aa. Similar to several of undefined function e.g. Mycobacterium tuberculosis TR: O05586 (EMBL: Z94752) hypothetical 55.5 KD protein (503 aa), fasta scores opt: 666 z-score: 775.7 E(): 0 39.0% identity in 544 aa overlap and Aeropyrum pernix TR:BAA79111 (EMBL:AP000058) 418aa long hypothetical protein (418 aa), fasta scores opt: 201 z-score: 235.2 E(): 9.9e-06 30.4% identity in 299 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.	Putative glycosyl transferase; SC6D7.16, possible glycosyl transferase, len: 302 aa. Similar to many eukaryotic dolichol-phosphate-mannose synthases e.g. Mus musculus (Mouse) TR:O70152 (EMBL:AB004789) (260 aa), fasta scores opt: 474 z-score: 560.2 E(): 7.9e-24 37.9% identity in 227 aa overlap. Also similar to a number of Prokaryotic proteins of undefined function e.g. Mycobacterium leprae TR:O32929 (EMBL:Z98604) hypothetical 30.1 KD protein (277 aa), fasta scores opt: 917 z-score: 1076.0 E():0 52.0% identity in 281 aa overlap. Contains a Pfam match to entry PF00535 Glycos_transf_2, Gly [...]	0.887
SCO4023	SCO1423	gene:17761653	gene:17759009	2SC10A7.27, possible integral membrane protein, len: 733 aa; similar to TR:O34575 (EMBL:Z99110) Bacillus subtilis YkcB protein, 716 aa; fasta scores: opt: 768 z-score: 610.1 E(): 1.8e-26; 29.8% identity in 742 aa overlap. Contains possible hydrophobic membrane spanning regions.	Putative glycosyl transferase; SC6D7.16, possible glycosyl transferase, len: 302 aa. Similar to many eukaryotic dolichol-phosphate-mannose synthases e.g. Mus musculus (Mouse) TR:O70152 (EMBL:AB004789) (260 aa), fasta scores opt: 474 z-score: 560.2 E(): 7.9e-24 37.9% identity in 227 aa overlap. Also similar to a number of Prokaryotic proteins of undefined function e.g. Mycobacterium leprae TR:O32929 (EMBL:Z98604) hypothetical 30.1 KD protein (277 aa), fasta scores opt: 917 z-score: 1076.0 E():0 52.0% identity in 281 aa overlap. Contains a Pfam match to entry PF00535 Glycos_transf_2, Gly [...]	0.515