STRINGSTRING
SCO1518 SCO1518 SCO1484 SCO1484 SCO1478 SCO1478 SCO1440 SCO1440 SCO1378 SCO1378 SCO1268 SCO1268 SCO1235 SCO1235 SCO1214 SCO1214 SCO1080 SCO1080 SCO1062 SCO1062 SCO0993 SCO0993 SCO0960 SCO0960 SCO0918 SCO0918 SCO0912 SCO0912 SCO0855 SCO0855 SCO0782 SCO0782 SCO0770 SCO0770 SCO0766 SCO0766 SCO0754 SCO0754 SCO0670 SCO0670 SCO0601 SCO0601 SCO0518 SCO0518 SCO0369 SCO0369 SCO0219 SCO0219 SCO0217 SCO0217 SCO0216 SCO0216 SCO0080 SCO0080 SCO1477 SCO1477 SCP1.302 SCP1.302 SCP1.285c SCP1.285c SCP1.162c SCP1.162c SCP1.160c SCP1.160c SCP1.159c SCP1.159c dnaN dnaN SCP1.68 SCP1.68 SCP1.52c SCP1.52c SCO7723 SCO7723 SCO7638 SCO7638 SCO7508 SCO7508 SCO7506 SCO7506 SCO7493 SCO7493 SCO7473 SCO7473 SCO7472 SCO7472 SCO7471 SCO7471 SCO7412 SCO7412 SCO7407 SCO7407 SCO7374 SCO7374 SCO7124 SCO7124 SCO7123 SCO7123 SCO6975 SCO6975 SCO6918 SCO6918 SCO6898 SCO6898 SCO6877 SCO6877 SCO6719 SCO6719 SCO6596 SCO6596 SCO6586 SCO6586 SCO6585 SCO6585 SCO6561 SCO6561 SCO6560 SCO6560 SCO6559 SCO6559 SCO6535 SCO6535 SCO6534 SCO6534 SCO6532 SCO6532 SCO6517 SCO6517 SCO6471 SCO6471 SCO6457 SCO6457 SCO6437 SCO6437 SCO6347 SCO6347 SCO6284 SCO6284 SCO6201 SCO6201 SCO6155 SCO6155 SCO6099 SCO6099 SCO6098 SCO6098 SCO6097 SCO6097 SCO5689 SCO5689 SCO5665 SCO5665 SCO5559 SCO5559 SCO5554 SCO5554 SCO5536 SCO5536 SCO5535 SCO5535 SCO5525 SCO5525 SCO5471 SCO5471 SCO5426 SCO5426 SCO5309 SCO5309 SCO5281 SCO5281 SCO5225 SCO5225 SCO5183 SCO5183 SCO5167 SCO5167 SCO5071 SCO5071 SCO5056 SCO5056 SCO5055 SCO5055 SCO4950 SCO4950 SCO4948 SCO4948 SCO4947 SCO4947 SCO4926 SCO4926 SCO4925 SCO4925 SCO4858 SCO4858 SCO4809 SCO4809 SCO4808 SCO4808 SCO4801 SCO4801 SCO4797 SCO4797 SCO4774 SCO4774 SCO4729 SCO4729 SCO4655 SCO4655 SCO4654 SCO4654 SCO4617 SCO4617 SCO4607 SCO4607 SCO4605 SCO4605 SCO4603 SCO4603 SCO4600 SCO4600 SCO4574 SCO4574 SCO4570 SCO4570 SCO4568 SCO4568 SCO4567 SCO4567 SCO4566 SCO4566 SCO4563 SCO4563 SCO4380 SCO4380 SCO4145 SCO4145 SCO4111 SCO4111 SCO4067 SCO4067 SCO3881 SCO3881 SCO3878 SCO3878 SCO3822 SCO3822 SCO3646 SCO3646 SCO3479 SCO3479 SCO3123 SCO3123 SCO3096 SCO3096 SCO2776 SCO2776 SCO2737 SCO2737 SCO2727 SCO2727 SCO2694 SCO2694 SCO2617 SCO2617 SCO2573 SCO2573 SCO2564 SCO2564 SCO2473 SCO2473 SCO2468 SCO2468 SCO2445 SCO2445 SCO2430 SCO2430 SCO2371 SCO2371 SCO2363 SCO2363 SCO2277 SCO2277 SCO2183 SCO2183 SCO2181 SCO2181 SCO2119 SCO2119 SCO2033 SCO2033 SCO1966 SCO1966 SCO1958 SCO1958 SCO1953 SCO1953 SCO1848 SCO1848 SCO1671 SCO1671 SCO1664 SCO1664 SCO1661 SCO1661 SCO1651 SCO1651 SCO1648 SCO1648 SCO1644 SCO1644 SCO1643 SCO1643 SCO1594 SCO1594 SCO1522 SCO1522 SCO1519 SCO1519
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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SCO1518Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (357 aa)
SCO1484SC9C5.08c, pyrAA, carbamoyl-phosphate synthase, pyrimidine-specific, small chain, len: 380 aa; similar to SW:CARA_BACCL (EMBL:X73308) Bacillus caldolyticus carbamoyl-phosphate synthase, pyrimidine-specific, small chain (EC 6.3.5.5) PyrAA, 364 aa; fasta scores: opt: 826 z-score: 913.3 E(): 0; 45.3% identity in 362 aa overlap. Contains Pfam matches to entries PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain and PF00117 GATase, Glutamine amidotransferase class-I and match to Prosite entry PS00442 Glutamine amidotransferases class-I active site; Belongs to t [...] (380 aa)
SCO1478Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (90 aa)
SCO14406,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (161 aa)
SCO1378Putative glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
SCO12682SCG18.15c, probable acyltransferase, len: 372 aa; similar to SW:ODO2_ECOLI (EMBL:J01619) Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB, 404 aa; fasta scores: opt: 281 z-score: 311.6 E(): 7.1e-10; 24.8% identity in 400 aa overlap. Contains Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes and match to Prosite entry PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. (372 aa)
SCO12352SCG1.10c, ureB, urease beta subunit, len: 103 aa; similar to SW:URE2_RHIME (EMBL:S69145) Rhizobium meliloti urease beta subunit UreB (EC 3.5.1.5), 101 aa; fasta scores: opt: 400 z-score: 525.2 E(): 8.7e-22; 59.8% identity in 102 aa overlap. Contains Pfam match to entry PF00699 Urease_beta, Urease beta subunit. (103 aa)
SCO12146-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (341 aa)
SCO1080SCG22.26c, hypothetical protein, len: 432 aa; C-terminal domain similar to TR:Q9ZBK3 (EMBL:AL035161) Streptomyces coelicolor putative lyase SC9C7.07c, 339 aa; fasta scores: opt: 163 z-score: 187.9 E(): 0.0054; 27.7% identity in 206 aa overlap; Belongs to the HpcH/HpaI aldolase family. (432 aa)
SCO1062SCG22.08c, possible hydrolase, len: 693 aa; similar to SW:BGLR_ECOLI (EMBL:M14641) Escherichia coli beta-glucuronidase (EC 3.2.1.31) GusA, 603 aa; fasta scores: opt: 386 z-score: 439.2 E(): 5.5e-17; 25.3% identity in 582 aa overlap and to TR:Q9RIU6 (EMBL: AL133278) Streptomyces coelicolor putative hydrolase SCM11.15c, 872 aa; fasta scores: opt: 977 z-score: 1111.4 E(): 0; 37.1% identity in 596 aa overlap; Belongs to the glycosyl hydrolase 2 family. (693 aa)
SCO09932SCG2.06, conserved hypothetical protein, len: 412 aa; similar to SW:Y4RH_RHISN (EMBL:AE000094) Rhizobium sp. hypothetical 52.5 kDa protein Y4rH, 478 aa; fasta scores: opt: 348 z-score: 384.2 E(): 7.1e-14; 26.3% identity in 400 aa overlap. (412 aa)
SCO0960SCM11.15c, possible hydrolase (putative secreted protein), len: 872 aa; similar to TR:Q9X0F2 (EMBL:AE001766) Thermotoga maritima beta-glucuronidase TM1062, 563 aa; fasta scores: opt: 420 z-score: 447.6 E(): 1.5e-17; 28.3% identity in 406 aa overlap and to SW:BGLR_ECOLI (EMBL:M14641) Escherichia coli beta-glucuronidase (EC 3.2.1.31) UidA or GusA or GurA, 603 aa; fasta scores: opt: 359 z-score: 382.2 E(): 6.6e-14; 26.2% identity in 454 aa overlap. Contains possible N-terminal region signal peptide sequence. (872 aa)
SCO0918SCM10.06, probable excinuclease ABC subunit A, len: 781 aa; similar to SW:UVRA_PSELE (EMBL:Z22595) Pseudomonas lemoignei putative excinuclease ABC subunit A (fragment) UvrA, 689 aa; fasta scores: opt: 1263 z-score: 1326.5 E(): 0; 57.5% identity in 670 aa overlap, to SW:UVRA_MICLU (EMBL:X15867) Micrococcus luteus excinuclease ABC subunit A UvrA, 992 aa; fasta scores: opt: 1096 z-score: 1149.1 E(): 0; 40.9% identity in 962 aa overlap and to S. coelicolor SC5F2A.02c, 752 aa; fasta scores: opt: 1207 z-score: 981.3 E(): 0; 44.8% identity in 772 aa overlap. Contains two Pfam matches to entry [...] (781 aa)
SCO0912Conserved hypothetical protein SCM1.45; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (271 aa)
SCO0855Putative acetyltransferase; SCM2.08c, possible acetyltransferase, len: 168 aa. Weak similarity to several other putative acetyltransferases e.g. Streptomyces coelicolor TR:CAB51273 (EMBL:AL096872) putative acetyltransferase SC5F7.12C (169 aa), fasta scores opt: 121 z-score: 155.1 E(): 0.29 31.3% identity in 147 aa overlap. Contains a Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. (168 aa)
SCO07823SCF60.14c, prsA, ribose-phosphate pyrophosphokinase, len: 317 aa; similar to SW:KPRS_SYNP7 (EMBL:D14994) Synechococcus sp. ribose-phosphate pyrophosphokinase (EC 2.7.6.1) PrsA, 331 aa; fasta scores: opt: 795 z-score: 931.4 E(): 0; 42.7% identity in 307 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. (317 aa)
SCO07703SCF60.02c, possible membrane protein, len: 185 aa. Contains possible hydrophobic membrane spanning region. (185 aa)
SCO0766SCF81.25c, possible secreted beta-galactosidase, len: 1028 aa; similar to SW:BGA2_ECOLI (EMBL:M64441) Escherichia coli evolved beta-galactosidase alpha-subunit (EC 3.2.1.23) (lactase) 1031 aa; fasta scores: opt: 482 z-score: 519.9 E(): 1.4e-21; 30.6% identity in 464 aa overlap. Contains N-terminal signal peptide sequence; Belongs to the glycosyl hydrolase 2 family. (1028 aa)
SCO0754SCF81.13, putative secreted protein, len: 268 aa. Contains possible N-teminal signal sequence peptide. (248 aa)
SCO0670SCF91.30, glpD, glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), len: 527 aa. Highly similar to many prokaryotic and eukaryotic glycerol-3-phosphate dehydrogenases including: Mycobacterium tuberculosis SW:GLPD_MYCTU (EMBL:Z70692) (516 aa), fasta scores opt: 1648 z-score: 1727.9 E():0 52.6% identity in 513 aa overlap and Caenorhabditis elegans SW:GPDM_CAEEL(EMBL:Z73906) (722aa), fasta score opt: 668 z-score: 700.9 E(): 1.2e-31 33.9% identity in 537 aa overlap. Contains a Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase and a Prosite hit to PS00 [...] (527 aa)
SCO0601Putative secreted protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (347 aa)
SCO0518SCF6.14, hypothetical protein, len: 86 aa. Gene fragment that is highly similar to Streptomyces coelicolor TR:Q9RI29 (EMBL:AL109989) putative nitrate reductase delta chain NarI2 (256 aa); fasta scores: opt: 409 Z-score: 526.8 bits: 103.5 E(): 9.3e-22; 74.390% identity in 82 aa overlap. (86 aa)
SCO0369SCF41.28c, putative secreted protein, len: 1085 aa. Contains a possible N-terminal signal peptide sequence. (1085 aa)
SCO0219SCJ12.31, narI2, possible nitrate reductase gamma chain, len: 256 aa. Similar to many including: Streptomyces coelicolor TR:O86714 (EMBL:AL031515) putative nitrate reductase gamma chain NarI SC5C7.17c (240 aa), fasta scores: opt: 755 z-score: 891.5 E(): 0 46.8% identity in 235 aa overlap and Bacillus subtilis SW:NARI_BACSU (EMBL:Z49884) nitrate reductase gamma chain (EC 1.7.99.4) (223 aa), fasta scores: opt: 668 z-score: 790.4 E(): 0 43.6% identity in 225 aa overlap. Contains possible membrane spanning hydrophobic domains. (256 aa)
SCO0217SCJ12.29, narH2, probable nitrate reductase beta chain, len: 522 aa. Highly similar to many e.g. Streptomyces coelicolor TR:O86716 (EMBL; AL031515) putative nitrate reductase beta chain NarH SC5C7.19c (531 aa), fasta scores: opt: 2348 z-score: 2413.0 E(): opt: 2348 z-score: 2413.0 E(): 0 65.3% identity in 496 aa overlap and Bacillus subtilis SW:NARH_BACSU (EMBL; Z49884) nitrate reductase beta chain (EC 1.7.99.4) NarH (487 aa), fasta scores: opt: 2081 z-score: 2139.7 E(): 0 57.1% identity in 485 aa overlap. Contains a PS00190 Cytochrome c family heme-binding site signature, a Pfam match [...] (522 aa)
SCO0216SCJ12.28, narG2, probable nitrate reductase alpha chain, len: 1233 aa. Highly similar to Streptomyces coelicolor TR:O86717 (EMBL; AL031515) putative nitrate reductase alpha chain NarG SC5C7.20c (1231 aa), fasta scores: opt: 5792 z-score: 6544.7 E(): 0 67.6% identity in 1230 aa overlap and Bacillus subtilis SW:NARG_BACSU (EMBL; Z49884) nitrate reductase alpha chain (EC 1.7.99.4) NarG (1228 aa), fasta scores: opt: 4331 z-score: 4891.8 E(): 0 52.9% identity in 1201 aa overlap. Contains a PS00551 Prokaryotic molybdopterin oxidoreductases signature 1, a Pfam match to entry PF00384 molybdopt [...] (1233 aa)
SCO0080Hypothetical protein; SCJ11.09, unknown, len: 171 aa. (171 aa)
SCO1477Putative flavoprotein homologue (partial); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (427 aa)
SCP1.302SCP1.302, possible lysase, len: 287aa; similar to many eg. SW:P17725 (CILB_KLEPN) citrate lyase beta chain (EC 4.1.3.6) (289 aa) fasta scores; opt: 392, z-score: 446.6, E(): 2.1e-17, 31.5% identity in 286 aa overlap. (287 aa)
SCP1.285cSCP1.285c, possible conserved secreted protein, len: 299aa; similar to many eg. TR:Q9XAF8 (EMBL:AL079356) hypothetical protein from Streptomyces coelicolor (365 aa) fasta scores; opt: 999, z-score: 1101.9, E(): 0, 52.8% identity in 303 aa overlap. Contains a possible cleavable N-terminal signal sequence. (299 aa)
SCP1.162cSCP1.162c, possible oxidoreductase subunit, len: 65aa; similar to the extreme C-terminus of many glycerol-3-phosphate dehydrogenases eg. TR:Q9ZBS0 (EMBL:AL034447) glycerol-3-phosphate dehydrogenase from Streptomyces coelicolor (336 aa) fasta scores; opt: 302, z-score: 432.6, E(): 1.3e-16, 76.9% identity in 65 aa overlap. Also similar to neighbouring CDS SCP1.162c fasta scores; opt: 238, z-score: 294.0, E(): 7.6e-12, 50.7% identity in 75 aa overlap. (65 aa)
SCP1.160cSCP1.160c, possible oxidoreductase, len: 525aa; similar to many eg. TR:Q9RDL3 (EMBL:AL136518) putative oxidoreductase from Streptomyces coelicolor (524 aa) fasta scores; opt: 308,1 z-score: 3329.1, E(): 0, 88.9% identity in 523 aa overlap and SW:P56913 (NUF2_RHIME) NADH dehydrogenase I chain F 2 (EC 1.6.5.3) from Rhizobium meliloti (Sinorhizobium meliloti) (421 aa) fasta scores; opt: 367, z-score: 400.3, E(): 7.9e-15, 28.4% identity in 395 aa overlap. (525 aa)
SCP1.159cSCP1.159c, possible oxidoreductase subunit, len: 90aa; similar to the extreme C-terminus of many glycerol-3-phosphate dehydrogenases eg. SW:P37606 (GPDA_ECOLI) glycerol-3-phosphate dehydrogenase from Escherichia coli (339 aa) fasta scores; opt: 176, z-score: 239.8 E(): 6.9e-06, 39.5% identity in 76 aa overlap and TR:Q9ZBS0 (EMBL:AL034447) glycerol-3-phosphate dehydrogenase from Streptomyces coelicolor (336 aa) fasta scores; opt: 252, z-score: 338.2, E(): 2.3e-11, 53.1% identity in 81 aa overlap. Also similar to neighbouring CDS SCP1.162c fasta scores; opt: 238, z-score: 294.0, E(): 7.6 [...] (69 aa)
dnaNPutative DNA-polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] (372 aa)
SCP1.68Putative conserved secreted protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (299 aa)
SCP1.52cSCP1.52c, possible lysase, len: 287aa; similar to many eg. SW:P17725 (CILB_KLEPN) citrate lyase beta chain (EC 4.1.3.6) (289 aa) fasta scores; opt: 392, z-score: 446.6, E(): 2.1e-17, 31.5% identity in 286 aa overlap; Belongs to the HpcH/HpaI aldolase family. (287 aa)
SCO7723Hypothetical protein SC8D11.14c; SC8D11.14c, unknown, len: 393 aa. (393 aa)
SCO7638Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
SCO7508SCBAC17A6.41c, conserved hypothetical protein, len: 277 aa; similar to many e.g. TR:AAK49792 (EMBL:AF228583) hypothetical protein from Burkholderia pseudomallei (278 aa) fasta scores: opt: 1084, Z-score: 1298.6, 55.636% identity (56.044% ungapped) in 275 aa overlap. (277 aa)
SCO7506SCBAC17A6.39, possible hydrolase, len: 606 aa; similar to many e.g. TR:Q9AHJ8 (EMBL:AF305888) beta-glucuronidase from Lactobacillus gasseri (598 aa) fasta scores: opt: 437, Z-score: 491.4, 25.054% identity (27.913% ungapped) in 459 aa overlap. Contains Pfam match to entry PF02837 Glyco_hydro_2_N, Glycosyl hydrolases family 2, sugar binding domain; Pfam match to entry PF00703 Glyco_hydro_2, Glycosyl hydrolases family 2, immunoglobulin-like beta-sandwich domain and Pfam match to entry PF02836 Glyco_hydro_2_C, Glycosyl hydrolases family 2, TIM barrel domain. (606 aa)
SCO7493SCBAC17A6.26, conserved hypothetical protein, len: 645 aa; similar to many e.g. TR:Q9K6N7 (EMBL:AP001519) BH3691 protein from Bacillus halodurans (702 aa) fasta scores: opt: 1188, Z-score: 1277.9, 34.802% identity (37.175% ungapped) in 658 aa overlap. (645 aa)
SCO7473SCBAC17A6.06, possible phenylacetic acid degradation protein PaaC, len: 275 aa: similar to many e.g. SW:P76079 (PAAC_ECOLI) phenylacetic acid degradation protein PaaC from Escherichia coli (248 aa) fasta scores; opt: 470, Z-score: 547.8, 41.057% identity (44.105% ungapped) in 246 aa overlap. (275 aa)
SCO7472SCBAC17A6.05, possible phenylacetic acid degradation protein PaaB, len: 103 aa: similar to many e.g. SW:P76078 (PAAB_ECOLI) phenylacetic acid degradation protein PaaB from Escherichia coli (95 aa) fasta scores; opt: 427, Z-score: 565.4, 66.667% identity (66.667% ungapped) in 90 aa overlap. (103 aa)
SCO7471SCBAC17A6.04, possible phenylacetic acid degradation protein PaaA, len: 328 aa: similar to many e.g. SW:P76077 (PAAA_ECOLI) phenylacetic acid degradation protein PaaA from Escherichia coli (309 aa) fasta scores; opt: 1540, Z-score: 1801.2, 69.967% identity (69.967% ungapped) in 303 aa overlap. (328 aa)
SCO7412SC6D11.08, possible pyruvate dehydrogenase (pyruvate oxidase), len: 600 aa. Highly similar to many including: Escherichia coli SW:POXB_ECOLI(EMBL:X04105) pyruvate dehydrogenase (572 aa), fasta scores opt: 770 z-score: 855.7 E(): 0 34.6% identity in 566 aa overlap and Streptomyces coelicolor TR:Q9ZBT3(EMBL:AL034446) pyruvate dehydrogenase (pyruvate oxidase), SC1A9.19 (580 aa), fasta scores opt: 866 z-score: 962.2 E():0 33.1% identity in 556 aa overlap. Contains a Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Also contains a Prosite hit to PS00187 Thiamine pyro [...] (600 aa)
SCO7407SC6D11.03c, probable beta-galactosidase, len: 681 aa. Similar to many beta-galactosidases e.g. Bacillus stearothermophilus SW:BGAL_BACST(EMBL:M13466) beta-galactosidase I (EC 3.2.1.23), BgaB, (672 aa), fasta scores opt: 1816 z-score: 2079.7 E(): 0 43.2% identity in 666 aa overlap. (681 aa)
SCO7374Nitrate reductase NarB (fragment); SC10G8.01c, possible oxidoreductase, partial CDS, len: > 355 aa. Similar to many e.g. Paracoccus denitrificans SW:NAPA_PARDT (EMBL:Z36773) periplasmic nitrate reductase precursor (EC 1.7.99.4) (831 aa), fasta scores opt: 550 z-score: 651.4 E(): 7.2e-29 33.1% identity in 317 aa overlap; SC9H11.28c, narB, nitrate reductase (EC 1.7.99.4), partial CDS, len: > 508 aa. Highly similar to many including: Synechocystis sp. (strain PCC 7942) SW:NARB_SYNP7 (EMBL:X74597) nitrate reductase (EC 1.7.99.4), NarB (729 aa), fasta scores opt: 583 z-score: 613.8 E(): 1e- [...] (830 aa)
SCO7124Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (895 aa)
SCO7123SC4B10.24c, probable acyltransferase, len: 417 aa; similar to SW:ODO2_ALCEU (EMBL:X91877) Alcaligenes eutrophus dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) SucB, 416 aa; fasta scores: opt: 793 z-score: 570.6 E(): 2.6e-24; 39.0% identity in 421 aa overlap, to C-terminal region of TR:Q9Z6I4 (EMBL:AF047034) Streptomyces seoulensis dihydrolipoamide acetyltransferase PdhB, 612 aa; fasta scores: opt: 1251 z-score: 887.0 E(): 0; 61.0% identity in 474 aa overlap and to TR:CAB51265 (EMBL:AL096872) Streptomyces coelicolor putative dihydrol [...] (417 aa)
SCO6975Putative acetolactate synthase; SC8F11.01c, possible amino acid synthase, partial CDS, len: > 237 aa. Similar to several enzymes requiring TPP as a cofactor including: Spirulina platensis SW:ILVB_SPIPL(EMBL:M75907) acetolactate synthase (EC 4.1.3.18) IlvY (579 aa), fasta scores opt: 166 z-score: 195.5 E(): 0.0019 27.7% identity in 238 aa overlap. Also highly similar, in parts, to the Bacillus subtilis SW:IOLD_BACSU(EMBL:D14399) hypothetical protein, IolD found within the inositol utilisation operon (580 aa), fasta scores opt: 577 z-score: 669.1 E(): 7.7e-30 47.2% identity in 178 aa ove [...] (624 aa)
SCO6918Hypothetical protein SC1B2.24c; SC1B2.24c, unknown, len: 580 aa. (580 aa)
SCO6898Putative carboxylase; SC1B2.04, possible carboxylase, len: 405 aa. Weakly similar to several e.g. Anabaena sp. (strain PCC 7120) SW:ACCC_ANASP(EMBL:L14862) biotin carboxylase (EC 6.3.4.14) (447 aa), fasta scores opt: 226 z-score: 262.2 E(): 3.8e-07 28.5% identity in 214 aa overlap. Contains a Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and a Prosite hit to PS00867 Carbamoyl-phosphate synthase subdomain signature 2. (405 aa)
SCO6877Hypothetical protein SC7F9.29c; SC7F9.29c, unknown, len: 260 aa. (260 aa)
SCO6719SC5F2A.02c, UvrA-like ABC transporter, len: 752 aa; similar to many egs. TR:O86699 (EMBL:AL031515) UvrA-like protein from Streptomyces coelicolor (796 aa) fasta scores; opt: 2047, z-score: 2164.0, E(): 0, (51.9% identity in 776 aa overlap) and SW:UVRA_ECOLI UvrA, excinuclease ABC subunit A from Escherichia coli (940 aa) fasta scores; opt: 634, z-score: 669.2, E(): 5.8e-30, (33.9% identity in 938 aa overlap). Contains two Pfam matches to entry PF00005 ABC_tran, ABC transporter and two Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop). Also contains possible membrane spann [...] (752 aa)
SCO6596SC8A6.17, probable secreted protein, len: 589 aa; co ntains N-terminal signal sequence and PS00213 Lipocalin sig nature. (589 aa)
SCO6586Succinyl-coa synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (308 aa)
SCO6585Succinyl-coa synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa)
SCO6561SC4B5.11c, respiratory chain oxidoreductase, len: 642 aa; similar to the C-terminal region of many proteins involved in electron transfer e.g. TR:P77908 (EMBL:U73807) FdhA formate dehydrogenase alpha subunit from Moorella thermoacetica (893 aa) fasta scores; opt: 1532, z-score: 1338.5, E(): 0, (43.1% identity in 619 aa overlap). Contains Pfam match to entry PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases, score 95.80, E-value 6.2e-30. Considering the corresponding homolgies, this CDS may have previously been located directly downsteam of SC4B5.09c. (642 aa)
SCO6560SC4B5.10c, respiratory chain oxidoreductase, len: 646 aa; C-terminal region is similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:O27592 (EMBL:AE000915) NADP-reducing hydrogenase, subunit C from Methanobacterium thermoautotrophicum (630 aa), fasta scores; opt: 121,4 z-score: 1170.7, E(): 0, (47.1% identity in 397 aa overlap). Contains PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. (646 aa)
SCO6559SC4B5.09c, respiratory chain oxidoreductase, len: 286 aa; similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:P77908 (EMBL:U73807) FdhA formate dehydrogenase alpha subunit from Moorella thermoacetica (893 aa), fasta scores; opt: 685, z-score: 791.8, E(): 0, (38.4% identity in 284 aa overlap). Contains PS00551 Prokaryotic molybdopterin oxidoreductases signature 1, PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and r [...] (286 aa)
SCO6535SC5C7.20c, narG, probable nitrate reductase alpha chain, len: 1231 aa; highly similar to many e.g. NARG_BACSU nitrate reductase alpha chain (EC 1.7.99.4) (1228 aa), fasta scores; opt: 4306 z-score: 3216.7 E(): 0, 51.5% identity in 1235 aa overlap. Contains PS00551 and PS00490 Prokaryotic molybdopterin oxidoreductases signatures 1 and 2 and Pfam match to entry PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases, score 79.90, E-value 1e-24; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1231 aa)
SCO6534SC5C7.19c, narH, probable nitrate reductase beta chain, len: 531 aa; highly similar to many e.g. NARH_BACSU nitrate reductase beta chain (EC 1.7.99.4) (487 aa), fasta scores; opt: 2099 z-score: 2179.2 E(): 0, 58.0% identity in 495 aa overlap. Contains PS00190 Cytochrome c family heme-binding site signature and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains, score 61.10, E-value 1.8e-16. (531 aa)
SCO6532SC5C7.17c, narI, probable nitrate reductase gamma chain; len: 240 aa; similar to many e.g. NARI_BACSU nitrate reductase gamma chain (EC 1.7.99.4) (223 aa), fasta scores; opt: 664 z-score: 1084.3 E(): 0, 41.5% identity in 217 aa overlap. Contains possible hydrophobic membrane spanning regions. (240 aa)
SCO6517SC5C7.02, uvrA-like protein, len: 796 aa; similar to Streptomyces peucetius TR:Q54827 (EMBL:L76359) daunorubicin resistance protein drrC (764 aa), fasta scores; opt: 2051 z-score: 2702.2 E(): 0, 51.1% identity in 775 aa overlap, and to many uvrA proteins e.g. UVRA_NEIGO excinuclease ABC subunit A (950 aa), fasta scores; opt: 412 z-score: 1697.0 E(): 0, 34.1% identity in 953 aa overlap. Contains 2x PS00017 ATP /GTP-binding= match to entry PF00005 ABC_tran, ABC transporters, scores 42.40, E-value 1.7e-10 and 71.20, E-value 2.2e-17. (796 aa)
SCO6471SC9C7.07c, probable citratelyase, len: 339 aa; similar to many e.g. SW:CILB_KLEPN citrate lyase beta chain from Klebsiella pneumoniae (289 aa) fasta scores; opt: 187, z-score: 643.3, E(): 1.5e-28, (30.5% identity in 298 aa overlap); Belongs to the HpcH/HpaI aldolase family. (339 aa)
SCO6457SC9B5.24, lacZ*, beta-galactosidase, len: 1307 aa; similar to many e.g. TR:O85167 (EMBL:AF047824) beta-galactosidase from Bacillus megaterium (1034 aa) fasta scores: opt: 1750, z-score: 2221.6, E(): 0, (37.4% identity in 1256 aa overlap). Note that this CDS is approx. 300 residues longer than the homologues due to an extra region around residues 600 to 900. Contains PS00719 Glycosyl hydrolases family 2 signature 1 and PS00608 Glycosyl hydrolases family 2 acid /base catalyst. Also contains Pfam match to entry PF00703 glycosyl_hydro7, Glycosyl hydrolases family 2. (1307 aa)
SCO6437Hypothetical protein SC9B5.04; SC9B5.04, unknown, len: 424 aa; similar to two hypothetical proteins SW:Y4RH_RHISN from Rhizobium sp. fasta scores; opt: 213, z-score: 366.1, E(): 4.2e-13, (26.3% identity in 335 aa overlap) and SW:YWFE_BACSU from Bacillus subtilis (472 aa) fasta scores; opt: 217, z-score: 289.2, E(): 8.1e-09, (29.4% identity in 364 aa overlap). Also weakly similar to carbomylphosphate synthetases eg. TR:O50302 (EMBL:AJ001805) carbomylphosphate synthetase large subunit from Bacillus subtilis (1064 aa) fasta scores; opt: 150, z-score: 196.8, E(): 0.0011, (25.8% identity in [...] (424 aa)
SCO6347Beta-galactosidase; SC3A7.15, probable beta-galactosidase, len: 595; similar to many e.g. TR:O31341 (EMBL:D88750) beta-galactosidase (EC 3.2.1.23) (lactase) from Bacillus circulans (586 aa), fasta scores; opt: 1648 z-score: 1500.8 E(): 0, 43.0% identity in 584 aa overlap., Contains PS01182 Glycosyl hydrolases family 35 putative active site. (595 aa)
SCO6284SC1G7.10, probable decarboxylase, len: 530 aa; similar to TR:AAK06793 (EMBL:AF324838) Streptomyces antibioticus putative simocyclinone biosynthesis decarboxylase involved in polyketide formation SimA12, 528 aa; fasta scores: opt: 2751 Z-score: 3055.0 bits: 574.9 E(): 1.4e-162; 75.803% identity in 529 aa overlap and to TR:O86517 (EMBL:AL031124) Streptomyces coelicolor putative carboyl transferase SC1C2.16, 527 aa; fasta scores: opt: 2715 Z-score: 3015.0 bits: 567.6 E(): 2.4e-160; 75.094% identity in 530 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferas [...] (530 aa)
SCO6201SC2G5.22, gcl, probable glyoxylate carboligase, acetohydroxy acid synthase-pyruvate oxidase family,len:594aa; highly similar to SW:GCL_ECOLI glyoxylate carboligase from Escherichia coli (592 aa) fasta scores;opt: 2905, z-score: 3262. 8,E(): 0, (72.7% identity in 586aa overlap). Contains Pfam match to entry PF00205TPP_enzymes, Thiamine pyrophosphate enzymes, score 427.80, E-value 4.7e-132. Note: as with the Escherichia coli homologue, this CDS is located close to a glyoxylate induced protein of unknown function. (594 aa)
SCO6155SC1A9.19, poxB, pyruvate oxidase, len: 580aa; similar to many including POXB_ECOLI (EMBL:X04105) PoxB, pyruvate oxidase from Escherichia coli (572 aa) fasta scores; opt:2086, z-score: 2458.4, E():0, (53.1% identity in 571 aa overlap). Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 499.70, E-value 2.4e-154. (580 aa)
SCO6099Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (178 aa)
SCO6098SCBAC1A6.22c, cysD, sulfate adenylyltransferase subunit 2, len: 312 aa; highly similar to SW:MMCV_STRLA (EMBL:AF127374) Streptomyces lavendulae sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) MmcV, 319 aa; fasta scores: opt: 1734 z-score: 2027.7 E(): 0; 81.6% identity in 309 aa overlap and to SW:CYSD_ECOLI (EMBL:M74586) Escherichia coli sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) CysD, 302 aa; fasta scores: opt: 909 z-score: 1066.6 E(): 0; 47.7% identity in 298 aa overlap. Contains Pfam match to entry PF01507 PAPS_reduct, Phosphoadenosine phosphosulfate reductase family. (312 aa)
SCO6097Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (451 aa)
SCO5689SC5H4.13, probable beta-galactosidase, len: 656 aa; similar to SW:BGAL_BACST (EMBL:M13466) Bacillus stearothermophilus beta-galactosidase I (EC 3.2.1.23) (lactase) BgaB, 672 aa; fasta scores: opt: 1761 z-score: 2065.7 E(): 0; 41.3% identity in 634 aa overlap and to TR:CAB76326 (EMBL:AL158061) Streptomyces coelicolor probable beta-galactosidase SC6D11.03c, 681 aa; fasta scores: opt: 1739 z-score: 1719.0 E(): 0; 46.0% identity in 670 aa overlap. (656 aa)
SCO5665SC6A9.02, unknown, len: 213 aa; some similarity to several hypothetical proteins from Caenorhabditis elegans e.g. TR:G3168942 (EMBL:AF068713) T24A6.7 (206 aa), fasta scores; opt: 256 z-score: 328.5 E(): 4.7e-11, 31.2% identity in 154 aa overlap. (213 aa)
SCO5559SC7A1.03, gpsA, glycerol-3-phosphate dehydrogenase, len: 366aa; similar to many eg. SW:GPDA_BACSU glycerol-3-phosphate dehydrogenase from Bacillus subtilis (345 aa) fasta scores; opt: 874, z-score: 1221.4, E(): 0, (41.8% identity in 330 aa overlap). Contains a possible PS00017 ATP /GTP-binding site motif A (P-loop) and Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase, score 295.10, E-value 8.8e-85. (336 aa)
SCO55543-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
SCO5536Hypothetical protein SC1C2.17; SC1C2.17, unknown, len: 65 aa. (65 aa)
SCO5535SC1C2.16, probable carboxyl transferase, len: 527 aa; similar to many e.g. Veillonella parvula TR:Q57079 (EMBL:Z24754) alpha-subunit, methylmalonyl-coa decarboxylase (509 aa), fasta scores; opt: 1929 z-score: 2387.4 E(): 0, 55.9% identity in 510 aa overlap and Myxococcus xanthus TR:O24789 (EMBL:AB007000) propionyl-coa carboxylase (524 aa), fasta scores; opt: 1922 z-score: 2359.6 E(): 0, 55.7% identity in 528 aa overlap. (527 aa)
SCO5525SC1C2.06, ureAB, probable fusion of urease beta and gamma subunits, len: 227 aa; N-terminus is similar to UreA e.g. URE3_ECOLI urease gamma subunit (EC 3.5.1.5) (100 aa), fasta scores; opt: 300 z-score: 398.9 E(): 5.7e-15, 44.4% identity in 99 aa overlap; C-terminus is similar to ureB e.g. URE2_YEREN urease beta subunit (EC 3.5.1.5) (163 aa), fasta scores; opt: 303 z-score: 390.6 E(): 1.6e-14, 40.9% identity in 132 aa overlap. This fusion also exists in Helicobacters, where it is called the urease alpha subunit; URE1_HELFE urease alpha subunit (EC 3.5.1.5) (237 aa), fasta scores; opt: [...] (227 aa)
SCO5471Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
SCO54266-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (341 aa)
SCO5309Conserved hypothetical protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (365 aa)
SCO5281SCCB12.05c, probable 2-oxoglutarate dehydrogenase, len: 1272 aa; similar to TR:P96746 (EMBL:D84102) Corynebacterium glutamicum 2-oxoglutarate dehydrogenase (EC 1.2.4.2) OdhA, 1257 aa; fasta scores: opt: 4321 z-score: 3452.7 E(): 0; 54.8% identity in 1262 aa overlap and to SW:ODO1_ECOLI (EMBL:J01619) Escherichia coli 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) SucA, 933 aa; fasta scores: opt: 2568 z-score: 2056.0 E(): 0; 46.5% identity in 881 aa overlap. Contains Pfam matches to entries PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) and PF0 [...] (1272 aa)
SCO5225Ribonucleotide-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (343 aa)
SCO51832SC3B6.07, possible ATP-dependent DNA helicase, len: 1159 aa; similar to TR:O53347 (EMBL:AL021646) Mycobacterium tuberculosis putative ATP-dependent DNA helicase, MTV014.45c, 1101 aa; fasta scores: opt: 349 z-score: 368.0 E(): 5e-13; 29.2% identity in 1144 aa overlap to SW:UVRD_ECOLI (EMBL:M87049) Escherichia coli DNA helicase II (EC 3.6.1.-) UvrD, 720 aa; fasta scores: opt: 241 z-score: 255.5 E(): 9.2e-07; 26.3% identity in 800 aa overlap and to Streptomyces coelicolor 2SC3B6.08, 1222 aa; fasta scores: opt: 406 z-score: 336.0 E(): 4.2e-13;30.4% identity in 977 aa overlap. Contains Pfa [...] (1159 aa)
SCO5167SCP8.30, conserved hypothetical protein, len: 260 aa; similar to TR:O05856 (EMBL:Z95120) Mycobacterium tuberculosis hypothetical 25.1 kD protein MTCY07D11.16, 231 aa; fasta scores: opt: 599 z-score: 647.2 E(): 1.4e-28; 42.5% identity in 233 aa overlap. Contains 4x degenerate repeat:T(G/A)G. (260 aa)
SCO5071SCBAC20F6.14c, ORFA hydroxylacyl-CoA dehydrogenase, len: 146 aa; identical to previously sequenced TR:Q53925 (EMBL:X62373) Streptomyces coelicolor hydroxylacyl-CoA dehydrogenase ORFA, 146 aa. (146 aa)
SCO5056Putative exoribonuclease large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (402 aa)
SCO5055Putative exoribonuclease; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (88 aa)
SCO49502SCK31.10, narI3, nitrate reductase gamma chain, len: 237 aa; highly similar to SW:NARI_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase gamma chain (EC 1.7.99.4) NarI, 223 aa; fasta scores: opt: 792 z-score: 991.9 E(): 0; 49.6% identity in 234 aa overlap and to TR:Q9RI29 (EMBL:109989) Streptomyces coelicolor putative nitrate reductase delta chain NarI2 SCJ12.31, 256 aa; fasta scores: opt: 813 z-score: 891.7 E(): 0; 54.3% identity in 230 aa overlap. Contains possible hydrophobic membrane spanning regions. (237 aa)
SCO49482SCK31.08, narH3, nitrate reductase beta chain, len: 548 aa; highly similar to SW:NARH_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase beta chain NarH, 487 aa; fasta scores: opt: 2088 z-score: 2047.9 E(): 0; 58.2% identity in 483 aa overlap and to TR:O86716 (EMBL:AL031515) Streptomyces coelicolor NarH, putative nitrate reductase beta chain SC5C7.19, 531 aa; fasta scores: opt: 2542 z-score: 2343.2 E(): 0; 71.6% identity in 503 aa overlap. (548 aa)
SCO49472SCK31.07, narG3, nitrate reductase alpha chain, len: 1227 aa; highly similar to SW:NARG_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase alpha chain (EC 1.7.99.4)NarG, 1228 aa; fasta scores: opt: 4080 z-score: 4618.0 E(): 0; 49.5% identity in 1206 aa overlap and to TR:O86717 (EMBL:AL031515) Streptomyces coelicolor NarG, putative nitrate reductase alpha chain SC5C7.20, 1231 aa; fasta scores: opt: 5648 z-score: 5294.1 E(): 0; 66.6% identity in 1232 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_bin [...] (1227 aa)
SCO4926SCK13.18c, pccB, propionyl-CoA carboxylase complex B subunit, len: 530 aa; identical to previously sequenced TR:Q9X4K7 (EMBL:AF113605) Streptomyces coelicolor propionyl-CoA carboxylase complex B subunit PccB, 530 aa and similar to TR:O86517 (EMBL:AL031124) Streptomyces coelicolor putative carboxyl transferase SC1C2.16, 527 aa; fasta scores: opt: 1958 z-score: 2071.4 E(): 0; 57.4% identity in 526 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. (530 aa)
SCO4925Hypothetical protein SCK13.17c; SCK13.17c, unknown, len: 69 aa. (69 aa)
SCO4858SC5G8.26c, dhsC, possible succinate dehydrogenase membrane subunit, len: 126aa; similar to many eg. TR:O53368 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (112 aa) fasta scores; opt: 484, z-score: 649.2, E(): 1e-28, 65.7% identity in 99 aa overlap. Also wealky similar to SW:P10446 (DHSC_ECOLI) succinate dehydrogenase cytochrome b-556 subunit from Escherichia coli (129 aa) fasta scores; opt: 121, z-score: 173.9, E(): 0.031, 29.6% identity in 71 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochr [...] (126 aa)
SCO4809Succinyl CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SCO4808succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
SCO4801Hypothetical protein SCD63A.12c; SCD63A.12c, unknown, len: 606 aa. High content in alanine amino acid residues. (606 aa)
SCO4797SCD63A.08, probable ATP-dependent DNA helicase II, len: 831 aa; similar to TR:P73465 (EMBL:D90906) Synechocystis sp. DNA helicase II UvrD, 793 aa; fasta scores: opt: 1417 z-score: 1459.4 E(): 0; 40.4% identity in 817 aa overlap and to SW:REP_ECOLI (EMBL:M87049) Escherichia coli ATP-dependent DNA helicase Rep, 673 aa; fasta scores: opt: 824 z-score: 849.5 E(): 0; 37.8% identity in 661 aa overlap. Contains Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). (831 aa)
SCO4774SCD63.06, probable glycerol phosphate dehydrogenase, len: 568 aa; similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD, 555 aa; fasta scores: opt: 815 z-score: 910.2 E(): 0; 32.1% identity in 546 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase and match to Prosite entry PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. (568 aa)
SCO4729DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa)
SCO4655DNA-directed RNA polymerase beta' chain (fragment); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1299 aa)
SCO4654DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1161 aa)
SCO4617SCD39.17c, possible ATP-binding protein, len: 490 aa. Contains match to Prosite entry and PS00017 ATP/GTP-binding site motif A (P-loop). (490 aa)
SCO4607SCD39.07, nuoM2, NADH dehydrogenase subunit, len: 534 aa; similar to SW:NUOM_ECOLI (EMBL:X68301) Escherichia coli NADH dehydrogenase I chain M (EC 1.6.5.3) NuoM, 509 aa; fasta scores: opt: 721 z-score: 798.7 E(): 0; 33.9% identity in 528 aa overlap and to TR:Q9XAR6 (EMBL:AL078618) Streptomyces coelicolor SCD16A.09c, NuoM, NADH dehydrogenase subunit, 523 aa; fasta scores: opt: 462 z-score: 441.4 E(): 6e-19; 34.1% identity in 537 aa overlap. Contains Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains and possible hydrophobic membrane spanni [...] (534 aa)
SCO4605NADH dehydrogenase subunit NuoK2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (130 aa)
SCO4603NADH dehydrogenase subunit NuoI2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (197 aa)
SCO4600NADH dehydrogenase subunit NuoB2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (232 aa)
SCO4574SCD16A.09c, nuoM, NADH dehydrogenase subunit, len: 523 aa; similar to many e.g. TR:O53307 (EMBL:AL021646) NuoM, NADH dehydrogenase subunit from Mycobacterium tuberculosis (553 aa) fasta scores; opt: 1621, z-score: 1842.0, E(): 0, (56.6% identity in 541 aa overlap) and SW:NUOM_ECOLI, NADH dehydrogenase subunit NuoM from Escherichia coli (509 aa) fasta scores; opt: 970, z-score: 1103.8, E(): 0, (35.1% identity in 513 aa overlap). Contains Pfam match to entry PF00361 oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains. Contains possible membrane spanning hydrophobic regions. (523 aa)
SCO4570NuoI, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (211 aa)
SCO4568NuoG, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I 75 kDa subunit family. (843 aa)
SCO4567NuoF, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I 51 kDa subunit family. (449 aa)
SCO4566SCD16A.17c, nuoE, NADH dehydrogenase subunit, len: 290 aa; similar to many e.g. TR:P95177 (EMBL:Z83867) NuoE, NADH dehydrogenase subunit from Mycobacterium tuberculosis (252 aa) fasta scores; opt: 1002, z-score: 1072.0, E(): 0, (69.5% identity in 213 aa overlap) and SW:NUHM_RAT NADH-ubiquinone dehydrogenase subunit from Rattus norvegicus (Rat) (241 aa) fasta scores; opt: 419, z-score: 454.9, E(): 5.2e-18, (38.1% identity in 181 aa overlap). Contains Pfam match to entry PF01257 complex1_24kD, Respiratory-chain NADH dehydrogenase 24 Kd subunit. (290 aa)
SCO4563NuoB, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
SCO4380SCD10.12, probable acetyl/propionyl CoA carboxylase, beta subunit, len: 532 aa; similar to TR:O86318 (EMBL:Z79700) Mycobacterium tuberculosis AccD2, 529 aa; fasta scores: opt: 2691 z-score: 3002.4 E(): 0; 75.5% identity in 530 aa overlap and to TR:AAF35258 (EMBL:AF059510) Arabidopsis thaliana 3-methylcrotonyl-CoA carbosylase non-biotinylated subunit (EC 6.4.1.4) MccB, 587 aa; fasta scores: opt: 1186 z-score: 1323.2 E(): 0; 48.0% identity in 546 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. (532 aa)
SCO4145Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (774 aa)
SCO4111Conserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (271 aa)
SCO4067DNA polymerase III subunit gamma; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (784 aa)
SCO3881Putative ribonuclease P component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (123 aa)
SCO3878DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (376 aa)
SCO3822SCGD3.23c, conserved hypothetical protein, len: 179 aa; unknown function, highly similar to SW:Y0GE_MYCTU (EMBL:Z80343) Mycobacterium tuberculosis hypothetical protein (178 aa), fasta scores; opt: 692 z-score: 731.2 E(): 0, 65.9% identity in 170 aa overlap. (179 aa)
SCO3646Putative oxidoreductase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (271 aa)
SCO3479SCE65.15c, possible beta-galatosidase, len: 995 aa; similar to SW:BGAL_ECOLI (EMBL:J01636) Escherichia coli beta-galactosidase (EC 3.2.1.23) (lactase) lacZ, 1023 aa; fasta scores: opt: 1594 z-score: 1693.3 E(): 0; 33.6% identity in 1039 aa overlap. Contains Pfam match to entry PF00703 Glyco_hydro_2, Glycosyl hydrolases family and match to Prosite entry PS00719 Glycosyl hydrolases family 2 signature 1. (995 aa)
SCO3123Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
SCO3096Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SCO2776SCC105.07, accD1, acetyl/propionyl CoA carboxylase, beta subunit, len: 538 aa; similar to TR:O06165 (EMBL:Z95556) Mycobacterium tuberculosis, hypothetical 56.7 kD protein MTCY07A7.08c, 529 aa; fasta scores: opt: 2749 z-score: 3110.3 E(): 0; 76.5% identity in 532 aa overlap and to TR:AAF35258 (EMBL:AF059510) Arabidopsis thaliana 3-methylcrotonyl-CoA carboxylase non-biotinylated subunit (EC 6.4.1.4) MccB, 587 aa; fasta scores: opt: 2185 z-score: 2471.8 E(): 0; 60.4% identity in 540 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. (538 aa)
SCO2737Putative deoxyribonuclease; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.; Belongs to the RecD family. RecD-like subfamily. (753 aa)
SCO2727Hypothetical protein SCC46.12c; SCC46.12c, improbable CDS predicted by HMM, len: 125 aa. (125 aa)
SCO2694Hypothetical protein; SCC61A.15, unknown, len: 180aa. (180 aa)
SCO2617ATP dependent Clp Protease ATP binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (428 aa)
SCO2573Putative oxidoreductase; SCC123.11, possible oxidoreductase, len: 524 aa. Weakly similar to several including: Homo sapiens (Human) SW:NUBM_HUMAN(EMBL:Y17379) NADH-ubiquinone oxidoreductase 51 KD subunit precursor (EC 1.6.5.3) (464 aa), fasta scores opt: 341 z-score: 369.2 E(): 3.6e-13 27.1% identity in 365 aa overlap and Streptomyces coelicolor TR:Q9XAQ9(EMBL:AL078618) NADH dehydrogenase subunit, NuoF (449 aa), fasta scores opt: 398 z-score: 430.5 E(): 1.4e-16 26.5% identity in 392 aa overlap. (524 aa)
SCO2564SCC123.02c, possible DNA-binding protein, len: 336 aa. Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:P71730 (EMBL:Z81368) hypothetical 33.1 KD protein (316 aa), fasta scores opt: 792 z-score: 880.3 E():0 42.4% identity in 316 aa overlap. Note that codon 21 may be an alternative translational start site. Contains a possible helix-turn-helix motif situated between residues 263..284 (+2.96 SD). (336 aa)
SCO2473SC7A8.12, probable nitrate reductase, len: 819 aa; similar to SW:NASC_BACSU (EMBL:D50453) Bacillus subtilis assimilatory nitrate reductase catalytic subunit (EC 1.7.99.4) NasC, 710 aa; fasta scores: opt: 1568 z-score: 1572.1 E(): 0; 37.9% identity in 816 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_binding, Molydopterin dinucleotide binding domain. Contains also glycine/serine rich region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (819 aa)
SCO2468DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (641 aa)
SCO2445SCC24.16, probable acetyl CoA carboxylase (alpha and beta subunits), len: 458 aa; N-terminal region similar to SW:ACCD_ECOLI (EMBL:M32445) Escherichia coli acetyl-Coenzyme A carboxylase carboxyl transferase subunit beta (EC 6.4.1.2) AccD, 304 aa; fasta scores: opt: 368 z-score: 366.2 E(): 5.8e-13; 32.4% identity in 238 aa overlap and C-terminal region similar to TR:AAF10787 (EMBL:AE001970) Deinococcus radiodurans acetyl-CoA carboxylase carboxyl transferase alpha subunit DR1214, 316 aa; fasta scores: opt: 366 z-score: 364.0 E(): 7.7e-13; 39.9% identity in 223 aa overlap. (458 aa)
SCO2430SCC24.01, possible sugar hydrolase (fragment) (putative secreted protein), len: >407 aa; similar to C-terminal region of SW:BGAL_ASPNG (EMBL:L06037) Aspergillus niger beta galactosidase precursor (EC 3.2.1.23) LacA, 1006 aa; fasta scores: opt: 214 z-score: 223.7 E(): 5e-05; 27.1% identity in 321 aa overlap; SCC42.11, probable secreted beta-galactosidase (fragment), len: >555 aa; similar to SW:BGAL_ASPNG (EMBL:L06037) Aspergillus niger beta-galactosidase precursor (EC 3.2.1.23) LacA, 1006 aa; fasta scores: opt: 413 z-score: 403.4 E(): 5.4e-15; 24.3% identity in 608 aa overlap. Contains [...] (933 aa)
SCO2371Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (918 aa)
SCO2363SCC8A.21c, possible ATP/GTP-binding protein, len: 388aa; similar to TR:AAF11768 (EMBL:AE002054) hypothetical protein from Deinococcus radiodurans (310 aa) fasta scores; opt: 146, z-score: 175.2, E(): 0.027, 32.0% identity in 347 aa overlap. Contains Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). (388 aa)
SCO2277SCC75A.23, possible membrane protein, len: 290 aa. Highly similar to many proteins of undefined function including: Escherichia coli SW:YCDN_ECOLI(EMBL:AE000203) YcdN (276 aa), fasta scores opt: 693 z-score: 817.1 E():0 41.6% identity in 267 aa overlap and Synechocystis sp. (strain PCC 6803) SW:Y964_SYNY3(EMBL:D90901) (308 aa), fasta scores opt: 363 z-score: 431.0 E(): 1.2e-16 30.4% identity in 303 aa overlap. (290 aa)
SCO2183Putative pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (899 aa)
SCO2181SC5F7.20, sucB, possible dihydrolipoamide succinyltransferase, len: 590 aa; similar to many egs. TR:AAC23517 (EMBL:AF068740) dihydrolipoamide succinyltransferase from Pseudomonas ovalis (407 aa) fasta scores; opt: 847, z-score: 602.5, E(): 3.2e-26, (41.9% identity in 453 aa overlap) and SW:ODO2_MYCTU dihydrolipoamide succinyltransferase from Mycobacterium tuberculosis (553 aa) fasta scores; opt: 1232, z-score: 866.2, E(): 0, (56.2% identity in 596 aa overlap). Contains two Pfam matches to entry PF00364 biotin_lipoyl, Biotin-requiring enzymes, Pfam match to entry PF00198 2-oxoacid_dh, 2 [...] (590 aa)
SCO21196-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (342 aa)
SCO2033SC4G6.02, possible citrate lyase beta chain, len: 274 aa; similar to SW:CILB_KLEPN citrate lyase beta chain from Klebsiella pneumoniae (289 aa) fasta scores; opt: 293, z-score: 325.3, E(): 8.5e-11, (33.5% identity in 284 aa overlap); Belongs to the HpcH/HpaI aldolase family. (274 aa)
SCO1966ABC excision nuclease subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissoc [...] (712 aa)
SCO1958ABC excision nuclease subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1014 aa)
SCO1953ABC excision nuclease subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (728 aa)
SCO1848Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa)
SCO1671SCI52.13, hypothetical protein, len: 772 aa; N-terminal region (first 89 aa) similar to N-terminal region of TR:O05479 (EMBL:M86351) Streptomyces sp. hypothetical protein 481 aa and rest of the CDS similar to C-terminal region of TR:Q9RT63 (EMBL:AE002029) Deinococcus radiodurans exodeoxyribonuclease V, subunit RecD, putative DR1902, 715 aa; fasta scores: opt: 298 Z-score: 242.2 bits: 55.5 E(): 6.5e-06; 31.023% identity in 577 aa overlap. (772 aa)
SCO1664SCI52.06, conserved hypothetical protein, len: 265 aa; similar to TR:O06242 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 28.3 kDa protein MTCY270.35, 262 aa; fasta scores: opt: 495 Z-score: 595.6 bits: 117.9 E(): 1.4e-25; 50.951% identity in 263 aa overlap. (265 aa)
SCO1661SCI52.03, probable glycerol-3-phosphate dehydrogenase, len: 538 aa; similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD, 555 aa; fasta scores: opt: 751 Z-score: 835.1 bits: 164.3 E(): 6.1e-39; 30.830% identity in 506 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase. (538 aa)
SCO1651Conserved hypothetical protein SCI41.34c; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (300 aa)
SCO1648AAA ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. (588 aa)
SCO164420S proteasome beta-subunit precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. (281 aa)
SCO164320S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity. Belongs to the peptidase T1A family. (254 aa)
SCO1594SCI35.16c, pheT, proabable phenylalanyl-tRNA synthetase beta chain, len: 840 aa; similar to many e.g. SYFB_ECOLI phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) (795 aa), fasta scores; opt: 988 z-score: 1290.9 E(): 0, 36.0% identity in 849 aa overlap. Contains PS00017 ATP/GTP-binding. (840 aa)
SCO1522Conserved hypothetical protein SCL2.12c; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (202 aa)
SCO1519Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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