STRINGSTRING
SCO6785 SCO6785 SCO2881 SCO2881 SCO3051 SCO3051 SCO3079 SCO3079 SCO3130 SCO3130 SCO3228 SCO3228 SCO3247 SCO3247 SCO3800 SCO3800 SCO4084 SCO4084 SCO4366 SCO4366 SCO4382 SCO4382 SCO4502 SCO4502 SCO4833 SCO4833 SCO4859 SCO4859 SCO4971 SCO4971 SCO4972 SCO4972 SCO5080 SCO5080 SCO5186 SCO5186 SCO0090 SCO0090 SCO0124 SCO0124 SCO0312 SCO0312 SCO0362 SCO0362 SCO0586 SCO0586 SCO0668 SCO0668 SCO0729 SCO0729 SCO5291 SCO5291 SCO5399 SCO5399 SCO5538 SCO5538 SCO5542 SCO5542 SCO5693 SCO5693 SCO5879 SCO5879 SCO5984 SCO5984 SCO6027 SCO6027 SCO6067 SCO6067 SCO6106 SCO6106 SCO6143 SCO6143 SCO6209 SCO6209 SCO6211 SCO6211 SCO6248 SCO6248 SCO6469 SCO6469 SCO6583 SCO6583 SCO6701 SCO6701 SCO6730 SCO6730 SCO6731 SCO6731 SCO6788 SCO6788 SCO6791 SCO6791 SCO6796 SCO6796 SCO6938 SCO6938 SCO6941 SCO6941 SCO6967 SCO6967 SCO7420 SCO7420 SCO7465 SCO7465 SCO7511 SCO7511 SCP1.04c SCP1.04c mmfH mmfH SCP1.350 SCP1.350 SCO0763 SCO0763 SCO0880 SCO0880 SCO0985 SCO0985 SCO1112 SCO1112 SCO1158 SCO1158 SCO1197 SCO1197 SCO1198 SCO1198 SCO1209 SCO1209 SCO1273 SCO1273 SCO1285 SCO1285 SCO1286 SCO1286 SCO1324 SCO1324 SCO1400 SCO1400 SCO1428 SCO1428 SCO1628 SCO1628 SCO1690 SCO1690 SCO1701 SCO1701 SCO1750 SCO1750 SCO1784 SCO1784 SCO1947 SCO1947 SCO2032 SCO2032 SCO2304 SCO2304 SCO2779 SCO2779
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SCO6785SC6A5.34, probable fatty acid co-A racemase, len: 387aa; similar to egs. TR:O06543 (EMBL:Z95584) hypothetical protein from Mycobacterium tuberculosis (360 aa) fasta scores; opt: 1304, z-score: 1373.1, E(): 0, (52.8% identity in 362 aa overlap) and TR:O09176 (EMBL:U89905) alpha-methylacyl-CoA racemase from rat liver (Rattus norvegicus) (361 aa) fasta scores; opt: 985, z-score: 1039.0, E(): 0, (44.4% identity in 342 aa overlap); Belongs to the CoA-transferase III family. (387 aa)
SCO2881SCE6.18, cvnC12, unknown, len: 117 aa. Similar to many proteins of undefined function from Streptomyces coelicolor e.g. TR:CAB71243 (EMBL:AL138598) SC1A2.05 (126 aa), fasta scores opt: 194 z-score: 251.3 E(): 1.4e-06 38.7% identity in 119 aa overlap and TR:Q9X834 (EMBL:AL049727) SC9B1.14C (119 aa), fasta scores opt: 192 z-score: 249.3 E(): 1.9e-06 37.9% identity in 124 aa overlap. (117 aa)
SCO3051SCBAC19G2.06c, fadE, acyl-CoA dehydrogenase, len: 385 aa: similar to many e.g. TR:Q9RIQ5 (EMBL:AJ250495) fatty acid acyl CoA dehydrogenase FadE from Streptomyces lividans (385 aa) fasta scores; opt: 2480, Z-score: 2753.5, 99.740% identity (99.740% ungapped) in 385 aa overlap and SW:P45867 (ACDA_BACSU) acyl CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores; opt: 1214, Z-score: 1351.1, 53.600% identity (54.472% ungapped) in 375 aa overlap. Also similar to TR:Q9RKY7 (EMBL:AL133213) SC6D7.11 Acd acyl CoA dehydrogenase from Streptomyces coelicolor (391 aa) fasta scores; opt: 10 [...] (385 aa)
SCO3079SCE25.20, probable thiolase, len: 406 aa; similar to SW:CATF_ACICA (EMBL:AF009224) Acinetobacter calcoaceticus beta-ketoadipyl CoA thiolase (EC 2.3.1.-) CatF, 401 aa; fasta scores: opt: 957 z-score: 1066.1 E(): 0; 40.0% identity in 415 aa overlap and to TR:CAB45575 (EMBL:AL079355) Streptomyces coelicolor PcaF, beta-ketoadipyl CoA thiolase SC4C6.11c, 400 aa; fasta scores: opt: 895 z-score: 916.7 E(): 0; 38.9% identity in 409 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase and match to Prosite entry PS00737 Thiolases signature 2; Belongs to the thiolase-like superfami [...] (406 aa)
SCO3130SCE66.09, possible dehydratase, len: 391 aa; similar to many e.g. SW:P31572 (CAIB_ECOLI) L-carnitine dehydratase from Escherichia coli (405 aa) fasta scores; opt: 440, z-score: 478.4, E(): 3.6e-19, 28.7% identity in 401 aa overlap; Belongs to the CoA-transferase III family. (391 aa)
SCO3228SCE63.05, probable glycolate oxidase, len: 377 aa; similar to many both prokaryotic and eukaryotic e.g. TR:O52792 (EMBL:AJ223998) similar to glycolate oxidase from a cluster of genes nvolved in the biosynthesis of a vancomycin group antibiotic in Amycolatopsis orientalis (Actinomycete) (357 aa) fasta scores; opt: 995, z-score: 998.4, E(): 0, (47.5% identity in 343 aa overlap) and SW:GOX_SPIOL glycolate oxidase from Spinacia oleracea (spinach) (369 aa) fasta scores; opt: 917, z-score: 920.7, E(): 0, (41.9% identity in 360 aa overlap). Contains Pfam match to entry PF01070 FMN_dh, FMN-dep [...] (377 aa)
SCO3247SCE29.16c, possible acyl CoA oxidase, len: 600 aa; similar to many acyl CoA oxidases, especially from eukaryotes e.g. SW:CAOP_RAT acyl CoA oxidase from Rattus norvegicus (rat) (661 aa) fasta scores; opt: 462, z-score: 477.6, E(): 2.7e-19, (27.8% identity in 425 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). (600 aa)
SCO3800SCGD3.01, possible acyl-CoA dehydrogenase, partial CDS, len: >491 aa; weakly similar to TR:P97088 (EMBL:Z92974), bcd, Clostridium thermosaccharolyticum butyryl-CoA dehydrogenase (379 aa), fasta scores; opt: 176 z-score: 203.7 E(): 0.00051, 28.0% identity in 318 aa overlap. Also highly similar to putative acyl-CoA dehydrogenases from mycobacteria e.g. TR:O69506 (EMBL:AL022486) Mycobacterium leprae probable acyl-CoA dehydrogenase (611 aa) (64.3% identity in 493 aa overlap). Contains two Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase; SCAC2.08, possible dehydrogenase (f [...] (608 aa)
SCO4084Hypothetical protein SCD25.20; SCD25.20, unknown, len: 437 aa. Similar in parts to Mycobacterium tuberculosis TR: O06627 (EMBL; Z95618) hypothetical 13.5 KD protein MTCY07H7A.02C (129 aa),fasta scores opt: 333 z-score: 391.1 E(): 2e-14 54.0% identity in 100 aa overlap and Mycobacterium leprae TR:O05761 (EMBL; Z95151) hypothetical 14.0 KD protein MLCB5.37 (131 aa), fasta scores opt: 328 z-score: 385.3 E(): 4.1e-14 52.5% identity in 101 aa overlap. (202 aa)
SCO4366Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa)
SCO4382SCD10.14, probable acyl CoA dehydrogenase, len: 382 aa; similar to SW:ACDB_MYCTU (EMBL:Z79700) Mycobacterium tuberculosis probable acyl CoA dehydrogenase MTCY10D7.02, 388 aa; fasta scores: opt: 1694 z-score: 1964.7 E(): 0; 64.3% identity in 387 aa overlap. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (382 aa)
SCO4502SCD35.09, probable ketoacyl CoA thiolase, len: 428 aa; similar to TR:O86361 (EMBL:AL021929) Mycobacterium tuberculosis FadA2, 440 aa; fasta scores: opt: 1585 z-score: 1791.9 E(): 0; 63.0% identity in 446 aa overlap and to SW:THIK_ECOLI (EMBL:M87049) Escherichia coli 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (fatty oxidation complex beta subunit) (beta-ketothiolase) (acetyl-CoA acyltransferase) FadA, 387 aa; fasta scores: opt: 453 z-score: 515.8 E(): 2.7e-21; 30.9% identity in 430 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase; Belongs to the thiolase-like superfamily. [...] (428 aa)
SCO4833SC5G8.01c, partial CDS, possible phosphorylmutase, len: >101 aa; similar to many e.g. SW:P11435 (CPPM_STRHY) carboxyvinyl-carboxyphosphonate phosphorylmutase from Streptomyces hygroscopicus (294 aa) fasta scores; opt: 185, z-score: 234.7, E(): 1.3e-05, 43.0% identity in 93 aa overlap; SC2A6.18c, possible transferase (fragment), len: >172 aa; similar to C-terminal part of SW:CPPM_BACSU (EMBL:D84432) Bacillus subtilis putative carboxyvinyl-carboxyphosphonate phosphorylmutase (EC 2.7.8.23) YqiQ, 301 aa; fasta scores: opt: 158 z-score: 187.0 E(): 0.0062; 31.0% identity in 116 aa overlap. (243 aa)
SCO4859Hypothetical protein; SC5G8.27c, unknown, len: 183 aa; similar to TR:Q9Z593 (EMBL:AL035478) hypothetical protein from Streptomyces coelicolor (191 aa) fasta scores; opt: 164, z-score: 195.7, E(): 0.0019, 32.6% identity in 187 aa overlap. (183 aa)
SCO49712SCK31.31, possible dehydrogenase, len: 497 aa; similar to N-terminal domain of SW:XDH_MOUSE (EMBL:X75129) Mus musculus xanthine dehydrogenase/oxidase Xdh, 1335 aa; fasta scores: opt: 345 z-score: 361.7 E(): 1.3e-12 31.5% identity in 483 aa overlap and to TR:O54050 (EMBL:AJ001013) Rhodobacter capsulatus xanthine dehydrogenase (EC 1.1.1.204) XdhA, 462 aa; fasta scores: opt: 631 z-score: 669.1 E(): 9.8e-30; 38.2% identity in 495 aa overlap. Contains Pfam matches to entries PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, PF01799 fer2_2, [2Fe-2S] binding domain and PF00941 dehydr [...] (497 aa)
SCO49722SCK31.32, possible dehydrogenase, len: 806 aa; similar to the C-terminal region of SW:XDH_MOUSE (EMBL:X75129) Mus musculus xanthine dehydrogenase/oxidase Xdh, 1335 aa; fasta scores: opt: 1456 z-score: 1610.8 E(): 0; 43.3% identity in 767 aa overlap. Contains Pfam match to entry PF01315 Ald_Xan_dh_C, Aldehyde oxidase and xanthine dehydrogenase, C terminus. (806 aa)
SCO5080Putative hydrolase; SCBAC28G1.06, actVA5, possible hydrolase, len: 381 aa; identical to previously sequenced TR:Q53907 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster, ActVA5, 381 aa and similar to TR:Q9F0J3 (EMBL:AF218066) Streptomyces arenae hydrolase NcnH, 405 aa; fasta scores: opt: 1391 Z-score: 1521.5 bits: 290.3 E(): 3.9e-77; 56.522% identity in 368 aa overlap. (381 aa)
SCO51862SC3B6.10, conserved hypothetical protein, len: 318 aa; similar to TR:O53345 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 33.8 kD protein MTV014.43c, 313 aa; fasta scores: opt: 334 z-score: 389.2 E(): 3.3e-14; 33.3% identity in 318 aa overlap. (318 aa)
SCO0090Putative transposase; SCJ11.19c, partial CDS, possible transposase, len: 140 aa; similar to SW:IS12_STRAL IS112 28,4 kD protein from Streptomyces albus (256 aa) fasta scores; opt: 349, z-score: 447.9, E(): 1.4e-17, (53.9% identity in 128 aa overlap). (140 aa)
SCO0124Hypothetical protein; SCJ21.05, unknown, len: 453 aa; similar in part to several polyketide synthases, e.g. HETM_ANASP polyketide synthase HETM (506 aa), fasta scores; opt: 252 z-score: 267.0 E(): 1.6e-07, 33.7% identity in 199 aa overlap, and TR:Q50858 (EMBL:U24657) saframycin MX1 synthetase A (2605 aa), fasta scores; opt: 244 z-score: 248.0 E(): 1.9e-06, 28.5% identity in 372 aa overlap. Contains TTA Leu codon; possible target for regulation by bldA. (453 aa)
SCO0312SC5G9.21, probable acyl-CoA dehydrogenase, len: 389 aa; similar to both bacterial and eukaryotic acyl-CoA dehydrogenases e.g. SW:ACDS_HUMAN (EMBL:M26393), AcaDS, Homo sapiens mitochondrial acyl-CoA dehydrogenase short-chain specific precursor (412 aa), fasta scores; opt: 653 z-score: 771.4 E(): 0, 34.8% identity in 376 aa overlap. Also similar to SCI30A.22C (EMBL:AL096811) Streptomyces coelicolor probable acyl-CoA dehydrogenase. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (389 aa)
SCO0362SCF41.21, possible racemase, len: 403 aa. Weakly similar to Eukaryotic and Prokaryotic racemases e.g. Homo sapiens (Human) TR:O43673 (EMBL; AF047020) alpha-methylacyl-CoA racemase (EC 5.1.99.4) (382 aa), fasta scores opt: 466 z-score: 544.7 E(): 5.5e-23 31.1% identity in 392 aa overlap and Streptomyces coelicolor TR:CAB40680 (EMBL; AL049587) putative racemase SC5F2A.13 (398 aa), fasta scores opt: 508 z-score: 593.2 E(): 1.1e-25 34.5% identity in 383 aa overlap; Belongs to the CoA-transferase III family. (403 aa)
SCO0586SCF55.10c, cvnC11, hypothetical protein, len: 113 aa; similar to various hypothetical proteins, e.g: TR:CAB41560 (EMBL:AL049727) Streptomyces coelicolor hypothetical 12.8 KD protein SC9B1.14c, 119 aa; fasta scores:opt: 264 z-score: 363.7 E(): 7e-13; 51.8% identity in 112 aa overlap. (113 aa)
SCO0668SCF91.28c, possible flavoprotein, len: 530 aa. Highly similar to two hypothetical proteins from Mycobacterium tuberculosis e.g. TR:O53525 (EMBL:AL021925) hypothetical 49.8 KD protein (457 aa), fasta scores opt: 1698 z-score: 1838.9 E():0 57.7% identity in 461 aa overlap. Also similar to several eukaryotic alkyldihydroxyacetonephosphate synthases (EC 2.5.1.26) e.g. from Homo sapiens (Human) SW:ADAS_HUMAN (EMBL:Y09443) (658 aa), fasta scores opt: 598 z-score: 648.1 E(): 1e-28 30.4% identity in 573 aa overlap. Contains a Pfam match to entry PF01565 FAD_binding_4, FAD binding domain. (530 aa)
SCO07293SC5B7.07, conserved hypothetical protein, len: 140 aa; similar to TR:O27449 (EMBL:AE000902) Methanobacterium thermoautotrophicum conserved protein MTH1398, 133 aa; fasta scores: opt: 122 z-score: 167.4 E(): 0.085; 26.7% identity in 116 aa overlap. (140 aa)
SCO5291SC6G9.42c, cvnC5, conserved hypothetical protein, len: 150 aa; similar to hypothetical proteins of varying length (divergent at the N-terminus) from S. coelicolor and Mycobacterium tuberculosis e.g. TR:O86523 (EMBL:AL031124) S.coelicolor hypothetical protein (132 aa), fasta scores; opt: 250 z-score: 312.1 E(): 4.7e-10, 43.7% identity in 135 aa overlap and TR:O50392 (EMBL:AL009198) Mycobacterium tuberculosis hypothetical protein (122 aa) (37.4% identity in 131 aa overlap). (150 aa)
SCO5399SC8F4.03, thiL, probable acetoacetyl-coA thiolase, len: 401aa; similar to many eg. SW:P14611 (THIL_ALCEU) acetoacetyl-coA thiolase from Alcaligenes eutrophus (393 aa) fasta scores; opt: 1272, z-score: 1344.2, E(): 0, 53.6% identity in 390 aa overlap. Also similar to TR:Q9XAM9 (EMBL:AL079355) beta-ketoadipyl-coA thiolase from Streptomyces coelicolor (cosmid 4C6) (400 aa) fasta scores; opt: 949, z-score: 919.8, E(): 0, 42.0% identity in 393 aa overlap. Contains Pfam match to entry PF00108 thiolase and Prosite matches to PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiola [...] (401 aa)
SCO5538Conserved hypothetical protein SC1C2.19c; SC1C2.19c, cvnC2, unknown, len: 190 aa; N-terminus is Pro-rich, C-terminus has similarity to M. tuberculosis hypothetical protein TR:O50392 (EMBL:AL009198) MTV004.20C (122 aa), fasta scores; opt: 231 z-score: 217.7 E(): 7.1e-05, 41.0% identity in 122 aa overlap. C-terminus is 84.7% identical to upstream gene SC3A9.23c. (190 aa)
SCO5542Hypothetical protein SC1C2.23c; SC1C2.23c, cvnC1, unknown, len: 132 aa; similar to M. tuberculosis hypothetical protein TR:O50392 (EMBL:AL009198) MTV004.20C (122 aa), fasta scores; opt: 236 z-score: 328.3 E(): 4.9e-11, 38.5% identity in 122 aa overlap. C-terminus is 84.7% identical to downstream gene SC1C2.19c. (132 aa)
SCO5693SC5H4.17, probable acyl CoA dehydrogenase, len: 658 aa; similar to SW:ACDV_BOVIN (EMBL:U30817) Bos taurus acyl-CoA dehydrogenase, very-long-chain specific precursor (EC 1.3.99.-) VlcaD, 655 aa; fasta scores: opt: 768 z-score: 864.8 E(): 0; 31.0% identity in 616 aa overlap. Contains 2x Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (658 aa)
SCO5879Acyl-coa dehydrogenase RedW; Involved in the biosynthesis of undecylprodigiosin. Catalyzes the desaturation of the L-prolyl-[prolyl-carrier protein] to yield 1H-pyrrole-2-carbonyl- [prolyl-carrier protein]. (391 aa)
SCO5984SCBAC16H6.19, possible acyl-CoA dehydrogenase, len: 391aa: similar to many eg. SW:P16219 (ACDS_HUMAN) acyl-CoA dehydrogenase from Homo sapiens (412 aa) fasta scores; opt: 676, Z-score: 741.3, 35.121% identity (37.006% ungapped) in 373 aa overlap and SW:P96879 (ACDP_MYCTU) probable acyl-CoA dehydrogenase from Mycobacterium tuberculosis (389 aa) fasta scores; opt: 735, Z-score: 805.9, 35.676% identity (37.394% ungapped) in 370 aa overlap. Contains Pfam match to entry PF02770 Acyl-CoA_dh_M, Acyl-CoA dehydrogenase, middle domain; Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogen [...] (391 aa)
SCO6027SC1C3.15c, probable acetyl-coA acetyltransferase (thiolase), len: 405 aa; similar to many e.g. E. coli TR:E242886 (EMBL:X97452 acetyl-coA acetyltransferase paaJ (401 aa), fasta scores; opt: 718 z-score: 1313.7 E(): 0, 42.6% identity in 408 aa overlap. Contains Pfam match to entry thiolase PF00108, Thiolases, score 410.31; Belongs to the thiolase-like superfamily. Thiolase family. (405 aa)
SCO6067Hypothetical protein; SC9B1.14c, cvnC6, unknown, len: 119 aa; similar to other hypothetical proteins egs. two from Streptomyces coelicolor: TR:O86520 (EMBL:AL031124) (190 aa) fasta scores; opt: 242, z-score: 321.0, E(): 1.5e-10, (39.8% identity in 118 aa overlap) and TR:O86523 (EMBL:AL031124) (132 aa) fasta scores; opt: 228, z-score: 305.7, E(): 1e-09, (39.3% identity in 112 aa overlap), and TR:O50392 (EMBL:AL009198) from Mycobacterium tuberculosis (122 aa) fasta scores; opt: 188, z-score: 255.2, E(): 6.8e-07, (37.5% identity in 120 aa overlap). (119 aa)
SCO6106SCBAC1A6.30c, possible acyl-CoA dehydrogenase, len: 557 aa; similar to SW:AIDB_ECOLI (EMBL:L20915) Escherichia coli AidB protein, 541 aa; fasta scores: opt: 916 z-score: 1055.7 E(): 0; 45.5% identity in 539 aa overlap and to TR:CAC13064 (EMBL:AL445503) Streptomyces coelicolor putative oxidoreductase 2SCG38.05, 567 aa; fasta scores: opt: 1480 z-score: 1414.3 E(): 0; 61.8% identity in 555 aa overlap. Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase and match to Prosite entry PS00072 Acyl-CoA dehydrogenases signature 1 and PS00073 Acyl-CoA dehydrogenases signature 2. (557 aa)
SCO6143SC1A9.07, hypothetical protein, len: 251 aa; similar to TR:O33986 (EMBL:U82823) hypothetical protein from Saccharopolyspora erythraea (266 aa), fasta scores; opt: 740, z-score: 869.0, E(): 0, (53.4% identity in 251 aa overlap). (251 aa)
SCO6209Hypothetical protein SC2G5.30; SC2G5.30, unknown, len: 191 aa; limited similarity to TR:O32141 (EMBL:Z99120) hypothetical protein from Bacillus subtilis (494 aa) fasta scores; opt: 204, z-score: 241.2,E(): 3.8e-06, (27.8% identity in 162 aa overlap). (191 aa)
SCO6211Putative uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (311 aa)
SCO6248SCAH10.13, possible allantoicase, len: 376 aa; similar to SW:ALC_NEUCR (EMBL:J02927) Neurospora crassa allantoicase (EC 3.5.3.4) Alc, 354 aa; fasta scores: opt: 270 z-score: 320.1 E(): 1.9e-10; 35.0% identity in 334 aa overlap; Belongs to the allantoicase family. (376 aa)
SCO6469SC9C7.05c, possible acyl-CoA dehydrogenase, len: 401aa; similar to many from prokaryotes and eukaryotes egs. SW:ACDB_BACSU acyl-CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores; opt: 520, z-score: 1209.6, E(): 0, (38.9% identity in 386 aa overlap) and SW:ACDM_MOUSE acyl-CoA dehydrogenase from Mus musculus (mouse) (421 aa) fasta scores; opt: 484, z-score: 1178.1, E(): 0, (40.3% identity in 390 aa overlap). Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (401 aa)
SCO6583Putative transferase; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl- CoA to oxalate (By similarity); Belongs to the CoA-transferase III family. Frc subfamily. (410 aa)
SCO6701SC4C6.11c, pcaF, beta-ketoadipyl-CoA thiolase, len: 400 aa; highly similar to pcaF (EMBL:AF117893) Streptomyces sp. 2065 beta-ketoadipyl-CoA thiolase (400 aa), fasta scores; opt: 2314 z-score: 2497.6 E(): 0, 87.4% identity in 397 aa overlap. Highly similar others from S.coelicolor e.g. (EMBL:AL049587), SC5F2A.14, S.coelicolor probable thiolase (404 aa) (40.2% identity in 423 aa overlap). Contains Pfam match to entry PF00108 thiolase, Thiolase, PS00099 Thiolases active site, PS00098 Thiolases acyl-enzyme intermediate signature and PS00737 Thiolases signature 2; Belongs to the thiolase-l [...] (400 aa)
SCO6730SC5F2A.13, possible racemase, len: 398aa; similar to many egs. TR:O06543 (EMBL:Z95584) hypothetical protein from Mycobacterium tuberculosis (360 aa) fasta scores; opt: 1338, z-score: 1408.4, E(): 0, (57.1% identity in 361 aa overlap) and TR:O09176 (EMBL:U89906) alpha-methylacyl-CoA racemase from Mus musculus (moues) (361 aa) fasta scores; opt: 953, z-score: 1005.2, E(): 0, (44.2% identity in 344 aa overlap). Also similar to SC6A5.34 (EMBL:AL049485) probable fatty acid co-A racemase from Streptomyces coelicolor (387 aa) fasta scores; opt: 1787, z-score: 1558.9, E(): 0, (69.9% identity i [...] (398 aa)
SCO6731SC5F2A.14, probable thiolase, len: 404aa; similar to many egs. TR:O53871 (EMBL:AL022004) putative beta-ketoadypyl coA tiolase from Mycobacterium tuberculosis (403 aa) fasta scores; opt: 1842, z-score: 1989.2, E(): 0, (67.6% identity in 404 aa overlap) and TR:O53017 (EMBL:X97452) acetyl coA thiolase from Escherichia coli (401 aa) fasta scores; opt: 819, z-score: 887.9, E(): 0, (41.7% identity in 424 aa overlap). Also similar to SC6A5.37 (EMBL:AL049485) probable acetyl coA acetyltransferase from Streptomyces coelicolor (404 aa) fasta scores; opt: 2480, z-score: 2352.6, E(): 0, (95.0% ide [...] (404 aa)
SCO6788SC6A5.37, probable acetyl coA acetyltransferase (thiolase), len: 404aa; similar to many eg. TR:O53017 (EMBL:X97452) acetyl coA acetyltransferase (thiolase) from Escherichia coli (401 aa) fasta scores; opt: 831, z-score: 891.0, E(): 0, (41.9% identity in 422 aa overlap). Contains Pfam match to entry PF00108 thiolase, Thiolase and Prosite matches to PS00737 Thiolases signature 2 and PS00099 Thiolases active site; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
SCO6791SC6A5.40c, partial CDS, probable acyl-coA dehydrogenase, len: 395aa; similar to many eg. TR:O34421 (EMBL:Z99113) from Bacillus subtilis (380 aa) fasta scores; opt: 777, z-score: 903.0, E(): 0, (36.6% identity in 383 aa overlap) and SW:ACDS_HUMAN acyl-coA dehydrogenase from Homo sapiens (Human) (412 aa) fasta scores; opt: 643, z-score: 747.6, E(): 0, (32.3% identity in 387 aa overlap). Contains three Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase and a Prosite match to PS00072 Acyl-CoA dehydrogenases signature 1. (379 aa)
SCO6796Hypothetical protein SC1A2.05; SC1A2.05, cvnC7, unknown, len: 126 aa. Highly similar to several proteins of unknown function from Streptomyces coelicolor including: TR:Q9X834 (EMBL:AL049727) SC9B1.14C (119 aa), fasta scores opt: 317 z-score: 414.9 E(): 1.1e-15 48.2% identity in 114 aa overlap and TR:CAB61280(EMBL:AL132991) SCF55.10C (113 aa), fasta scores opt: 261 z-score: 344.5 E(): 8.8e-12 44.3% identity in 106 aa overlap. (126 aa)
SCO6938SC1G8.10c, probable acyl-CoA dehydrogenase, len: 417 aa. Similar to Bacillus subtilis TR:ACDB_BACSU (EMBL:U29084) acyl-CoA dehydrogenase (EC 1.3.99.-) MmgC (379 aa), fasta scores opt: 651 z-score: 737.5 E(): 0 31.1% identity in 380 aa overlap and Streptomyces coelicolor TR:CAB87216 (EMBL:AL163641) acyl-CoA dehydrogenase, SCC105.10 (386 aa), fasta scores opt: 575 z-score: 651.8 E(): 7.6e-29 31.7% identity in 382 aa overlap. Contains a Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase and contains possible membrane spanning hydrophobic domains. (417 aa)
SCO6941Hypothetical protein SC1G8.13c; SC1G8.13c, cvnC8, unknown, len: 135 aa. Similar to many proteins of undefined function from Streptomyces coelicolor including: TR:O86520 (EMBL:AL031124) SC1C2.19C (132 aa), fasta scores opt: 204 z-score: 259.5 E(): 5.4e-07 35.6% identity in 118 aa overlap and TR:Q9X834 (EMBL:AL049727) SC9B1.14C (119 aa), fasta scores opt: 137 z-score: 181.4 E(): 0.012 42.2% identity in 90 aa overlap. (135 aa)
SCO6967SC6F7.20, pcaF, beta-ketoadipyl-CoA thiolase, len: 395 aa. Highly similar to many including: Pseudomonas putida SW:PCAF_PSEPU(EMBL:U10895) beta-ketoadipyl CoA thiolase (EC 2.3.1.-) (400 aa), fasta scores opt: 1352 z-score: 1491.2 E(): 0 53.9% identity in 399 aa overlap and Streptomyces coelicolor TR:Q9XAM9(EMBL:AL079355) beta-ketoadipyl-CoA thiolase, SC4C6.11C (400 aa), fasta scores opt: 1450 z-score: 1598.9 E(): 0 56.9% identity in 401 aa overlap. Contains a Pfam match to entry PF00108 thiolase, Thiolase and Prosite hits to PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 [...] (395 aa)
SCO7420Hypothetical protein SC6D11.16c; SC6D11.16c, cvnC10, unknown, len: 115 aa. Highly similar to many proteins of undefined function from Streptomyces coelicolor including: TR:CAB61280 (EMBL:AL132991) SCF55.10c. (113 aa), fasta scores opt: 407 z-score: 530.3 E(): 4.1e-22 63.1% identity in 111 aa overlap and TR:Q9X834 (EMBL:AL049727) SC9B1.14C (119 aa), fasta scores opt: 249 z-score: 330.7 E(): 5.3e-11 46.2% identity in 117 aa overlap. (115 aa)
SCO7465SCBAC14E8.05, cvnC13, hypothetical protein, len: 125 aa; similar to TR:Q9X834 (EMBL:AL049727) Streptomyces coelicolor hypothetical 12.8 kDa protein SC9B1.14c, 119 aa; fasta scores: opt: 288 Z-score: 370.8 bits: 74.1 E(): 4.5e-13; 45.082% identity in 122 aa overlap. Contains a TTA leucine codon, possible target for bldA regulation. (125 aa)
SCO7511SCBAC25F8.03, gap2, glyceraldehyde 3-phosphate dehydrogenase, len: 332 aa; highly similar to SW:G3P_STRAU (EMBL:U21191) Streptomyces aureofaciens glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) Gap, 332 aa; fasta scores: opt: 1898 Z-score: 2070.6 bits: 391.5 E(): 1e-107; 88.855% identity in 332 aa overlap and to TR:CAB38137 (EMBL:AL035591) Streptomyces coelicolor glyceraldehyde 3-phosphate dehydrogenase Gap or SCC54.07c, 337 aa; fasta scores: opt: 1272 Z-score: 1174.4 bits: 225.7 E(): 1.1e-59; 57.831% identity in 332 aa overlap. Contains Pfam matches to entries PF00044 gpdh, Gly [...] (332 aa)
SCP1.04cHypothetical protein; SCP1.04c, unknown, len: 78aa. (78 aa)
mmfHSCP1.244, mmfH, possible oxidoreductase involvedin 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid biosynthesis, len: 400aa; previously sequenced and annotated as hypothetical protein TR:Q9JN91 (EMBL:AJ276673). similar to many possible oxidoreductases eg. TR:O68921 (EMBL:AF058302) putative enoyl reductase, FrnT from polyketide antibiotic frenolicin biosynthetic cluster of Streptomyces roseofulvus (396 aa) fasta scores; opt: 867, z-score: 921.4, E(): 0, 48.0% identity in 329 aa overlap. (400 aa)
SCP1.350Hypothetical protein; SCP1.350, unknown, len: 78aa. (78 aa)
SCO0763SCF81.22, probable oxidoreductase, len: 535 aa; similar to SW:LA2M_MYCSM (EMBL:J05402) Mycobacterium smegmatis lactate 2-monooxygenase (EC 1.13.12.4) (lactate oxidase) La2M, 393 aa; fasta scores: opt: 1102 z-score: 1235.6 E(): 0; 44.6% identity in 379 aa overlap. Contains match to Pfam entry PF01070 FMN_dh, FMN-dependent dehydrogenase and to Prosite entry PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. (389 aa)
SCO0880Putative membrane protein; SCM1.13, possible membrane protein, len: 138 aa. Contains a possible membrane spanning hydrophobic domain and an N-terminal signal sequence. (138 aa)
SCO0985Putative methionine synthase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa)
SCO11122SCG38.05, probable oxidoreductase, len: 567 aa; similar to SW:AIDB_ECOLI (EMBL:L20915) Escherichia coli putative acyl-CoA dehydrogenase; adaptive response AidB protein, 541 aa; fasta scores: opt: 1437 z-score: 1553.6 E(): 0; 45.8% identity in 517 aa overlap. Contains 2x Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase and match to Prosite entry PS00073 Acyl-CoA dehydrogenases signature 2. (567 aa)
SCO1158SCG8A.12c, cvnC3, hypothetical protein, len: 137 aa; strongly similar to many from Streptomyces coelicolor eg. TR:O86523 (EMBL:AL031124) hypothetical protein (132 aa) fasta scores; opt: 284, z-score: 351.0, E(): 4.2e-12, 42.6% identity in 129 aa overlap. (137 aa)
SCO1197SCG11A.28c, possible acyl-CoA dehydrogenase, len:362 aa; low similarity to TR:AAD44195 (EMBL:AF142581) Streptomyces coelicolor acyl-CoA dehydrogenase AcdH, 386 aa; fasta scores: opt: 266 z-score: 294.1 E(): 5.2e-09; 28.3% identity in 392 aa overlap and to SW:ACDS_CLOAB (EMBL:U17110) Clostridium acetobutylicum acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2) (ScaD) (butyryl-CoA dehydrogenase) Bcd, 379 aa; fasta scores: opt: 231 z-score: 256.5 E(): 6.5e-07; 26.5% identity in 378 aa overlap. Contains two matches to Pfam entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (362 aa)
SCO1198SCG11A.29c, probable acyl-CoA dehydrogenase, len:393 aa; similar to TR:Q54857 (EMBL:) Streptomyces purpurascens acyl-CoA dehydrogenase FamB (fragment), 288 aa; fasta scores: opt: 1195 z-score: 1377.5 E(): 0; 83.2% identity in 208 aa overlap and to SW:ACD_MYCLE (EMBL:U00012) Mycobacterium leprae acyl-CoA dehydrogenase (EC 1.3.99.-) Acd or B1308_F1_34, 389 aa; fasta scores: opt: 386 z-score: 447.1 E(): 1.6e-17; 28.5% identity in 376 aa overlap. Contains two matches to Pfam entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (393 aa)
SCO12092SCG58.09c, probable acyl-CoA dehydrogenase, len: 408 aa; similar to SW:ACDA_BACSU (EMBL:Z49782) Bacillus subtilis acyl-CoA dehydrogenase (EC 1.3.99.-) AcdA, 379 aa; fasta scores: opt: 512 z-score: 587.6 E(): 2.9e-25; 41.3% identity in 400 aa overlap. Contains 2x Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase and match to Prosite entry PS00073 Acyl-CoA dehydrogenases signature 2. (408 aa)
SCO12732SCG18.20c, probable reductase, len: 372 aa; similar to C-terminal domain of SW:HETM_ANASP (EMBL:L22883) Anabaena sp. polyketide synthase HetM, 506 aa; fasta scores: opt: 333 z-score: 389.0 E(): 3.5e-14; 35.7% identity in 395 aa overlap and to Streptomyces coelicolor 2SCG18.32c, 373 aa; fasta scores: opt: 241 z-score: 242.2 E(): 6.9e-08; 27.0% identity in 330 aa overlap. Contains TTA leucine codon, possible target for bldA regulation. (372 aa)
SCO12852SCG18.32c, possible ketoreductase, len: 373 aa; similar to N-terminal region of TR:O50417 (EMBL:AL009198) Mycobacterium tuberculosis multi-functional enzyme MTV004.49, 650 aa; fasta scores: opt: 215 z-score: 237.4 E(): 9.7e-06; 30.5% identity in 377 aa overlap and to TR:Q9XC69 (EMBL:AF147704) Streptomyces fradiae MDP-hexose 4-ketoreductase TylCIV, 347 aa; fasta scores: opt: 182 z-score: 205.6 E(): 0.00057; 26.8% identity in 291 aa overlap and to Streptomyces coelicolor 2SCG18.20, 372 aa; fasta scores: opt: 241 z-score: 231.1 E(): 2.8e-07; 27.0% identity in 330 aa overlap. (373 aa)
SCO12862SCG18.33, probable oxidoreductase, len: 374 aa; similar to TR:P96072 (EMBL:U76606) Streptomyces viridifaciens isobutylamine N-hydroxylase (EC 1.14.-.-) (IBAH) VlmH, 378 aa; fasta scores: opt: 1020 z-score: 1177.8 E(): 0; 45.9% identity in 379 aa overlap. (374 aa)
SCO13242SCG61.06c, possible 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase, len: 389 aa; similar to many e.g. SW:P21151 (THIK_ECOLI) 3-ketoacyl-CoA thiolase (EC 2.3.1.16)from Escherichia coli (387 aa) fasta scores; opt: 892, z-score: 980.9, E(): 0, 42.7% identity in 403 aa overlap and SW:P54810 (THIL_PARDE) acetyl-CoA acetyltransferase (EC 2.3.1.9) from Paracoccus denitrificans (391 aa) fasta scores; opt: 892, z-score: 980.9, E(): 0, 41.7% identity in 403 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase and Prosite match to PS00737 Thiolases signature 2; Belongs to th [...] (389 aa)
SCO1400Conserved hypothetical protein; SC1A8A.20c, cvnC4, unknown, len: 131 aa; similar to others from Streptomyces coelicolor and Mycobacterium tuberculosis eg. TR:O86523 (EMBL:AL031124) hypothetical protein from Streptomyces coelicolor (132 aa) fasta scores; opt: 262, z-score: 339.3, E(): 1.8e-11, 41.9% identity in 124 aa overlap and to TR:Q9KZI7 (EMBL:AL353863) Streptomyces coelicolor hypothetical protein SCG8A.12c, 137 aa; fasta scores: opt: 480 Z-score: 582.4 E(): 8.3e-25; 59.690% identity in 129 aa overlap. Local genetic arrangement also seems to be conserved for the Streptomyces coelic [...] (131 aa)
SCO1428SC6D7.11, acd, acyl-CoA dehydrogenase (EC 1.3.99.-), len: 391 aa. Highly similar to many Prokaryotic and eukaryotic acyl-CoA dehydrogenases including: Megasphaera elsdenii SW:ACDS_MEGEL(EMBL:L04528) acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2) (383 aa), fasta scores opt: 926 z-score: 1026.2 E():0 40.9% identity in 372 aa overlap and Homo sapiens (Human) SW:ACDS_HUMAN(EMBL:M26393) acyl-CoA dehydrogenase, short-chain precursor (EC 1.3.99.2) (412 aa, fasta scores opt: 924 z-score: 1023.5 E():0 41.2% identity in 376 aa overlap. Also similar to Streptomyces coelicolor TR:CAB46 [...] (391 aa)
SCO1628SCI41.11c, cvnC9, hypothetical protein, len: 138 aa. Similar to TR:CAB41560 (EMBL:AL049727) Streptomyces coelicolor SC9B1.14C hypothetical 12.8 kd protein, 119 aa; fasta scores: opt: 240 z-score: 262.1 E(): 3.1e-07; 45.0% identity in 109 aa overlap and to TR:Q9AJP2 (EMBL:AB044803) Streptomyces griseus ORF3, 123 aa; fasta scores: opt: 472 Z-score: 497.8 E(): 4.3e-20; 58.273% identity in 139 aa overlap. (138 aa)
SCO1690SCI30A.11, possible acyl-CoA dehydrogenase, len: 404 aa; varying similarity to many e.g. TR:P96831 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (403 aa) fasta scores; opt: 1464, z-score: 1688.2, E(): 0, (57.3% identity in 400 aa overlap) and SW:ACDB_BACSU acyl-CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores; opt: 465, z-score: 539.6, E(): 1e-22, (32.0% identity in 347 aa overlap). Contains two Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (404 aa)
SCO1701SCI30A.22c, probable acyl-CoA dehydrogenase, len: 383 aa; similar to many both prokaryote and eukaryote eg. SW:ACDB_BACSU acyl-CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores; opt: 109,1 z-score: 1197.8, E(): 0, (43.8% identity in 377 aa overlap) and SW:ACDS_RAT acyl-CoA dehydrogenase from Rattus norvegicus (Rat) (412 aa) fasta scores; opt: 1079, z-score: 1184.2, E(): 0, (44.6% identity in 372 aa overlap). Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (383 aa)
SCO17502SCI34.03c, probable acyl CoA dehydrogenase, len: 397 aa; similar to many dehydrogenases, e.g. SW:GCDH_HUMAN (EMBL:U69141) Homo sapiens (Human) glutaryl-CoA dehydrogenase, mitochondrial precursor (EC 1.3.99.7) GcdH, 438 aa; fasta scores: opt: 1208 z-score: 1358.9 E(): 0; 48.2% identity in 398 aa overlap. Contains 2x Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (397 aa)
SCO1784SCI51.24, hypothetical protein, len: 115 aa; unknown function, probable CDS suggested by GC frameplot, positional base preference and amino acid composition. (115 aa)
SCO1947Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] (336 aa)
SCO2032Hypothetical protein; SC4G6.01, partial CDS, unknown, len: >35 aa; SC3A3.10, hypothetical protein, len: 404 aa; unknown function, similar to both bacterial dehydratases e.g. SW:CAIB_ECOLI (EMBL:X67748) Escherichia coli L-carnitine dehydratase (405 aa), fasta scores; opt: 579 z-score: 647.7 E(): 1e-28, 28.9% identity in 409 aa overlap and to eukaryotic isomerases e.g. TR:O43673 (EMBL:AF047020) Homo sapiens alpha-methylacyl-CoA racemase (382 aa) (31.2% identity in 398 aa overlap). Similar to others from S.coelicolor e.g. SC5F2A.13 (EMBL:AL049587) S.coelicolor possible racemase (398 aa) ( [...] (404 aa)
SCO2304SCC30.12c, possible dehydrogenase, len: 333 aa; similar to SW:DHB4_HUMAN (EMBL:X87176) Homo sapiens, estradiol 17 beta-dehydrogenase 4 (EC 1.1.1.62) Hsd17b4, 736 aa; fasta scores: opt: 611 z-score: 633.2 E(): 8e-28; 34.7% identity in 288 aa overlap. Contains Pfam match to entry PF01575 MaoC_like, MaoC like domain. (333 aa)
SCO2779SCC105.10, acdH, acyl-CoA dehydrogenase, len: 386 aa; identical to previously sequenced TR:Q9XCG6 (EMBL:AF142581) Streptomyces coelicolor acyl-CoA dehydrogenase AcdH, 386 aa. Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase and matches to Prosite entries PS00072 Acyl-CoA dehydrogenases signature 1 and PS00073 Acyl-CoA dehydrogenases signature 2. (386 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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