STRINGSTRING
SCO3901 SCO3901 SCO7399 SCO7399 SCO7233 SCO7233 SCO7050 SCO7050 SCO6820 SCO6820 SCO6444 SCO6444 SCO6428 SCO6428 SCO6407 SCO6407 SCO6381 SCO6381 SCO6378 SCO6378 SCO6356 SCO6356 SCO6355 SCO6355 SCO6065 SCO6065 SCO6004 SCO6004 SCO5945 SCO5945 SCO5674 SCO5674 SCO5646 SCO5646 SCO5497 SCO5497 SCO5149 SCO5149 SCO5039 SCO5039 SCO4847 SCO4847 SCO4843 SCO4843 SCO4439 SCO4439 SCO4368 SCO4368 SCO4133 SCO4133 SCO4085 SCO4085 SCO3977 SCO3977 SCO3923 SCO3923 SCO3811 SCO3811 SCO3803 SCO3803 SCO3704 SCO3704 SCO2933 SCO2933 SCO2897 SCO2897 SCO2780 SCO2780 SCO2409 SCO2409 SCO2313 SCO2313 SCO2001 SCO2001 SCO1753 SCO1753 SCO1737 SCO1737 SCO1606 SCO1606 SCO1336 SCO1336 SCO1102 SCO1102 SCO1047 SCO1047 SCO1014 SCO1014 SCO0959 SCO0959 SCO0830 SCO0830 SCO0503 SCO0503 SCO0494 SCO0494 SCO0480 SCO0480 SCO0417 SCO0417 SCO0402 SCO0402
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO3901SCH24.23, probable secreted penicillin-binding protein, len: 795 aa; similar to many e.g. SW:PBPF_BACSU (EMBL:Y14083), PbpF, Bacillus subtilis penicillin-binding protein 1A (714 aa), fasta scores; opt: 439 z-score: 369.7 E(): 2.8e-13, 31.2% identity in 683 aa overlap. Contains hydrophobic, possible membrane-spanning region at N-terminus. Contains Pfam matches to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 49.60, E-value 2.8e-11 and entry PF00912 Transglycosyl, Transglycosylase, score 172.40, E-value 7.3e-48. Contains PS00017 ATP/GTP-binding sit [...] (795 aa)
SCO7399SC10G8.27c, possible binding-protein-dependent transport lipoprotein, len: 327 aa. Similar to many including: Escherichia coli SW:FHUD_ECOLI(EMBL:X05810) ferrichrome-binding periplasmic protein precursor FhuD (296 aa), fasta scores opt: 231 z-score: 249.9 E(): 1.7e-06 24.8% identity in 270 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains a Pfam match to entry PF01497 Peripla_BP_2, Periplasmic binding protein. (327 aa)
SCO7233Putative secreted protein; SC2H12.32, possible secreted protein, len: 934 aa. Note the product of this CDS is rich in the amino acid proline. Contains a possible N-terminal signal sequence. Contains a TTA /leucine codon, possible target for bldA regulation. (934 aa)
SCO7050SC4G1.16c, probable D-alanyl-D-alanine carboxypeptidase, len: 413 aa; similar to TR:CAB89066 (EMBL:AL353872) Streptomyces coelicolor putative D-alanyl-D-alanine carboxypeptidase SC5G8.15c, 424 aa; fasta scores: opt: 704 z-score: 719.2 E(): 1.4e-32; 47.7% identity in 390 aa overlap and to SW:DACF_BACSU (EMBL:M85047) Bacillus subtilis penicillin-binding protein DacF precursor, 389 aa; fasta scores: opt: 330 z-score: 341.5 E(): 1.5e-11; 27.1% identity in 262 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase. (413 aa)
SCO6820Putative oxidoreductase; SC1A2.29c, possible oxidoreductase, len: 776 aa. Similar to a number of formate dehydrogenases e.g. Escherichia coli SW:FDHF_ECOLI(EMBL:M13563) formate dehydrogenase H (EC 1.2.1.2) (715 aa), fasta scores opt: 503 z-score: 564.0 E(): 5.2e-24 29.4% identity in 799 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_binding, Molydopterin dinucleotide binding domain.; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (776 aa)
SCO6444SC9B5.11, probable gamma-glutamyl transferase, len: 647 aa; similar to many gamma-glutamyl transferases eg. TR:Q54353 (EMBL:X79146) LmbA, gamma-glutamyl transferase involved in lincomycin production in Streptomyces lincolnensis 78-11 (601 aa) fasta scores; opt: 871, z-score: 1756.8, E(): 0, (48.1% identity in 619 aa overlap). Also similar to TR:O54174 (EMBL:AL021411) probable transferase (606aa) from Streptomyces coelicolor fasta scores: opt: 953, z-score: 1203.1, E(): 0, (53.7% identity in 635 aa overlap). Contains Pfam match to entry PF01019 G_glu_transpept, Gamma-glutamyltranspeptidase. (647 aa)
SCO6428SC1A6.17c, possible secreted protein, len: 2314 aa; has short segment of similarity to acid phosphatases e.g. PHOC_MORMO P28581 morganella morganii acid phosphatase (249aa), fasta scores; opt: 251 z-score: 206.3 E(): 0.00023, 32.1% identity in 162 aa overlap and to TR:CAC37553 (EMBL:AL590983) Streptomyces coelicolor conserved hypothetical protein (fragment) SCBAC1C11.07c, 676 aa; fasta scores: opt: 490 Z-score: 458.2E(): 6.9e-18; 26.124% identity in 712 aa overlap. Contains possible N-terminalsignal sequence and PS01157 Class A bacterial acid phosphatases signature. (2314 aa)
SCO6407SC3C8.26, possible gamma-glutamyltranspeptidase (putative secreted protein), len: 603 aa; similar to many e.g. GGT_BACSU gamma-glutamyltranspeptidase precursor (EC 2.3.2.2) (587 aa), fasta scores; opt: 705 z-score: 863.9 E(): 0, 36.9% identity in 591 aa overlap, and to PAC1_PSESV cephalosporin acylase I (EC 3.5.1.-) (557 aa), fasta scores; opt: 377 z-score: 819.8 E(): 0, 34.1% identity in 569 aa overlap. Contains probable N-terminal signal sequence. (603 aa)
SCO6381SC4A2.17c, probable lipoprotein, len: 447 aa; contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (447 aa)
SCO6378Putative membrane protein; SC4A2.14c, small hydrophobic protein, len: 99 aa; contains segment of similarity to BCRC_BACLI bacitracin transport permease protein BcrC (203 aa), fasta scores; opt: 123 z-score: 260.1 E(): 3.1e-07, 60.6% identity in 33 aa overlap. Similar in parts to downstream ORF SC3A7.24c (57.0% identity in 114 aa overlap). Contains possible hydrophobic membrane spanning region. (99 aa)
SCO6356SC3A7.24c, probable integral membrane protein, len: 201 aa; some similarity to e.g. BCRC_BACLI bacitracin transport permease protein bcrC (203 aa), fasta scores; opt: 203 z-score: 285.3 E(): 1.2e-08, 29.3% identity in 147 aa overlap. (201 aa)
SCO6355SC3A7.23c, probable integral membrane protein, len: 272 aa. Contains possible hydrophobic membrane spanning regions. (272 aa)
SCO6065SC9B1.12, probable secreted substrate-binding protein, len: 320aa; similar to many eg. TR:O69725 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (315 aa) fasta scores; opt: 574, z-score: 637.7, E(): 3.4e-28, (35.8% identity in 313 aa overlap) and SW:PROX_BACSU glycine betaine/L-proline binding protein from Bacillus subtilis (313 aa) fasta scores; opt: 136, z-score: 157.8, E(): 0.18, (25.7% identity in 311 aa overlap). Contains possible N-terminal signal sequence. (320 aa)
SCO6004SC7B7.01c, putative secreted ATP/GTP binding protein, partial ORF, len: >626 aa; contains possible N-terminal signal sequence and PS00017 ATP/GTP-binding site motif A (P-loop); SCBAC1C11.07c, conserved hypothetical protein (fragment), len: >676 aa; similar to C-terminal domain of TR:Q9WXI8 (EMBL:AB025248) Bacillus sp. M-90 alpha-1,2-mannosidase precursor AmaN2, 1976 aa; fasta scores: opt: 1575 z-score: 1715.3 E(): 0; 45.7% identity in 705 aa overlap. (1268 aa)
SCO5945SC7H1.15, probable transferase, len: 606 aa; similar to TR:Q54353 (EMBL:X64651) S.lincolnensis lmbA gene for lincomycin condensing protein (601 aa), fasta scores; opt: 921 z-score: 1470.0 E(): 0, 45.8% identity in 600 aa overlap and to other gamma-glutamyl transferases. (606 aa)
SCO5674SC8B7.04, probable integral membrane protein, len: 247 aa. Contains possible hydrophobic membrane spanning regions. (247 aa)
SCO5646SC6A9.21c, probable solute binding lipoprotein, len: 373 aa; similar to e.g. TBPA_ECOLI thiamin-binding periplasmic protein (327 aa), fasta scores; opt: 220 z-score: 423.3 E(): 2.4e-16, 28.4% identity in 327 aa overlap. Contains N-terminla signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (373 aa)
SCO5497Conserved hypothetical protein; SC8D9.09, unknown, len: 164aa; similar to many of undefined function eg. TR:O06336 (EMBL:Z95390) hypothetical protein from Mycobacterium tuberculosis (177 aa) fasta scores; opt: 171, z-score: 213.4, E(): 0.00014, (34.9% identity in 109 aa overlap). (164 aa)
SCO5149SCP8.12, possible protease, len: 542 aa; C-terminal region similar to TR:O53896 (EMBL:AL021999) Mycobacterium tuberculosis putative serine protease MTV044.11, 464 aa; fasta scores: opt: 803 z-score: 614.5 E(): 9.2e-27; 39.4% identity in 469 aa overlap and to TR:AAF61294 (EMBL:AF155705) Lactococcus lactis serine protease HtrA, 408 aa; fasta scores: opt: 536 z-score: 415.8 E(): 1.1e-15; 34.8% identity in 310 aa overlap. Contains Pfam matches to entries PF00089 trypsin, Trypsin and PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). (542 aa)
SCO5039SCK7.12, possible penicillin-binding protein, len: 773 aa; similar to TR:CAB88838 (EMBL:AL353832) Streptomyces coelicolor probable penicillin-binding protein SCE6.34, 756 aa; fasta scores: opt: 1080 z-score: 911.6 E(): 0; 46.0% identity in 733 aa overlap and to SW:PBPD_BACSU (EMBL:U11882) Bacillus subtilis penicillin-binding protein 4 precursor PbpD, 624 aa; fasta scores: opt: 513 z-score: 438.2 E(): 6.1e-17; 28.7% identity in 582 aa overlap. Contains Pfam matches to entries PF00912 Transglycosyl, Transglycosylase and PF00905 Transpeptidase, Penicillin binding protein transpeptidase do [...] (716 aa)
SCO4847SC5G8.15c, possible D-alanyl-D-alanine carboxypeptidase, len: 455 aa; similar to many e.g. TR:O53380 (EMBL:AL021841) proposed penicillin-binding protein from Mycobacterium tuberculosis (405 aa) fasta scores; opt: 392, z-score: 369.1, E(): 4.2e-13, 31.7% identity in 439 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase. Position of translational start uncertain. (424 aa)
SCO4843SC5G8.11, possible integral membrane protein, len: 169aa; similar to many of undefined function eg. TR:O53584 (EMBL:AL022076) hypothetical protein from Mycobacterium tuberculosis (165 aa) fasta scores; opt: 324, z-score: 386.8, E(): 4.3e-14, 41.5% identity in 159 aa overlap. Contains Pfam match to entry PF01569 PAP2, PAP2 superfamily and possible membrane-spanning hydrophobic regions. (169 aa)
SCO4439SCD6.17c, possible D-alanyl-D-alanine carboxypeptidase, len: 832 aa; similar to TR:O54201 (EMBL:AJ001743) Streptomyces clavuligerus Pbp2 protein (penicillin binding protein PbpA), 696 aa; fasta scores: opt: 955 z-score: 744.1 E(): 0; 37.0% identity in 757 aa overlap. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase and high content in alanine, aspartic acid and glycine amino acid residues. Contains degenerate repeats: 2X (G/A)GAAPDSGSG(T/A)DATXXXPAPD(T/A) KPDQEPDADSEPAPDAQAASSRDGDAD. (832 aa)
SCO4368SCD19.23c, possible lipase (putative secreted protein), len: 386 aa; similar to TR:Q9Z360 (EMBL:AL035654) Streptomyces coelicolor putative lipase SCE8.12c, 391 aa; fasta scores: opt: 867 z-score: 923.3 E(): 0; 44.3% identity in 393 aa overlap. Contains possible N-terminal region signal peptide sequence. (386 aa)
SCO4133SCD72A.19, possible integral membrane protein, len: 238aa; N-terminal region similar to others eg. TR:O86625 (EMBL:AL031155) putative integral membrane protein from Streptomyces coelicolor (201 aa) fasta scores; opt: 321, z-score: 379.3, E(): 1.1e-13, 35.8% identity in 179 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match to entry PF01569 PAP2, PAP2 superfamily. (238 aa)
SCO4085SCD25.21, lipoprotein, len: 202 aa. Contains a possible N-terminal signal sequence and a Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (277 aa)
SCO3977SCBAC25E3.14, possible protease (putative secreted protein), len: 519aa: similar to many eg. TR:Q9FBK9 (EMBL:AL390975) putative protease SCP8.12 from Streptomyces coelicolor (542 aa) fasta scores; opt: 1265, Z-score: 796.4, 43.636% identity (47.431% ungapped) in 550 aa overlap and TR:O06291 (EMBL:Z98260) HtrA from Mycobacterium tuberculosis (549 aa) fasta scores; opt: 614, Z-score: 396.6, 34.870% identity (37.826% ungapped) in 499 aa overlap. Contains Pfam match to entry PF00089 trypsin, Trypsin and Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Contains possi [...] (519 aa)
SCO3923SCQ11.06, hypothetical protein, len: 105 aa; previously sequenced as SW:YPT2_STRCO (EMBL:U37580) hypothetical 8.2 kD protein in PtpA 5' region (77 aa), with different putative start codon. Start codon position is suggested here by GC frameplot analysis. Similar to others e.g. to part of TR:O06336 (EMBL:Z95390) Mycobacterium tuberculosis hypothetical protein (177 aa), fasta scores; opt: 145 z-score: 207.2 E(): 0.00033, (42.1% identity in 57 aa overlap) and to TR:Q59013 (EMBL:U67602) Methanococcus jannaschii hypothetical protein (125 aa) (30.2% identity in 63 aa overlap). Weakly similar [...] (105 aa)
SCO3811SCGD3.12, dacA, probable D-alanyl-D-alanine carboxypeptidase, len: 314 aa; highly similar to SW:DACX_STRSK (EMBL:X59965) Streptomyces sp. (strain K15) D-alanyl-D-alanine carboxypeptidase (291 aa), fasta scores; opt: 1322 z-score: 1435.8 E(): 0, 73.8% identity in 302 aa overlap. Also similar to many other penicillin-binding proteins. Contains Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase and PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible hydrophobic membrane spanning region. (314 aa)
SCO3803SCGD3.04c, hypothetical protein, len: 134 aa; shows similarity to TR:P96597 (EMBL:AB001488), YdbB, Bacillus subtilis hypothetical protein (113 aa), fasta scores; E(): 2.8e-05, 35.6% identity in 87 aa overlap and to hypothetical proteins from Neisseria meningitidis serogroup A, e.g. NMA0576, hypothetical protein (107 aa), blastp scores: Expect= 4.6e-11. Probable member of the cupin superfamily. (134 aa)
SCO3704SCH35.20c, possible substrate-binding transport protein, len: 269aa; similar to many egs. TR:O31229 (EMBL:Y10817) molybdate-binding periplasmic transport protein from Arthrobacter nicotinovorans (260 aa) fasta scores; opt: 613, z-score: 670.6, E(): 5e-30, (43.4% identity in 256 aa overlap) and SW:MODA_ECOLI molybdate-binding periplasmic transport protein from Escherichia coli (257 aa) fasta scores; opt: 163, z-score: 186.1, E(): 0.0049, (31.7% identity in 249 aa overlap). Contains possible N-terminal signal sequence. (269 aa)
SCO2933SCE19A.33, probable permease binding-protein component, len: 322 aa; similar to SW:PROX_BACSU (EMBL:U38418), proX, Bacillus subtilis glycine betaine-binding protein precursor (313 aa), fasta scores; opt: 300 z-score: 341.4 E(): 1.1e-11, 27.5% identity in 320 aa overlap and to similar putative permease components. Similar to SC9B1.12 (EMBL:AL049727) S.coelicolor probable secreted substrate-binding protein (320 aa) (30.4% identity in 329 aa overlap). Contains a probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. [...] (322 aa)
SCO2897SCE6.34, probable secreted penicillin-binding protein, len: 756 aa. Similar to many including: Bacillus subtilis SW:PBPD_BACSU(EMBL:U11882) penicillin-binding protein 4 precursor (624 aa), fasta scores opt: 550 z-score: 456.8 E(): 5.5e-18 28.1% identity in 572 aa overlap and Helicobacter pylori TR:O25319(EMBL:AE000573) penicillin-binding protein 1A (659 aa), fasta scores opt: 750 z-score: 619.0 E(): 5.1e-27 31.9% identity in 605 aa overlap. Contains Pfam matches to entries PF00912 Transglycosyl, Transglycosylase and PF00905 Transpeptidase, Penicillin binding protein transpeptidase doma [...] (756 aa)
SCO2780SCC105.11, possible secreted protein, len: 349 aa; similar to TR:CAB53324 (EMBL:AL109974) Streptomyces coelicolor putative iron-siderophore binding lipoprotein SCF34.13c, 350 aa; fasta scores: opt: 288 z-score: 297.2 E(): 4.1e-09; 28.3% identity in 332 aa overlap. Contains possible N-terminal region signal peptide sequence. (349 aa)
SCO2409SC4A7.37c, possible secreted protein, len: 421 aa; similar to various hypothetical proteins, e.g. TR:CAB52057 (EMBL:AL109732) Streptomyces coelicolor hypothetical 61.4 kD protein SC7H2.15c, 597 aa; fasta scores: opt: 1148 z-score: 809.3 E(): 0; 51.3% identity in 388 aa overlap. Contains proline-rich region and possible N-terminal region signal peptide sequence. (421 aa)
SCO2313SCC53.04, possible membrane protein, len: 336aa; similar to TR:O69684 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (241 aa) fasta scores; opt: 536, z-score: 436.5, E(): 7.6e-17, 41.2% identity in 233 aa overlap. Contains Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase and possible hydrophobic membrane spanning region. (336 aa)
SCO2001SC7H2.15c, putative secreted protein, len: 597 aa; similar to TR:O86313 (EMBL:Z98260) hypothetical protein from Mycobacterium tuberculosis (411 aa) fasta scores; opt: 548, z-score: 447.1, E(): 1.4e-17, (33.7% identity in 380 aa overlap). Contains possible N-terminal region signal peptide sequence. (597 aa)
SCO17532SCI34.06, possible integral membrane protein, len: 340 aa. Contains Pfam match to entry PF01569 PAP2, PAP2 superfamily and possible hydrophobic membrane spanning regions. Also presents high content of alanine, arginine, leucine and proline amino acid residues. (340 aa)
SCO1737SCI11.26, hypothetical protein, len: 124 aa; unknown function, similar to TR:O86372 (EMBL:AL022003) Mycobacterium tuberculosis hypothetical protein (116 aa), fasta scores; opt: 129 z-score: 177.0 E(): 0.016, 34.7% identity in 98 aa overlap. (124 aa)
SCO1606SCI35.28, possible membrane protein, len: 322 aa; similar to S. coelicolor TR:O69914 (EMBL:AL023861) putative secreted protein SC3C8.01 (302 aa), fasta scores; opt: 730 z-score: 709.0 E(): 3e-32, 48.0% identity in 275 aa overlap. Contains possible hydrophobic membrane spanning region. (322 aa)
SCO1336Putative lipoprotein N-acyltransferase (integral membrane); Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (524 aa)
SCO11022SCG4.18, possible integral membrane protein, len: 223 aa; similar to TR:Q06074 (EMBL:Z21972) Bacillus megaterium hypothetical 24.9 kD protein in cytochrome P450MEG gene 3' region, 216 aa; fasta scores: opt: 298 z-score: 353.5 E(): 3.3e-12; 27.5% identity in 207 aa overlap. Contains Pfam match to entry PF01569 PAP2, PAP2 superfamily. Also contains possible hydrophobic membrane spanning regions. (223 aa)
SCO1047SCG20A.27, possible integral membrane protein, len: 230 aa; similar to TR:O86625 (EMBL:AL031155) Streptomyces coelicolor putative integral membrane protein SC3A7.24c, 201 aa; fasta scores: opt: 277 z-score: 278.6 E(): 4.9e-08; 41.7% identity in 168 aa overlap. Contains Pfam match to entry PF01569 PAP2, PAP2 superfamily and possible hydrophobic membrane spanning regions. (230 aa)
SCO1014Putative transferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (537 aa)
SCO0959SCM11.14c, possible secreted protein, len: 772 aa; similar to N-terminus of TR:O69822 (EMBL:AL023496) Streptomyces coelicolor putative secreted protein SC1A6.17c, 2314 aa; fasta scores: opt: 444 z-score: 500.2 E(): 1.8e-20; 30.0% identity in 818 aa overlap and low similarities to TR: (EMBL:) Pseudomonas sp. acetaldehyde dehydrigenase (acylating) PhnI, 312 aa; fasta scores: opt: 125 z-score: 146.1 E(): 0.92; 23.7% identity in 177 aa overlap. Contains possible signal peptide sequence. (772 aa)
SCO0830SCF43A.20c, possible penicillin-binding protein, len: 359 aa; weakly similar to penicillin-binding proteins, carboxypeptidases and beta-lactamases e.g. SW:AMPH_ECOLI (EMBL:AE000144), AmpH, Escherichia coli penicillin-binding protein (376 aa), fasta scores; opt: 274 z-score: 305.5 E(): 1.1e-09, 26.5% identity in 343 aa overlap, SW:DAC_STRSQ (EMBL:M26842) Streptomyces sp. D-alanyl-D-alanine carboxypeptidase precursor (406 aa) (23.8% identity in 344 aa overlap) and SW:AMPC_PSEAE (EMBL:X54719), AmpC, Pseudomonas aeruginosa beta-lactamase precursor (397 aa) (27.3% identity in 381 aa overlap [...] (359 aa)
SCO0503SCF34.22, hypothetical protein, len: 326 aa; unknown function, shows weak similarity to the N-terminal half of SCH10.22C (EMBL:AL049754) Streptomyces coelicolor putative lipase/esterase (301 aa), fasta scores; opt: 178 z-score: 202.4 E(): 0.00065, 30.1% identity in 163 aa overlap. (326 aa)
SCO0494SCF34.13c, probable iron-siderophore binding lipoprotein, len: 350 aa; similar to TR:Q46023 (EMBL:U02617) Corynebacterium diphtheriae DtxR/iron-regulated lipoprotein precursor (355 aa), fasta scores; opt: 479 z-score: 518.8 E(): 1.5e-21, 34.4% identity in 358 aa overlap and SW:FATB_VIBAN (EMBL:J03529), FatB, Vibrio anguillarum plasmid pJM1 ferric anguibactin-binding protein precursor (322 aa) (26.2% identity in 305 aa overlap). Also similar to other iron-siderophore binding proteins. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and [...] (350 aa)
SCO0480Hypothetical protein; SCF80.01, unknown, partial CDS, len: >193 aa. Similar in parts to Streptomyces coelicolor TR:CAB53333 (EMBL;AL109974) hypothetical 34.2 KD protein SCF34.22 (326 aa), fasta scores opt:opt: 296 z-score: 300.2 E(): 2.4e-09 40.5% identity in 148 aa overlap; SCF76.20, unknown, partial CDS, len: >49 aa. (210 aa)
SCO0417SCF51.16c, hypothetical protein, len: 248 aa; similar to TR:P74164 (EMBL:D90912) Synechocystis sp. (strain PCC 6803) hypothetical 33.9 KD protein, 300 aa; fasta scores: opt: 361 z-score: 423.5 E(): 3.2e-16; 35.9% identity in 259 aa overlap. (248 aa)
SCO0402Putative integral membrane protein; SCF51.01c, unknown, len: >48 aa; SCF62.28c, possible integral membrane protein, partial CDS, len: >248 aa. Weakly similar in parts to Streptomyces coelicolor TR:O86624 (EMBL: AL031155) putative integral membrane protein SC3A7.23C (272 aa), fasta scores opt: 189 z-score: 228.1 E(): 2.5e-05 31.6% identity in 190 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. (250 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.