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SCO6008 SCO6008 SCO0063 SCO0063 SCO0275 SCO0275 SCO0734 SCO0734 SCO0794 SCO0794 SCO1039 SCO1039 SCO1060 SCO1060 SCO1077 SCO1077 SCO7568 SCO7568 SCO7543 SCO7543 SCO1171 SCO1171 SCO1261 SCO1261 SCO1447 SCO1447 SCO2126 SCO2126 SCO2657 SCO2657 SCO2846 SCO2846 SCO4285 SCO4285 SCO7486 SCO7486 SCO6600 SCO6600 SCO6566 SCO6566 SCO6260 SCO6260 SCO6115 SCO6115 SCO6110 SCO6110 SCO5059 SCO5059
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO6008SC7B7.05, probable transcriptional repressor protein, len 403 aa; similar to many eg. XYLR_ANATH Q44406 xylose repressor from Anaerocellum thermophilum (399 aa), fasta scores; opt: 548 z-score: 767.3 E(): 0, 33.1% identity in 393 aa overlap. Contains PS01125 ROK family signature and helix-turn-helix motif at aa positions 29-50 (Score 2016, +6.05 SD). (403 aa)
SCO0063SCJ4.44c, possible glucokinase, len: 311 aa; similar to many eg. SW:GLK_STRCO glucokinase from Streptomyces coelicolor (317 aa) fasta scores; opt: 175, z-score: 195.7, E(): 0.0015, (28.2% identity in 326 aa overlap). Contains Pfam match to entry PF00480 ROK, ROK family. (311 aa)
SCO0275SCF85.03, possible transcriptional repressor protein, len: 385 aa. Low similarity to many repressor proteins e.g. Anaerocellum thermophilum SW:XYLR_ANATH (EMBL; Z69782)xylose repressor (399 aa), fasta scores opt: 325 z-score: 375.7 E(): 1.4e-13 23.3% identity in 395 aa overlap and Streptomyces coelicolor TR:O50502 (EMBL; AL009199) probable transcriptional repressor protein SC7B7.05 (403 aa), fasta scores opt: 402 z-score: 463.7 E(): 1.8e-18 29.7% identity in 404 aa overlap. Contains a Pfam match to entry PF00480 ROK, ROK family and has a possible helix turn helix motif between aa 30..51. (385 aa)
SCO07343SC5B7.12c, probable transcriptional repressor, len: 424 aa; similar to SW:MLC_ECOLI (EMBL:D32222) Escherichia coli transcriptional regulator Mlc protein, 406 aa; fasta scores: opt: 387 z-score: 414.7 E(): 1.4e-15; 24.1% identity in 344 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and possible helix-turn-helix motif at residues 64..85 (+6.19 SD). (424 aa)
SCO0794SCF43.05c, possible ROK family transcriptional regulator, len: 429 aa. Similar to Anaerocellum thermophilum SW:XYLR_ANATH (EMBL:Z69782) xylose repressor (399 aa), fasta scores opt: 519 z-score: 575.9 E(): 1.1e-24 28.1% identity in 402 aa overlap. Also highly similar to Streptomyces coelicolor TR:O87855(EMBL:AL031013) putative transcriptional regulator SC8A6.21c (441 aa), fasta scores opt: 2034 z-score: 2241.7 E():0 71.4% identity in 434 aa overlap. Contains a Pfam match to entry PF00480 ROK, ROK family and a putative helix-turn-helix motif situated between residues 30..51 (+3.09 SD). (429 aa)
SCO1039SCG20A.19c, possible ROK family regulatory protein, len: 412 aa; similar to TR:O50502 (EMBL:AL009199) Streptomyces coelicolor probable transcriptional repressor protein SC7B7.05, 403 aa; fasta scores: opt: 456 z-score: 485.8 E(): 1.4e-19; 27.7% identity in 390 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family. (412 aa)
SCO1060SCG22.06, probable transcriptional repressor, len: 413 aa; similar to TR:O05180 (EMBL:Z71474) Bacillus megaterium Xyl repressor XylR, 388 aa; fasta scores: opt: 382 z-score: 417.8 E(): 8.5e-16; 31.3% identity in 386 aa overlap and to TR:CAB61583 (EMBL:AL133210) Streptomyces coelicolor possible xylose repressor SCF37.02, 402 aa; fasta scores: opt: 586 z-score: 523.0 E(): 1.5e-23; 48.0% identity in 396 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and a possible helix-turn-helix motif at residues 35..56 (+3.03 SD). (413 aa)
SCO1077SCG22.23c, probable sugar kinase, len: 317 aa; similar to SW:GLK_BACSU (EMBL:D84432) Bacillus subtilis glucokinase (EC 2.7.1.2) GlcK, 321 aa; fasta scores: opt: 495 z-score: 504.0 E(): 1.3e-20; 31.4% identity in 312 aa overlap. Contains match to Prosite entry PS01125 ROK family signature. (317 aa)
SCO7568SC5F1.22c, possible regulatory protein, len: 319 aa; similar to TR:O50502 (EMBL:AL009199) Streptomyces coelicolor probable transcriptional repressor protein SC7B7.05, 403 aa; fasta scores: opt: 377 z-score: 404.3 E(): 5.5e-15; 29.3% identity in 290 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family. (319 aa)
SCO7543SC8G12.19, possible Crp-family transcriptional regulator, len: 424 aa. Similar to several including: Bacillus subtilis SW:XYLR_BACSU (EMBL:M27248) xylose repressor (384 aa), fasta scores opt: 339 z-score: 347.1 E(): 7.1e-12 23.3% identity in 390 aa overlap and Streptomyces coelicolor TR:O50502 (EMBL:AL009199) probable transcriptional repressor protein, SC7B7.05 (403 aa), fasta scores opt: 691 z-score: 697.8 E(): 2.1e-31 33.9% identity in 387 aa overlap. Contains a Prosite hit to PS01125 ROK family signature and Pfam hits to PF00480 ROK, ROK family and PF00325 crp, Bacterial regulatory [...] (424 aa)
SCO1171SCG11A.02, possible xylose repressor, len: 402 aa; similar to SW:XYLR_BACSU (EMBL:M27248) Bacillus subtilis xylose repressor xylR, 384 aa; fasta scores: opt: 612 z-score: 642.4 E(): 2.1e-28; 29.4% identity in 381 aa overlap. Contains match to Pfam entry PF00480 ROK, ROK family and a possible helix-turn-helix motif at residues 43..64 (+3.15 SD). (402 aa)
SCO12612SCG18.08, probable transcriptional regulatory protein, len: 384 aa; similar to TR:Q9S2D8 (EMBL:AL110470) Streptomyces coelicolor putative transcriptional repressor protein SCF85.03, 385 aa; fasta scores: opt: 980 z-score: 1062.5 E(): 0; 44.2% identity in 380 aa overlap and to SW:XYLR_ANATH (EMBL:Z69782) Anaerocellum thermophilum xylose repressor XylR, 399 aa; fasta scores: opt: 376 z-score: 411.5 E(): 1.9e-15; 25.4% identity in 394 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and possible helix-turn-helix motif at residues 30..51 (+2.57 SD). (384 aa)
SCO1447SCL6.04c, possible ROK-family transcriptional regulatory protein, len: 399 aa; similar to TR:CAB71832 (EMBL:AL138662) Streptomyces coelicolor putative ROK-family regulatory protein SC8E4A.27, 409 aa; fasta scores: opt: 938 z-score: 965.1 E(): 0; 42.5% identity in 398 aa overlap and to SW:XYLR_ANATH (EMBL:Z69782) Anaerocellum thermophilum xylose repressor XylR, 399 aa; fasta scores: opt: 327 z-score: 341.8 E(): 1.3e-1; 22.2% identity in 397 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and possible helix-turn-helix motif at residues 26..47 (+2.84 SD). (399 aa)
SCO2126Glucokinase; Required for glucose repression of many different genes; Belongs to the ROK (NagC/XylR) family. (317 aa)
SCO2657SC8E4A.27, possible ROK-family transcriptional regulatory protein, len: 409 aa; similar to TR:O69941 (EMBL:AL023862) Streptomyces coelicolor hypothetical ROK family protein (fragment) SC3F9.01, 403 aa; fasta scores: opt: 456 z-score: 480.7 E(): 2.3e-19; 30.8% identity in 396 aa overlap and to SW:XYLR_CALSR (EMBL:L18965) Caldicellulosiruptor sp. putative xylose repressor XylR, 399 aa; fasta scores: opt: 381 z-score: 402.9 E(): 5e-15; 25.2% identity in 361 aa overlap. Contains Pfam match to entry PF00325 crp, Bacterial regulatory proteins, crp family and Pfam match to entry PF00480 ROK, [...] (409 aa)
SCO2846SCE20.20c, possible transcriptional regulatory protein, len: 406 aa. Similar in parts to several proteins of the ROK (NagC/XylR) family including: Bacillus subtilis SW:GLK_BACSU (EMBL:D84432) glucokinase (EC 2.7.1.2) (glucose kinase) (321 aa), fasta scores opt: 320 z-score: 310.6 E(): 6.4e-10 34.1% identity in 164 aa overlap and Thermotoga maritima TR:Q9X1I0 (EMBL:AE001798) glucokinase (317 aa), fasta scores opt: 385 z-score: 370.1 E(): 3.1e-13 33.6% identity in 360 aa overlap. Contains a Prosite hits to PS01125 ROK family signature and PS01228 Hypothetical cof family signature 1. Also [...] (406 aa)
SCO4285SCD95A.18, possible sugar kinase, len: 326 aa; similar to TR:CAB60179 (EMBL:AL132824) Streptomyces coelicolor putative sugar kinase SCAH10.25, 382 aa; fasta scores: opt: 449 z-score: 453.3 E(): 8.7e-18; 37.2% identity in 301 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and 5x degenerate repeat: (S/A)AP. (326 aa)
SCO7486SCBAC17A6.19c, possible ROK-family transcriptional regulator, len: 405 aa; similar to many e.g. TR:P95610 (EMBL:X99622) putative regulator from Rhodococcus erythropolis (397 aa) fasta scores: opt: 548, Z-score: 588.4, 36.776% identity (38.220% ungapped) in 397 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and Prosite match to PS01125 ROK family signature. (405 aa)
SCO6600SC8A6.21c, probable transcriptional regulator, len: 441 aa; some similarity to members of the ROK family e.g. XYLR_ANATH xylose repressor (399 aa), fasta scores; opt: 365 z-score: 361.7 E(): 6.6e-13, 27.2% identity in 397 aa over lap. Contains Pfam match to entry PF00480 ROK, ROK family, score 38.10, E-value 3e-10. (441 aa)
SCO6566Putative ROK family protein; SC3F9.01, unknown, partial CDS, len: >403 aa; similar to many members of the ROK (nagC/xylR) family e.g. NAGC_ECOLI N-acetylglucosamine repressor (406 aa), fasta scores; opt: 513 z-score: 578.8 E(): 5e-25, 28.6% identity in 388 aa overlap and GLK_STRCO glucokinase (EC 2.7.1.2) (glucose kinase) (317 aa), fasta scores; opt: 544 z-score: 570.9 E(): 1.4e-24, 34.4% identity in 317 aa overlap. Contains PS01125 ROK family signature and Pfam match to entry ROK PF00480, ROK family, score 164.11. Also similar to S. coelicolor SC7B7.05, probable transcriptional repres [...] (460 aa)
SCO6260SCAH10.25, possible sugar kinase, len: 382 aa; similar to SW:GLK_STRCO (EMBL:X65932) Streptomyces coelicolor glucokinase (EC 2.7.1.2) (glucose kinase) Glk, 317 aa; fasta scores: opt: 1022 z-score: 1142.9 E(): 0; 46.6% identity in 311 aa overlap and to TR:CAB51974 EMBL:SC6E10 Streptomyces coelicolor SC6E10.20c, 317 aa; fasta scores: opt: 1022 z-score: 1035.4 E(): 0; 46.6% identity in 311 aa overlap. Contains a match to Pfam entry PF00480 ROK, ROK family and Prosite entry PS01125 ROK family signature. (382 aa)
SCO6115SC9B2.02, possible ROK family transcriptional regulator, len: 407 aa; similar to many e.g. SW:XYLR_BACSU xylose repressor XylR from Bacillus subtilis (384 aa) fasta scores; opt: 470, z-score: 522.8, E(): 7.9e-22, (28.4% identity in 370 aa overlap). Contains Pfam match to entry PF00480 ROK, ROK family. Also contains a probable helix-turn-helix (+3.71 SD) at residues 32 to 53. (407 aa)
SCO6110SCBAC1A6.34c, probable sugar kinase, len: 308 aa; similar to SW:GLK_STRCO (EMBL:X65932) Streptomyces coelicolor glucokinase (EC 2.7.1.2) Glk or SC6E10.20c, 317 aa; fasta scores: opt: 391 z-score: 407.0 E(): 4.3e-15; 34.4% identity in 314 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and match to Prosite entry PS01125 ROK family signature. (308 aa)
SCO5059SCBAC20F6.02, ppgK, polyphosphate glucokinase, len: 246 aa; highly similar to SW:PPGK_MYCTU (EMBL:U44834) Mycobacterium tuberculosis polyphosphate glucokinase (EC 2.7.1.63) PpgK or RV2702 or MTCY05A6.23, 265 aa; fasta scores: opt: 912 Z-score: 1042.8 bits: 200.5 E(): 1.7e-50; 57.322% identity in 239 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family. (246 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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