STRINGSTRING
SCO7733 SCO7733 SCO0110 SCO0110 SCO0148 SCO0148 SCO0160 SCO0160 SCO0174 SCO0174 SCO0233 SCO0233 SCO0236 SCO0236 SCO0307 SCO0307 SCO0376 SCO0376 SCO0891 SCO0891 SCO0981 SCO0981 SCO1200 SCO1200 SCO1227 SCO1227 SCO1242 SCO1242 SCO1312 SCO1312 SCO1489 SCO1489 SCO1619 SCO1619 SCO1979 SCO1979 SCO2246 SCO2246 SCO7724 SCO7724 SCO7706 SCO7706 SCO7615 SCO7615 SCO7579 SCO7579 SCO7279 SCO7279 SCO7140 SCO7140 SCO7027 SCO7027 SCO6950 SCO6950 SCO6802 SCO6802 SCO6770 SCO6770 SCO6713 SCO6713 SCO6675 SCO6675 SCO6629 SCO6629 SCO6598 SCO6598 SCO6539 SCO6539 SCO6537 SCO6537 SCO6410 SCO6410 SCO6299 SCO6299 SCO6236 SCO6236 SCO6129 SCO6129 SCO6003 SCO6003 SCO5998 SCO5998 SCO5755 SCO5755 SCO5692 SCO5692 SCO5614 SCO5614 SCO5611 SCO5611 SCO5427 SCO5427 SCO2253 SCO2253 SCO2381 SCO2381 SCO2501 SCO2501 SCO2513 SCO2513 SCO2537 SCO2537 SCO2865 SCO2865 SCO2869 SCO2869 SCO3272 SCO3272 SCO3308 SCO3308 SCO3421 SCO3421 SCO3537 SCO3537 SCO3782 SCO3782 SCO5337 SCO5337 SCO5125 SCO5125 SCO5095 SCO5095 SCO4998 SCO4998 SCO4944 SCO4944 SCO4826 SCO4826 SCO4810 SCO4810 SCO4743 SCO4743 SCO4680 SCO4680 SCO4678 SCO4678 SCO4543 SCO4543 SCO4441 SCO4441 SCO4176 SCO4176 SCO4301 SCO4301 SCO4198 SCO4198 mmyB mmyB SCP1.186 SCP1.186 SCP1.89c SCP1.89c SCP1.60 SCP1.60 SCO7817 SCO7817 SCO7767 SCO7767 SCO3365 SCO3365 SCO3506 SCO3506
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SCO7733SC8D11.24, possible transcriptional regulatory protein, len: 739 aa. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. Also contains a possible helix-turn-helix motif at residues 40..61 (+4.44 SD). (739 aa)
SCO0110SCJ11.39c, possible DNA-binding protein, len: 279 aa; similar to TR:O86721 (EMBL:AL031515) hypothetical protein from Streptomyces coelicolor (272 aa) fasta scores; opt: 123, z-score: 148.4, E(): 0.66, (26.6% identity in 278 aa overlap). Contains possible helix-turn-helix motif 40-61 aa (+3.21 SD). (279 aa)
SCO0148SCJ33.12, possible transcriptional regulatory protein, len: 81 aa. Highly similar to Bacillus subtilis TR:O31834 (EMBL:Z99114) YozG protein (84 aa), fasta scores opt: 307 z-score: 443.1 E(): 2.6e-17 61.8% identity in 68 aa overlap. Contains a Pfam match to entry PF01381 HTH_3, Helix-turn-helix which lies between residues 17..38 (+3.45 SD). (81 aa)
SCO0160SCJ1.09c, possible DNA-binding protein, len: 195 aa, similarity to Mycobacterium tuberculosis TR:O53625 (EMBL; AL021428) hypothetical 16.6 KD protein (152 aa), fasta scores opt: 182 z-score: 220.8 E(): 6.1e-05 34.2% identity in 155 aa overlap and Mycobacterium tuberculosis TR:O05803 (EMBL; Z95150) hypothetical 12.3 KD protein (110 aa), fasta scores opt: 142 z-score: 177.2 E(): 0.016 34.8% identity in 89 aa overlap. Contains a Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 34..55 (+3.91 SD). (233 aa)
SCO0174SCJ1.23c, possible DNA-binding protein, len: 323 aa. Similar in parts to many, e.g. Mycobacterium tuberculosis TR:O53625 (EMBL; AL021428) hypothetical 16.6 KD protein MTV030.24 (152 aa), fasta scores opt: 224 z-score: 258.5 E(): 4.9e-07 34.3% identity in 134 aa overlap and Mycobacterium tuberculosis SW:YU07_MYCTU (EMBL; Z77163) hypothetical 8.6 KD protein MTCY339.07C (80 aa), fasta scores opt: 182 z-score: 216.4 E(): 0.00011 42.3% identity in 71 aa overlap. Also similar to TR:Q9RJ05 (EMBL:AL109962) Streptomyces coelicolor possible DNA-binding protein SCJ1.09c, 233 aa; fasta scores: opt [...] (323 aa)
SCO0233SCJ9A.12c, possible DNA-binding protein, len: 279 aa; N-terminal similar to TR:O86721 (EMBL:AL031515) hypothetical protein from Streptomyces coelicolor (272 aa) fasta scores; opt: 135, z-score: 165.1, E(): 0.079, (29.3% identity in 150 aa overlap). Contains possible helix-turn-helix motif (+3.31 SD) 37-58 aa. (279 aa)
SCO0236SCJ9A.15c, possible DNA-binding protein, len: 290 aa; prediction based on GC Frameplot, Hidden Markov Model and amino acid usage. Similar to TR:CAC44562 (EMBL:AL596144) Streptomyces coelicolor putative DNA-binding protein SCBAC12C8.07c, 284 aa; fasta scores: opt: 636 Z-score: 730.2 E(): 4.9e-33; 43.060% identity in 281 aa overlap. Contains possible helix-turn-helix motif (+3.31 SD) residues 39-60. (290 aa)
SCO0307SC5G9.16, possible DNA-binding protein, len: 295 aa; probable CDS suggested by GC frameplot and positional base preference. Similar to possible DNA-binding proteins from S. coelicolor e.g. SCJ9A.15c (cosmid SCJ9A), S. coelicolor possible DNA-binding protein (290 aa) (39.3% identity in 298 aa overlap). Contains probable helix-turn-helix motif at residues 35-56 (Score 1197, +3.26 SD). (295 aa)
SCO0376SCF62.02, possible transcriptional regulator, len: 200 aa. Similar to several proteins of undefined function from Streptomyces sp. e.g. Streptomyces coelicolor TR:CAB51134 (EMBL; Y18817) hypothetical 20.6 KD protein (190 aa), fasta scores opt: 352 z-score: 424.9 E(): 2.6e-16 37.0% identity in 189 aa overlap. Contains a Pfam match to entry PF01381 HTH_3, Helix-turn-helix between residues 29..50 (+5.17 SD). (200 aa)
SCO0891SCM1.24, possible DNA-binding protein, len: 279 aa. Highly similar to many Streptomyces coelicolor putative DNA-binding proteins e.g. TR:CAB53273 (EMBL:AL109972) SCJ9A.12C (279 aa), fasta scores opt: 564 z-score: 639.5 E(): 2.8e-28 37.2% identity in 269 aa overlap. Contains a Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a Prosite hit to PS00092 N-6 Adenine-specific DNA methylases signature. The putative helix-turn-helix motif is situated between residues 35..56 (+4.25 SD). (279 aa)
SCO0981SCBAC19F3.08c, possible DNA-binding protein, len: 489aa: similar to many eg. TR:AAK44705 (EMBL:AE006950) putative DNA-binding protein MT0481 from Mycobacterium tuberculosis (474 aa) fasta scores; opt: 1753, Z-score: 1963.4, 56.780% identity (58.009% ungapped) in 472 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). (489 aa)
SCO1200SCG11A.31c, probable regulatory protein, len 191 aa; similar to TR:Q54855 (EMBL:X61931) Streptomyces purpurascens ORF1, 90 aa; fasta scores: opt: 560 z-score: 686.7 E(): 7.2e-31; 85.6% identity in 90 aa overlap and to TR:CAB39703 (EMBL:AL049485) Streptomyces coelicolor putative DNA-binding protein SC6A5.19, 204 aa; fasta scores: opt: 382 z-score: 468.0 E(): 1.1e-18; 39.2% identity in 176 aa overlap and to Streptomyces coelicolor SC6G4.21, fasta scores: opt: 717 z-score: 721.2 E(): 8e-35; 60.0% identity in 190 aa overlap. Contains match to Pfam entry PF01381 HTH_3, Helix-turn-helix and [...] (191 aa)
SCO12272SCG1.02c, possible DNA-binding protein, len: 489 aa; similar to TR:CAB89011 (EMBL:AL353870) Streptomyces coelicolor hypothetical 50.9 kD protein SC6F7.03, 467 aa; fasta scores: opt: 177 z-score: 183.6 E(): 0.0092; 26.7% identity in 476 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 44..65 (+3.67 SD). Also contains a TTA leucine codon (159), possible target for bldA regulation. (489 aa)
SCO12422SCG1.17, probable DNA-binding protein, len: 286 aa; similar to TR:CAB8844 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 626 z-score: 747.0 E(): 0; 40.0% identity in 280 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 25..46 (+4.46 SD). Also contains a TTA leucine codon (58), possible target for bldA regulation. (286 aa)
SCO1312SCBAC36F5.23c, probable transcriptional regulatory protein, len: 201 aa; similar to TR:Q9I1G3 (EMBL:AE004657) Pseudomonas aeruginosa probable transcriptional regulator PA2312, 193 aa; fasta scores: opt: 339 Z-score: 397.1 bits: 80.3 E(): 1.6e-14; 35.519% identity in 183 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and two possible helix-turn-helix domains at residues 35..56 (+2.92 SD) and 64..85 (+4.24 SD). (201 aa)
SCO1489SC9C5.13, bldD, putative DNA-binding protein, len: 167 aa; identical to previously sequenced TR:O52732 (EMBL:AF045549) Streptomyces coelicolor putative DNA binding protein BldD, 167 aa. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (167 aa)
SCO1619SCI41.02c, possible transcriptional regulatory protein, len: 189 aa; similarity with TR:O53759 (EMBL:AL021933) Mycobacterium tuberculosis putative regulatory protein (140 aa); fasta scores: opt: 164 z-score: 208.0 E(): 0.00032, 31.3% identity in 112 aa overlap. Contains Pfam match PF01381 HTH_3, Helix-turn-helix. Contains probable helix-turn-helix motif at aa 25-46 (Score 1293, +3.59 SD). (189 aa)
SCO1979SC3C9.14c, probable DNA-binding protein, len: 286 aa; similar to many Streptomyces DNA-binding proteins e.g. TR:Q9F3E2 (EMBL:AL450289) Streptomyces coelicolor putative DNA-binding proteins SC2H2.13, 290 aa; fasta scores: opt: 1019 Z-score: 1178.0 bits: 225.9 E(): 5.2e-58; 55.000% identity in 280 aa overlap and TR:O86719 (EMBL:AL031515) SC5C7.22c, 287 aa; fasta scores: opt: 1360 Z-score: 1390.2 bits: 265.1 E(): 1e-71; 69.338% identity in 287 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 28..49 (+4.23 SD). (286 aa)
SCO2246Conserved hypothetical protein SC1G2.08c; SC1G2.08c, unknown, len: 258 aa. Similar to several proteins of undefined function from Streptomyces coelicolor including: TR:O86676(EMBL:AL031371) SC4G2.03 (277 aa), fasta scores opt: 604 z-score: 734.8 E():0 46.3% identity in 229 aa overlap and TR:Q9X8M2(EMBL:AL049628) SCE94.16C (280 aa), fasta scores opt: 469 z-score: 572.0 E(): 1.8e-24 35.2% identity in 230 aa overlap. This gene is duplicated on this cosmid and shares 76.1 % identity, in 259 aa overlap, with the downstream gene, SC1G2.15c. (258 aa)
SCO7724SC8D11.15c, hypothetical protein, len: 471 aa; similar to TR:Q9WX25 (EMBL:AL079345) Streptomyces coelicolor putative membrane protein SCE68.06c, 464 aa; fasta scores: opt: 428 z-score: 361.4 E(): 1.4e-12; 40.4% identity in 478 aa overlap. (471 aa)
SCO7706SCBAC12C8.07c, putative DNA-binding protein, len: 284aa: similar to many from Streptomyces coelicolor eg. TR:Q9ADL0 (EMBL:AL451182) putative DNA-binding protein 2SCK31.04c (291 aa) fasta scores; opt: 731, Z-score: 816.6, 47.778% identity in 270 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (284 aa)
SCO7615SC2H2.13, possible DNA-binding protein, len: 290 aa; similar to many Streptomyces coelicolor putative DNA-binding proteins, e.g. TR:CAC01466 (EMBL:AL391014) putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 613 z-score: 722.6 E(): 1e-32; 41.8% identity in 261 aa overlap and TR:CAA20634 (EMBL:AL031515) hypothetical protein SC5C7.22c, 287 aa; fasta scores: opt: 917 z-score: 1027.9 E(): 0; 50.0% identity in 292 aa overlap. Contains possible helix-turn-helix motif at residues 33..54 (+4.70 SD). (290 aa)
SCO7579SC5F1.33, possible DNA-binding protein, len: 291 aa; similar to TR:Q9KZY5 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 643 z-score: 787.2 E(): 0; 37.0% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. Also contains possible helix-turn-helix motif at residues 31..52 (+6.28 SD). (291 aa)
SCO7279SC5H1.13c, possible DNA-binding protein, len: 157 aa; contains region similar to TR:O33287 (EMBL:AL008967) Mycobacterium tuberculosis possible transcriptional regulator (112 aa), fasta scores; opt: 254 z-score: 260.9 E(): 3.3e-07, 50.0% identity in 94 aa overlap and TR:O86815 (EMBL:AL031031), SC7C7.10, S.coelicolor hypothetical protein (126 aa) (55.6% identity in 72 aa overlap). Possible DNA-binding function as it contains probable helix-turn-helix motif at aa 77-98 (Score 1354, +3.80 SD) and Pfam match to entry PF01381 HTH_3, Helix-turn-helix, score 41.30, E-value 2.2e-08. PQATR repea [...] (157 aa)
SCO7140SC9A4.02, probable DNA-binding protein, len: 276 aa; highly similar to TR:Q9S1Q8 (EMBL:AL109972) Streptomyces coelicolor putative DNA-binding protein SCJ9A.12c, 279 aa; fasta scores: opt: 1046 z-score: 1203.5 E(): 0; 59.1% identity in 274 aa overlap. Contains a possible helix-turn-helix motif at residues 36..57 (+3.89 SD). (276 aa)
SCO7027SC1H10.16c, probable LacI-family transcriptional regulator, len: 339 aa. Highly similar to Streptomyces lividans TR:Q9ZI18 (EMBL:AF043654) LacI-GalR family regulatory protein, BxlR (338 aa), fasta scores opt: 2136 z-score: 2395.5 E(): 0 96.5% identity in 340 aa overlap and Escherichia coli SW:CYTR_ECOLI (EMBL:X03683) transcriptional repressor, CytR (341 aa), fasta scores opt: 553 z-score: 625.0 E(): 2.2e-27 32.7% identity in 330 aa overlap. Also highly similar to Streptomyces coelicolor TR:O86795(EMBL:AL031317) putative transcriptional regulator, SC6G4.32 (355 aa), fasta scores opt: 13 [...] (339 aa)
SCO6950Conserved hypothetical protein SC6F7.03; SC6F7.03, unknown, len: 467 aa. Weakly similar to several including: Streptomyces coelicolor TR:Q9X7U7(EMBL:AL049863) putative regulatory protein, SC5H1.40C (502 aa), fasta scores opt: 315 z-score: 356.4 E(): 2.1e-12 26.4% identity in 488 aa overlap. (467 aa)
SCO6802SC1A2.11, possible DNA-binding protein, len: 192 aa. Similar to Streptomyces coelicolor TR:Q9X7W5 (EMBL:AL049485) putative DNA-binding protein, SC6A5.19 (204 aa), fasta scores opt: 213 z-score: 254.6 E(): 9e-07 30.9% identity in 178 aa overlap. Contains a Pfam match to entry PF01381 HTH_3, Helix-turn-helix with the putative helix-turn-helix motif situated between residues 28..49 (+7.43 SD). (192 aa)
SCO6770SC6A5.19, probable DNA-binding protein, len: 204 aa; similar to several of undefined function eg. TR:O86784 (EMBL:AL031317) hypothetical protein from Streptomyces coelicolor (201 aa) fasta scores; opt: 297, z-score: 356.2, E(): 1.5e-12, (34.9% identity in 212 aa overlap). Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (204 aa)
SCO6713SC4C6.23, probable lacI-family transcriptional regulator, len: 352 aa; similar to many e.g. TR:O87590 (EMBL:AF086819), CelR, Thermomonospora fusca transcriptional regulator of cellulase genes (340 aa), fasta scores; opt: 991 z-score: 1119.2 E(): 0, 51.9% identity in 324 aa overlap. Similar to others from S. coelicolor e.g. TR:O86795 (EMBL:AL031317) S. coelicolor putative transcriptional regulator (355 aa) (36.3% identity in 342 aa overlap). Contains Pfam matches to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family and to entry PF00356 lacI, Bacterial regulator [...] (352 aa)
SCO6675SC5A7.25c, possible DNA-binding protein, len: 218 aa. Contains probable helix-turn-helix motif from aa 92-113 (Score 1665, +4.86 SD). (218 aa)
SCO6629SC4G2.03, hypothetical protein, len: 277 aa; similar to TR:Q9F345 (EMBL:AL391751) Streptomyces coelicolor hypothetical protein SC9E12.10c, 287 aa; fasta scores: opt: 769 Z-score: 890.8 E(): 5.5e-42; 48.736% identity in 277 aa overlap. (277 aa)
SCO6598SC8A6.19, probable transcriptional regulator, len: 246 aa; similar to many members of the lacI family, e.g. CCP A_BACSU glucose-resistance amylase regulator (334 aa), fast a scores; opt: 313 z-score: 569.6 E(): 1.7e-24, 31.2% identity in 317 aa overlap. Contains PS00356 Bacterial regulatory proteins, lacI family signature, helix-tur-helix motif at aa 7-28 (Score 2389, +7.32 SD) and Pfam matches to entry P F00532 Peripla_BP_like, Periplasmic binding proteins and LacI family, score 86.50, E-value 5.3e-22 and Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, sc [...] (346 aa)
SCO6539SC5C7.24c, hypothetical protein, len: 272 aa; similar to TR:Q985F1 (EMBL:AP003012) Rhizobium loti (Mesorhizobium loti) MLL7704 protein, 270 aa; fasta scores: opt: 786 Z-score: 877.1 E(): 3.2e-41; 48.638% identity in 257 aa overlap. (272 aa)
SCO6537SC5C7.22c, unknown, len: 287 aa; similar to S. coelicolor hypothetical protein SC4G2.03 (E(): 2.2e-08, 29.2% identity in 257 aa overlap). Contains possible helix-turn-helix motif at aa 29-50 (Score 1251, +3.45 SD). (287 aa)
SCO6410SC3C8.29, possible DNA-binding protein, len: 83 aa; contains probable helix-turn-helix motif at aa 29 to 50 (Score 1589, +4.60 SD)). (83 aa)
SCO6299SCIF3.01c, probable tetR-family transcriptional regulator, len: >248 aa; similar to TR:Q9XDV7 (EMBL:AB023642) Streptomyces griseus DNA-binding protein ORF2, 289 aa; fasta scores: opt: 847 z-score: 994.6 E(): 0; 65.3% identity in 245 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 28..49 (+3.30 SD); SCBAC8D1.12c, possible DNA-binding protein (fragment), len: >72 aa; similar to TR:Q9XDV7 (EMBL:AB023642) Streptomyces griseus DNA-binding protein ORF2, 289 aa; fasta scores: opt: 247 Z-score: 31 [...] (285 aa)
SCO6236SCAH10.01c, possible DNA-binding protein, len: >270 aa; similar to TR:Q9Z543 (EMBL:AL035212) Streptomyces coelicolor putative binding protein, SC9B2.16c, len: 303 aa; fasta scores: opt: 466 z-score: 574.2 E(): 1.3e-24; 34.1% identity in 252 aa overlap. Contains a possible helix-turn-helix motif between residues 612..677 (+3.39 SD); SC2H4.18c, unknown, partial CDS, len: >55 aa; some similarity to the C-terminus of S. coelicolor hypothetical protein SC4G2.03, fasta scores; (E(): 0.018, 32.7% identity in 52 aa overlap). (291 aa)
SCO6129SC9B2.16c, possible DNA-binding protein, len: 303aa; similar to proteins of unknown function egs. TR:O86676 (EMBL:AL031371) hypothetical 30.7 kD protein from Streptomyces coelicolor (277 aa) fasta scores; opt: 552, z-score: 663.3, E(): 1.2e-29, (37.7% identity in 257 aa overlap) and SW:ENTD_SALTY EntD, a protein from Salmonella typhimurium with undefined involvement in enterobactin biosynthesis (232 aa) fasta scores; opt: 102, z-score: 129.9, E(): 6, (26.7% identity in 191 aa overlap). Contains a probable helix-turn-helix (+3.37 SD) at residues 60 to 81. (303 aa)
SCO6003SCBAC1C11.06c, possible DNA-binding protein, len: 286 aa; similar to TR:CAC01466 (EMBL:AL391014) Streptomyces coelicolor putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 528 z-score: 639.9 E(): 4.2e-28; 37.4% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 27..48 (+4.04 SD). (286 aa)
SCO5998Putative UDP-N-acetylglucosamine transferase; SCBAC1C11.01c, murA2, possible bifunctional protein (fragment), len: >138 aa; N-terminal domain similar to TR:Q9X153 (EMBL:AE001787) Thermotoga maritima lacI-family transcriptional regulator, putative TM1330, 111 aa; fasta scores: opt: 139 z-score: 193.0 E(): 0.0033; 39.4% identity in 66 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 22..43 (+7.45 SD) and C-terminal domain similar to TR:Q9PJT7 (EMBL:AE002342) Chlamydia muridarum UDP-N-acetylglucosamine 1-carboxyvinylt [...] (509 aa)
SCO5755Hypothetical protein SC7C7.10; SC7C7.10, unknown, len: 126 aa; highly similar to M. tuberculosis TR:O33287 (EMBL:AL008967) possible transcriptional regulator MTV002.10C (Rv2745c) (112 aa), fasta scores; opt: 300 z-score: 454.0 E(): 4.7e-18, 60.5% identity in 86 aa overlap. (126 aa)
SCO5692SC5H4.16c, probable transcriptional regulator, len: 337 aa; similar to SW:CELR_THEFU (EMBL:AF086819) Thermomonospora fusca transcription regulator CelR, 340 aa; fasta scores: opt: 440 z-score: 531.7 E(): 3.7e-22; 31.6% identity in 339 aa overlap. Contains Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI family and PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family and match to Prosite entry PS00356 Bacterial regulatory proteins, lacI family signature. Contains also possible helix-turn-helix motif at residues 2..23 [...] (337 aa)
SCO5614SC2E1.31, possible prophage transcriptional regulator, len: 63 aa; similar to the N-terminus of many e.g. TR:E264367 (EMBL:X87420) Salmonella typhimurium bacteriophage ES18 gene C2 (216 aa), fasta scores; opt: 133 z-score: 207.9E(): 0.00024, 35.8% identity in 53 aa overlap. Contains probable helix-turn-helix motif at aa 17 to 38 (Score 1786, +5.27 SD). (63 aa)
SCO5611SC2E1.28, possible prophage transcriptional regulator, len: 71 aa; similar to the N-terminus of many e.g. TR:Q37946 Salmonella typhimurium bacteriophage L repressor protein C2 (220 aa), fasta scores; opt: 127 z-score: 227.1 E():2e-05, 45.7% identity in 46 aa overlap. Contains probable helix-turn-helix motif at aa 21 to 42 (Score 1829, +5.42 SD). (71 aa)
SCO5427Hypothetical protein SC6A11.03c; SC6A11.03c, unknown, len: 237 aa; no significant database similarities. (237 aa)
SCO2253Conserved hypothetical protein SC1G2.15c; SC1G2.15c, unknown, len: 258 aa. Similar to several proteins of undefined function from Streptomyces coelicolor including: TR:O86676(EMBL:AL031371) SC4G2.03 (277 aa), fasta scores opt: 758 z-score: 919.8 E():0 46.7% identity in 276 aa overlap and TR:Q9X8M2(EMBL:AL049628) SCE94.16C (280 aa), fasta scores opt: 476 z-score: 580.1 E(): 6.2e-25 32.7% identity in 260 aa overlap. This gene is duplicated on this cosmid and shares 76.1 % identity, in 259 aa overlap, with the upstream gene, SC1G2.08c. (284 aa)
SCO2381SC4A7.09, hypothetical protein, len: 278 aa; simialr to various hypothetical proteins, e.g. TR:Q9X8M2 (EMBL:AL049628) Streptomyces coelicolor hypothetical 31.5 kD protein SCE94.16c, 280 aa; fasta scores: opt: 1333 z-score: 1595.1 E(): 0; 76.4% identity in 271 aa overlap. (278 aa)
SCO2501SCC121.04c, possible DNA-binding protein, len: 298 aa; similar to TR:CAB52924 (EMBL:AL109949) Streptomyces coelicolor putative DNA-binding protein SCJ11.39c, 279 aa; fasta scores: opt: 713 z-score: 847.3 E(): 0; 44.0% identity in 266 aa overlap and to TR:CAB53273 (EMBL:AL109972) Streptomyces coelicolor putative DNA-binding protein SCJ9A.12c, 279 aa; fasta scores: opt: 416 z-score: 497.4 E(): 2.6e-20; 35.1% identity in 276 aa overlap. (298 aa)
SCO2513SCC121.16, hypothetical protein, len: 277 aa; similar to various hypothetical proteins, e.g. TR:Q9X8M2 (EMBL:AL049628) Streptomyces coelicolor hypothetical 31.5 kD protein SCE94.16c, 280 aa; fasta scores: opt: 538 z-score: 655.5 E(): 4.1e-29; 37.1% identity in 259 aa overlap. (277 aa)
SCO2537SCC77.04c, possible DNA-binding protein, len: 294 aa. Highly similar to several other Streptomyces coelicolor proteins including: TR:CAB52924 (EMBL:AL109949) putative DNA-binding protein SCJ11.39C (279 aa), fasta scores opt: 575 z-score: 702.8 E(): 9.3e-32 41.2% identity in 257 aa overlap and TR:CAB55664 (EMBL:AL117385) hypothetical 32.2 KD protein SC5G9.16 (295 aa), fasta scores opt: 521 z-score: 637.0 E(): 4.3e-28 36.5% identity in 288 aa overlap. Contains a putative helix-turn-helix motif situated between residues 47..68 (+2.88 SD). (294 aa)
SCO2865Putative regulatory protein; SCE6.02, possible regulatory protein, len: 280 aa. Similar to several proteins of undefined function including: Streptomyces albulus TR:BAA89264 (EMBL:AB025200) hypothetical protein ORF312 (285 aa), fasta scores opt: 585 z-score: 728.2 E():0 38.2% identity in 280 aa overlap and Streptomyces coelicolor TR:Q9Z543 (EMBL:AL035212) putative DNA binding protein, SC9B2.16C (303 aa), fasta scores opt: 313 z-score: 391.9 E(): 2.1e-14 31.0% identity in 284 aa overlap. Also weakly similar to SCE6.06, also located on this cosmid, fasta scores opt: 269 z-score: 293.0 E( [...] (280 aa)
SCO2869Putative regulatory protein; SCE6.06, possible regulatory protein, len: 281 aa. Similar to several proteins of undefined function e.g. Streptomyces albulus TR:BAA89264(EMBL: AB025200) plasmid pNO33 protein ORF312 (285 aa), fasta scores opt: 356 z-score: 441.0 E(): 3.9e-17 30.9% identity in 282 aa overlap. Also weakly similar to SCE6.02, also located on this cosmid, fasta scores opt: 269 z-score: 293.0 E(): 8.1e-11 27.5% identity in 265 aa overlap. Contains a putative helix-turn-helix motif situated between residues 27..48 (+4.07 SD). (281 aa)
SCO3272SCE39.22c, possible DNA-binding protein, len: 122aa; some similarity to TR:O64356 (EMBL:AF064539) Gp48 protein from bacteriophage N15 (95 aa) fasta scores; opt: 114, z-score: 155.2, E(): 0.25, (36.6% identity in 71 aa overlap). Contains probable helix-turn-helix (+6.85 SD) 82-103aa. (122 aa)
SCO3308SCE68.06c, probable DNA-binding protein, len: 464 aa; similar to TR:Q9AK04 (EMBL:AL512944) Streptomyces coelicolor hypothetical protein SC8D11.15c, 471 aa; fasta scores: opt: 428 Z-score: 331.6 E(): 7.7e-11; 40.377% identity in 478 aa overlap; probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. Contains a hydrophobic, possible membrane-spanning region, followed by a low-complexity proline- and serine-rich region from aa 210 to 250 approx. Contains probable helix-turn-helix motif at aa 20-41 (Score 1605, +4.65 SD). (464 aa)
SCO3421SCE9.28c, hypothetical protein, len: 274 aa; similar others from S.coelicolor e.g. TR:O86719 (EMBL:AL031515), SC5C7.22C, hypothetical protein (287 aa), fasta scores; opt: 727 z-score: 871.9 E(): 0, 44.7% identity in 273 aa overlap. (274 aa)
SCO3537SCE2.18c, possible DNA-binding protein, len: 390 aa; similar to TR:O53463 (EMBL:AL021899) putative regulator from Mycobacterium tuberculosis (346 aa) fasta scores; opt: 208, z-score: 251.9, E(): 1e-06, (32.8% identity in 302 aa overlap). Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (390 aa)
SCO3782SCH63.29c, possible regulatory protein, len: 449 aa; similar to TR:O86603 (EMBL:AL031155) Streptomyces coelicolor transcriptional regulator SC3A7.02c, 892 aa; blastp scores: Score = 148 (52.1 bits), Expect = 6.7e-07, P = 6.7e-07; Identities = 98/317 (30%), Positives = 130/317 (41%). Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and 4x matches to entry PF00515 TPR, TPR Domain. (449 aa)
SCO5337Hypothetical protein SCBAC5H2.06c; SCBAC5H2.06c, unknown, len: 243 aa. (243 aa)
SCO5125SC9E12.10c, hypothetical protein, len: 287 aa; similar to TR:Q9RDR4 (EMBL:AL136500) Streptomyces coelicolor hypothetical 31.7 kDa protein SC1G2.15c, 284 aa; fasta scores: opt: 1240 z-score: 1466.1 E(): 0; 67.2% identity in 287 aa overlap. (287 aa)
SCO5095SCBAC28G1.21, ORF9, probable DNA-binding protein, len: 190 aa; identical to previously sequenced as TR:Q9X9V0 (EMBL:Y18817) Streptomyces coelicolor A3(2) hypothetical 20.6 kDa protein ORF9, 190 aa and similar to TR:O86784 (EMBL:AL031317) Streptomyces coelicolor SC6G4.21, 202 aa; fasta scores: opt: 642 Z-score: 656.2 bits: 128.2 E(): 7.9e-31; 53.968% identity in 189 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 25..46 (+6.01 SD). (190 aa)
SCO49982SCK36.21c, hypothetical protein, len: 283 aa; similar to TR:Q9XD96 (EMBL:AF106004) Streptomyces coelicolor hypothetical 31.8 kDa protein ORF3, 283 aa; fasta scores: opt: 815 Z-score: 959.3 bits: 185.4 E(): 8e-46; 45.230% identity in 283 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (283 aa)
SCO49442SCK31.04c, possible DNA-binding protein, len: 314 aa; similar to TR:Q9RI67 (EMBL:AL109949) Streptomyces coelicolor putative DNA-binding protein SCJ11.39c, 279 aa; fasta scores: opt: 544 z-score: 640.7 E(): 3.8e-28; 40.2% identity in 249 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 64..85 (+4.67 SD). (291 aa)
SCO4826SC2A6.11, possible membrane protein, len: 498 aa. Contains 5x degenerate repeat: (G/D)AY(G/D)(E/G)-(3) and possible hydrophobic membrane spanning region. (498 aa)
SCO4810SCD63A.21c, hypothetical protein, len: 342 aa; similar to TR:Q9Z9I2 (EMBL:AB024056) Streptomyces fradiae unknown protein, 306 aa; fasta scores: opt: 645 z-score: 632.8 E(): 8.7e-28; 44.5% identity in 281 aa overlap. (342 aa)
SCO4743Conserved hypothetical protein; SC6G4.21, unknown, len: 201 aa; similar, in part, to a hypothetical protein from Streptomyces purpurascens TR:Q 54855 (EMBL:X61931) (90 aa), fasta scores; opt: 376 z-score : 584.3 E(): 2.8e-25, 58.5% identity in 94 aa overlap. Cont ains helix-turn-helix motif at aa 28-49 (Score 2176, +6.60 SD). (201 aa)
SCO4680SCD31.05c, possible DNA-binding protein, len: 296 aa; similar to TR:CAB53273 (EMBL:AL109972) Streptomyces coelicolor putative DNA binding protein SCJ9A.12c, 279 aa; fasta scores: opt: 782 z-score: 910.0 E(): 0; 46.1% identity in 271 aa overlap. (296 aa)
SCO4678SCD31.03, conserved hypothetical protein, len: 282 aa; similar to various hypothetical proteins, e.g. TR:CAB66187 (EMBL:AL136500) Streptomyces coelicolor hypothetical 31.7 kD protein SC1G2.15c, 284 aa; fasta scores: opt: 1359 z-score: 1611.1 E(): 0; 71.7% identity in 279 aa overlap. (282 aa)
SCO45432SCD4.14c, hypothetical protein, len: 283 aa; identical to previously sequenced TR:Q9XD96 (EMBL:AF106004) Streptomyces coelicolor hypothetical 31.8 kDa protein, 283 aa. (283 aa)
SCO4441SCD6.19, possible DNA-binding protein, len: 295 aa; similar to many other S. coelicolor hypothetical proteins, e.g. TR:Q9X8K0 (EMBL:AL049841) Streptomyces coelicolor hypothetical 30.9 kD protein SCE9.28c, 274 aa; fasta scores: opt: 717 z-score: 834.5 E(): 0; 42.6% identity in 263 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 37..58 (+5.84 SD). (295 aa)
SCO4176SCD66.13, conserved hypothetical protein, len: 280 aa; similar to TR:O86676 (EMBL:AL031371) Streptomyces coelicolor hypothetical 30.7 kD protein SC4G2.03, 277 aa; fasta scores: opt: 378 z-score: 466.2 E(): 1.7e-18; 31.7% identity in 262 aa overlap. (280 aa)
SCO4301SCD95A.34c, possible DNA-binding protein, len: 279 aa; similar to various S. coelicolor hypothetical proteins, e.g. TR:CAB69734 (EMBL:AL137166) Streptomyces coelicolor hypothetical 30.4 kD protein SCC121.16, 277 aa; fasta scores: opt: 731 z-score: 897.3 E(): 0; 45.2% identity in 259 aa overlap and to TR:CAB88448 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 388 z-score: 478.8 E(): 3.3e-19; 34.3% identity in 286 aa overlap. Contains TTA leucine codon, possible target for bldA regulation and a possible helix-turn-helix motif at r [...] (279 aa)
SCO41982SCD46.12, probable DNA-binding protein, len: 141 aa; N-terminal region similar to many eg. TR:O53759 (EMBL:AL021933) putative regulatory protein from Mycobacterium tuberculosis (140 aa) fasta scores; opt: 412, z-score: 503.0, E(): 1.6e-20, 56.6% identity in 113 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and two helix-turn-helix motifs; (Score 979 (+2.52 SD)) at residue 51-72 and (Score 1963 (+5.87 SD)) at residue 22-43. (141 aa)
mmyBSCP1.230, mmyB, possible DNA-binding protein, len: 313aa; previously sequenced and annotated as TR:Q9JN77 (EMBL:AJ276673). Similar to many from Streptomyces coelicolor eg. TR:Q9RDF4 (EMBL:AL136503) putative DNA-binding protein (294 aa) fasta scores; opt: 670, z-score: 810.9, E(): 0, 43.1% identity in 255 aa overlap. Contains helix-turn-helix motif at residue 52-73 (Score 1329 (+3.71 SD)). Contains a TTA encoded leucine at residue 23, possible target for bldA regulation. (313 aa)
SCP1.186SCP1.186, conserved hypothetical protein, len: 282aa; similar to other hypothetical proteins from streptomycetes eg. SCE6.06 (TR:Q9KZT2 EMBL:AL353832) from Streptomyces coelicolor (281 aa) fasta scores; opt: 882, z-score: 1083.5, E(): 0, 47.9% identity in 280 aa overlap. Note possible alternative downstream translational start site. (282 aa)
SCP1.89cHypothetical protein; SCP1.89c, unknown, len: 389aa. (389 aa)
SCP1.60SCP1.60, possible conserved DNA-binding protein, len: 290aa; similar to many from streptomycetes eg. TR:Q9RHR7 (EMBL:AB025200) ORF312 protein from plasmid pNO33 of Streptomyces albulus (285 aa) fasta scores; opt: 857, z-score: 1027.5, E(): 0, and TR:Q9KZY5 (EMBL:AL353815) putative DNA-binding protein from Streptomyces coelicolor (295 aa) fasta scores; opt: 706, z-score: 847.4, E(): 0, 40.8% identity in 282 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (290 aa)
SCO7817SC8E7.14, possible DNA-binding protein, len: 280 aa. Highly similar to many other putative DNA-binding proteins e.g. Streptomyces coelicolor TR:Q9S1Q8 (EMBL:AL109972) SCJ9A.12C (279 aa), fasta scores opt: 946 z-score: 1117.2 E(): 0 54.1% identity in 268 aa overlap. Contains a putative helix-turn-helix motif situated between residues 131..153 (+3.68 SD). (280 aa)
SCO7767SC5E9.15c, possible DNA-binding protein, len: 275 aa; similar to many e.g. TR:Q9RD19 (EMBL:AL133422) putative DNA-binding protein from Streptomyces coelicolor (279 aa) fasta scores; opt: 510, z-score: 601.1, E(): 5.1e-26, 36.4% identity in 275 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 40..61 (+3.20 SD). (275 aa)
SCO3365Conserved hypothetical protein; SCE94.16c, unknown, len: aa; similar to others from Streptomyces coelicolor eg. TR:E1370777 (EMBL:AL035212) possible DNA binding protein (303 aa) fasta scores; opt: 420, z-score: 512.3, E(): 3.2e-21, (32.5% identity in 265 aa overlap). (280 aa)
SCO3506SCE134.07, possible lacI-family transcriptional regulator, len: 353 aa; similar to many e.g. SW:MALR_STRCO maltose operon transcriptional repressor MalR from Streptomyces coelicolor (344 aa) fasta scores; opt: 440, z-score: 508.9, E(): 4.9e-21, (32.4% identity in 352 aa overlap). Contains Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI family and PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family. (353 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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