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SCO6561 SCO6561 SCO0216 SCO0216 SCO1711 SCO1711 SCO2004 SCO2004 SCO2473 SCO2473 SCO4568 SCO4568 SCO4947 SCO4947 SCO6535 SCO6535 SCO6820 SCO6820 SCO7374 SCO7374 SCO7525 SCO7525
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO6561SC4B5.11c, respiratory chain oxidoreductase, len: 642 aa; similar to the C-terminal region of many proteins involved in electron transfer e.g. TR:P77908 (EMBL:U73807) FdhA formate dehydrogenase alpha subunit from Moorella thermoacetica (893 aa) fasta scores; opt: 1532, z-score: 1338.5, E(): 0, (43.1% identity in 619 aa overlap). Contains Pfam match to entry PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases, score 95.80, E-value 6.2e-30. Considering the corresponding homolgies, this CDS may have previously been located directly downsteam of SC4B5.09c. (642 aa)
SCO0216SCJ12.28, narG2, probable nitrate reductase alpha chain, len: 1233 aa. Highly similar to Streptomyces coelicolor TR:O86717 (EMBL; AL031515) putative nitrate reductase alpha chain NarG SC5C7.20c (1231 aa), fasta scores: opt: 5792 z-score: 6544.7 E(): 0 67.6% identity in 1230 aa overlap and Bacillus subtilis SW:NARG_BACSU (EMBL; Z49884) nitrate reductase alpha chain (EC 1.7.99.4) NarG (1228 aa), fasta scores: opt: 4331 z-score: 4891.8 E(): 0 52.9% identity in 1201 aa overlap. Contains a PS00551 Prokaryotic molybdopterin oxidoreductases signature 1, a Pfam match to entry PF00384 molybdopt [...] (1233 aa)
SCO1711SCI30A.32c, possible dehydrogenase, len: 747aa; similar to many e.g. TR:O53648 (EMBL:AL021928) hypothetical protein from Mycobacterium tuberculosis (762 aa) fasta scores; opt: 617, z-score: 625.8, E(): 1.6e-27, (29.9% identity in 762 aa overlap) and SW:FDHF_ECOLI formate dehydrogenase from Escherichia coli (715 aa) fasta scores; opt: 466, z-score: 473.3, E(): 4.9e-19, (24.0% identity in 716 aa overlap); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (747 aa)
SCO2004SC7H2.18, possible formate dehydrogenase, len: 759 aa; similar to many formate dehydrogenase e.g. SW:FDHF_ECOLI formate dehydrogenase H from Escherichia coli (715 aa) fasta scores; opt: 386, z-score: 441.8, E(): 2.8e-17, (26.3% identity in 670 aa overlap). Also similar to SW:YX31_MYCTU hypothetical protein from Mycobacterium tuberculosis (779 aa) fasta scores; opt: 3038, z-score: 3497.1, E(): 0, (59.7% identity in 767 aa overlap); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa)
SCO2473SC7A8.12, probable nitrate reductase, len: 819 aa; similar to SW:NASC_BACSU (EMBL:D50453) Bacillus subtilis assimilatory nitrate reductase catalytic subunit (EC 1.7.99.4) NasC, 710 aa; fasta scores: opt: 1568 z-score: 1572.1 E(): 0; 37.9% identity in 816 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_binding, Molydopterin dinucleotide binding domain. Contains also glycine/serine rich region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (819 aa)
SCO4568NuoG, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I 75 kDa subunit family. (843 aa)
SCO49472SCK31.07, narG3, nitrate reductase alpha chain, len: 1227 aa; highly similar to SW:NARG_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase alpha chain (EC 1.7.99.4)NarG, 1228 aa; fasta scores: opt: 4080 z-score: 4618.0 E(): 0; 49.5% identity in 1206 aa overlap and to TR:O86717 (EMBL:AL031515) Streptomyces coelicolor NarG, putative nitrate reductase alpha chain SC5C7.20, 1231 aa; fasta scores: opt: 5648 z-score: 5294.1 E(): 0; 66.6% identity in 1232 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_bin [...] (1227 aa)
SCO6535SC5C7.20c, narG, probable nitrate reductase alpha chain, len: 1231 aa; highly similar to many e.g. NARG_BACSU nitrate reductase alpha chain (EC 1.7.99.4) (1228 aa), fasta scores; opt: 4306 z-score: 3216.7 E(): 0, 51.5% identity in 1235 aa overlap. Contains PS00551 and PS00490 Prokaryotic molybdopterin oxidoreductases signatures 1 and 2 and Pfam match to entry PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases, score 79.90, E-value 1e-24; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1231 aa)
SCO6820Putative oxidoreductase; SC1A2.29c, possible oxidoreductase, len: 776 aa. Similar to a number of formate dehydrogenases e.g. Escherichia coli SW:FDHF_ECOLI(EMBL:M13563) formate dehydrogenase H (EC 1.2.1.2) (715 aa), fasta scores opt: 503 z-score: 564.0 E(): 5.2e-24 29.4% identity in 799 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_binding, Molydopterin dinucleotide binding domain.; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (776 aa)
SCO7374Nitrate reductase NarB (fragment); SC10G8.01c, possible oxidoreductase, partial CDS, len: > 355 aa. Similar to many e.g. Paracoccus denitrificans SW:NAPA_PARDT (EMBL:Z36773) periplasmic nitrate reductase precursor (EC 1.7.99.4) (831 aa), fasta scores opt: 550 z-score: 651.4 E(): 7.2e-29 33.1% identity in 317 aa overlap; SC9H11.28c, narB, nitrate reductase (EC 1.7.99.4), partial CDS, len: > 508 aa. Highly similar to many including: Synechocystis sp. (strain PCC 7942) SW:NARB_SYNP7 (EMBL:X74597) nitrate reductase (EC 1.7.99.4), NarB (729 aa), fasta scores opt: 583 z-score: 613.8 E(): 1e- [...] (830 aa)
SCO7525SC8G12.01, possible oxidoreductase, partial CDS, len: >169 aa. Highly similar to several including: Streptomyces coelicolor TR:CAB52060(EMBL:AL109732) putative formate dehydrogenase, SC7H2.18 (759 aa), fasta scores opt:670 z-score: 812.0 E(): 0 62.3% identity in 167 aa overlap and Mycobacterium tuberculosis TR:YX31_MYCTU(EMBL:Z74024) hypothetical 84.6 kd protein (779 aa), fasta scores opt: 571 z-score: 692.2 E(): 4.3e-31 55.2% identity in 172 aa overlap; SCBAC25F8.17, probable oxidoreductase (fragment), len: >629 aa; similar to N-terminal reguion of TR:AAK47294 (EMBL:AE007119) Mycobact [...] (764 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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