STRINGSTRING
SCO0185 SCO0185 SCO6760 SCO6760 SCO6763 SCO6763 SCO7700 SCO7700 SCP1.212 SCP1.212 SCO6073 SCO6073 SCO6759 SCO6759 SCO0187 SCO0187 SCO0565 SCO0565 SCO0568 SCO0568 SCO5222 SCO5222 SCO4583 SCO4583 SCO5250 SCO5250
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO0185SCJ1.34, crtB, possible geranylgeranyl pyrophosphate synthase, len: 392 aa. Shares a high level of similarity with Streptomyces griseus TR:Q54193 (EMBL:L37405) geranylgeranyl pyrophosphate synthase (425 aa), fasta scores: opt: 964 z-score: 1076.9 E(): 0 48.0% identity in 381 aa overlap and Mycobacterium tuberculosis TR:O53507 (EMBL:AL021957) geranylgeranyl pyrophosphate synthase (352 aa), fasta scores opt: 742 z-score: 831.2 E(): 0 43.0% identity in 328 aa overlap. Contains a PS00723 Polyprenyl synthetases signature 1. (392 aa)
SCO6760SC6A5.09, probable phytoene synthase, len: 312aa; similar to many egs. SW:CRTB_MYCTU probable phytoene synthase from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 791, z-score: 925.6, E(): 0, (48.3% identity in 286 aa overlap) and SW:PSY_ARATH phytoene synthase precusor from Arabidopsis thaliana (mouse ear cress) (423 aa) fasta scores; opt: 493, z-score: 577.3, E(): 7.4e-25, (34.4% identity in 282 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 168.70, E-value 9.4e-47 and Prosite matches to PS01044 Squalene and phytoene synthas [...] (312 aa)
SCO6763SC6A5.12, probable polyprenyl synthatase, len: 378aa; similar to many eg. SW:GGPP_MYCTU probable geranylgeranyl pyrophosphate synthatase from Mycobacterium tuberculosis (359 aa) fasta scores; opt: 1103, z-score: 1231.0, E(): 0, (49.3% identity in 355 aa overlap) and SW:IDSA_METTM short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum (324 aa) fasta scores; opt: 547, z-score: 614.0, E(): 6.7e-27, (38.2% identity in 293 aa overlap). Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases, score 176.70, E-value 3.9e-49 and Prosite matches [...] (378 aa)
SCO7700Putative cyclase; Catalyzes the cyclization of 2-methylgeranyl diphosphate (2- MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%). Belongs to the terpene synthase family. 2-methylisoborneol synthase subfamily. (440 aa)
SCP1.212Putative bifunctional undecaprenyl pyrophosphate synthetase/phytoene synthase; Catalyzes the reaction from prephytoene diphosphate to phytoene; In the N-terminal section; belongs to the phytoene/squalene synthase family. (564 aa)
SCO6073Putative cyclase; Tow-domain protein where the N-terminal domain catalyzes the cyclization of farnesyl diphosphate (FPP) to a 85:15 mixture of the sesquiterpene alcohol germacradienol and the sesquiterpene hydrocarbon germacrene D. The C-terminal domain partially converts the germacradienol formed into geosmin, the characteristic odoriferous ('earthy aroma') constituent of Streptomyces species. (726 aa)
SCO6759SC6A5.08, probable phytoene synthase, len: 303aa; similar to many eg. TR:Q50892 (EMBL:Z21955) phytoene synthase from the light-induced carotenoid biosynthesis cluster of Myxococcus xanthus (336 aa) fasta scores; opt: 322, z-score: 379.7, E(): 7.5e-14, (31.8% identity in 274 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 34.70, E-value 1.2e-08. (303 aa)
SCO0187SCJ1.36, crtI, probable phytoene synthase, len: 331 aa. Shares a high level of similarity with Streptomyces griseus SW:CRTB_STRGR (EMBL; L37405) phytoene synthase (342 aa), fasta scores opt: 1388 z-score: 1657.5 E(): 0 67.6% identity in 343 aa overlap and Mycobacterium marinum TR: O05423 (EMBL; U92075) phytoene synthase (319 aa), fasta scores opt: 996 z-score: 1191.5 E():0 52.2% identity in 316 aa overlap. Contains a PS01045 Squalene and phytoene synthases signature 2 and a Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases. (331 aa)
SCO0565SCF73.12c, probable polyprenyl synthetase, len: 352 aa; similar to members of the FPP/GGPP synthetases family e.g. GGPP_MYCTU probable geranylgeranyl pyrophosphate synthetase (359 aa), fasta scores; opt: 253 z-score: 299.8 E(): 2.5e-09 30.1% identity in 346 aa overlap, and ISPB_ECOLI octaprenyl-diphosphate synthase (323 aa), fasta scores; opt: 222 z-score: 264.3 E(): 2.4e-07, 30.0% identity in 337 aa overlap. Contains PS00444 Polyprenyl synthetases signature 2, and Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases. (352 aa)
SCO0568St8B3.02c, possible polyprenyl synthetase, len: 279 aa: similar to many e.g. TR:Q54193 (EMBL:L37405) geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa) fasta scores; opt: 479, Z-score: 544.9, 36.242% identity (38.710% ungapped) in 298 aa overlap and SW:P22939 (ISPA_ECOLI) geranyltransferase from Escherichia coli (299 aa) fasta scores; opt: 350, Z-score: 401.9, 31.939% identity (34.855% ungapped) in 263 aa overlap. Contains Prosite match to PS00723 Polyprenyl synthetases signature 1 and Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetase. (357 aa)
SCO5222Putative lyase; Catalyzes the cyclization of farnesyl diphosphate (FPP) to the sesquiterpene epi-isozizaene. (361 aa)
SCO4583SCD20.01, putative polyprenyl diphosphate synthase, len: 336 aa; similar to SW:HEP2_BACSU (EMBL:M80245) Bacillus subtilis heptaprenyl diphosphate synthase component II (EC 2.5.1.30) HepT, 348 aa; fasta scores: opt: 586 z-score: 674.6 E(): 4.2e-30; 33.0% identity in 309 aa overlap. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases and match to Prosite entry PS00444 Polyprenyl synthetases signature 2. (336 aa)
SCO52502SC7G11.12, gtr, polyprenyl synthetase, len: 386 aa; previously sequenced as TR:Q9RGW1 (EMBL:AF104994) Streptomyces coelicolor A3(2) geranyl transferase Gtr, 386 aa. Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases and match to Prosite entry PS00723 Polyprenyl synthetases signature 1; Belongs to the FPP/GGPP synthase family. (386 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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