STRINGSTRING
SCO4161 SCO4161 SCO4855 SCO4855 SCO4294 SCO4294 SCO2941 SCO2941 SCO2911 SCO2911 SCO2222 SCO2222 SCO2108 SCO2108 SCO1513 SCO1513 SCO1134 SCO1134 SCO6171 SCO6171 SCO5794 SCO5794 SCO5106 SCO5106 SCO5061 SCO5061 SCO4971 SCO4971 SCO7475 SCO7475 SCO6678 SCO6678 SCO0922 SCO0922 SCO0689 SCO0689
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO4161SCD84.28, possible molybdopterin converting factor, len: 84 aa; similar to TR:O53880 (EMBL:AL022004) Mycobacterium tuberculosis putative molybdopterin converting factor (subunit 1) MoaD-2, 92 aa; fasta scores: opt: 191 z-score: 269.0 E(): 1.6e-07; 45.9% identity in 85 aa overlap. (84 aa)
SCO4855SC5G8.23c, dhsB, probable succinate dehydrogenase iron-sulfur subunit, len: 257aa; strongly similar to many eg. SW:P07014 (DHSB_ECOLI) succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa) fasta scores; opt: 729, z-score: 839.1, E(): 0, 44.3% identity in 237 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Belongs to the succinate [...] (257 aa)
SCO4294SCD95A.27, hypothetical protein, len: 91 aa; similar to SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical 9.6 kD protein MTCY130.20, 93 aa; fasta scores: opt: 369 z-score: 480.3 E(): 2.7e-19; 63.4% identity in 93 aa overlap, to TR:CAB50992 (EMBL:AL096852) Streptomyces coelicolor hypothetical protein SCE19A.11c, 92 aa; fasta scores: opt: 332 z-score: 416.4 E(): 1.2e-17; 54.9% identity in 91 aa overlap and highly similar to TR:Q9EUR9 (EMBL:AJ250537) Streptomyces hygroscopicus hypothetical protein, 92 aa; fasta scores: opt: 496 Z-score: 626.4 E(): 2.9e-27; 83.516% identi [...] (91 aa)
SCO2941Conserved hypothetical protein SCE56.05c; SCE56.05c, unknown, len: 773 aa; similar to C-terminal region of TR:Q9VYQ2 (EMBL:AE003488) Drosophila melanogaster CG2779 protein, 1612 aa; fasta scores: opt: 651 Z-score: 464.7 E(): 3e-18; 31.405% identity in 847 aa overlap. High content in proline, glycine and alanine. Contains Pfam matches to entries PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and PF01799 fer2_2, [2Fe-2S] binding domain and match to Prosite entry PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. (773 aa)
SCO2911SCE19A.11c, conserved hypothetical protein, len: 92 aa; unknown function, similar to hypothetical proteins from other organisms e.g. SW:Y03K_MYCTU (EMBL:Z73902) Mycobacterium tuberculosis hypothetical protein (93 aa), fasta scores; opt: 341 z-score: 451.3 E(): 8.3e-18, 57.0% identity in 93 aa overlap. (92 aa)
SCO2222SC10B7.17, probable iron-sulfur oxidoreductase (putative secreted protein), len: 364 aa; similar to TR:O88034 (EMBL:AL031107) Streptomyces coelicolor iron-sulfur oxidoreductase beta subunit SC5A7.28c, 313 aa; fasta scores: opt: 1032 z-score: 1177.8 E(): 0; 55.2% identity in 310 aa overlap and to SW:POBB_PSEPS (EMBL:X78823) Pseudomonas pseudoalcaligenes phenoxybenzoate dioxygenase beta subunit (EC 1.-.-.-.) PobB, 319 aa; fasta scores: opt: 680 z-score: 777.9 E(): 0; 40.8% identity in 314 aa overlap. Contains two matches to Pfam entries Pfam match to entry PF00175 oxidored_fad, Oxidoredu [...] (364 aa)
SCO2108SC6E10.02, conserved hypothetical protein, len: 66 aa; unknown function, similar to e.g. SW:THIS_ECOLI (EMBL:M88701), ThiS, ThiG1, Escherichia coli hypothetical protein in thiamine biosynthetic operon (66 aa), fasta scores; opt: 138 z-score: 203.8 E(): 0.0005, 30.3% identity in 66 aa overlap and to TR:P96262 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical protein (68 aa) (39.7% identity in 68 aa overlap). (66 aa)
SCO1513GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. PppGpp could play an essential role in triggering antibiotic production under some nutritional conditions; Belongs to the RelA/SpoT family. (847 aa)
SCO11342SCG38.27c, probable oxidoreductase, iron-sulphur binding subunit, len: 200 aa; similar to TR:Q52589 (EMBL:X77931) Pseudomonas thermocarboxydovorans carbon monoxide oxygenase [cytochrome B-561], small chain (EC 1.2.2.4) CutC, 163 aa; fasta scores: opt: 405 z-score: 478.3 E(): 3.4e-19; 45.6% identity in 169 aa overlap and to TR:Q9RK27 (EMBL:AL132856) Streptomyces coelicolor putative oxidoreductase, iron-sulphur binding subunit StF15.10, 211 aa; fasta scores: opt: 729 z-score: 804.0 E(): 0; 62.3% identity in 175 aa overlap. Contains Pfam matches to entries PF00111 fer2, 2Fe-2S iron-sulfu [...] (200 aa)
SCO6171Putative oxidoreductase; SC6C5.07, probable iron-sulphur binding oxidoreductase subunit, len: 196aa; similar to many eg. TR:P95635 (EMBL:U65440) 4-hydroxybenzoyl-CoA reductase from Rhodopseudomonas palustris (163 aa) fasta scores; opt: 288, z-score: 720.8, E(): 7.4e-33, (42.2% identity in 187 aa overlap) and TR:P72223 (EMBL:X98131) quinoline 2-oxidoreductase from Pseudomonas putida (168 aa) fasta scores; opt: 264, z-score: 703.7, E(): 6.6e-32, (40.4% identity in 198 aa overlap). Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. (196 aa)
SCO5794SC4H2.15, possible kinase/phosphohydrolase, len: 725; similar to many RelA and SpoT genes e.g. RELA_STRCO P52560 GTP pyrophosphokinase (ec 2.7.6.5) (847 aa), fasta scores; opt: 1049 z-score: 1312.4 E(): 0, 39.5% identity in 792 aa overlap and SPOT_ECOLI P17580 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (702 aa), fasta scores; opt:1040 z-score: 867.0 E(): 0, 33.8% identity in 695 aa overlap. (725 aa)
SCO5106SCBAC31E11.02c, shdB2, probable succinate dehydrogenase iron-sulfur subunit, len: 259 aa; highly similar to TR:AAK44479 (EMBL:AE006934) Mycobacterium tuberculosis ferredoxin, 2Fe-2S MT0261, 248 aa; fasta scores: opt: 1355 Z-score: 1588.1 bits: 301.4 E(): 7.7e-81; 74.900% identity in 251 aa overlap and to SW:DHSB_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase iron-sulfur protein SdhB, 252 aa; fasta scores: opt: 365 Z-score: 434.1 bits: 87.9 E(): 1.4e-16; 30.603% identity in 232 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. (259 aa)
SCO5061Putative ATP/GTP binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (362 aa)
SCO49712SCK31.31, possible dehydrogenase, len: 497 aa; similar to N-terminal domain of SW:XDH_MOUSE (EMBL:X75129) Mus musculus xanthine dehydrogenase/oxidase Xdh, 1335 aa; fasta scores: opt: 345 z-score: 361.7 E(): 1.3e-12 31.5% identity in 483 aa overlap and to TR:O54050 (EMBL:AJ001013) Rhodobacter capsulatus xanthine dehydrogenase (EC 1.1.1.204) XdhA, 462 aa; fasta scores: opt: 631 z-score: 669.1 E(): 9.8e-30; 38.2% identity in 495 aa overlap. Contains Pfam matches to entries PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, PF01799 fer2_2, [2Fe-2S] binding domain and PF00941 dehydr [...] (497 aa)
SCO7475SCBAC17A6.08, possible phenylacetic acid degradation NADH oxidoreductase PaaE, len: 368 aa; similar to many e.g. SW:P76081 (PAAE_ECOLI) probable phenylacetic acid degradation NADH oxidoreductase PaaE from Escherichia coli (356 aa) fasta scores; opt: 871, Z-score: 943.6, 39.943% identity (40.870% ungapped) in 353 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains; Pfam match to entry PF00175 NAD_binding, Oxidoreductase FAD/NAD-binding domain; Pfam match to entry PF00970 FAD_binding_6, Oxidoreductase FAD-binding domain and Prosite match to P [...] (368 aa)
SCO6678SC5A7.28c, probable iron-sulfur oxidoreductase beta subunit, len: 313 aa; similar to many e.g. POBB_PSEPS phenoxybenzoate dioxygenase beta subunit (Pseudomonas pseudoalcaligenes) (319 aa), fasta scores; opt: 824 z-score: 993.1 E(): 0, 45.9% identity in 303 aa overlap. C-terminus is a 2Fe-2S ferredoxin domain similar to e.g. FERV_ANAVA ferredoxin, vegetative (Anabaena variabilis) (98 aa), fasta scores; opt: 187 z-score: 222.4 E(): 3.8e-05, 38.2% identity in 68 aa overlap. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and Pfam match to entry PF00111 fer2, 2Fe- [...] (313 aa)
SCO0922SCM10.10c, probable reductase iron-sulfur protein, len: 248 aa; similar to SW:FRDB_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase iron-sulfur protein (EC 1.3.99.1) FrdB, 247 aa; fasta scores: opt: 288 z-score: 321.7 E(): 1.6e-10; 28.9% identity in 239 aa overlap. Contains Pfam matches to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and to Prosite entries PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00198 4Fe-4S ferredoxins, iron-sulfu [...] (248 aa)
SCO0689SCF15.10, possible oxidoreductase, iron-sulphur binding subunit, len: 187 aa. Similar to many multipartite proteins including: the small subunit of quinoline 2-oxidoreductase from Pseudomonas putida TR:P72223(EMBL:X98131) QorS (168 aa), fasta scores opt: 371 z-score: 438.8 E(): 4.6e-17 44.7% identity in 170 aa overlap and Acetobacter europaeus TR:O30328(EMBL:Y08696) aldehyde dehydrogenase subunit III precursor (157 aa), fasta scores opt: 309 z-score: 367.9 E(): 4e-13 39.3% identity in 163 aa overlap. Also similar to the N-terminal iron-sulphur binding domain of Rhodobacter capsulatus ( [...] (211 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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