STRINGSTRING
SCO3406 SCO3406 SCO3334 SCO3334 SCO3304 SCO3304 SCO3303 SCO3303 SCO0167 SCO0167 SCO0172 SCO0172 SCO0178 SCO0178 SCO0180 SCO0180 SCO0181 SCO0181 SCO0184 SCO0184 SCO0198 SCO0198 SCO0200 SCO0200 SCO0207 SCO0207 SCO0386 SCO0386 SCO0506 SCO0506 SCO0842 SCO0842 SCO0937 SCO0937 SCO1081 SCO1081 SCO1082 SCO1082 SCO1663 SCO1663 SCO2615 SCO2615 SCO2579 SCO2579 SCO2571 SCO2571 SCO2238 SCO2238 SCO2076 SCO2076 SCO1818 SCO1818 SCP1.20c SCP1.20c SCP1.16c SCP1.16c SCO7299 SCO7299 SCO7247 SCO7247 SCO7156 SCO7156 SCO7036 SCO7036 SCO6436 SCO6436 SCO6187 SCO6187 SCO6100 SCO6100 SCO6098 SCO6098 SCO6059 SCO6059 SCO5871 SCO5871 SCO5711 SCO5711 SCO5568 SCO5568 SCO5547 SCO5547 SCO5488 SCO5488 SCO4839 SCO4839 SCO4785 SCO4785 SCO4629 SCO4629 SCO4235 SCO4235 SCO4115 SCO4115 SCO3792 SCO3792 SCO3383 SCO3383
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO3406Conserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (352 aa)
SCO3334Tryptophanyl tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (336 aa)
SCO3304SCE68.02, argS, probable arginyl-tRNA synthetase, len: 586 aa; similar to many e.g. SW:SYR_ECOLI (EMBL:X15320), argS, Escherichia coli arginyl-tRNA synthetase (577 aa), fasta scores; opt: 1415 z-score: 1562.9 E(): 0, 43.8% identity in 587 aa overlap. Contains Pfam match to entry PF00750 tRNA-synt_1d, tRNA synthetases class I (R) and PS00178 Aminoacyl-transfer RNA synthetases class-I signature. (586 aa)
SCO3303SCE68.01c, possible lysyl-tRNA synthetase, len: >76 aa; similar to SW:SYK_METMP (EMBL:AF009824) LysS, Methanococcus maripaludis lysyl-tRNA synthetase (533 aa), fasta scores; opt: 114 z-score: 145.7 E(): 0.86, 44.7% identity in 38 aa overlap and to many hypothetical lysyl-tRNA synthetases. The remainder of this CDS is SCE15.20c, partial CDS, possible lysyl-tRNA in EMBL:AL049707; SCE15.20c, partial CDS, possible lysyl-tRNA synthetase, len: >545aa; similar to many eg. SW:SYK_METJA lysyl-tRNA synthetase from Methanococcus jannaschii (530 aa) fasta scores; opt: 419, z-score: 468.7, E(): 8.5 [...] (580 aa)
SCO0167Conserved hypothetical protein SCJ1.16c; SCJ1.16c, unknown, len: 294 aa, similar to many including: Mycobacterium tuberculosis TR:O06189 (EMBL; Z95387)hypothetical 31.7 KD protein MTCY1A10.09C (297 aa), fasta scores opt: 407 z-score: 484.5 E(): 1.3e-19 32.7% identity in 303 aa overlap and Mycobacterium tuberculosis SW:YW12_MYCTU (EMBL; Z74025) hypothetical 30.9 KD protein MTCY39.12 (295 aa), fasta scores opt: 401 z-score: 477.5 E(): 3.1e-19 34.7% identity in 294 aa overlap. Also similar to S. coelicolor SCJ1.29c (283 aa), fasta scores opt: 806 z-score: 761.9 E(): 0 46.4% identity in 29 [...] (294 aa)
SCO0172SCJ1.21, hypothetical protein, len: 152 aa. Similar to many hypothetical proteins including: Mycobacterium tuberculosis TR:O53472 (EMBL; AL021899) hypothetical 31.5 KD protein MTV018.13C (294 aa), fasta scores opt: 248 z-score: 298.8 E(): 2.8e-09 35.6% identity in 160 aa overlap and Methanobacterium thermoautotrophicum TR:O27074 (EMBL; AE000872) conserved protein (143 aa), fasta scores opt: 195 z-score: 241.7 E(): 4.2e-06 32.4% identity in 142 aa overlap. Contains a Pfam match to entry PF00582 Usp, Universal stress protein family. (152 aa)
SCO0178Hypothetical protein SCJ1.27; SCJ1.27, unknown, len: 148 aa. Weak similarity to Mycobacterium tuberculosis SW:YW23_MYCTU (EMBL; Z74025) hypothetical 33.9 KD protein MTCY39.23C (317 aa), fasta scores opt: 201 z-score: 231.7 E(): 1.5e-05 33.1% identity in 136 aa overlap and Mycobacterium tuberculosis TR:O06189 (EMBL; Z95387)hypothetical 31.7 KD protein MTCY1A10.09C (297 aa), fasta scores opt: 199 z-score: 229.8 E(): 1.9e-05 33.3% identity in 153 aa overlap. (148 aa)
SCO0180Conserved hypothetical protein SCJ1.29c; SCJ1.29c, unknown, len: 283 aa. Similar to many including: Mycobacterium tuberculosis TR:O53472 (EMBL; AL021899) hypothetical 31.5 KD protein (294 aa), fasta scores opt: 329 z-score: 389.0 E(): 2.6e-14 32.1% identity in 293 aa overlap and Mycobacterium tuberculosis TR:O06189 (EMBL; Z95387) hypothetical 31.7 KD protein (297 aa), fasta scores opt: 330 z-score: 390.1 E(): 2.3e-14 31.8% identity in 296 aa overlap. Also similar to S. coelicolor SCJ1.16c (294 aa), fasta scores opt: 806 z-score: 748.1 E():0 46.1% identity in 295 aa overlap. Contains a [...] (283 aa)
SCO0181Hypothetical protein SCJ1.30c; SCJ1.30c, unknown, len: 328 aa. Similar to many including: Mycobacterium tuberculosis SW:YW23_MYCTU (EMBL; Z74025) hypothetical 33.9 KD protein MTCY39.23C (317 aa) fasta scores opt: 382 z-score: 439.2 E(): 4.2e-17 32.6% identity in 319 aa overlap and Mycobacterium tuberculosis TR:O53472 (EMBL; AL021899) hypothetical 31.5 KD protein (294 aa), fasta scores opt: 382 z-score: 439.2 E(): 4.2e-17 32.6% identity in 319 aa overlap. Contains a Pfam match to entry PF00582 Usp, Universal stress protein family. (328 aa)
SCO0184Conserved hypothetical protein SCJ1.33; SCJ1.33 unknown, len: 604 aa. Highly similar to Synechocystis sp. (strain PCC6803) TR:P74080 (EMBL;D90912) hypothetical 58.1 KD protein (504 aa), fasta scores opt: 931 z-score: 996.4 E(): 0 38.8% identity in 479 aa overlap and Methanobacterium thermoautotrophicum TR:O27804 (EMBL;AE000932) conserved protein MTH1776 (491 aa), fasta scores opt: 572 z-score: 613.5 E(): 8.1e-27 31.7% identity in 483 aa overlap. Also shares a low level of similarity with Streptomyces coelicolor TR:CAB48919 (EMBL;AL096837) putative deoxyribodipyrimidine photolyase SCF43 [...] (604 aa)
SCO0198SCJ12.10c, unknown, len: 288 aa. Similar to several hypothetical proteins including: Mycobacterium tuberculosis SW:YW12_MYCTU (EMBL; Z74025) hypothetical 30.9 KD protein MTCY39.12 (295 aa), fasta scores opt: 363 z-score: 441.0 E(): 3.3e-17 32.3% identity in 288 aa overlap and Mycobacterium tuberculosis TR:O06189 (EMBL; Z95387) hypothetical 31.7 KD protein MTCY1A10.09C (297 aa), fasta scores opt: 336 z-score: 408.6 E(): 2.1e-15 29.3% identity in 294 aa overlap. Also highly similar to S. coelicolor hypothetical proteins (AL109962) SCJ1.29c (283 aa), fasta scores opt: 1161 z-score: 1097.2 [...] (288 aa)
SCO0200SCJ12.12c, unknown, len: 301 aa. Similar to several hypothetical proteins including: Mycobacterium tuberculosis SW:YW23_MYCTU (EMBL; Z74025) hypothetical 33.9 KD protein MTCY39.23C (317 aa), fasta scores opt: 380 z-score: 447.3 E(): 1.5e-17 33.5% identity in 316 aa overlap and S. coelicolor (EMBL;AL109962) SCJ1.30c (328 aa)fasta scores opt: 1274 z-score: 1163.7 E():0 65.3% identity in 300 aa overlap. Contains 2x Pfam match to entry PF00582 Usp, Universal stress protein family. (301 aa)
SCO0207Conserved hypothetical protein; SCJ12.19c, unknown, len: 201 aa. Weakly similar to many hypotheticals e.g. Thermus aquaticus SW:YQA3_THEAQ (EMBL; D87664) hypothetical 14.6 KD protein in QAH/OAS sulfhydrylase 3'region (137 aa), fasta scores opt: 172 z-score: 213.8 E(): 0.00015 35.9% identity in 142 aa overlap. Also similar to the N-terminal region of TR:Q9RI46 (EMBL:AL109989) Streptomyces coelicolor hypothetical protein SCJ12.12c, 301 aa; fasta scores: opt: 466 Z-score: 532.5 E(): 5e-22; 42.500% identity in 200 aa overlap. (201 aa)
SCO0386SCF62.12, putative asparagine synthetase, len: 644 aa. Highly similar to many e.g. Mycobacterium tuberculosis SW:ASNH_MYCTU (EMBL; Z70283) putative asparagine synthetase (glutamine-hydrolysing) (EC 6.3.5.4) (652 aa), fasta scores opt: 752 z-score: 874.8 E():0 32.8% identity in 655 aa overlap. Contains a Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. (644 aa)
SCO0506NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (276 aa)
SCO0842SCF43A.32, phr, probable deoxyribodipyrimidine photolyase, len: 458 aa; highly similar to many deoxyribodipyrimidine photolyases e.g. SW:PHR_STRGR (EMBL:X15060), phr, Streptomyces griseus deoxyribodipyrimidine photolyases (455 aa), fasta scores; opt: 2043 z-score: 1879.8 E(): 0, 67.1% identity in 459 aa overlap. Contains Pfam match to entry PF00875 DNA_photolyase, DNA photolyase, PS00394 DNA photolyases class 1 signature 1 and PS00691 DNA photolyases class 1 signature 2. (458 aa)
SCO0937SCM10.25, hypothetical protein, len: 153 aa; similar to various hypothetical proteins, e.g. TR:BAA86264 (EMBL:AB023785) Streptomyces griseus ORF2, 173 aa; fasta scores: opt: 218 z-score: 266.9 E(): 1.8e-07; 35.5% identity in 138 aa overlap. (153 aa)
SCO1081SCG22.27c, probable electron transfer flavoprotein, alpha subunit, len: 320 aa; similar to SW:ETFA_PARDE (EMBL:L14864) Paracoccus denitrificans electron transfer flavoprotein, alpha subunit EftA, 307 aa; fasta scores: opt: 673 z-score: 707.8 E(): 6e-32; 44.3% identity in 316 aa overlap and to SW:ETFA_MYCTU (EMBL:AL021287) Mycobacterium tuberculosis electron transfer flavoprotein alpha-subunit EftA or MTV012.43c, 318 aa; fasta scores: opt: 1161 z-score: 1212.8 E(): 0; 59.4% identity in 323 aa overlap. Contains Pfam match to entry PF00766 ETF_alpha, Electron transfer flavoprotein alpha s [...] (320 aa)
SCO1082SCG22.28c, probable electron transfer flavoprotein, beta subunit, len: 262 aa; similar to SW:ETFB_MYCTU (EMBL:AL021287) Mycobacterium tuberculosis putative electron transfer flavoprotein, beta subunit FixA or MTV012.44c, 266 aa; fasta scores: opt: 860 z-score: 939.3 E(): 0; 52.5% identity in 263 aa overlap. Contains Pfam match to entry PF01012 ETF_beta, Electron transfer flavoprotein beta subunit. (262 aa)
SCO1663Putative cysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins. (409 aa)
SCO2615Valyl tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (874 aa)
SCO2579Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (238 aa)
SCO2571SCC123.09c, leuS, leucyl-tRNA synthetase (EC 6.1.1.4) len: 966 aa. Highly similar to many leucyl-tRNA synthetases including: Bacillus subtilis SW:SYL_BACSU(EMBL:M88581) (804 aa), fasta scores opt: 508 z-score: 575.2 E(): 1.2e-24 48.1% identity in 941 aa overlap and Mycobacterium leprae SW:SYL_MYCLE(EMBL:Y14967) (972 aa), fasta scores opt: 3887 z-score: 4430.5 E():0 60.1% identity in 977 aa overlap. Contains a Prosite hit to PS00178 Amino-acyl-transfer RNA synthetases class-I signature and a Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). (966 aa)
SCO2238NAD(+) synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (613 aa)
SCO2076Putative isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1047 aa)
SCO1818tyrosyl-tRNA synthetase (EC 6.1.1.1); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (422 aa)
SCP1.20cHypothetical protein; SCP1.20c, unknown, len: 260aa. (260 aa)
SCP1.16cHypothetical protein; SCP1.16c, unknown, len: 194aa. (194 aa)
SCO7299Putative stress-inducible protein; SC5F8.09, possible stress-inducible protein, len:312 aa. Highly similar to many proteins of undefined function e.g. Streptomyces coelicolor TR:Q9RIY4(EMBL:AL109962) hypothetical 34.7 kd protein, SCJ1.30C (328 aa), fasta scores opt: 604 z-score: 654.8 E(): 5.3e-29 41.8% identity in 328 aa overlap. Contains 2xPfam match to entry PF00582 Usp, Universal stress protein family. (312 aa)
SCO7247Conserved hypothetical protein; SC7A12.14, unknown, len: 300 aa. Similar to many proteins of undefined function including: Streptomyces coelicolor TR:Q9RIZ8 (EMBL:AL109962) conserved hypothetical protein, SCJ1.16C (294 aa), fasta scores opt: 524 z-score: 574.4 E(): 1.6e-24 38.8% identity in 309 aa overlap and Mycobacterium tuberculosis TR:O06188 (EMBL:Z95387) hypothetical protein (272 aa), fasta scores opt: 240 z-score: 268.6 E(): 1.7e-07 28.6% identity in 290 aa overlap. Contains a 2x Pfam matches to entries PF00582 Usp, Universal stress protein family. (300 aa)
SCO7156SC9A4.18c, conserved hypothetical protein, len: 152 aa; similar to TR:Q9RRW9 (EMBL:AE002067) Deinococcus radiodurans conserved hypothetical protein DR2363, 160 aa; fasta scores: opt: 161 z-score: 210.3 E(): 0.0003; 34.0% identity in 147 aa overlap. (181 aa)
SCO7036SC4G1.02, argG, argininosuccinate synthase, len: 481 aa; identical to previously sequenced SW:ASSY_STRCO (EMBL:D00799) Streptomyces coelicolor argininosuccinate synthase (EC 6.3.4.5) ArgG, 480 aa. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase and matches to Prosite entries PS00564 Argininosuccinate synthase signature 1 and PS00565 Argininosuccinate synthase signature 2; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (481 aa)
SCO6436SC9B5.03, probable tRNA synthetase, len: 506 aa; similar to many eg. SW:SYM_METTH methionyl-tRNA synthetase from Methanobacterium thermoautotrophicum (651 aa) fasta scores; opt: 610, z-score: 560.9, E(): 5.9e-24, (28.9% identity in 402 aa overlap). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature. (506 aa)
SCO6187Putative bifunctional synthase/transferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (463 aa)
SCO6100Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (236 aa)
SCO6098SCBAC1A6.22c, cysD, sulfate adenylyltransferase subunit 2, len: 312 aa; highly similar to SW:MMCV_STRLA (EMBL:AF127374) Streptomyces lavendulae sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) MmcV, 319 aa; fasta scores: opt: 1734 z-score: 2027.7 E(): 0; 81.6% identity in 309 aa overlap and to SW:CYSD_ECOLI (EMBL:M74586) Escherichia coli sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) CysD, 302 aa; fasta scores: opt: 909 z-score: 1066.6 E(): 0; 47.7% identity in 298 aa overlap. Contains Pfam match to entry PF01507 PAPS_reduct, Phosphoadenosine phosphosulfate reductase family. (312 aa)
SCO6059Hypothetical protein SC9B1.06; SC9B1.06, unknown, len: 181 aa. (181 aa)
SCO5871Putative turgor pressure sensor; SC2E9.12, kdpD, two-component sensor/protein kinase, len: 848 aa; similar to Escherichia coli turgor pressure sensor KDPD_ECOLI P21865 sensor protein kdpD (ec 2.7.3.-) (894 aa), fasta scores; opt: 997 z-score: 1347.4 E(): 0, 34.8% identity in 877 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry signal PF00512, Signal C terminal domain, score 184.57. Contains possible hydrophobic membrane spanning regions. (848 aa)
SCO5711SC9F2.05c, probable riboflavin kinase (FAD synthetase), len: 318 aa; similar to many e.g. SW:RIBF_CORAM riboflavin kinase from Corynebacterium ammoniagenes (338 aa) fasta scores; opt: 801, z-score: 904.5, E(): 0, (45.4% identity in 326 aa overlap). (318 aa)
SCO5568Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
SCO5547glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (494 aa)
SCO5488tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (376 aa)
SCO4839tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (339 aa)
SCO4785GMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa)
SCO4629Conserved hypothetical protein; The imp locus inhibits the extrachromosomal maintenance of the streptomyces plasmid SLP1. May function as a transcriptional activator. (221 aa)
SCO4235SCD8A.08, probable cysteinyl-tRNA synthetase, len: 613 aa; C-terminal region highly similar to SW:SYC_ECOLI (EMBL:X56234) Escherichia coli cysteinyl-tRNA synthetase (EC 6.1.1.16) CysS, 461 aa; fasta scores: opt: 1267 z-score: 1248.2 E(): 0; 43.7% identity in 469 aa overlap. Contains Pfam match to entry PF01406 tRNA-synt_1e, tRNA synthetases class I (C) and a N-terminal region degenerate 6x repeat; Belongs to the class-I aminoacyl-tRNA synthetase family. (613 aa)
SCO4115Putative secreted protein; SCD72A.01, unknown, partial CDS, len: >590 aa; SCD17A.07, possible secreted protein (fragment), len: >151 aa. Contains possible and cleavable N-terminal region signal peptide sequence. (707 aa)
SCO3792Putative methionyl tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (538 aa)
SCO3383Putative pantoate-amino acid ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (337 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.