(10 nodes) Glutamine synthetase/guanido kinase, catalytic domain network (Streptomyces coelicolor)

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	SCO7331	Conserved hypothetical protein SC4G10.10c; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (363 aa)
	SCO7509	SCBAC25F8.01c, conserved hypothetical protein (fragment), len: >291 aa; similar to TR:AAK48168 (EMBL:AE007177) Mycobacterium tuberculosis CDC1551 hypothetical 56.9 kDa protein MT3801, 509 aa; fasta scores: opt: 1078 Z-score: 1264.7 bits: 242.8 E(): 7.8e-63; 52.577% identity in 291 aa overlap and to TR:CAC32297 (EMBL:AL583943) Streptomyces coelicolor conserved hypothetical protein SC10A9.15c, 506 aa; fasta scores: opt: 1071 Z-score: 1149.0 bits: 221.3 E(): 2.8e-58; 54.639% identity in 291 aa overlap; SCBAC17A6.42c, conserved hypothetical protein, len: >234aa; similar to C-terminal regio [...] (492 aa)
	SCO0910	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (433 aa)
	SCO2198	Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
	SCO2210	SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...] (343 aa)
	SCO1613	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39. (462 aa)
	SCO1373	SC10A9.15c, conserved hypothetical protein, len: 505 aa; similar to TR:O69666 (EMBL:AL022121) Mycobacterium tuberculosis hypothetical 56.9 kDa protein MTV025.046, 509 aa; fasta scores: opt: 1720 z-score: 2047.1 E(): 0; 53.6% identity in 494 aa overlap. (505 aa)
	SCO2241	SC1G2.03, probable glutamine synthetase (EC 6.3.1.2), len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa), fasta scores opt: 1017 z-score: 1188.9 E():0 44.4% identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa), fasta scores opt: 2114 z-score: 2469.2 E():0 70.2% identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase putative ATP-binding region signature. (453 aa)
	SCO5501	Probable Glu-tRNAGln amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity); Belongs to the GatB/GatE family. GatB subfamily. (504 aa)
	SCO6962	Putative glutamine synthetase; SC6F7.15c, possible glutamine synthetase (EC 6.3.1.2), len: 466 aa. Similar to many glutamine synthetases e.g. Bacillus subtilis SW:GLNA_BACSU(EMBL:M22811) GlnA (443 aa), fasta scores opt: 540 z-score: 593.0 E(): 1.4e-25 28.5% identity in 421 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase. (466 aa)

Your Current Organism:

Streptomyces coelicolor

NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SCO0910	SCO1613	gene:17758493	gene:17759206	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39.	0.800
SCO0910	SCO2198	gene:17758493	gene:17759795	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.	Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.	0.800
SCO0910	SCO2210	gene:17758493	gene:17759807	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.	SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...]	0.800
SCO0910	SCO2241	gene:17758493	gene:17759838	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.	SC1G2.03, probable glutamine synthetase (EC 6.3.1.2), len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa), fasta scores opt: 1017 z-score: 1188.9 E():0 44.4% identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa), fasta scores opt: 2114 z-score: 2469.2 E():0 70.2% identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase putative ATP-binding region signature.	0.800
SCO0910	SCO6962	gene:17758493	gene:17764620	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.	Putative glutamine synthetase; SC6F7.15c, possible glutamine synthetase (EC 6.3.1.2), len: 466 aa. Similar to many glutamine synthetases e.g. Bacillus subtilis SW:GLNA_BACSU(EMBL:M22811) GlnA (443 aa), fasta scores opt: 540 z-score: 593.0 E(): 1.4e-25 28.5% identity in 421 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase.	0.800
SCO0910	SCO7331	gene:17758493	gene:17764991	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.	Conserved hypothetical protein SC4G10.10c; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.	0.902
SCO1613	SCO0910	gene:17759206	gene:17758493	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39.	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.	0.800
SCO1613	SCO2198	gene:17759206	gene:17759795	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39.	Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.	0.921
SCO1613	SCO2210	gene:17759206	gene:17759807	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39.	SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...]	0.917
SCO1613	SCO2241	gene:17759206	gene:17759838	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39.	SC1G2.03, probable glutamine synthetase (EC 6.3.1.2), len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa), fasta scores opt: 1017 z-score: 1188.9 E():0 44.4% identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa), fasta scores opt: 2114 z-score: 2469.2 E():0 70.2% identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase putative ATP-binding region signature.	0.922
SCO1613	SCO6962	gene:17759206	gene:17764620	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39.	Putative glutamine synthetase; SC6F7.15c, possible glutamine synthetase (EC 6.3.1.2), len: 466 aa. Similar to many glutamine synthetases e.g. Bacillus subtilis SW:GLNA_BACSU(EMBL:M22811) GlnA (443 aa), fasta scores opt: 540 z-score: 593.0 E(): 1.4e-25 28.5% identity in 421 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase.	0.930
SCO1613	SCO7331	gene:17759206	gene:17764991	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39.	Conserved hypothetical protein SC4G10.10c; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.	0.800
SCO2198	SCO0910	gene:17759795	gene:17758493	Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.	0.800
SCO2198	SCO1613	gene:17759795	gene:17759206	Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39.	0.921
SCO2198	SCO2210	gene:17759795	gene:17759807	Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.	SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...]	0.983
SCO2198	SCO2241	gene:17759795	gene:17759838	Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.	SC1G2.03, probable glutamine synthetase (EC 6.3.1.2), len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa), fasta scores opt: 1017 z-score: 1188.9 E():0 44.4% identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa), fasta scores opt: 2114 z-score: 2469.2 E():0 70.2% identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase putative ATP-binding region signature.	0.927
SCO2198	SCO6962	gene:17759795	gene:17764620	Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.	Putative glutamine synthetase; SC6F7.15c, possible glutamine synthetase (EC 6.3.1.2), len: 466 aa. Similar to many glutamine synthetases e.g. Bacillus subtilis SW:GLNA_BACSU(EMBL:M22811) GlnA (443 aa), fasta scores opt: 540 z-score: 593.0 E(): 1.4e-25 28.5% identity in 421 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase.	0.935
SCO2198	SCO7331	gene:17759795	gene:17764991	Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.	Conserved hypothetical protein SC4G10.10c; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.	0.800
SCO2210	SCO0910	gene:17759807	gene:17758493	SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...]	Conserved hypothetical protein SCM1.43; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.	0.800
SCO2210	SCO1613	gene:17759807	gene:17759206	SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...]	SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39.	0.917