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SCO3317 SCO3317 SCO1553 SCO1553 SCO1555 SCO1555 SCO1853 SCO1853 SCO1855 SCO1855 SCO1856 SCO1856 SCO1857 SCO1857 SCO3153 SCO3153 SCO6971 SCO6971
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO3317SCE68.15c, possible uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, len: 565 aa; similar to many e.g. SW:HEM4_CLOJO (EMBL:D28503), hemD, Clostridium josui porphyrin biosynthesis probable bifunctional protein (504 aa), fasta scores; opt: 519 z-score: 562.5 E(): 5.2e-24, 29.8% identity in 533 aa overlap. The C-terminal half is similar to the monofunctional SW:HEM4_SYNP7 (EMBL:X70966) Synechococcus sp. uroporphyrinogen-III synthase (264 aa) (29.7% identity in 263 aa overlap). May be involved in cysteine biosynthesis and/or porphyrin biosynthesis. Contains Pfam match to [...] (565 aa)
SCO1553SCL11.09c, probable uroporphyrin-III methyltransferase, len: 410 aa; similar to TR:O05812 (EMBL:Z95207) Mycobacterium tuberculosis CysG, 405 aa; fasta scores: opt: 1487 z-score: 1630.7 E(): 0; 58.7% identity in 409 aa overlap and to SW:SUMT_BACME (EMBL:M62881) Bacillus megaterium uroporphyrin-III C-methyltransferase (EC 2.1.1.107) CobA, 238 aa; fasta scores: opt: 719 z-score: 794.9 E(): 0; 48.1% identity in 233 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases and match to Prosite entry PS00840 Uroporphyrin-III C-methyltransferase [...] (410 aa)
SCO1555SCL11.11c, probable methyltransferase, len: 408 aa; similar to TR:Q55879 (EMBL:D64004) Synechocystis sp. precorrin-6Y methylase CbiE, 425 aa; fasta scores: opt: 379 z-score: 405.5 E(): 3.6e-15; 29.9% identity in 354 aa overlap and to SW:CBIE_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-6Y C5,15-methyltransferase [decarboxylating] (EC 2.1.1.132) CbiE, 201 aa; fasta scores: opt: 250 z-score: 274.2 E(): 7.5e-08; 33.3% identity in 204 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (408 aa)
SCO1853SCI8.38, cobI, precorrin-2 C20-methyltransferase (EC 2.1.1.130), len: 243 aa. Similar to many including: Pseudomonas denitrificans SW:COBI_PSEDE (EMBL: M59301) precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-methionine-precorrin-2 methyltransferase) (SP2MT) (244 aa), fasta scores opt: 322 z-score: 369.3 E(): 3.3e-13 30.0% identity in 240 aa overlap and to the N-terminus of the CobI/J fusion protein from Mycobacterium tuberculosis SW:COBI_MYCTU (EMBL: Z73966) cobalamin biosynthesis protein CobIJ [includes: precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-met [...] (243 aa)
SCO1855SCI39.02, probable precorrin-4 C11-methyltransferase, len: 281 aa; similar to TR:O87696 (EMBL:AJ000758) Bacillus megaterium precorrin-4 methylase CbiF, 258 aa; fasta scores: opt: 674 Z-score: 771.2 bits: 150.4 E(): 2.3e-35; 41.502% identity in 253 aa overlap and to SW:COBM_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-4 C11-methyltransferase (EC 2.1.1.133) CobM, 253 aa; fasta scores: opt: 652 Z-score: 746.5 bits: 145.8 E(): 5.5e-34; 43.145% identity in 248 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (281 aa)
SCO1856SCI39.03, probable precorrin-6Y C5,15-methyltransferase, len: 410 aa; similar to SW:COBL_PSEDE (EMBL:M59301) Pseudomonas denitrificans precorrin-6Y C5,15-methyltransferase [decarboxylating] (EC 2.1.1.132) CobL, 413 aa; fasta scores: opt: 614 Z-score: 634.0 bits: 126.3 E(): 1e-27; 37.500% identity in 408 aa overlap. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (410 aa)
SCO1857SCI39.04, probable bifunctional protein (CbiGH), len: 583 aa; N-terminal region similar to SW:CBIG_SALTY (EMBL:L12006) Salmonella typhimurium involved in cobalamin synthesis CbiG protein, 351 aa; fasta scores: opt: 312 Z-score: 304.6 bits: 65.6 E(): 2.2e-09; 32.986% identity in 288 aa overlap and C-terminal region similar to SW:CBIH_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-3B C17-methyltransferase (EC 2.1.1.131) CbiH, 241 aa; fasta scores: opt: 684 Z-score: 658.7 bits: 130.6 E(): 4.3e-29; 46.862% identity in 239 aa overlap. Contains Pfam match to entry PF01890 CbiG, CbiG an [...] (583 aa)
SCO3153Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (286 aa)
SCO6971SC6F7.24c, possible methylase, len: 257 aa. Highly similar to Pseudomonas denitrificans SW:COBF_PSEDE(EMBL:M59301) cobalamin biosynthesis protein, CobF (261 aa), fasta scores opt: 869 z-score: 1009.4 E():0 53.6% identity in 252 aa overlap. Contains a Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases. (257 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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