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SCO5470 SCO5470 SCO5486 SCO5486 SCO5655 SCO5655 SCO5676 SCO5676 SCO5746 SCO5746 SCO5799 SCO5799 SCO5890 SCO5890 SCO5892 SCO5892 SCO1577 SCO1577 SCO1587 SCO1587 SCO1859 SCO1859 SCO1865 SCO1865 SCO1868 SCO1868 SCO1921 SCO1921 SCO2017 SCO2017 SCO2053 SCO2053 SCO2146 SCO2146 SCO2157 SCO2157 SCO2408 SCO2408 SCO2782 SCO2782 SCO3227 SCO3227 SCO5941 SCO5941 SCO6222 SCO6222 SCO1417 SCO1417 SCO3306 SCO3306 SCO3385 SCO3385 SCO1378 SCO1378 SCO7034 SCO7034 SCO6800 SCO6800 SCO6769 SCO6769 SCO6522 SCO6522 SCO1360 SCO1360 SCO1223 SCO1223 SCO1243 SCO1243 SCO1245 SCO1245 SCO1284 SCO1284 SCO1289 SCO1289 SCO1294 SCO1294 SCO7537 SCO7537 SCO7311 SCO7311 SCO4469 SCO4469 SCO4366 SCO4366 SCO3944 SCO3944 SCO3920 SCO3920 SCO3658 SCO3658 SCO3645 SCO3645 SCO3622 SCO3622 SCO4645 SCO4645 SCO4836 SCO4836 SCO4837 SCO4837 SCO4958 SCO4958 SCO4984 SCO4984 SCO5136 SCO5136 SCO1087 SCO1087 SCO1054 SCO1054 SCO0731 SCO0731 SCO3416 SCO3416 SCO0435 SCO0435 SCO0401 SCO0401 SCO6279 SCO6279 SCO6412 SCO6412 SCO5364 SCO5364
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query proteins and first shell of interactors
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proteins of unknown 3D structure
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SCO5470Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
SCO5486SC2A11.20, probable pyridoxal-phosphate-dependent aminotransferase, len: 389 aa; similar to many e.g. NIFS_ANASP Anaebaena NifS protein (400 aa), fasta scores; opt: 855 z-score: 1070.8 E(): 0, 40.4% identity in 384 aa overlap and SPL1_CANAL Candida albicans tRNA splicing protein SPL1 (488 aa), fasta scores; opt: 791 z-score: 912.8 E(): 0, 36.6% identity in 388 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V, score 259.00, E-value 6.2e-74. (389 aa)
SCO5655SC6A9.12, probable aminotransferase, len: 457 aa; similar to many e.g. BIOA_BACSU adenosylmethionine-8-amino-7-oxononanoate aminotransferase (448 aa), fasta scores; opt: 895 z-score: 881.6 E(): 0, 35.6% identity in 449 aa overlap. Also highly similar to M. tuberculosis putative aminotransferase TR:O53379 (EMBL:AL021841) MTV016.29; 70.3% identity in 438 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate, score 355.70, E-value 3.5e-123; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
SCO5676SC8B7.02, gabT, probable 4-aminobutyrate aminotransferase, len: 444 aa; highly similar to e.g. GABT_ECOLI 4-aminobutyrate aminotransferase (EC 2.6.1.19) (426 aa), fasta s cores; opt: 1194 z-score: 1404.8 E(): 0, 45.5% identity in 424 aa overlap. Contains PS00600 Aminotransferases class-II I pyridoxal-phosphate attachment site and Pfam match to ent ry PF00202 aminotran_3, Aminotransferases class-III pyridox al-phosphate, score 516.20, E-value 5e-179; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
SCO5746Hypothetical protein SC7C7.01; SC7C7.01, unknown, len: 225 aa; some similarity to hydrophobic region from B. subtilis DEGT_BACST pleiotropic regulatory protein (372 aa), fasta scores; opt: 289 z-score: 450.7 E(): 7.2e-18, 51.7% identity in 89 aa overlap. Also similar to e.g. TR:P72452 (EMBL:Y00459) aminotransferase from Streptomyces griseus(378 aa), fasta scores; opt: 250 z-score: 429.3 E(): 1.1e-16, 29.4% identity in 309 aa overlap. (225 aa)
SCO5799SC4H2.20, probable aminotransferase, len: 532; similar to many e.g. GABT_ECOLI P22256 4-aminobutyrate aminotransferase (426 aa), fasta scores; opt: 355 z-score: 385.5 E(): 3e-14, 28.8% identity in 427 aa overlap. Contains two repetitive regions: GSGSGTGPGSGTGPGTGTGPGTGPGTGPG between aa 82-104, and VTVTDAVTVTDAVTDADADAD between aa 241-261, that are not present in other aminotransferases. Also contains 2x match to Pfam match to entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, scores 72.94 and 175.90, and TTA leucine codon; a potential target for actionof bldA. (532 aa)
SCO5890SC3F7.10, redN, putative 8-amino-7-oxononanoate synthase, len: 640 aa; similar to many diverse transferases eg. BIOF_BACSH P22806 8-amino-7-oxononanoate synthase (389 aa), fasta scores; opt: 926 z-score: 888.4 E(): 0, 42.1% identity in 361 aa overlap. Also simlar to SC3F7.12 from aa 1700 to end (E(): 3.6e-15, 31.9% identity in 630 aa overlap). Contains Pfam match to entry aminotran_2 PF00222, Aminotransferases class-II, score 292.92 in C-terminus. (640 aa)
SCO5892SC3F7.12, redL, probable polyketide synthase, len: 2297 aa; contains 3 modules: N-terminus (start to approx. aa 700) similar to eg. N-terminus of TR:Q50857 (EMBL:U24657) saframycin mx1 synthetase B from Myxococcus xanthus (1770 aa) (fasta scores; E(): 0, 45.0% identity in 691 aa overlap), contains Pfam match to AMP-binding PF00501, AMP-binding enzymes, score 166.66; central module (approx aa 795 to 1800) similar to eg. TR:G2317861 (EMBL:U78289) Streptomyces fradiae tylactone synthase module 3 (1864 aa) (E(): 0, 39.9% identity in 1125 aa overlap), contains PS00606 Beta-ketoacyl synthase [...] (2297 aa)
SCO1577SCL24.13c, argD, acetonitrile aminotransferase, len: 402 aa; highly similar to SW:ARGD_CORGL (EMBL:X86157) Corynebacterium glutamicum acetylornithine aminotransferase (EC 2.6.1.11) ArgD, 389 aa; fasta scores: opt: 1247 z-score: 1362.1 E(): 0; 52.0% identity in 379 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (402 aa)
SCO1587SCI35.09c, possible transcriptional regulator, len: 480 aa; similar to hypothetical proteins e.g. TR:P96681 (EMBL:AB001488) YdfD (B. subtilis) (482 aa), fasta scores; opt: 535 z-score: 419.1 E(): 4.2e-16, 26.1% identity in 471 aa overlap and YRDX_RHOSH hypothetical transcriptional regulator (456 aa), fasta scores; opt: 299 z-score: 407.0 E(): 2e-15, 27.2% identity in 464 aa overlap. Contains probable helix-turn-helix motif at aa 17-38 (Score 1327, +3.71 SD) and Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family, score 41.30, E-value 3.4e-11. (480 aa)
SCO1859SCI39.06, probable aminotransferase, len: 339 aa; similar to SW:HIS8_ECOLI (EMBL:X03416) Escherichia coli histidinol-phosphate aminotransferase (EC 2.6.1.9) HisC, 356 aa; fasta scores: opt: 351 Z-score: 375.7 bits: 78.0 E(): 2.4e-13; 29.450% identity in 309 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferase class-II and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. (339 aa)
SCO1865Putative aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa)
SCO1868SCI39.15c, conserved hypothetical protein, len: 364 aa; similar to SW:YCBU_BACSU (EMBL:AB000617) Bacillus subtilis hypothetical protein homologue of class-V proteins of pyridoxal-phosphate-dependent aminotransferase YcbU, aa; fasta scores: opt: 277 Z-score: 303.9 bits: 64.9 E(): 2.5e-09; 27.707% identity in 314 aa overlap. (364 aa)
SCO1921Putative aminotransferase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (418 aa)
SCO2017SC7H2.31c, possible amino acid decarboxylase, len: 452aa; similar to many eg. TR:Q43908 (EMBL:D55724) L-2,4-diaminobutyrate decarboxylase of Acinetobacter baumannii (510 aa) fasta scores; opt: 532, z-score: 544.9, E(): 5e-23, (31.8% identity in 431 aa overlap). Contains Pfam match to entry PF00282 pyridoxal_deC, Pyridoxal-dependent decarboxylase conserved domain. (452 aa)
SCO2053SC4G6.22c, hisC1, histidinol-phosphate aminotransferase, len: 369aa; previously sequenced therefore identical to SW:HIS8_STRCO. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and Prosite match to PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. (369 aa)
SCO2146SC6G10.19c, possible aminotransferase, len: 476 aa; similar to SW:CSDB_ECOLI (EMBL:AE000263) Escherichia coli selenocysteine lyase (EC 4.4.1.16) CsdB, 406 aa; fasta scores: opt: 565 Z-score: 628.7 E(): 2.3e-27; 33.862% identity in 378 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V. Note: C-terminus overlaps with downstream gene. (476 aa)
SCO2157SC6G10.30, probable aminotransferase, len: 460 aa; similar to many NifS-like proteins e.g. SW:NIFS_RHOSH NifS protein from Rhodobacter sphaeroides (387 aa) fasta scores; opt: 702, z-score: 760.5, E(): 0, (37.4% identity in 390 aa overlap). Contains Pfam matches to entry PF00266 aminotran_5, Aminotransferases class-V and entry PF01206 UPF0033, Uncharacterized protein family UPF0033; Belongs to the sulfur carrier protein TusA family. (460 aa)
SCO2408SC4A7.36, possible aminotransferase, len: 541 aa; similar to SW:HIS8_METJA (EMBL:U67539) Methanococcus jannaschii probable histidinol-phosphate aminotransferase (EC 2.6.1.9) HisC, 373 aa; fasta scores: opt: 390 z-score: 299.5 E(): 2.6e-09; 25.1% identity in 334 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II. (541 aa)
SCO2782SCC105.13, probable pyridoxal-dependent decarboxylase, len: 480 aa; similar to SW:RHSB_RHIME (EMBL:AF110737) Rhizobium meliloti L-2,4-diaminobutyrate decarboxylase (EC 4.1.1.-) RhsB, 495 aa; fasta scores: opt: 1111 z-score: 1326.2 E(): 0; 41.9% identity in 458 aa overlap. Contains Pfam match to entry PF00282 pyridoxal_deC, Pyridoxal-dependent decarboxylase conserved domain. (480 aa)
SCO3227SCE8.20c, partial CDS, possible aminotransferase, len: 431 aa; similar to many of undefined function e.g. TR:O52815 (EMBL:AJ223998) a protein similar to aminotransferase, from a cluster of genes involved in the biosynthesis of a vancomycin group antibiotic in Amycolatopsis orientalis (Actinomycete) (438 aa) fasta scores; opt: 953, z-score: 1093.1, E(): 0, (48.4% identity in 426 aa overlap). Also similar to TR:Q64602 (EMBL:Z50144) kynurenine/alpha-aminoadipate aminotransferase from rat (Rattus norvegicus) kidney (425 aa) fasta scores; opt: 293, z-score: 338.4, E(): 1.5e-11, (25.8% ident [...] (444 aa)
SCO5941Aminotransferase; SC7H1.11, probable aminotransferase, len: 382; similar to many eg. AAT_BACST Q59228 aspartate aminotransferase (ec 2.6.1.1 (393 aa), fasta scores; opt: 683 z-score: 686.1 E(): 5.1e-31, 35.0% identity in 374 aa overlap. Contains Pfam match to entry aminotran_1 PF00155, Aminotransferases class-I, score 177.68. (382 aa)
SCO6222SC2H4.04c, probable aminotransferase, len: 402 aa; smilar to many e.g. AAT_BACST aspartate aminotransferase (EC 2.6.1.1) (393 aa), fasta scores; opt: 657 z-score: 607.8 E(): 1.3e-26, 33.9% identity in 386 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I, score 136.00, E-value 6.9e-37. (402 aa)
SCO1417SC6D7.22, possible GntR-family regulatory protein, len: 500 aa. Similar to several including: Streptomyces coelicolor TR:O88047 (EMBL:AL031541) putative transcriptional regulator SCI35.09C (480 aa), fasta scores opt: 403 z-score: 439.9 E(): 4e-17 29.0% identity in 483 aa overlap and Streptomyces venezuelae TR:AAF01064 (EMBL:AF189258) transcriptional regulator (fragment) (507 aa), fasta scores opt: 444 z-score: 484.0 E(): 1.4e-19 31.8% identity in 462 aa overlap. Contains a Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and a Prosite hit to PS00043 Bacteria [...] (500 aa)
SCO3306SCE68.04c, possible aminotransferase, len: 404 aa; similar to TR:Q56232 (EMBL:D38459), aspC, Thermus aquaticus aspartate aminotransferase (385 aa), fasta scores; opt: 379 z-score: 433.6 E(): 7.9e-17, 28.9% identity in 370 aa overlap and to many hypothetical aminotransferases. Similar to many from S.coelicolor e.g. SCH10.36 (EMBL:AL049754) probable aspartate aminotransferase (396 aa) (33.2% identity in 404 aa overlap). Alternative start codons are present at codons 3 and 7. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. (404 aa)
SCO3385Putative L-allo-threonine aldolase; SCE126.03, possible lyase, len: 403aa; weakly similar to many eg. SW:LTAA_AERJA L-allo-threonine aldolase from Aeromonas jandaei DK-39 (338 aa) fasta scores; opt: 257, z-score: 293.4, E(): 5e-09, (31.4% identity in 255 aa overlap). (403 aa)
SCO1378Putative glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
SCO7034SC2C3.01, probable aminotransferase (fragment), len: >275 aa; similar to SW:GABT_ECOL (EMBL:M88334) Escherichia coli 4-aminobutyrate aminotransferase (EC 2.6.1.19) GabT, 426 aa; fasta scores: opt: 634 z-score: 729.2 E(): 0; 40.8% identity in 233 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; SC1H10.23, possible aminotransferase, partial CDS len: > 187 aa. Similar to Escherichia coli SW:ARGD_ECOLI (EMBL:M32796) acetylornithine [...] (422 aa)
SCO68002-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa)
SCO6769SC6A5.18, probable aminotransferase, len: 461 aa; similar to many e.g. SW:ARGD_BACSU acetylornithine aminotransferase from Bacillus subtilis (385 aa) fasta scores; opt: 663, z-score: 757.6, E(): 0, (37.8% identity in 341 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and Prosite match to PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
SCO6522Hypothetical protein SC5C7.07; SC5C7.07, unknown, len: 480 aa. (480 aa)
SCO1360SC10A9.02c, probable gntR-family transcriptional regulator, len: 445 aa; similar to SW:PTSJ_SALTY (EMBL:U11243) Salmonella typhimurium putative transcriptional regulatory protein PtsJ, 430 aa; fasta scores: opt: 968 z-score: 1010.8 E(): 0; 40.4% identity in 433 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and possible helix-turn-helix motif at residues 35..56 (+4.36 SD). (445 aa)
SCO12232SCG58.23, rocD, ornithine aminotransferase, len: 407 aa; highly similar to SW:OAT_BACSU (EMBL:X81802) Bacillus subtilis ornithine aminotransferase (EC 2.6.1.13) RocD, 401 aa; fasta scores: opt: 1356 z-score: 1462.1 E(): 0; 50.4% identity in 395 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (407 aa)
SCO12432SCG1.18c, bioF, 8-amino-7-oxononanoate synthase, len: 375 aa; similar to SW:BIOF_BACSH (EMBL:M29291) Bacillus sphaericus 8-amino-7-oxononanoate synthase (EC 2.3.1.47) BioF, 389 aa; fasta scores: opt: 774 z-score: 785.6 E(): 0; 39.1% identity in 379 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and match to Prosite entry PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. (375 aa)
SCO1245Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (428 aa)
SCO12842SCG18.31c, probable aminotransferase (putative secreted protein), len: 461 aa; similar to TR:CAB76097 (EMBL:AL157956) Streptomyces coelicolor acetonitrile amonitransferase ArgD, 402 aa; fasta scores: opt: 783 z-score: 776.7 E(): 0; 41.6% identity in 385 aa overlap and to SW:OAT_BACSU (EMBL:X81802) Bacillus subtilis ornithine amonitransferase (EC 2.6.1.13) RocD, 401 aa; fasta scores: opt: 692 z-score: 687.5 E(): 8.3e-31; 32.4% identity in 380 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 [...] (461 aa)
SCO12892SCG18.36, probable gntR-family regulatory protein, len: 507 aa; similar to TR:CAB89055 (EMBL:AL353872) Streptomyces coelicolor putative gntR-family regulator SC5G8.04, 462 aa; fasta scores: opt: 1289 z-score: 1152.7 E(): 0; 49.3% identity in 436 aa overlap and to SW:MOCR_RHIME (EMBL:X78503) Rhizobium meliloti probable rhizopine catabolism regulatory protein MocR, 493 aa; fasta scores: opt: 584 z-score: 527.8 E(): 6.5e-22; 34.8% identity in 451 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family. (507 aa)
SCO1294SCBAC36F5.05c, possible cystathionine gamma-synthase, len: 407 aa; similar to SW:METB_HAEIN (EMBL:U32694) Haemophilus influenzae cystathionine gamma-synthase (EC 4.2.99.9) MetB or HI0086, 369 aa; fasta scores: opt: 625 Z-score: 685.3 bits: 135.6 E(): 1.5e-30; 34.127% identity in 378 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS01050 Uncharacterized protein family UPF0031 signature 2. (407 aa)
SCO7537Aminotransferase; SC8G12.13c, aminotransferase, len: 437 aa. Highly similar to several including the bifunctional aminotransferring decarboxylase: 2,2-dialkylglycine decarboxylase (EC 4.1.1.64) from Burkholderia cepacia SW:DGDA_BURCE(EMBL:J05282) (432 aa), fasta scores opt: 1723 z-score: 1953.5 E(): 0 63.7% identity in 422 aa overlap and Mycobacterium leprae SW:GABT_MYCLE(EMBL:U00011) 4-aminobutyrate aminotransferase (EC 2.6.1.19) (446 aa), fasta scores opt: 697 z-score: 792.4 E(): 0 34.0% identity in 418 aa overlap. Contains a Prosite hit to PS00600 Aminotransferases class-III pyridox [...] (437 aa)
SCO7311SC5F8.21c, probable amino acid decarboxylase, len: 492 aa. Similar to many e.g. Bacillus subtilis SW:DCLY_BACSU (EMBL:X58433) lysine decarboxylase (EC 4.1.1.18) (490 aa), fasta scores: opt: 1108 z-score: 1197.8 E():0 35.6% identity in 494 aa overlap. Contains a Pfam match to entry PF01276 OKR_DC_1, Orn/Lys/Arg decarboxylase. (492 aa)
SCO4469SCD65.12, hemL, glutamate-1-semialdehyde 2,1-aminomutase, len: 438 aa; highly similar to SW:GSA_ECOLI (EMBL:X53696) Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) HemL, 426 aa; fasta scores: opt: 1425 z-score: 1497.5 E(): 0; 52.0% identity in 425 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. (438 aa)
SCO4366Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (363 aa)
SCO3944Putative histidinol-phophate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
SCO3920SCQ11.03c, cysA, probable cystathionine/methionine gamma-synthase/lyase, len: 392 aa; previously sequenced as SW:CYSA_STRCO (EMBL:U37580), cysA, S.coelicolor putative cystathionine gamma-lyase (392 aa). Similar to many e.g. SW:MEGL_PSEPU (EMBL:D88554), mdeA, Pseudomonas putida methionine gamma-lyase (398 aa), fasta scores; opt: 608 z-score: 653.6 E(): 4.5e-29, 36.9% identity in 404 aa overlap. Highly similar to TR:Q53668 (EMBL:X91393) Streptomyces antibioticus hypothetical protein found upstream of the abaB gene (232 aa) (87.1% identity in 232 aa overlap). Contains Pfam match to PF0105 [...] (392 aa)
SCO3658SCH10.36, probable aspartate aminotransferase, len: 399 aa; similar to many e.g. TR:Q56232 (EMBL:D38459) Thermus aquaticus aspartate aminotransferase (385 aa), fasta scores; opt: 731 z-score: 825.9 E(): 0, 36.5% identity in 392 aa overlap. Note that there are three possible start codons. Similar to many putative aminotransferases from Streptomyces coelicolor e.g. TR:O54170 (EMBL:AL021411) SC7H1.11, putative aminotransferase (382 aa) (36.6% identity in 331 aa overlap). Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I, score 159.80, E-value 4.6e-44. (396 aa)
SCO3645Putative hydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (410 aa)
SCO3622SC66T3.33, probable aminotransferase, len: 451 aa; similar to many e.g. SW:GABT_ECOLI (EMBL:M88334), gabT, Escherichia coli 4-aminobutyrate aminotransferase (426 aa), fasta scores; opt: 706 z-score: 815.4 E(): 0, 32.3% identity in 427 aa overlap. Also similar to TR:O86744 (EMBL:AL031035) S.coelicolor probable aminotransferase (457 aa) (37.3% identity in 362 aa overlap). Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate [...] (451 aa)
SCO4645SCD82.16c, aspC, aspartate aminotransferase, len: 408 aa; highly similar to SW:AAT_STRVG (EMBL:D50624) Streptomyces virginiae aspartate aminotransferase AspC, 397 aa; fasta scores: opt: 2346 z-score: 2655.6 E(): 0; 89.4% identity in 396 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. (408 aa)
SCO4836SC5G8.04, possible gntR-family regulator, len: 462 aa; similar to many proposed regulators eg. TR:AAF01064 (EMBL:AF189258) transcriptional regulator (fragment) from Streptomyces venezuelae (507 aa) fasta scores; opt: 1010, z-score: 1115.6, E(): 0, 45.2% identity in 389 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family. (462 aa)
SCO4837Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (481 aa)
SCO49582SCK31.18, metB, cystathionine gamma-synthase, len: 386 aa; highly similar to TR:Q9RQ97 (EMBL:AF126953) Corynebacterium glutamicum cystathionine gamma-synthase MetB, 396 aa; fasta scores: opt: 1497 z-score: 1715.4 E(): 0; 59.2% identity in 377 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. (386 aa)
SCO49842SCK36.07c, probable aminotransferase, len: 403 aa; similar to many, e.g. TR:O86587 (EMBL:AL031514) Streptomyces coelicolor putative aminotransferase SC2H4.04c, 402 aa; fasta scores: opt: 1881 Z-score: 2193.7 bits: 414.8 E(): 1.4e-114; 65.920% identity in 402 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferase class-I. (403 aa)
SCO5136SC9E12.21, probable aminotransferase, len: 365 aa; similar to TR:O50434 (EMBL:AL010186) Mycobacterium tuberculosis aminotransferase MTV005.14, 362 aa; fasta scores: opt: 1448 z-score: 1704.1 E(): 0; 61.7% identity in 360 aa overlap. Contains match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. (365 aa)
SCO10872SCG4.03c, probable aldolase, len: 356 aa; similar to TR:O50584 (EMBL:AB001577) Pseudomonas sp. low specificity L-threonine aldolase, 346 aa; fasta scores: opt: 832 z-score: 977.3 E(): 0; 41.3% identity in 339 aa overlap and to SW:LTAA_AERJA (EMBL:D87890) Aeromonas jandaei L-allo-threonine aldolase (EC 4.1.2.-) LtaA, 338 aa; fasta scores: opt: 270 z-score: 321.1 E(): 2.1e-10; 26.9% identity in 324 aa overlap. (356 aa)
SCO1054SCG20A.34, possible aminotransferase, len: 400 aa; similar to TR:Q9XAD5 (EMBL:AL096839) Streptomyces coelicolor putative aminotransferase SCC22.03c, 418 aa; fasta scores: opt: 397 z-score: 446.1 E(): 2.3e-17; 27.7% identity in 423 aa overlap and to TR:Q9RY03 (EMBL:AE001877) Deinococcus radiodurans NifS-related protein DR0151, 401 aa; fasta scores: opt: 791 z-score: 884.2 E(): 0; 41.2% identity in 396 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V. (400 aa)
SCO07313SC5B7.09c, probable transferase, len: 444 aa; similar to SW:MALY_ECOLI (EMBL:M60722) Escherichia coli aminotransferase MalY protein, 390 aa; fasta scores: opt: 522 z-score: 589.7 E(): 2.5e-25; 30.8% identity in 370 aa overlap. (393 aa)
SCO3416SCE9.23, gad, probable glutamate decarboxylase, len: 475 aa; similar to many e.g. SW:DCEA_ECOLI (EMBL:M84024), gadA, Escherichia coli glutamate decarboxylase alpha (466 aa), fasta scores; opt: 1433 z-score: 1665.2 E(): 0, 50.0% identity in 426 aa overlap. Contains Pfam match to entry PF00282 pyridoxal_deC, Pyridoxal-dependent decarboxylase conserved domain, score 276.70, E-value 1.1e-79; Belongs to the group II decarboxylase family. (475 aa)
SCO0435Aminotransferase; SCF51A.13, malY, aminotransferase, len: 401 aa. Highly similar to Escherichia coli SW:MALY_ECOLI (EMBL; M60722) MalY protein (EC 2.6.1.-) (390 aa), fasta scores opt: 1577 z-score: 1814.7 E():0 58.5% identity in 386 aa overlap. (401 aa)
SCO0401SCF62.27, possible aminotransferase, len: 441 aa. Similar to many including Pseudomonas aeruginosa SW:GSA_PSEAE (EMBL:X82072) glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) (glutamate-1-semialdehyde aminotransferase) (427 aa), fasta scores opt: 475 z-score: 540.8 E(): 9.5e-23 34.8% identity in 434 aa overlap and Streptomyces coelicolor TR:CAB39702 (EMBL: AL049485) probable aminotransferase SC6A5.18 (461 aa), fasta scores opt: 464 z-score: 527.9 E(): 4.9e-22 32.4% identity in 407 aa overlap. Contains 2x Pfam matches to entry PF00202 aminotran_3, Aminotransferases class-III pyrido [...] (441 aa)
SCO6279SC1G7.05, probable diaminobutyrate-pyruvate aminotransferase, len: 518 aa; similar to SW:RHSA_RHIME (EMBL:AF110737) Rhizobium meliloti diaminobutyrate-pyruvate aminotransferase (EC 2.6.1.76) RhsA, 470 aa; fasta scores: opt: 423 Z-score: 464.1 bits: 95.4 E(): 2.9e-18; 30.704% identity in 469 aa overlap. Contains 2x Pfam matches to entry PF00202 aminotran_3, Aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (518 aa)
SCO6412SC1A6.01, probable aminotransferase, partial CDS, len: 190 aa; similar to many members of the class-III family of pyridoxal-phosphate-dependent aminotransferases e.g. ARGD_ANASP P54752 anabaena sp. acetylornithine aminotransferase (427 aa), fasta scores; opt: 315 z-score: 402.3 E(): 2.8e-15, 36.0% identity in 189 aa overlap. Contains Pfam matchto entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, score 147.18; SC3C8.31, probable aminotransferase, partial CDS, len: > 270 aa; similar to many members of the class-III pyridoxal-phosphate-dependent aminotransferase [...] (427 aa)
SCO5364Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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