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SCO1547 SCO1547 SCO2043 SCO2043 SCO2117 SCO2117 SCO3214 SCO3214 SCO7691 SCO7691
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SCO1547SCL11.03c, possible anthranilate synthase, len: 353 aa; similar to SW:TRPE_THEMA (EMBL:X74075) Thermotoga maritima Anthranilate synthase component I (EC 4.1.3.27) TrpE, 457 aa; fasta scores: opt: 459 z-score: 510.1 E(): 5.4e-21; 37.2% identity in 285 aa overlap. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme. (353 aa)
SCO2043Putative anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (502 aa)
SCO2117SC6E10.11, trpE1, probable anthranilate synthase, len: 634 aa; highly similar to many anthranilate synthases e.g. TR:O30589 (EMBL:AF012627), TrpE, Streptomyces venezuelae anthranilate synthase (623 aa), fasta scores; opt: 3108 z-score: 3257.7 E(): 0, 80.0% identity in 620 aa overlap. Anthranilate synthases may have one or two components. This protein is similar at the C-terminus to TR:Q9Z4W8 (EMBL:AL035654), TrpG, S.coelicolor probable anthranilate synthase component II (200 aa) (32.7% identity in 202 aa overlap) and centrally to TR:Q9Z4W7 (EMBL:AL035654), trpE2, S.coelicolor probable [...] (634 aa)
SCO3214Probable anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (511 aa)
SCO7691SC4C2.26, possible lyase, len: 471 aa; C-terminal region similar to C-terminal region of SW:TRPE_HALVO (EMBL:M83788) Halobacterium volcanii anthranilate synthase component I(EC 4.1.3.27) TrpE, 523 aa; fasta scores: opt: 545 z-score: 624.2 E(): 3.1e-27; 38.7% identity in 300 aa overlap. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme. (471 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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