(4 nodes) Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal network (Streptomyces coelicolor)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCO0541	SCF11.21, probable alpha-galactosidase, len: 441 aa; similar to SW:AGAL_BACSU (EMBL:AF008220) Bacillus subtilis alpha-galactosidase (EC 3.2.1.22) (Melibiase) MelA, 432 aa; fasta scores: opt: 1068 z-score: 1240.5 E(): 0; 39.3% identity in 427 aa overlap. (441 aa)
	SCO2661	SC6D10.04, possible sugar hydrolase, len: 421 aa; similar to SW:CELF_ECOLI (EMBL:X52890) Escherichia coli 6-phospho-beta-glucosidase (EC 3.2.1.86) CelF, 450 aa; fasta scores: opt: 556 z-score: 624.0 E(): 2.4e-27; 36.0% identity in 431 aa overlap and to SW:AGAL_ECOLI (EMBL:X04894) Escherichia coli alpha-galactosidase (EC 3.2.1.22) (melibiase) MelA, 451 aa; fasta scores: opt: 300 z-score: 338.4 E(): 1.9e-11; 25.5% identity in 459 aa overlap. (421 aa)
	SCO4827	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H). (329 aa)
	SCO6670	SC5A7.20, probable glucosidase, len: 441 aa; similar to e.g. CELF_ECOLI 6-phospho-beta-glucosidase (450 aa), fasta scores; opt: 537 z-score: 628.7 E(): 8.8e-28, 31.8% identity in 456 aa overlap. (441 aa)

Your Current Organism:

Streptomyces coelicolor

NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SCO2661	SCO6670	gene:17760267	gene:17764328	SC6D10.04, possible sugar hydrolase, len: 421 aa; similar to SW:CELF_ECOLI (EMBL:X52890) Escherichia coli 6-phospho-beta-glucosidase (EC 3.2.1.86) CelF, 450 aa; fasta scores: opt: 556 z-score: 624.0 E(): 2.4e-27; 36.0% identity in 431 aa overlap and to SW:AGAL_ECOLI (EMBL:X04894) Escherichia coli alpha-galactosidase (EC 3.2.1.22) (melibiase) MelA, 451 aa; fasta scores: opt: 300 z-score: 338.4 E(): 1.9e-11; 25.5% identity in 459 aa overlap.	SC5A7.20, probable glucosidase, len: 441 aa; similar to e.g. CELF_ECOLI 6-phospho-beta-glucosidase (450 aa), fasta scores; opt: 537 z-score: 628.7 E(): 8.8e-28, 31.8% identity in 456 aa overlap.	0.919
SCO6670	SCO2661	gene:17764328	gene:17760267	SC5A7.20, probable glucosidase, len: 441 aa; similar to e.g. CELF_ECOLI 6-phospho-beta-glucosidase (450 aa), fasta scores; opt: 537 z-score: 628.7 E(): 8.8e-28, 31.8% identity in 456 aa overlap.	SC6D10.04, possible sugar hydrolase, len: 421 aa; similar to SW:CELF_ECOLI (EMBL:X52890) Escherichia coli 6-phospho-beta-glucosidase (EC 3.2.1.86) CelF, 450 aa; fasta scores: opt: 556 z-score: 624.0 E(): 2.4e-27; 36.0% identity in 431 aa overlap and to SW:AGAL_ECOLI (EMBL:X04894) Escherichia coli alpha-galactosidase (EC 3.2.1.22) (melibiase) MelA, 451 aa; fasta scores: opt: 300 z-score: 338.4 E(): 1.9e-11; 25.5% identity in 459 aa overlap.	0.919