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SCO4570 SCO4570 SCO7676 SCO7676 SCO4603 SCO4603 SCO7110 SCO7110 SCO6559 SCO6559 SCO5966 SCO5966 SCO7572 SCO7572 SCO3673 SCO3673 SCO2025 SCO2025 SCO1977 SCO1977 SCO0922 SCO0922 SCO0816 SCO0816 SCO0773 SCO0773 SCO5135 SCO5135 SCO5106 SCO5106 SCO4948 SCO4948 SCO0217 SCO0217 SCO4855 SCO4855 SCO4781 SCO4781 SCO6534 SCO6534 SCO4367 SCO4367
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO4570NuoI, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (211 aa)
SCO7676SC4C2.11, probable ferredoxin, len: 73 aa; similar to SW:FER2_STRGO (EMBL:M32239) Streptomyces griseolus ferredoxin 2 SubB, 64 aa; fasta scores: opt: 236 z-score: 326.6 E(): 1.2e-10; 55.7% identity in 61 aa overlap. (73 aa)
SCO4603NADH dehydrogenase subunit NuoI2; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (197 aa)
SCO7110Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (129 aa)
SCO6559SC4B5.09c, respiratory chain oxidoreductase, len: 286 aa; similar to the N-terminal region of many proteins involved in electron transfer e.g. TR:P77908 (EMBL:U73807) FdhA formate dehydrogenase alpha subunit from Moorella thermoacetica (893 aa), fasta scores; opt: 685, z-score: 791.8, E(): 0, (38.4% identity in 284 aa overlap). Contains PS00551 Prokaryotic molybdopterin oxidoreductases signature 1, PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and r [...] (286 aa)
SCO5966SCBAC16H6.01c, possible oxidase, len: >1032aa: similar to many of undefined function eg. TR:Q9EZK2 (EMBL:AF289509) putative oxidase YdiJ-like protein from Pseudomonas putida (1006 aa) fasta scores; opt: 880, Z-score: 889.5, 27.930% identity (31.672% ungapped) in 1024 aa overlap and TR:Q9F2Y0 (EMBL:AL392149) putative oxidoreductase SCD19.22 from Streptomyces coelicolor (951 aa) fasta scores; opt: 622, Z-score: 628.7, 49.698% identity (53.813% ungapped) in 994 aa overlap. Contains Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Pfam match to entry PF029 [...] (1047 aa)
SCO7572SC5F1.26, possible oxidoreductase, len: 998 aa; similar to TR:Q9KKW5 (EMBL:AE004425) Vibrio cholerae oxidoreductase/iron-sulfur cluster-binding protein VCA0985, 959 aa; fasta scores: opt: 1999 z-score: 2189.0 E(): 0; 35.3% identity in 966 aa overlap. Contains Pfam matches to entries PF01565 FAD_binding_4, FAD binding domain and PF00037 fer4, 4Fe-4S binding domain and matches to Prosite entries PS00422 Granins signature 1 and PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. (998 aa)
SCO3673SCH35.51c, probable iron-sulphur-binding reductase, len: 433 aa; similar to many eg. TR:P96797 (EMBL:Y09870) heterodisulphide reductase from Methanosarcina barkeri (409 aa) fasta scores; opt: 427, z-score: 463.9, E(): 1.6e-18, (28.9% identity in 443 aa overlap). Contains 2 Pfam matches to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and 2 Prosite matches to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. Contains also possible hydrophobic membrane spanning regions. (760 aa)
SCO2025SC3A3.03c, gltD, probable glutamate synthase small subunit, len: 487 aa; similar to bacterial glutamate synthases e.g. TR:Q51584 (EMBL:D85230), gltD, Plectonema boryanum small subunit of NADH-dependent glutamate synthase (492 aa), fasta scores; opt: 1295 z-score: 1405.0 E(): 0, 51.2% identity in 500 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.1% identity in 489 aa overlap). Contains Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulf [...] (487 aa)
SCO1977SC3C9.12c, possible glutamate synthase small subunit, len: 496 aa; similar to C-terminal part of SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa glutamate synthase [NADH], chloroplast precursor (EC 1.4.1.14) (NADH-GOGAT) GlsN, 2194 aa; fasta scores: opt: 1473 Z-score: 1543.9 bits: 297.3 E(): 2.2e-78; 47.551% identity in 490 aa overlap and to TR:Q9S2Z0 (EMBL:AL109849) Streptomyces coelicolor putative glutamate synthase small subunit SC3A3.03c, 487 aa; fasta scores: opt: 2145 Z-score: 2259.1 bits: 427.5 E(): 3.2e-118; 66.398% identity in 497 aa overlap. Contains Pfam match to entry PF00070 p [...] (496 aa)
SCO0922SCM10.10c, probable reductase iron-sulfur protein, len: 248 aa; similar to SW:FRDB_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase iron-sulfur protein (EC 1.3.99.1) FrdB, 247 aa; fasta scores: opt: 288 z-score: 321.7 E(): 1.6e-10; 28.9% identity in 239 aa overlap. Contains Pfam matches to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and to Prosite entries PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00198 4Fe-4S ferredoxins, iron-sulfu [...] (248 aa)
SCO0816SCF43A.06, conserved possible iron-sulfur protein, len: 492 aa; similar to several putative iron-sulfur proteins e.g. SW:YKGF_ECOLI (EMBL:AE000137) Escherichia coli hypothetical protein (475 aa), fasta scores; opt: 1148 z-score: 1249.5 E(): 0, 39.7% identity in 481 aa overlap, which contains 2 putative 4Fe-4S centres. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. (492 aa)
SCO07733SCF60.05c, soyB2, probable ferredoxin, len: 66 aa; identical to TR:O85696 (EMBL:AF072709) Streptomyces lividans putative ferredoxin, 66 aa and similar to SW:FERS_STRGR (EMBL:X63601) Streptomyces griseus ferredoxin SoyB, 65 aa; fasta scores: opt: 269 z-score: 369.1 E(): 5e-13; 61.9% identity in 63 aa overlap. (66 aa)
SCO5135Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (106 aa)
SCO5106SCBAC31E11.02c, shdB2, probable succinate dehydrogenase iron-sulfur subunit, len: 259 aa; highly similar to TR:AAK44479 (EMBL:AE006934) Mycobacterium tuberculosis ferredoxin, 2Fe-2S MT0261, 248 aa; fasta scores: opt: 1355 Z-score: 1588.1 bits: 301.4 E(): 7.7e-81; 74.900% identity in 251 aa overlap and to SW:DHSB_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase iron-sulfur protein SdhB, 252 aa; fasta scores: opt: 365 Z-score: 434.1 bits: 87.9 E(): 1.4e-16; 30.603% identity in 232 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. (259 aa)
SCO49482SCK31.08, narH3, nitrate reductase beta chain, len: 548 aa; highly similar to SW:NARH_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase beta chain NarH, 487 aa; fasta scores: opt: 2088 z-score: 2047.9 E(): 0; 58.2% identity in 483 aa overlap and to TR:O86716 (EMBL:AL031515) Streptomyces coelicolor NarH, putative nitrate reductase beta chain SC5C7.19, 531 aa; fasta scores: opt: 2542 z-score: 2343.2 E(): 0; 71.6% identity in 503 aa overlap. (548 aa)
SCO0217SCJ12.29, narH2, probable nitrate reductase beta chain, len: 522 aa. Highly similar to many e.g. Streptomyces coelicolor TR:O86716 (EMBL; AL031515) putative nitrate reductase beta chain NarH SC5C7.19c (531 aa), fasta scores: opt: 2348 z-score: 2413.0 E(): opt: 2348 z-score: 2413.0 E(): 0 65.3% identity in 496 aa overlap and Bacillus subtilis SW:NARH_BACSU (EMBL; Z49884) nitrate reductase beta chain (EC 1.7.99.4) NarH (487 aa), fasta scores: opt: 2081 z-score: 2139.7 E(): 0 57.1% identity in 485 aa overlap. Contains a PS00190 Cytochrome c family heme-binding site signature, a Pfam match [...] (522 aa)
SCO4855SC5G8.23c, dhsB, probable succinate dehydrogenase iron-sulfur subunit, len: 257aa; strongly similar to many eg. SW:P07014 (DHSB_ECOLI) succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa) fasta scores; opt: 729, z-score: 839.1, E(): 0, 44.3% identity in 237 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Belongs to the succinate [...] (257 aa)
SCO4781SCD63.13, possible cholesterol oxidase, len: 602 aa; similar to TR:Q59530 (EMBL:U00015) Mycobacterium leprae probable cholesterol oxidase precursor (EC 1.1.3.6) ChoD, 585 aa; fasta scores: opt: 1114 z-score: 1181.0 E(): 0; 60.5% identity in 583 aa overlapand to SW:CHOD_BREST (EMBL:D00712) Brevibacterium sterolicum cholesterol oxidase precursor (EC 1.1.3.6) ChoD, 552 aa; fasta scores: opt: 228 z-score: 244.5 E(): 3.4e-06; 26.9% identity in 576 aa overlap. (602 aa)
SCO6534SC5C7.19c, narH, probable nitrate reductase beta chain, len: 531 aa; highly similar to many e.g. NARH_BACSU nitrate reductase beta chain (EC 1.7.99.4) (487 aa), fasta scores; opt: 2099 z-score: 2179.2 E(): 0, 58.0% identity in 495 aa overlap. Contains PS00190 Cytochrome c family heme-binding site signature and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains, score 61.10, E-value 1.8e-16. (531 aa)
SCO4367SCD19.22, possible oxidoreductase, len: 951 aa; N-terminal domain similar to SW:GLCD_ECOLI (EMBL:L43490) Escherichia coli glycolate oxidase subunit GlcD, 499 aa; fasta scores: opt: 351 z-score: 387.8 E(): 4.3e-14; 31.2% identity in 497 aa overlap and C-terminal domain similar to SW:GLCF_ECOLI (EMBL:L43490) Escherichia coli glycolate oxidase iron-sulfur subunit GlcF, 407 aa; blastp scores: Score= 113 (39.8 bits), Expect= 8.0e-10, Sum P(2)= 8.0e-10; Identities= 26/78 (33%), Positives= 39/78 (50%) and Identities= 61/237 (25%), Positives= 91/237 (38%). Contains Pfam match to entry PF01565 [...] (951 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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