STRINGSTRING
SCO1376 SCO1376 SCO1956 SCO1956 SCO4401 SCO4401 SCO4158 SCO4158 SCO3943 SCO3943 SCO3667 SCO3667 SCO4754 SCO4754 SCO0062 SCO0062 SCO0289 SCO0289 SCO0360 SCO0360 SCO0449 SCO0449 SCO0456 SCO0456 SCO0629 SCO0629 SCO0659 SCO0659 SCO0706 SCO0706 SCO0806 SCO0806 SCO0808 SCO0808 SCO0886 SCO0886 SCO0953 SCO0953 SCO1066 SCO1066 SCO3506 SCO3506 SCO3485 SCO3485 SCO2794 SCO2794 SCO2753 SCO2753 SCO2747 SCO2747 SCO2745 SCO2745 SCO2404 SCO2404 SCO2232 SCO2232 SCO2008 SCO2008 SCO4884 SCO4884 SCO4885 SCO4885 SCO5692 SCO5692 SCO6009 SCO6009 SCO6070 SCO6070 SCO6233 SCO6233 SCO6257 SCO6257 SCO6349 SCO6349 SCO6569 SCO6569 SCO6598 SCO6598 SCO6713 SCO6713 SCO6979 SCO6979 SCO6986 SCO6986 SCO7014 SCO7014 SCO7016 SCO7016 SCO7027 SCO7027 SCO7185 SCO7185 SCO7411 SCO7411 SCO7502 SCO7502 SCO7554 SCO7554 SCO7606 SCO7606 SCO1078 SCO1078 SCO1186 SCO1186 SCO1642 SCO1642
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SCO1376SC10A9.18, probable lacI-family transcriptional regulatory protein, len: 356 aa; similar to SW:CELR_THEFU (EMBL:AF086819) Thermomonospora fusca transcription regulator CelR, 340 aa; fasta scores: opt: 681 z-score: 700.7 E(): 1.4e-31; 40.7% identity in 339 aa overlap and to TR:O86795 (EMBL:AL031317) Streptomyces coelicolor probable transcriptional regulator SC6G4.32, 355 aa; fasta scores: opt: 1196 z-score: 1059.6 E(): 0; 56.7% identity in 344 aa overlap. Contains Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI family and PF00532 Peripla_BP_like, Periplasmic bi [...] (356 aa)
SCO1956SCC54.16, probable transcriptional regulator (lacI family), len: 368 aa; similar to many lacI family transcriptional regulators e.g. SW:RBSR_ECOLI RbsR, ribose operon repressor from Escherichia coli (329 aa) fasta scores; opt: 611, z-score: 696.2, E(): 1.8e-31, (34.2% identity in 336 aa overlap). Contains PS00356 Bacterial regulatory proteins, lacI family signature and Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family, score 102.80, E-value 6.7e-27. Also contains Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score [...] (368 aa)
SCO4401SCD10.33c, possible lipoprotein, len: 438 aa; N-terminal domain similar to N-terminal domain of TR:O68027 (EMBL:AF010496) Rhodobacter capsulatus potential Leu/Ile/Val-binding protein precursor, 400 aa; fasta scores: opt: 151 z-score: 166.0 E(): 0.09; 29.8% identity in 131 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. (438 aa)
SCO4158SCD84.25c, probable LacI-family regulatory protein, len: 340 aa; similar to TR:CAB66206 (EMBL:AL136502) Streptomyces coelicolor putative LacI-family transcriptional regulatory protein SCF43.17c, 341 aa; fasta scores: opt: 572 z-score: 669.2 E(): 8e-30; 37.3% identity in 338 aa overlap and to SW:CCPA_BACME (EMBL:L26052) Bacillus megaterium glucose-resistance amylase regulator (catabolite control protein) CcpA, 332 aa; fasta scores: opt: 564 z-score: 660.1 E(): 2.6e-29; 34.3% identity in 309 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins an [...] (340 aa)
SCO3943SCD78.10c, probable transcriptional regulator, len: 370 aa; identical to TR:G3644044 (EMBL:AF090833) putative transcriptional regulator (RstP) from Streptomyces coelicolor. Also similar to members of the lacI family of transcriptional regulators e.g. PURR_ECOLI ((EMBL:J04212)(fasta scores; opt: 345, z-score: 356.4, E(): 1.3e-12, 28.2% identity in 347 aa overlap) purine nucleotide synthesis repressor from Escherichia coli. Contains PS00356 Bacterial regulatory proteins, lacI family signature and Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family, s [...] (370 aa)
SCO3667SCH44.07c, probable secreted solute-binding protein, len: 372 aa; similar to TR:O50503 (EMBL:AL009199) Streptomyces coelicolor possible solute-binding protein SC7B7.06, 371 aa; fasta scores: opt: 1441 z-score: 1539.7 E(): 0; 60.6% identity in 376 aa overlap and to SW:XYLF_ECOLI (EMBL:U00039) Escherichia coli D-xylose-binding periplasmic protein precursor XylF, 330 aa; fasta scores: opt: 559 z-score: 602.9 E(): 4.1e-26; 34.3% identity in 318 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family and corr [...] (372 aa)
SCO4754SC6G4.32, probable transcriptional regulator, len: 355 aa; similar to many members of the lacI family e.g. RBSR _ECOLI ribose operon repressor (329 aa), fasta scores; opt: 588 z-score: 718.4 E(): 9.4e-33, 34.8% identity in 305 aa overlap. Contains PS00356 Bacterial regulatory proteins, lacI family signature, helix-turn-helix motif at aa 20-41 (Score 2255, +6.87 SD) and Pfam matches to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 36.90, E -value 6.1e-09 and to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family, score 127.80, E-va lue 2e-34. (355 aa)
SCO0062SCJ4.43c, probable LacI family transcriptional regulator, len: 367 aa; similar to many transcriptional regulators e.g. SW:GALR_ECOLI galactose operon repressor (343 aa) fasta scores; opt: 549, z-score: 636.2, E(): 4.5e-28, (32.5% identity in 332 aa overlap). Contains Pfam matches to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family and entry PF00356 lacI, Bacterial regulatory proteins, lacI family. Contains possible helix-turn-helix motif (+3.86 SD) 26-47. (367 aa)
SCO0289SCF85.17c, probable transcriptional regulator, len: 342 aa. Similar to many e.g. Streptomyces lividans TR:Q9ZI18 (EMBL; AF043654) BxlR (338 aa), fasta scores opt: 753 z-score: 849.8 E(): 0 42.9% identity in 333 aa overlap and Streptomyces coelicolor TR:O86795 (EMBL; AL031317) putative transcriptional regulator SC6G4.32 (355 aa), fasta scores opt: 880 z-score: 991.6 E(): 0 47.5% identity in 339 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family, Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family and a [...] (342 aa)
SCO0360SCF41.19c, probable DNA-binding, LacI family, regulator. len: 330 aa. Similar to Escherichia coli SW:GNTR_ECOLI (EMBL:D84362) gluconate utilization system GNT-I transcriptional repressor (331 aa), fasta scores opt: 674 z-score: 767.8 E(): 0 36.9% identity in 320 aa overlap. Contains a PS00356 Bacterial regulatory proteins, lacI family signature, a PS00237 G-protein coupled receptors signature, Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family and a Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, LacI family. Contains a possible h [...] (330 aa)
SCO0449SCF51A.27, possible secreted solute-binding lipoprotein, len: 359 aa. Weakly similar to many solute-binding proteins e.g. Streptomyces coelicolor TR:O69944 (EMBL; AL023862) putative secreted solute binding protein SC3F9.04 (348 aa), fasta scores opt: 231 z-score: 259.4 E(): 4.3e-07 23.2% identity in 366 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to, PS00013, a prokaryotic membrane lipoprotein lipid attachment site. (359 aa)
SCO0456SCF51A.34, possible LacI family transcriptional regulator, len: 347 aa. Highly similar to several including: Escherichia coli SW:CYTR_ECOLI (EMBL; X03683) transcriptional repressor CytR (341 aa), fasta scores opt: 504 z-score: 574.2 E(): 1.3e-24 31.6% identity in 339 aa overlap and Streptomyces coelicolor TR:O86598 (EMBL; AL031514) putative transcriptional regulator SC2H4.15 (342 aa), fasta scores opt: 807 z-score: 915.3 E(): 0 44.4% identity in 333 aa overlap. Contains a Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, a Pfam match to entry PF00532 Peripla [...] (347 aa)
SCO0629SCF56.13c, possible transcriptional regulator, len: 369 aa; similar to TR:Q9Z509 (EMBL:AL035591) Streptomyces coelicolor putative transcriptional regulator (LacI family) SCC54.16, 368 aa; fasta scores: opt: 367 z-score: 401.8 E(): 5.4e-15; 33.2% identity in 352 aa overlap and to SW:CCPA_BACME (EMBL:L26052) Bacillus megaterium glucose-resistance amylase regulator CcpA, 332 aa; fasta scores: opt: 263 z-score: 290.5 E(): 8.4e-09; 26.3% identity in 339 aa overlap. Contains possible helix-turn-helix motif at residuees 25..46 (+5.42 SD). (369 aa)
SCO0659SCF91.19, possible DeoR-family transcriptional regulator, len: 368 aa. Similar to many DNA-binding regulatory proteins including: Streptomyces reticuli TR:CAB46346(EMBL:AJ009798) regulator CebR (350 aa), fasta scores opt: 287 z-score: 337.9 E(): 1.9e-11 30.6% identity in 359 aa overlap and Streptomyces lividans SW:REGL_STRLI (EMBL:X98242) transcription regulatory protein RegL (345 aa), fasta scores opt: 276 z-score: 325.3 E(): 9.6e-11 28.9% identity in 353 aa overlap. Contains Pfam matches to entries PF00455 deoR, Bacterial regulatory proteins, deoR family and Pfam match to entry PF005 [...] (368 aa)
SCO0706Putative lipoprotein; SCF42.16c, possible lipoprotein, len: 427 aa, Weakly similar to Pseudomonas aeruginosa SW:BRAC_PSEAE(EMBL:M31071) leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor (373 aa), fasta scores opt: 239 z-score: 250.6 E(): 1.4e-06 24.0% identity in 341 aa overlap. Contains an appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and a possible N-terminal signal sequence. (427 aa)
SCO0806SCF43.17c, possible LacI-family transcriptional regulatory protein, len: 341 aa. Similar to many regulators including: Escherichia coli SW:RBSR_ECOLI (EMBL:M13169) ribose operon repressor, RbsR (329 aa), fasta scores opt: 646 z-score: 726.9 E(): 0 35.9% identity in 334 aa overlap and Streptomyces coelicolor TR:Q9Z509 (EMBL:AL035591) putative transcriptional regulator (LacI family) SCC54.16 (368 aa), fasta scores opt: 659 z-score: 740.7 E(): 0 39.2% identity in 337 aa overlap. Contains a Pfam matches to entries PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family and Pf [...] (341 aa)
SCO0808SCF43.19c, possible secreted solute-binding lipoprotein, len: 360 aa. Similar to many bacterial extracellular solute-binding proteins including: Bacillus subtilis SW:RBSB_BACSU(EMBL:Z92953) D-ribose-binding protein precursor, RbsB (305 aa), fasta scores opt: 234 z-score: 252.1 E(): 1.2e-06 24.9% identity in 277 aa overlap and Streptomyces coelicolor TR:CAB56679(EMBL:AL121596) possible secreted solute-binding lipoprotein SCF51A.27 (359 aa), fasta scores opt: 1487 z-score: 1547.8 E(): 0 63.1% identity in 360 aa overlap. Contains an appropriately positioned Prosite hit to PS00013 Prokaryo [...] (360 aa)
SCO0886SCM1.19c, possible LacI-family transcriptional regulator, len: 344 aa. Similar to many including: Escherichia coli SW:RBSR_ECOLI (EMBL:M13169) ribose operon repressor (329 aa), fasta scores opt: 353 z-score: 387.9 E(): 2.9e-14 30.7% identity in 313 aa overlap. Also similar to several Streptomyces coelicolor putative LacI-family transcriptional regulators e.g. TR:CAB59495 (EMBL:AL132648) (350 aa), fasta scores opt: 377 z-score: 413.3 E(): 1.1e-15 33.9% identity in 345 aa overlap and TR:O87600 (EMBL:AF086832) (350 aa), fasta scores opt: 377 z-score: 413.3 E(): 1.1e-15 33.9% identity in 3 [...] (344 aa)
SCO0953SCM11.08, probable lacI-family transcriptional regulator, len: 349 aa; similar to TR:O86598 (EMBL:AL031514) Streptomyces coelicolor putative transcriptional regulator, SC2H4.15, 342 aa; fasta scores opt: 949 z-score: 1067.0 E(): 0; 44.6% identity in 341 aa overlap and to SW:ASCG_ECOLI (EMBL:M73326) Escherichia coli cryptic asc operon repressor, 336 aa; fasta scores: opt: 409 z-score: 463.9 E(): 1.8e-18; 28.4% identity in 334 aa overlap. Contains Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI family, score 37.90, E-value 3.1e-09 and PF00532 Peripla_BP_like, Pe [...] (349 aa)
SCO1066SCG22.12, probable lacI-family transcriptional regulator, len: 340 aa; similar to SW:CYTR_ECOLI (EMBL:X03683) Escherichia coli transcriptional repressor CytR, 341 aa; fasta scores: opt: 608 z-score: 692.2 E(): 4.4e-31; 34.2% identity in 339 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family and match to Prosite entry PS00356 Bacterial regulatory proteins, lacI family signature and possible helix-turn-helix motif at residues 4..25 (+6.04 SD). (340 aa)
SCO3506SCE134.07, possible lacI-family transcriptional regulator, len: 353 aa; similar to many e.g. SW:MALR_STRCO maltose operon transcriptional repressor MalR from Streptomyces coelicolor (344 aa) fasta scores; opt: 440, z-score: 508.9, E(): 4.9e-21, (32.4% identity in 352 aa overlap). Contains Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI family and PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family. (353 aa)
SCO3485SCE65.21c, probable lacI-family transcriptional regulator, len: 349 aa; similar to TR:AAD42741 (EMBL:AF105219) Thermomonospora curvata putative regulatory protein AglR, 347 aa; fasta scores: opt: 563 z-score: 648.1 E(): 1e-28; 34.9% identity in 341 aa overlap and to SW:CYTR_ECOLI (EMBL:X03683) Escherichia coli, transcriptional repressor CytR 341 aa; fasta scores: opt: 552 z-score: 635.6 E(): 5e-28; 30.5% identity in 347 aa overlap. Contains matches to Pfam entries PF00356 lacI, Bacterial regulatory proteins, lacI family PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI. Co [...] (349 aa)
SCO27942SCC13.02c, lacI-family transcriptional regulatory protein, len: 351 aa; highly similar to TR:Q9X9R3 (EMBL:AJ009798) Streptomyces reticuli CebR protein, 350 aa; fasta scores: opt: 2011 z-score: 2174.4 E(): 0; 89.4% identity in 350 aa overlap and C-terminal region identical to TR:BAB03462 (EMBL:AB036424) Streptomyces coelicolor transcriptional regulator (fragment) ORF5-H, 193 aa. Contains Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI family and PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family and match to Prosi [...] (351 aa)
SCO2753SCC57A.24, possible LacI-family transcriptional regulator, len: 348 aa. Similar to many other putative Streptomyces coelicolor LacI-family regulators including: TR:Q9X862 (EMBL:AL049661) SCE134.07 (353 aa), fasta scores opt: 489 z-score: 554.3 E(): 1.8e-23 33.8% identity in 358 aa overlap and TR:O86795 (EMBL:AL031317) SC6G4.32 (355 aa), fasta scores opt: 460 z-score: 521.7 E(): 1.2e-21 37.1% identity in 353 aa overlap. Contains a Prosite hit to PS00356 Bacterial regulatory proteins, lacI family signature and Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI fami [...] (348 aa)
SCO2747SCC57A.18, bifunctional carbohydrate binding and transport protein, len: 613 aa. The N-terminus is highly similar to many ribose transport system permeases e.g. Escherichia coli SW:RBSC_ECOLI(EMBL:L10328) ribose transport system permease protein RbsC (321 aa), fasta scores opt: 846 z-score: 833.8 E(): 0 47.1% identity in 310 aa overlap. The C-terminus is highly similar to many ribose-binding proteins e.g. Escherichia coli SW:RBSB_ECOLI(EMBL:K00511) D-ribose-binding periplasmic protein precursor (296 aa), fasta scores opt: 863 z-score: 847.0 E():0 46.9% identity in 303 aa overlap. Conta [...] (651 aa)
SCO2745SCC57A.16, probable LacI-family transcriptional regulator, len: 347 aa. Highly similar to many other regulators including: Escherichia coli SW:CYTR_ECOLI (EMBL:X03683) transcriptional repressor CytR (341 aa), fasta scores opt: 714 z-score: 751.4 E(): 0 34.9% identity in 332 aa overlap and Streptomyces coelicolor TR:Q9Z509 (EMBL:AL035591) putative transcriptional regulator SCC54.16 (368 aa), fasta scores opt: 843 z-score: 885.1 E():0 43.4% identity in 348 aa overlap. Contains a Prosite hit to PS00356 Bacterial regulatory proteins, lacI family signature and Pfam hits to PF00356 lacI, Bac [...] (347 aa)
SCO2404SC4A7.32, probable sugar-binding receptor, len: 369 aa; similar to SW:CVE2_AGRTU (EMBL:X97456) Agrobacterium tumefaciens multiple sugar-binding periplasmic receptor chve precursor, ChvE, 354 aa; fasta scores: opt: 1391 z-score: 1497.2 E(): 0; 60.3% identity in 350 aa overlap. Contains possible signal peptide sequence, Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family and Prosite match correctly situated PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (369 aa)
SCO2232Maltose operon transcriptional repressor; Transcriptional repressor of the maltosaccharide utilization operon malEFG. (344 aa)
SCO2008SC7H2.22, possible branched chain amino acid binding protein, len: 481aa; similar to many eg. SW:LIVK_ECOLI leucine-specific binding protein from Escherichia coli (369 aa) fasta scores; opt: 360, z-score: 374.0, E(): 1.6e-13, (28.4% identity in 352 aa overlap). Contains possible N-terminal signal sequence. (418 aa)
SCO48842SCK8.10, probable lipoprotein, len: 347 aa; similar to SW:YUFN_BACSU (EMBL:Z93937) Bacillus subtilis hypothetical lipoprotein precursor YufN, 350 aa; fasta scores: opt: 690 z-score: 727.5 E(): 0; 37.4% identity in 348 aa overlap, to TR:CAC14304 (EMBL:AJ276209) Clostridium sticklandii putative substrate binding lipoprotein precursor of an ABC transporter BmpA, 349 aa; fasta scores: opt: 557 z-score: 589.0 E(): 3.1e-25; 36.6% identity in 352 aa overlap and to Streptomyces coelicolor probable lipoprotein 2SCK8.11, 348 aa; fasta scores: opt: 1727 z-score: 1625.1 E(): 0; 78.4% identity in [...] (347 aa)
SCO48852SCK8.11, probable lipoprotein, len: 348 aa; similar to SW:YUFN_BACSU (EMBL:Z93937) Bacillus subtilis hypothetical lipoprotein precursor YufN, 350 aa; fasta scores: opt: 663 z-score: 689.2 E(): 8e-31; 36.8% identity in 334 aa overlap, to TR:CAC14304 (EMBL:AJ276209) Clostridium sticklandii putative substrate binding lipoprotein precursor of an ABC transporter BmpA, 349 aa; fasta scores: opt: 560 z-score: 583.6 E(): 6e-25; 36.1% identity in 355 aa overlap and to Streptomyces coelicolor probable lipoprotein 2SCK8.10, 347 aa; fasta scores: opt: 1727 z-score: 1622.6 E(): 0; 78.4% identity i [...] (348 aa)
SCO5692SC5H4.16c, probable transcriptional regulator, len: 337 aa; similar to SW:CELR_THEFU (EMBL:AF086819) Thermomonospora fusca transcription regulator CelR, 340 aa; fasta scores: opt: 440 z-score: 531.7 E(): 3.7e-22; 31.6% identity in 339 aa overlap. Contains Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI family and PF00532 Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family and match to Prosite entry PS00356 Bacterial regulatory proteins, lacI family signature. Contains also possible helix-turn-helix motif at residues 2..23 [...] (337 aa)
SCO6009SC7B7.06, probable solute-binding protein of transmembrane transport system, len: 403 aa; similar to many eg. XYLF_ECOLI P37387 d-xylose-binding periplasmic protein precursor (330 aa), fasta scores; opt: 619 z-score: 573.4 E(): 8.9e-25, 35.7% identity in 325 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (371 aa)
SCO6070SC9B1.17c, possible secreted solute binding protein, len: 337aa; similarity to many eg. SW:RBSB_BACSU D-ribose binding protein from Bacillus subtilis (305 aa) fasta scores; opt: 251, z-score: 270.5, E(): 9.6e-08, (26.4% identity in 288 aa overlap). Contains possible N-terminal signal sequence and Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (337 aa)
SCO6233SC2H4.15, probable transcriptional regulator, len: 342 aa; similar to many members of the lacI family e.g. CCPA_BACME glucose-resistance amylase regulator (Bacillus megaterium) (332 aa), fasta scores; opt: 448 z-score: 548.6 E(): 2.6e-23, 29.8% identity in 336 aa overlap. Contains helix-turn-helix motif from aa 9-30 (Score 1778, +5.24 SD) and Pfam matches to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 30.40, E-value 4.7e-07 and to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family, score 44.00, E-value 3.4e-09. (342 aa)
SCO6257SCAH10.22, probable ABC transport system sugar binding lipoprotein, len: 334 aa; similar to TR:CAB41563 (EMBL:AL049727) Streptomyces coelicolor putative secreted solute binding protein, 337 aa; fasta scores: opt: 1003 z-score: 1130.9 E():0; 49.8% identity in 325 aa overlap, to SW:RBSB_BACSU (EMBL:Z92953) Bacillus subtilis D-ribose-binding protein precursor RbsB, 305 aa; fasta scores: opt: 206 z-score: 238.7 E(): 6.3e-06; 23.0% identity in 235 aa overlap and to TR:CAB41563 (EMBL:SC9B1) Streptomyces coelicolor SC9B1.17c, 337 aa; fasta scores: opt: 1003 z-score: 1045.2 E(): 0; 49.8% ident [...] (334 aa)
SCO6349SC3A7.17, probable transcriptional regulator, len: 361 aa; similar to many of the lacI family e.g. LACI_ECOLI lactose operon repressor (360 aa), fasta scores; opt: 518 z-score: 705.7 E(): 4.6e-32, 33.6% identity in 339 aa overlap. Contains helix-turn-helix motif from aa 27-48 (Score 1760, +5.18 SD), and Pfam matches to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, score 35.20, E-value 1.9e-08 and to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family, score 78.80, E-value 1.1e-19. (361 aa)
SCO6569SC3F9.04, probable secreted solute binding protein, len: 348 aa; similar to many e.g. RBSB_HAEIN D-ribose-binding periplasmic protein precursor (292 aa), fasta scores; opt: 341 z-score: 284.7 E(): 1.2e-08, 29.2% identity in 271 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (348 aa)
SCO6598SC8A6.19, probable transcriptional regulator, len: 246 aa; similar to many members of the lacI family, e.g. CCP A_BACSU glucose-resistance amylase regulator (334 aa), fast a scores; opt: 313 z-score: 569.6 E(): 1.7e-24, 31.2% identity in 317 aa overlap. Contains PS00356 Bacterial regulatory proteins, lacI family signature, helix-tur-helix motif at aa 7-28 (Score 2389, +7.32 SD) and Pfam matches to entry P F00532 Peripla_BP_like, Periplasmic binding proteins and LacI family, score 86.50, E-value 5.3e-22 and Pfam match to entry PF00356 lacI, Bacterial regulatory proteins, lacI family, sc [...] (346 aa)
SCO6713SC4C6.23, probable lacI-family transcriptional regulator, len: 352 aa; similar to many e.g. TR:O87590 (EMBL:AF086819), CelR, Thermomonospora fusca transcriptional regulator of cellulase genes (340 aa), fasta scores; opt: 991 z-score: 1119.2 E(): 0, 51.9% identity in 324 aa overlap. Similar to others from S. coelicolor e.g. TR:O86795 (EMBL:AL031317) S. coelicolor putative transcriptional regulator (355 aa) (36.3% identity in 342 aa overlap). Contains Pfam matches to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family and to entry PF00356 lacI, Bacterial regulator [...] (352 aa)
SCO6979SC8F11.05, probable solute-binding lipoprotein, len: 340 aa. Highly similar to many sugar transport proteins including Bacillus subtilis SW:RBSB_BACSU(EMBL:Z92953) D-ribose-binding protein precursor, RbsB (305 aa), fasta scores opt: 222 z-score: 243.9 E(): 3.7e-06 23.0% identity in 256 aa overlap and several examples from Streptomyces coelicolor e.g. TR:Q9X837(EMBL:AL049727) putative secreted solute binding protein, SC9B1.17C (337 aa), fasta scores opt: 1281 z-score: 1360.6 E():0 59.1% identity in 328 aa overlap. Contains a possible N-terminal signal sequence and an appropriately posit [...] (340 aa)
SCO6986SC8F11.12, possible DNA-binding protein, len: 348 aa. Weakly similar to a hypothetical protein located on the Agrobacterium tumefaciens Ti-plasmid TR:BAA87720 (EMBL:AB016260) TiORF95 (336 aa), fasta scores opt: 464 z-score: 513.2 E(): 3.7e-21 29.8% identity in 329 aa overlap and to TR:CAC46423 (EMBL:AL591788) Rhizobium meliloti hypothetical transcription regulator protein SMC00163, 340 aa; fasta scores: opt: 1133 Z-score: 1207.2 E(): 1.3e-59; 52.959% identity in 338 aa overlap. Contains a putative helix-turn-helix motif situated between residues 5..26 (+5.89 SD). (348 aa)
SCO7014SC1H10.03c, probable LacI-family transcriptional regulatory protein, len: 337 aa. Identical to Streptomyces lividans protein encoded on the 1 kb TR:Q57276 (EMBL:X65466) right direct repeat sequence contained within the amplifiable AUD1 element (337 aa), fasta scores opt: 2188 z-score: 2534.7 E():0 99.7% identity in 337 aa overlap. Also highly similar to Streptomyces coelicolor SW:MALR_STRCO (EMBL:Y07706) maltose operon transcriptional repressor, MalR or SC10B7.03c (344 aa), fasta scores opt: 1114 z-score: 1293.5 E():0 53.3% identity in 336 aa overlap. This gene is duplicated on this co [...] (337 aa)
SCO7016SC1H10.05c, possible LacI-family transcriptional regulatory protein, len: 336 aa. Identical to Streptomyces lividans protein encoded on the 1 kb TR: Q57094(EMBL:U22894) left direct repeat sequence contained within the amplifiable AUD1 element (336 aa), fasta scores opt: 2173 z-score: 2549.4 E():0 99.4% identity in 336 aa overlap. Also highly similar to Streptomyces coelicolor SW:MALR_STRCO (EMBL:Y07706) maltose operon transcriptional repressor, MalR or SC10B7.03c (344 aa), fasta scores opt: 1137 z-score: 1336.5 E():0 53.7% identity in 341 aa overlap. This gene is duplicated on this cos [...] (336 aa)
SCO7027SC1H10.16c, probable LacI-family transcriptional regulator, len: 339 aa. Highly similar to Streptomyces lividans TR:Q9ZI18 (EMBL:AF043654) LacI-GalR family regulatory protein, BxlR (338 aa), fasta scores opt: 2136 z-score: 2395.5 E(): 0 96.5% identity in 340 aa overlap and Escherichia coli SW:CYTR_ECOLI (EMBL:X03683) transcriptional repressor, CytR (341 aa), fasta scores opt: 553 z-score: 625.0 E(): 2.2e-27 32.7% identity in 330 aa overlap. Also highly similar to Streptomyces coelicolor TR:O86795(EMBL:AL031317) putative transcriptional regulator, SC6G4.32 (355 aa), fasta scores opt: 13 [...] (339 aa)
SCO7185SC8A11.13, probable branched amino acid binding secreted protein, len: 396 aa; similar to SW:LIVK_ECOLI (EMBL:M29378) Escherichia coli leucine-specific binding protein precursor LivK, 369 aa; fasta scores: opt: 233 z-score: 262.9 E(): 3.6e-07; 24.7% identity in 360 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. (396 aa)
SCO7411SC6D11.07, possible LacI-family transcriptional regulator, len: 352 aa. Similar to several including Escherichia coli SW:LACI_ECOLI (EMBL:V00294) lactose operon repressor LacI (360 aa), fasta scores opt: 595 z-score: 670.0 E(): 6.7e-30 34.8% identity in 333 aa overlap and Streptomyces coelicolor TR:O86618 (EMBL:AL031155) putative transcriptional regulator SC3A7.17 (361 aa), fasta scores opt: 887 z-score: 995.3 E(): 0 46.0% identity in 350 aa overlap. Contains Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI family and PF00532 Peripla_BP_like, Periplasmic bindin [...] (352 aa)
SCO7502SCBAC17A6.35c, possible LacI-family transcriptional regulator, len: 346 aa; similar to many e.g. SW:P46828 (CCPA_BACME) glucose-resistance amylase regulator CcpA from Bacillus megaterium (332 aa) fasta scores: opt: 528, Z-score: 565.6, 30.769% identity (31.902% ungapped) in 338 aa overlap and TR:Q9K433 (EMBL:AL359779) putative LacI-family transcriptional regulator from Streptomyces coelicolor (340 aa) fasta scores: opt: 993, Z-score: 1055.5, 49.422% identity (51.506% ungapped) in 346 aa overlap. Contains Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and suga [...] (346 aa)
SCO7554SC5F1.08c, probable lacI-family transcriptional regulator, len: 337 aa; similar to TR:Q9X9R3 (EMBL:AJ009798) Streptomyces reticuli CebR protein, 350 aa; fasta scores: opt: 1152 z-score: 1278.6 E(): 0; 54.6% identity in 339 aa overlap and to SW:CELR_THEFU (EMBL:AF086819) Thermomonospora fusca transcription regulator CelR, 340 aa; fasta scores: opt: 1031 z-score: 1145.4 E(): 0; 52.1% identity in 340 aa overlap. Also similar to TR:CAC10103 (EMBL:AL442165) Streptomyces coelicolor lacI-family transcriptional regulatory protein CebR 2SCC13.02c, 351 aa; fasta scores: opt: 1082 z-score: 996.3 [...] (337 aa)
SCO7606SC2H2.04, possible amino acid binding protein, len: 373 aa; low similarity to TR:O68027 (EMBL:AF010496) Rhodobacter capsulatus potential Leu/Ile/Val-binding protein precursor, 400 aa; fasta scores: opt: 226 z-score: 253.4 E(): 1.4e-06; 25.2% identity in 322 aa overlap. (373 aa)
SCO1078SCG22.24, probable lacI-family transcriptional regulator, len: 349 aa; similar to TR:Q9S1T0 (EMBL:AL109950) Streptomyces coelicolor putative lacI-family transcriptional regulator SCJ4.43c, 367 aa; fasta scores: opt: 786 z-score: 894.0 E(): 0; 38.5% identity in 353 aa overlap and to SW:GALR_ECOLI (EMBL:V00280) Escherichia coli galactose operon repressor GalR, 343 aa; fasta scores: opt: 504 z-score: 575.9 E(): 1.3e-24; 31.3% identity in 336 aa overlap. Contains Pfam matches to entries PF00356 lacI, Bacterial regulatory proteins, lacI family and PF00532 Peripla_BP_like, Periplasmic bindin [...] (349 aa)
SCO1186SCG11A.17, probable lacI-family transcriptional regulator, len: 341 aa; similar to TR:CAB46346 (EMBL:AJ009798) Streptomyces reticuli regulatory protein CebR, 350 aa; fasta scores: opt: 1241 z-score: 1440.4 E(): 0; 57.9% identity in 347 aa overlap and to SW:PURR_ECOLI (EMBL:J04212) Escherichia coli purine nucleotide synthesis repressor PurR, 340 aa; fasta scores: opt: 587 z-score: 684.5 E(): 9.5e-31; 35.7% identity in 336 aa overlap and to Streptomyces coelicolor SC4G6.23; fasta scores: opt: 989 z-score: 952.6 E(): 0; 53.8% identity in 316 aa overlap. Contains matches to Pfam entries PF [...] (341 aa)
SCO1642SCI41.25, putative LacI family regulator, len 336 aa. Identical to TR:O87600 (EMBL:AF086832) Streptomyces coelicolor ORF4 and similar to TR:AAD36030 (EMBL:AE001758) Thermotoga maritima TM0949 transcriptional regulator, LacI family, 332 aa; fasta scores: opt: 476 z-score: 517.4 E(): 1.9e-21; 29.5% identity in 339 aa overlap. Contains possible helix-turn-helix motif at aa 23-44.(Score 1430, +4.06 SD). (350 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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