(10 nodes) Flavoprotein-like superfamily network (Streptomyces coelicolor)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCO6447	SC9B5.14c, possible NAD(P)H oxidoreductase, len: 246aa; similar to many (prokaryotic and eukaryotic) eg. SW:DHQV_HUMAN NAD(P)H dehydrogenase from Homo sapiens (human) (231 aa) fasta scores; opt: 182, z-score: 338.0, E(): 1.6e-11, (30.9% identity in 181 aa overlap). (246 aa)
	SCO0046	Putative hydrolase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family. (220 aa)
	SCO4587	SCD20.05c, hypothetical protein, len: 200 aa; similar to TR:P96726 (EMBL:Z92952) Bacillus subtilis hypothetical 20.5 kDa protein YwqN, 181 aa; fasta scores: opt: 357 z-score: 457.0 E(): 5.5e-18; 33.9% identity in 177 aa overlap. (200 aa)
	SCO3295	SCE15.12c, possible oxidoreductase, len: 222aa; similar to TR:O85762 (EMBL:AF075709) NADH dependent FMN reductase from Pseudomonas putida (200 aa) fasta scores; opt: 208, z-score: 241.1, E(): 4e-06, (35.7% identity in 129 aa overlap). (222 aa)
	SCO2478	SC7A8.17c, possible reductase, len: 195 aa; similar to TR:Q9ZGD0 (EMBL:AF080235) Streptomyces cyanogenus reductase homolog LanO, 193 aa; fasta scores: opt: 780 z-score: 927.8 E(): 0; 60.1% identity in 188 aa overlap and to TR:AAF00220 (EMBL:AF164961) Streptomyces fradiae UrdO, 197 aa; fasta scores: opt: 775 z-score: 921.8 E(): 0; 55.7% identity in 194 aa overlap. (195 aa)
	SCO0888	SCM1.21, possible secreted protein, len: 187 aa. Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis TR:P95105 (EMBL:Z83866) hypothetical 19.1 KD protein (184 aa), fasta scores opt: 651 z-score: 722.6 E(): 6.7e-33 56.6% identity in 175 aa overlap. Contains a possible N-terminal signal sequence. (187 aa)
	SCO0637	SCF56.21, hypothetical protein, len: 151 aa; similar to TR:O33313 (EMBL:AL008967) Mycobacterium tuberculosis hypothetical 16.0 kD protein MTV002.36c, 150 aa; fasta scores: opt: 671 z-score: 800.1 E(): 0; 67.8% identity in 146 aa overlap. (151 aa)
	SCO0595	SCF55.19, hypothetical protein, len: 197 aa; similar to TR:O05917 (EMBL:Z95210) Mycobacterium tuberculosis hypothetical 26.9 KD protein MTCY21C12.19c, 245 aa; fasta scores: opt: 459 z-score: 543.0 E(): 7.2e-23; 39.3% identity in 201 aa overlap. (197 aa)
	SCO7741	SC8D11.32c, possible bifunctional protein, len: 354 aa; N-terminal region similar to TR:Q9RKU1 (EMBL:AL132824) Streptomyces coelicolor putative reductase SCAH10.16, 185 aa; fasta scores: opt: 387 z-score: 473.3 E(): 8e-19; 39.0% identity in 187 aa overlap and C-terminal region similar to SW:YIEF_ECOLI (EMBL:L10328) Escherichia coli hypothetical 20.4 kDa protein YieF, 188 aa; blastp scores: Score= 148 (52.1 bits), Expect= 7.0e-10, P= 7.0e-10; Identities= 49/139 (35%), Positives= 78/139 (56%). Contains Pfam match in C-terminal region to entry PF00583 Acetyltransf, Acetyltransferase (GNAT [...] (354 aa)
	SCO6251	SCAH10.16, possible reductase, len: 185 aa; similar to TR:Q9ZGD0 (EMBL:AF080235) Streptomyces cyanogenus reductase homologue LanO, len: 193 aa; fasta scores: opt: 398 z-score: 505.3 E(): 9e-21; 41.0% identity in 188 aa overlap. (185 aa)