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SCO3574 SCO3574 SCO3566 SCO3566 SCO3540 SCO3540 SCO3415 SCO3415 SCO3396 SCO3396 SCO3233 SCO3233 SCO3232 SCO3232 SCO3219 SCO3219 SCO3171 SCO3171 SCO2886 SCO2886 SCO2761 SCO2761 SCO2723 SCO2723 SCO2516 SCO2516 SCO2375 SCO2375 SCO2332 SCO2332 SCO2208 SCO2208 SCO2123 SCO2123 SCO2069 SCO2069 SCO1989 SCO1989 SCO1843 SCO1843 SCO1735 SCO1735 SCO1265 SCO1265 SCO1264 SCO1264 SCO1230 SCO1230 SCO1175 SCO1175 SCO1097 SCO1097 SCO1025 SCO1025 SCO0964 SCO0964 SCO0047 SCO0047 SCO0135 SCO0135 SCO0470 SCO0470 SCO0145 SCO0145 SCO0490 SCO0490 SCO0492 SCO0492 SCO0501 SCO0501 SCO0503 SCO0503 SCO0526 SCO0526 SCO0556 SCO0556 SCO0635 SCO0635 SCO0713 SCO0713 SCO0805 SCO0805 SCO0878 SCO0878 SCO0939 SCO0939 SCO0899 SCO0899 SCO0267 SCO0267 SCO0288 SCO0288 SCO0321 SCO0321 SCO0427 SCO0427 SCO0461 SCO0461 SCO0465 SCO0465 SCO3772 SCO3772 SCO3954 SCO3954 SCO4160 SCO4160 SCO4219 SCO4219 SCO4241 SCO4241 SCO4298 SCO4298 SCO4368 SCO4368 SCO4392 SCO4392 SCO4395 SCO4395 SCO4479 SCO4479 SCO4746 SCO4746 SCO4799 SCO4799 SCO4900 SCO4900 SCO5067 SCO5067 SCO5122 SCO5122 SCO5165 SCO5165 SCO5172 SCO5172 SCO5179 SCO5179 SCO5180 SCO5180 SCO5215 SCO5215 SCO5489 SCO5489 SCO5894 SCO5894 SCO5943 SCO5943 SCO5986 SCO5986 SCO6043 SCO6043 SCO6127 SCO6127 SCO6175 SCO6175 SCO6277 SCO6277 SCO6287 SCO6287 SCO6339 SCO6339 SCO6351 SCO6351 SCO6432 SCO6432 SCO6479 SCO6479 SCO6488 SCO6488 SCO6609 SCO6609 SCO6612 SCO6612 SCO6697 SCO6697 SCO6966 SCO6966 SCO7057 SCO7057 SCO0254 SCO0254 SCO7095 SCO7095 SCO7100 SCO7100 SCO7121 SCO7121 SCO7131 SCO7131 SCO7132 SCO7132 SCO7205 SCO7205 SCO7233 SCO7233 SCO7245 SCO7245 SCO7256 SCO7256 SCO7359 SCO7359 SCO7396 SCO7396 SCO7440 SCO7440 SCO7477 SCO7477 SCO7609 SCO7609 SCO7650 SCO7650 SCO7683 SCO7683 SCO7687 SCO7687 SCO7739 SCO7739 SCO7777 SCO7777 SCO7787 SCO7787 mmyT mmyT SCO3690 SCO3690 SCO3644 SCO3644 SCO3643 SCO3643 SCO3610 SCO3610 SCO3599 SCO3599
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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SCO3574SCH17.08c, possible epoxide hydrolase, len: 354 aa; similar to eukaryotic epoxide hydrolases e.g. TR:Q42566 (EMBL:D16628), atseH, Arabidopsis thaliana epoxide hydrolase (321 aa), fasta scores; opt: 501 z-score: 542.6 E(): 6.8e-23, 37.7% identity in 332 aa overlap. Similar to others from S.coelicolor e.g. SCH5.29 (EMBL:AL035636) putative hydrolase (324 aa) (33.6% identity in 348 aa overlap). Alternative start codons are present at codons 6 and 30, but these have no apparent RBS. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (354 aa)
SCO3566SCH5.29, possible hydrolase, len: 324aa; similar to many egs. TR:O69638 (EMBL:AL022121) putative epoxide hydrolase from Mycobacterium tuberculosis (327 aa) fasta scores; opt: 687, z-score: 786.1, E(): 0, (40.7% identity in 327 aa overlap) and TR:Q39856 (EMBL:D63781) epoxide hydrolase from Glycine max (soybean) (341 aa) fasta scores; opt: 396, z-score: 455.4, E(): 4.6e-18, (29.1% identity in 316 aa overlap). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 68.70, E-value 1.3e-16. (324 aa)
SCO3540SCH5.02c, slpD, proteinase (putative secreted protein), len: 539 aa; identical to the previously sequenced TR:Q54398 (EMBL:L42758) SlpD, mycelium-associated (lipoprotein) proteinase from Streptomyces lividans 66 (539 aa) fasta scores; opt: 3608, z-score: 3750.3, E(): 0, (100.0% identity in 539 aa overlap). Also similar to two other peptidases from Streptomyces coelicolor SC9C7.15c (EMBL:AL035161) fasta scores; opt: 666, z-score: 603.6, E(): 9.4e-29, (35.7% identity in 502 aa overlap) and SC1B5.03c (EMBL:AL023517) fasta scores; opt: 661, z-score: 598.9, E(): 1.7e-28, (32.6% identity in [...] (539 aa)
SCO3415SCE9.22, probable esterase, len: 266 aa; similar to many e.g. SW:BAH_STRHY (EMBL:M64783), bah, Streptomyces hygroscopicus acetyl-hydrolase in bialaphos biosynthetic gene cluster (299 aa), fasta scores; opt: 637 z-score: 678.5 E(): 1.8e-30, 45.3% identity in 236 aa overlap. Contains PS01173 Lipolytic enzymes 'G-D-X-G' family, putative histidine active site. (266 aa)
SCO3396SCE9.03c, possible membrane protein, len: 370 aa; unknown function, similar to SW:YLI2_CORGL (EMBL:X60312) Corynebacterium glutamicum hypothetical protein (426 aa), fasta scores; opt: 274 z-score: 307.1 E(): 8.8e-10, 23.9% identity in 351 aa overlap and TR:P94973 (EMBL:Z85982) Mycobacterium tuberculosis hypothetical protein (489 aa) (23.1% identity in 386 aa overlap). Contains hydrophobic regions at N-terminus, possibly a membrane anchor. (377 aa)
SCO3233SCE29.02, probable hydrolase, len: 272 aa; similar to many e.g. TR:O52809 (EMBL:AJ223998) from the vancomycin biosynthesis cluster of Amycolatopsis orientalis (276 aa) fasta scores; opt: 892, z-score: 1028.9, E(): 0, (50.9% identity in 271 aa overlap) and TR:O67982 (EMBL:AF003947) PcaL; single polypeptide combining 3-oxoadipate enol-lactone hydrolyzing and 4-carboxymuconolactone decarboxylating activityfrom Rhodococcus opacus (400 aa) fasta scores; opt: 288, z-score: 335.4, E(): 2.3e-11, (32.0% identity in 256 aa overlap). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hy [...] (272 aa)
SCO3232SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] (2417 aa)
SCO3219SCE8.12c, possible lipase (putative secreted protein), len: 391 aa; weak similarity to many eukaryotic lipases e.g. SW:PAFA_CAVPO platelet-activating factor-acetylhydrolase from guinea pig (Cavia porcellus) (436 aa) fasta scores; opt: 153, z-score: 161.7, E(): 0.11, (22.9% identity in 319 aa overlap). Contains PS00120 Lipases, serine active site. Contains possible N-terminal region signal peptide sequence. (391 aa)
SCO3171SCE87.22c, possible hydrolase, len: 314 aa: Similar to several e.g. Mycobacterium tuberculosis TR:O53321 (EMBL: AL021646) hypothetical 32.1 KD protein (299 aa), fasta scores opt: 261 z-score: 297.3 E(): 3.5e-09 31.7% identity in 281 aa overlap and Streptomyces lividans SW:PRXC_STRLI (EMBL: U02635) non-heme chloroperoxidase (EC 1.11.1.10) (275 aa), fasta scores opt: 241 z-score: 275.2 E(): 5.9e-08 30.0% identity in 287 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (314 aa)
SCO2886SCE6.23c, possible hydrolase, len: 294 aa. Similar to several including: Mycobacterium sp. TR:Q9ZER0 (EMBL:AJ012627) haloalkane dehalogenase, DhaAF (307 aa), fasta scores opt: 347 z-score: 425.8 E(): 2.7e-16 27.4% identity in 292 aa overlap and Deinococcus radiodurans TR:AAF12090 (EMBL:AE002084) epoxide hydrolase-related protein (278 aa), fasta scores opt: 402 z-score: 493.2 E(): 4.8e-2032.4% identity in 284 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (294 aa)
SCO2761SCC57A.32c, possible secreted tripeptidyl aminopeptidase, len: 474 aa. Identical to Streptomyces lividans TR:Q54408(EMBL:L46588) tripeptidyl aminopeptidase precursor (474 aa), fasta scores opt: 3236 z-score: 3793.9 E(): 0; 99.6% identity in 474 aa overlap. Contains a possible N-terminal signal sequence. (474 aa)
SCO2723SCC46.08c, probable ABC transporter ATP-binding protein, len: 866 aa; C-terminal region similar to SW:YHCH_BACSU (EMBL:X96983) Bacillus subtilis hypothetical ABC transporter ATP-binding protein 2 in GlpD-CspB intergenic region, YhcH, 305 aa; fasta scores: opt: 597 z-score: 577.6 E(): 9.3e-25; 36.6% identity in 303 aa overlap and to SW:BCRA_BACLI (EMBL:L20573) Bacillus licheniformis bacitracin transport ATP-binding protein BcrA, 306 aa; fasta scores: opt: 581 z-score: 562.3 E(): 6.6e-24; 38.8% identity in 304 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and [...] (866 aa)
SCO2516SCC121.19, possible secreted protein, len: 499 aa; similar to TR:O69831 (EMBL:AL023517) Streptomyces coelicolor putative secreted protease SC1B5.03C, 543 aa; fasta scores: opt: 772 z-score: 821.6 E(): 0; 32.2% identity in 537 aa overlap. Contains possible N-terminal region signal peptide sequence. (499 aa)
SCO2375SC4A7.03, possible secreted protein, len: 406 aa; similar to various hypothetical proteins, e.g. TR:Q9X8R0 (EMBL:AL049754) Streptomyces coelicolor hypothetical 33.9 kD protein, SCH10.21c, 329 aa; fasta scores: opt: 634 z-score: 714.7 E(): 2e-32; 39.3% identity in 346 aa overlap. Contains possible N-terminal signal peptide sequence. (406 aa)
SCO2332SCC53.23, possible hydrolase, len: 259 aa; similar to many e.g. SW:Q59695 (ACOC_PSEPU) acetoin dehydrogenase E2 component from Pseudomonas putida (370 aa) fasta scores; opt: 213, z-score: 235.6, E(): 1.2e-05, 30.5% identity in 249 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. Also contains possible stem loop structure in %' half of CDS. (259 aa)
SCO2208SC10B7.03c, probable carboxylesterase, len: 290 aa; identical to previously sequenced TR:Q9X956 (EMBL:Y13833) Streptomyces coelicolor hypothetical 30.8 kD protein, 290 aa and similar to TR:Q59248 (EMBL:X82892) Bacillus subtilis carboxylesterase NP (EC 3.1.1.1) Nap, 300 aa; fasta scores: opt: 438 z-score: 516.3 E(): 2.2e-21; 31.5% identity in 292 aa overlap. (290 aa)
SCO2123SC6E10.17, possible esterase/lipase, len: 267 aa; similar to esterases e.g. SW:EST_BACST (EMBL:D12681), Est, Bacillus stearothermophilus carboxylesterase precursor (247 aa), fasta scores; opt: 333 z-score: 387.6 E(): 2.9e-14, 32.7% identity in 251 aa overlap. (267 aa)
SCO2069SC4A10.02c, hypothetical protein, len: 196 aa; similar to the plasmid borne TR:CAC48425 (EMBL:AL603642) Rhizobium meliloti (Sinorhizobium meliloti) conserved hypothetical protein SMB20022, 188 aa; fasta scores: opt: 485 Z-score: 576.0 E(): 1.9e-24; 45.198% identity in 177 aa overlap. Probable CDS suggested by GC frameplot, positional base preference and amino acid composition. Annotated in cosmid 4G6 as SC4G6.38c. (196 aa)
SCO1989Putative aminopeptidase; Specifically catalyzes the removal of N-terminal proline residues from peptides. (323 aa)
SCO1843SCI8.28c, possible secreted protein, len: 411 aa; similar to TR:Q9RRL1 (EMBL:AE002077) Deinococcus radiodurans hypothetical protein DR2478, 407 aa; fasta scores: opt: 516 Z-score: 552.7 E(): 3.8e-23; 30.469% identity in 384 aa overlap. Contains a Prosite hit to PS00120 Lipases, serine active site. Contains a possible N-terminal signal sequence. (375 aa)
SCO1735SCI11.24c, probable secreted lipase, len: 290 aa; similar to many lipases e.g. TR:O33969 (EMBL:U80063), lipA, Streptomyces cinnamoneus lipase (275 aa), fasta scores; opt: 575 z-score: 653.1 E(): 4.8e-29, 47.6% identity in 254 aa overlap. Contains probable N-terminal signal sequence. (290 aa)
SCO12652SCG18.12c, probable lipase, len: 289 aa; similar to TR:Q59644 (EMBL:X99255) Propionibacterium acnes triacylglycerol lipase precursor (EC 3.1.1.3) GehA, 339 aa; fasta scores: opt: 423 z-score: 498.8 E(): 2.7e-20; 36.9% identity in 233 aa overlap and to TR:Q9S295 (EMBL:AL096849) Streptomyces coelicolor putative secreted lipase SCI11.24c, 290 aa; fasta scores: opt: 682 z-score: 722.5 E(): 1.2e-34; 47.0% identity in 264 aa overlap. Contains Pfam match to entry PF01674 Lipase_2, Lipase. (289 aa)
SCO12642SCG18.11, probable hydrolase, len: 316 aa; similar to TR:CAB88827 (EMBL:AL353832) Streptomyces coelicolor putative hydrolase SCE6.23c, 294 aa; fasta scores: opt: 302 z-score: 345.4 E(): 9.3e-12; 31.5% identity in 276 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (316 aa)
SCO1230Putative secreted tripeptidylaminopeptidase; Cleaves tripeptides from the N-termini of proteins. Does not cleave mono- or dipeptides, or N-terminally blocked peptides (By similarity); Belongs to the peptidase S33 family. (541 aa)
SCO1175SCG11A.06c, hypothetical protein, len: 153 aa; similar to C-terminus of TR:O52556 (EMBL:AF040570) Amycolatopsis mediterranei esterase, 310 aa; fasta scores: opt: 303 z-score: 372.1 E(): 2.4e-13; 45.1% identity in 113 aa overlap. (135 aa)
SCO10972SCG4.13, probable hydrolase, len: 292 aa; similar to TR:O52866 (EMBL:AJ224332) Corynebacterium sp. soluble epoxide hydrolase (EC 3.3.2.3) Ceh, 285 aa; fasta scores: opt: 601 z-score: 728.8 E(): 0; 35.8% identity in 288 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (292 aa)
SCO1025SCG20A.05c, possible integral membrane protein, len: 785 aa. Contains possible hydrophobic membrane spanning regions. High content in alanine and leucine amino acid residues. (785 aa)
SCO0964Hypothetical protein SCM11.19c; SCM11.19c, unknown, len: 143 aa. (143 aa)
SCO0047SCJ4.28c, possible transcriptional regulator, len: 384 aa; C-terminal similar to many transcriptional regulator eg. SW:SLYA_ECOLI transcriptional regulator from Escherichia coli (146 aa) fasta scores; opt: 156, z-score: 184.9, E(): 0.0061, (24.6% identity in 122 aa overlap). Contains Pfam match to entry PF01047 MarR, MarR family. (384 aa)
SCO0135SCJ21.16, unknown, len: 239 aa; similar to two hypothetical proteins from S. coelicolor TR:O86620 (EMBL:AL031155) SC3A7.19 (232 aa), fasta scores; opt: 188 z-score: 222.0 E(): 5.1e-05, 33.6% identity in 238 aa overlap, and TR:Q9ZBN4 (EMBL:AL034492) SC6C5.11 (327 aa), fasta scores; opt: 149 z-score: 176.2 E(): 0.018, 30.0% identity in 203 aa overlapand to TR:Q988L9 (EMBL:AP003009) Rhizobium loti MLR6684 protein, 259 aa; fasta scores: opt: 764 Z-score: 831.4 E(): 1.1e-38; 51.883% identity in 239 aa overlap. (239 aa)
SCO0470SCF76.10, possible hydrolase, len: 302 aa. Weakly similar to hydrolases e.g. the N-terminal, domain of Streptomyces coelicolor TR:O86608 (EMBL:AL031155) 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase (449 aa), fasta scores opt: 387 z-score: 428.9 E(): 1.6e-16 33.7% identity in 258 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (302 aa)
SCO0145SCJ33.09, possible secreted protein, len: 342 aa. Similar to Streptomyces coelicolor TR:CAB45466 (EMBL; AL079348) hypothetical 33.9 KD protein SC66T3.10C (318 aa), fasta scores opt: 272 z-score: 301.5 E(): 2e-09 34.0% identity in 300 aa overlap. Contains a TTA /leucine codon, possible target for bldA regulation. Contains a possible N-terminal signal sequence. (342 aa)
SCO0490SCF34.09, possible esterase, len: 363 aa; similar to enterochelin esterases e.g. SW:FES_ECOLI (EMBL:J04216), Fes, Escherichia coli enterochelin esterase (374 aa), fasta scores; opt: 422 z-score: 474.2 E(): 4.7e-19, 32.5% identity in 332 aa overlap. (363 aa)
SCO0492SCF34.11c, probable peptide synthetase, len: 3643 aa; similar to parts of many antibiotic peptide synthetases e.g. the C-terminal half of TR:Q9Z4X6 (EMBL:AL035640) Streptomyces coelicolor CDA peptide synthetase I (7463 aa), fasta scores; opt: 1948 z-score: 1929.3 E(): 0, 33.7% identity in 3723 aa overlap. Also similar to parts of putative peptide synthetases from the exochelin biosynthesis locus of Mycobacterium smegmatis TR:O87314 (EMBL:AF027770), FxbC, putative peptide synthetase (4976 aa) (42.3% identity in 3756 aa overlap). Contains 3 Pfam matches to entry PF00550 pp-binding, Phosp [...] (3643 aa)
SCO0501SCF34.20c, putative secreted protein, len: 650 aa; unknown function, shows very weak similarity to SW:Y0D8_MYCTU (EMBL:Z78020) Mycobacterium tuberculosis hypothetical protein (628 aa), fasta scores; opt: 233 z-score: 232.7 E(): 1.3e-05, 23.6% identity in 512 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (650 aa)
SCO0503SCF34.22, hypothetical protein, len: 326 aa; unknown function, shows weak similarity to the N-terminal half of SCH10.22C (EMBL:AL049754) Streptomyces coelicolor putative lipase/esterase (301 aa), fasta scores; opt: 178 z-score: 202.4 E(): 0.00065, 30.1% identity in 163 aa overlap. (326 aa)
SCO0526SCF11.06, possible oxidoreductase, len: 277 aa; similar to TR:O53622 (EMBL:AL021428) Mycobacterium tuberculosis putative oxidoreductase MTV030.21c, 276 aa; fasta scores: opt: 276 z-score: 329.4 E(): 5.6e-11; 24.7% identity in 267 aa overlap and to SW:PRXC_PSEFL (EMBL:AF031153) Pseudomonas fluorescens non-heme chloroperodixase (EC 1.11.1.10) (chloride peroxidase) (CPO-F) (chloropeorixidase F) Cpo or CpoF; fasta scores: opt: 233 z-score: 279.3 E():3.5e-08; 26.1% identity in 283 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (277 aa)
SCO0556Hypothetical protein SCF73.03c; SCF73.03c, unknown, len: 507 aa. (507 aa)
SCO0635SCF56.19, hypothetical protein, len: 297 aa; similar to TR:Q9XAK3 (EMBL:AL079348) Streptomyces coelicolor hypothetical 33.9 kD protein SC66T3.10c, 318 aa; fasta scores: opt: 133 z-score: 153.6 E(): 0.36; 31.6% identity in 212 aa overlap. (297 aa)
SCO0713SCF42.23c, lipA, lipase (putative secreted protein), len: 310 aa. Identical to the previously sequenced and characterised: Streptomyces coelicolor TR:Q9ZIW6(EMBL:AF009336) lipase, LipA (310 aa). Contains a Prosite hit to PS00120 Lipases, serine active site and a possible hydrophobic domain close to the N-terminus. (310 aa)
SCO0805Putative prolyl aminopeptidase; SCF43.16c, possible prolyl aminopeptidase, len: 433 aa. Highly similar to several peptidases including: Aeromonas sobria SW:PIP_AERSO(EMBL:D30714) proline iminopeptidase (EC 3.4.11.5) (prolyl aminopeptidase) (424 aa), fasta scores opt: 954 z-score: 1113.1 E():0 48.6% identity in 428 aa overlap and Hafnia alvei TR:P94800(EMBL:D61383) prolyl aminopeptidase (427 aa), fasta scores opt: 1208 z-score: 1408.6 E():0 47.2% identity in 432 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (433 aa)
SCO0878SCM1.11, possible hydrolase, len: 292 aa. Highly similar to several including: Streptomyces peucetius TR:Q54809(EMBL:L40425) 10-carbomethoxy-13-deoxycarminomycin esterase (298 aa), fasta scores opt: 670 z-score: 757.9 E():0 40.3% identity in 288 aa overlap and Streptomyces purpurascens TR:Q54528(EMBL:U10405:) possible C-C hydrolase, RdmC (298 aa) fasta scores opt: 709 z-score: 801.6 E():0 41.2% identity in 289 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (292 aa)
SCO0939SCM10.27c, probable hydrolase, len: 287 aa; similar to TR:CAB56657 (EMBL:AL121596) Streptomyces coelicolor putative hydrolase SCF51A.05, 278 aa; fasta scores: opt: 325 z-score: 381.1 E(): 7.7e-14; 32.9% identity in 283 aa overlap and to SW:PRXC_STRAU (EMBL:AF031242) Streptomyces aureofaciens non-heme chloroperoxidase (EC 1.11.1.10) CpoT, 278 aa; fasta scores: opt: 239 z-score: 282.3 E(): 2.5e-08; 30.4% identity in 253 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (287 aa)
SCO0899Putative hydrolase; SCM1.32, possible hydrolase, len: 298 aa. Similar to many including: Moraxella sp. SW:DEH1_MORSP (EMBL:D90422:) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa), fasta scores opt: 669 z-score: 782.5 E():0 39.2% identity in 296 aa overlap and Streptomyces coelicolor TR:O86546 (EMBL:AL031350) putative hydrolase SC1F2.09C (309 aa), fasta scores opt: 336 z-score: 396.1 E(): 1e-14 31.1% identity in 305 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (298 aa)
SCO0267SCF1.09, possible hydrolase, len: 258 aa; similar to many e.g. TR:O67982 (EMBL:AF003947) 3-oxoadipate enol-lactone hydrolase from Rhodococcus opacus (400 aa) fasta scores; opt: 259, z-score: 300.,1 E(): 2.4e-09, (31.5% identity in 251 aa overlap). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (258 aa)
SCO0288Hypothetical protein SCF85.16; SCF85.16, unknown, len: 146 aa. (146 aa)
SCO0321SC5G9.30, probable carboxylesterase, len: 518 aa; similar to many eukaryotic and bacterial e.g. SW:PNBA_BACSU (EMBL:U06089), PrnbA, Bacillus subtilis 4-nitrobenzyl esterase (489 aa), fasta scores; opt: 718 z-score: 774.9 E(): 0, 36.3% identity in 479 aa overlap. Similar to TR:Q9Z545 (EMBL:AL035212) Streptomyces coelicolor probable carboxylesterase (502 aa) (41.3% identity in 521 aa overlap). Contains 2 Pfam matches to entry PF00135 COesterase, Carboxylesterases and PS00122 Carboxylesterases type-B serine active site; Belongs to the type-B carboxylesterase/lipase family. (518 aa)
SCO0427SCF51A.05, possible hydrolase, len: 278 aa. Similar to many e.g. Pseudomonas fluorescens SW:PRXC_PSEFL (EMBL:AF031153) non-heme chloroperoxidase (EC 1.11.1.10) (chloride peroxidase), fasta scores opt: 243 z-score: 282.1 E(): 2.4e-08 28.4% identity in 275 aa overlap and many putative hydrolases: Streptomyces coelicolor TR:CAB44393 (EMBL; AL078610) putative hydrolase SCH35.34C (269 aa), fasta scores opt: 259 z-score: 300.1 E(): 2.3e-09 29.7% identity in 269 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (278 aa)
SCO0461SCF76.01, possible hydrolase, partial CDS, len: >228 aa. Similar to several hypothetical proteins e.g. from Saccharomyces cerevisiae SW:YN93_YEAST (EMBLL:Z71679) (290 aa), fasta scores opt: 609 z-score: 749.0 E():0 42.4% identity in 229 aa overlap. Also weakly similar to Xanthobacter autotrophicus SW:HALO_XANAU (EMBL:M26950) haloalkane dehalogenase (EC 3.8.1.5) (310 aa), fasta scores opt: 151 z-score: 190.4 E():0.003 22.9% identity in 231 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold; SCF51A.39, possible hydrolase, partial CDS, len: >113 aa. [...] (289 aa)
SCO0465SCF76.05c, non-heme chloroperoxidase (chloride peroxidase), len: 276 aa. Identical to Streptomyces lividans SW:PRXC_STRLI (EMBL; U02635) non-heme chloroperoxidase (EC 1.11.1.10) (chloride peroxidase)(CPO-L) (chloroperoxidase L) (275 aa), fasta scores opt: 1866 z-score: 2162.6 E():0 99.3% identity in 275 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (276 aa)
SCO3772SCH63.19c, possible secreted protein, len: 348 aa; similar to TR:AAG03932 (EMBL:AE004490) Pseudomonas aeruginosa hypothetical 35.1 kDa protein PA0543, 322 aa; fasta scores: opt: 419 z-score: 410.9 E(): 2.3e-15; 33.6% identity in 295 aa overlap. Contains possible N-terminal region signal peptide sequence. (348 aa)
SCO3954SCD78.21c, putative oxidoreductase, len: 584 aa; N-terminal region similar to Y00P_MYCTU (EMBL:Z70283) putative oxidoreductase from Mycobacterium tuberculosis (650 aa), fasta scores; opt: 1457, z-score: 840.1, E(): 0, 41.0% identity in 652 aa overlap. Contains PS00061 short chain dehydrogenases /reductases family signature. (585 aa)
SCO4160SCD84.27, possible hydrolase, len: 278 aa; similar to TR:AAF25687 (EMBL:AF218823) Thermomonospora fusca putative dienelactone hydrolase DlhA, 265 aa; fasta scores: opt: 786 z-score: 885.1 E(): 0; 50.0% identity in 262 aa overlap. (278 aa)
SCO42192SCD46.33, possible hydrolase (dienelactone hydrolase family), len: 254aa; similar to many eg. SW:P27136 (TFE1_ALCEU) carboxymethylenebutenolidase I (EC 3.1.1.45) from Alcaligenes eutrophus (Ralstonia eutropha) (234 aa) fasta scores; opt: 215, z-score: 250.7, E(): 1.7e-06, 28.3% identity in 230 aa overlap and TR:CAB92202 (EMBL:AL356592) putative hydrolase from Streptomyces coelicolor (251 aa) fasta scores; opt: 754, z-score: 853.2, E(): 0, 48.4% identity in 248 aa overlap. Contains Pfam match to entry PF01738 DLH, Dienelactone hydrolase family. (254 aa)
SCO4241SCD8A.14c, possible proteinase precursor, len: 545 aa; similar to TR:Q54398 (EMBL:L42758) Streptomyces lividans proteinase SlpD, 539 aa; fasta scores: opt: 1116 z-score: 1193.2 E(): 0; 40.1% identity in 541 aa overlap and to TR:Q54399 (EMBL:L42759) Streptomyces lividans proteinase SlpE, 513 aa; fasta scores: opt: 1004 z-score: 1074.0 E(): 0; 47.7% identity in 539 aa overlap, and to TR:Q54398 (EMBL:AL035636) Streptomyces coelicolor SCH5.02c, proteinase SlpD, 539 aa; fasta scores: opt: 1116 z-score: 1004.4 E(): 0; 40.1% identity in 541 aa overlap. Contains Pfam match to entry PF00561 abh [...] (545 aa)
SCO4298SCD95A.31, probable carboxylesterase, len: 513 aa; similar to TR:Q9Z545 (EMBL:AL035212) Streptomyces coelicolor putative carboxylesterase SC9B2.14, 502 aa; fasta scores: opt: 1093 z-score: 1041.3 E(): 0; 44.6% identity in 511 aa overlap and to SW:PNBA_BACSU (EMBL:U06089) Bacillus subtilis para-nitrobenzyl esterase (EC 3.1.1.-) PnbA, 489 aa; fasta scores: opt: 823 z-score: 786.2 E(): 0; 38.1% identity in 501 aa overlap. Contains Pfam match to entry PF00135 COesterase, Carboxylesterases and match to Prosite entry PS00122 Carboxylesterases type-B serine active site; Belongs to the type-B [...] (513 aa)
SCO4368SCD19.23c, possible lipase (putative secreted protein), len: 386 aa; similar to TR:Q9Z360 (EMBL:AL035654) Streptomyces coelicolor putative lipase SCE8.12c, 391 aa; fasta scores: opt: 867 z-score: 923.3 E(): 0; 44.3% identity in 393 aa overlap. Contains possible N-terminal region signal peptide sequence. (386 aa)
SCO4392SCD10.24, possible esterase, len: 241 aa; similar to TR:Q9RBI4 (EMBL:AF150928) Acinetobacter sp. ADP1 alkyl salicylate esterase SalE, 239 aa; fasta scores: opt: 360 z-score: 411.1 E(): 2e-15; 28.6% identity in 241 aa overlap. (241 aa)
SCO4395SCD10.27, possible hydrolase, len: 352 aa; similar to TR:Q9RCX1 (EMBL:AL133469) Streptomyces coelicolor putative hydrolase SCM10.27c, 287 aa; fasta scores: opt: 290 z-score: 298.8 E(): 3.6e-09; 28.5% identity in 277 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (352 aa)
SCO4479SCD65.22c, possible secreted hydrolase, len: 297 aa; similar to TR:O31386 (EMBL:Y10223) Bradyrhizobium japonicum b-ketoadipate enol-lactone hydrolase (EC 3.1.1.24) PcaD, 260 aa; fasta scores: opt: 188 z-score: 220.7 E(): 8e-05; 32.1% identity in 156 aa overlap. Contains match to Prosite entry PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. Contains possible N-terminal region signal peptide sequence. (297 aa)
SCO4746SC6G4.24, possible lipase, len: 420 aa; some similar ity to e.g. TR:Q59695 (EMBL:L35343) Pseudomonas putida dihy drolipoamide acetyltransferase (370 aa), fasta scores; opt: 134 z-score: 204.4 E(): 0.00041, 27.0% identity in 352 aa overlap. Contains PS00120 Lipases, serine active site and P fam match to entry PF00561 abhydrolase, alpha/beta hydrolas e fold, score 79.50, E-value 7e-20. Contains possible hydrophobic membrane spanning region. (420 aa)
SCO4799SCD63A.10c, possible secreted lipase, len: 331 aa; similar to SW:LIP_BACSU (EMBL:M74010) Bacillus subtilis lipase precursor (EC 3.1.1.3) LipA, 212 aa; fasta scores: opt: 188 z-score: 190.5 E(): 0.0038; 26.5% identity in 211 aa overlap and to TR:AAF11628 (EMBL:AE002044) Deinococcus radiodurans lipase, putative, 237 aa; fasta scores: opt: 309 z-score: 302.6 E(): 2.2e-09; 32.0% identity in 200 aa overlap. Contains match to Prosite entry PS00120 Lipases, serine active site and possible N-terminal region signal peptide sequence. (331 aa)
SCO49002SCK8.26c, hypothetical protein, len: 253 aa; similar to TR:Q9RD48 (EMBL:AL133424) Streptomyces coelicolor hypothetical 31.2 kDa protein SCF56.19, 297 aa; fasta scores: opt: 376 z-score: 449.5 E(): 1.8e-17; 36.4% identity in 253 aa overlap. (253 aa)
SCO5067SCBAC20F6.10, probable carboxylesterase, len: 497 aa; similar to SW:PNBA_BACSU (EMBL:U06089) Bacillus subtilis para-nitrobenzyl esterase (EC 3.1.1.*) PnbA, 489 aa; fasta scores: opt: 784 Z-score: 827.6 bits: 162.6 E(): 1.6e-38; 37.205% identity in 508 aa overlap. Contains 2x Pfam matches to entry PF00135 COesterase, Carboxylesterase and match to Prosite entry PS00122 Carboxylesterases type-B serine active site; Belongs to the type-B carboxylesterase/lipase family. (497 aa)
SCO5122SC9E12.07c, probable peptidase, len: 707 aa; similar to TR:P95782 (EMBL:D83263) Xanthomonas maltophilia dipeptidyl peptidase IV, 741 aa; fasta scores: opt: 442 z-score: 478.1 E(): 3.7e-19; 33.2% identity in 733 aa overlap. Contains Pfam matches to entries PF00930 DPPIV_N_term, Dipeptidyl peptidase IV (DPP IV) N-terminal region and PF00326 Peptidase_S9, Prolyl oligopeptidase family and match to Prosite entry PS00708 Prolyl endopeptidase family serine active site. (707 aa)
SCO5165SCP8.28c, possible hydrolase, len: 298 aa; similar to TR:Q9RL59 (EMBL:AL121596) Streptomyces coelicolor putative hydrolase SCF51A.05, 278 aa; fasta scores: opt: 217 z-score: 249.2 E(): 2e-06; 27.0% identity in 267 aa overlap and to SW:THCF_RHOER (EMBL:U95170) Rhodococcus erythropolis non-heme haloperoxidase (EC 1.11.1.-) ThcF, 274 aa; fasta scores: opt: 185 z-score: 213.7 E(): 0.00019l; 29.0% identity in 241 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold and match to Prosite entry PS00120 Lipases, serine active site. (298 aa)
SCO5172SCP8.35, possible hydrolase, len: 358 aa; similar to SW:ACOC_ALCEU (EMBL:M66060) Alcaligenes eutrophus dihydrolipoamide acetyltransferase component of acetoin cleaving system (EC 2.3.1.12) AcoC, 373 aa; fasta scores: opt: 224 z-score: 254.0 E(): 1.1e-06; 29.7% identity in 273 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (358 aa)
SCO5179Peptidase; 2SC3B6.03c, peptidase, len: 513 aa; identical to TR:Q54399 (EMBL:L42759) Streptomyces lividans proteinase SlpE, 513 aa and highly similar to Streptomyces coelicolor 2SC3B6.04c, 516 aa; fasta scores: opt: 1544 z-score: 1384.8 E(): 0; 50.2% identity in 526 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence. (513 aa)
SCO51802SC3B6.04c, peptidase, len: 516 aa; highly similar to TR:Q54399 (EMBL:L42759) Streptomyces lividans proteinase SlpE, 513 aa; fasta scores: opt: 1543 z-score: 1741.5 E(): 0; 50.2% identity in 526 aa overlap and to Streptomyces coelicolor putative peptidase 2SC3B6.03c, 513 aa; fasta scores: opt: 1544 z-score: 1465.5 E(): 0; 50.2% identity in 526 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal [...] (516 aa)
SCO5215SC7E4.12, hypothetical protein, len: 211 aa; similar to TR:P96267 (EMBL:Z84724) Mycobacterium tuberculosis hypothetical 21.7 kD protein MTCY22G10.18c, 209 aa; fasta scores: opt: 255 z-score: 287.1 E(): 1.6e-08; 29.8% identity in 205 aa overlap. (211 aa)
SCO5489Hypothetical protein; SC8D9.01c, unknown, len: >299 aa; proline and glycine rich. This CDS lies in a region of DNA with high GC content. The CDS lies in frame 4 and was designated based upon a Hidden Markov algorithm prediction. Note that Frameplot predicts two ORFs at (approx.) 125-500bp and 500-902bp. High quality sequence was obtained for this region from two independent cosmids suggesting that a real frameshift exist on the chromosome. (312 aa)
SCO5894Thioesterase; SC3F7.14, redJ, probable thioesterase, len: 280 aa; similar to many e.g. TR:Q00442 (EMBL:X60379) erythomycin A biosynthesis thioesterase (EC 3.1.-.-.) from Saccharopolyspora erythraea (Streptomyces erythraeus) (247 aa), fasta scores; opt: 451 z-score: 472.9 E(): 3.8e-19, 38.0% identity in 237 aa overlap. (280 aa)
SCO5943SC7H1.13, probable hydrolase, len: 261; weak similarity to several diverse hydrolases eg. TODF_PSEPU P23133 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase (276 aa), fasta scores; opt: 196 z-score: 344.3 E(): 5.5e-12, 30.7% identity in 270 aa overlap. (261 aa)
SCO5986SCBAC16H6.21, possible oxidoreductase, len: 275aa: similar to many eg. TR:O53622 (EMBL:AL021428) putative oxidoreductase from Mycobacterium tuberculosis (276 aa) fasta scores; opt: 521, Z-score: 601.4, 36.364% identity (38.314% ungapped) in 275 aa overlap and TR:Q53042 (EMBL:AF060871) haloalkane dehalogenase from Rhodococcus rhodochrous (293 aa) fasta scores; opt: 249, Z-score: 291.2, 28.417% identity (31.102% ungapped) in 278 aa overlap. (275 aa)
SCO6043SC1B5.03c, probable secreted protease, len: 543 aa;similar to e.g. Streptomyces lividans TR:Q54410 (EMBL:L27466) tripeptidylaminopeptidase (537 aa), fasta scores; opt: 1839 z-score: 1633.9 E(): 0, 51.9% identity in 538 aa overlap. Contains possible N-terminal signal sequence. (543 aa)
SCO6127SC9B2.14, probable carboxylesterase, len: 502aa; similar to many both prokaryotic and eukaryotic eg. SW:PCD_ARTOX phenylcarbamate hydrolase, Pcd, from Arthrobacter oxidans (493 aa) fasta scores; opt: 924, z-score: 897.3, E(): 0, (37.2% identity in 503 aa overlap). Contains PS00122 Carboxylesterases type-B serine active site and 2x Pfam match to entry PF00135 COesterase, Carboxylesterases; Belongs to the type-B carboxylesterase/lipase family. (502 aa)
SCO6175SC6C5.11, hypothetical protein, len: 327 aa; similar to TR:Q9LAB8 (EMBL:AF144381) Burkholderia gladioli esterase EstC, 298 aa; fasta scores: opt: 532 Z-score: 590.8 E(): 2.8e-25; 38.014% identity in 292 aa overlap. (327 aa)
SCO6277SC1G7.03, possible epoxide hydrolase, len: 286 aa; similar to TR:Q42566 (EMBL:D16628) Arabidopsis thaliana epoxide hydrolase (EC 3.3.2.3) Seh or F18A8.11, 321 aa; fasta scores: opt: 351 Z-score: 406.4 bits: 83.3 E(): 4.8e-15; 29.560% identity in 318 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (286 aa)
SCO6287SC1G7.13, scoT thioesterase II, len: 268 aa; identical to previously sequenced TR:AAF43096 (EMBL:AF109727) Streptomyces coelicolor A3(2) thioesterase II ScoT, 268 aa. Contains Pfam match to entry PF00975 Thioesterase, Thioesterase domain. (268 aa)
SCO6339SC3A7.07, probable 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase, len: 449 aa; Similar in N- and C- termini to Rhodococcus opacus TR:G2935027 (EMBL:EMBL; AF003947) 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase (400 aa), fasta scores; opt: 551 z-score: 916.0 E(): 0, 35.2% identity in 435 aa overlap. N-terminus (to 250aa) is similar to e.g. Acinetobacter calcoaceticus TR:Q59093 (EMBL:L05770) beta-ketoadipate enol-lactone hydrolase (266 aa), fasta scores; opt: 445 z-score: 470.5 E(): 5.9e-19, 30.3% identity in 244 aa overlap. C-terminu [...] (449 aa)
SCO6351Hypothetical protein SC3A7.19; SC3A7.19, unknown, len: 232 aa. (232 aa)
SCO6432SC1A6.21, probable peptide synthase, len: 1407 aa; similar to many e.g. TR:Q54959 (EMBL:X98690) Streptomyces pristinaespiralis Pristinamycin I synthase 2 (2591 aa), fasta scores; opt: 743 z-score: 754.8 E(): 0, 33.1% identity in1298 aa overlap. Contains PS00455 Putative AMP-binding domain signature, PS00012 Phosphopantetheine attachment site, PS00120 Lipases, serine active site and Pfam match to entry AMP-binding PF00501, AMP-binding enzymes, score 430.73. (1407 aa)
SCO6479SC9C7.15c, probable secreted peptidase, len: 529aa; similar to many eg. TR:Q54410(EMBL:L27466) secreted tripeptidyl aminopeptidase from Streptomyces lividans 66 (537 aa) fasta scores; opt: 1362, z-score: 1170.0, E(): 0, (43.2% identity in 526 aa overlap), has probable N-terminal signal sequence. Contains Pfam match to entry PF00561 abhydrolase, alpha /beta hydrolase fold. Also similar to TR:O69831 (EMBL:AL023517) from Streptomyces coelicolor cosmid 1B5 (543 aa) fasta scores; opt: 1205, z-score: 1105.7, E(): 0, (42.3% identity in 541 aa overlap). (529 aa)
SCO6488SC9C7.24, possible acyl-peptide hydrolase, len: 651aa; similar to many acyl-peptide hydrolases and hypothetical proteins egs. TR:Q55413 (EMBL:D64003) hypothetical protein from Synechocystis sp. (strain PCC 6803) (637 aa) fasta scores; opt: 1306, z-score: 1326.5, E(): 0, (39.6% identity in 647 aa overlap) and TR:P70479 (EMBL:X14915) acyl-peptide hydrolase from Rattus norvegicus (rat) (729 aa) fasta scores; opt: 258, z-score: 199.2, E(): 0.00083, (28.2% identity in 234 aa overlap). (655 aa)
SCO6609SC1F2.06, probable secreted protein, len: 342 aa; some similatity to secreted antigenic proteins 85A, 85B and 85C from Mycobacteria e.g. A85B_MYCLE (327 aa), fasta scores; opt: 325 z-score: 247.2 E(): 1.6e-06, 28.5% identity in 319 aa overlap and to secreted antigenic protein PS1 from Cornebacterium glutamicum CSP1_CORGL (657 aa), fasta scores; opt: 479 z-score: 421.7 E(): 3e-16, 28.2% identity in 333 aa overlap. Contains possible N-terminal signal sequence. (342 aa)
SCO6612SC1F2.09c, probable hydrolase, len: 309 aa; similar to many e.g. XYLF_PSEPU 2-hydroxymuconic semialdehyde hydrolase (281 aa), fasta scores; opt: 236 z-score: 348.2 E(): 3.8e-12, 29.0% identity in 283 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha /beta hydrolase fold, score 52.80, E-value 7.5e-12. (309 aa)
SCO6697SC4C6.07c, pcaL, probable 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase, len: 375 aa; similar to TR:O67982 (EMBL:AF003947), pcaL, Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase (400 aa), fasta scores; opt: 401 z-score: 464.7 E(): 1.5e-18, 46.3% identity in 387 aa overlap the first approx. 260 aa is similar to SW:ELH2_ACICA (EMBL:AF009224), catD, Acinetobacter calcoaceticus 3-oxoadipate enol-lactonase II (266 aa) (35.1% identity in 248 aa overlap) while the remainder is similar to SW:DC4C_ACICA (EMBL:L05770), pcaC, [...] (375 aa)
SCO6966Putative lipase; SC6F7.19c, possible lipase, len: 269 aa. Similar to many other putative lipases e.g. Thermotoga maritima TR:Q9X171(EMBL:AE001789) lipase, putative (259 aa), fasta scores opt: 345 z-score: 396.1 E(): 1.3e-14 33.1% identity in 239 aa overlap. contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (269 aa)
SCO7057SC4G1.23c, possible esterase, len: 322 aa; similar to TR:O33842 (EMBL:U58632) Thermotoga neapolitana acetyl xylan esterase AxeA, 325 aa; fasta scores: opt: 1173 z-score: 1264.6 E(): 0; 54.2% identity in 321 aa overlap. (322 aa)
SCO0254SCJ9A.33c, hypothetical protein, len: 246 aa; weakly similar to TR:Q18926 (EMBL:U23517) hypothetical protein from the eukaryote Caenorhabditis elegans (243 aa) fasta scores; opt: 354, z-score: 396.7, E(): 9.9e-15, (28.3% identity in 240 aa overlap). Also weakly similar to TR:O87611 (EMBL:AF087482) dienelactone hydrolase from Pseudomonas aeruginosa (236 aa) fasta scores; opt: 212, z-score: 241.9, E(): 4.1e-06, (27.4% identity in 230 aa overlap). Similar also to TR:Q9I4H1 (EMBL:AE004547) Pseudomonas aeruginosa hypothetical protein PA1166, 262 aa; fasta scores: opt: 474 Z-score: 515.3 E() [...] (246 aa)
SCO7095SC3A4.21c, possible hydrolase. len: 318 aa. Similar in parts to several e.g. Moraxella sp. SW:DEH1_MORSP(EMBL:D90422) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa), fasta scores opt: 245 z-score: 286.4 E(): 1.7e-08 37.4% identity in 131 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (318 aa)
SCO7100SC4B10.01, probable oxidoreductase, len: 260 aa; similar to TR:Q9RK83 (EMBL:AL132662) Streptomyces coelicolor possible oxidoreductase SCF11.06, 277 aa; fasta scores: opt: 208 z-score: 258.9 E(): 5.9e-07; 25.5% identity in 243 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (260 aa)
SCO7121SC4B10.22, possible secreted protein, len: 281 aa; similar to TR:Q9S1Z1 (EMBL:AL109747) Streptomyces coelicolor hypothetical 24.6 kDa protein SCJ21.16, 239 aa; fasta scores: opt: 989 z-score: 1075.6 E(): 0; 64.4% identity in 233 aa overlap and to Streptomyces coelicolor SC4B10.33, 239 aa; fasta scores: opt: 1034 z-score: 972.0 E(): 0; 67.0% identity in 233 aa overlap. Contains possible N-terminal region signal peptide sequence. (281 aa)
SCO7131SC4B10.32, possible lipase, len: 316 aa; similar to TR:O52270 (EMBL:AF034088) Pseudomonas sp. lipase (EC 3.1.1.-) LipP, 308 aa; fasta scores: opt: 675 z-score: 762.7 E(): 0; 38.0% identity in 303 aa overlap. (316 aa)
SCO7132SC4B10.33, conserved hypothetical protein, len: 239 aa; highly similar to TR:Q9S1Z1 (EMBL:AL109747) Streptomyces coelicolor hypothetical 24.6 kDa protein SCJ21.16, 239 aa; fasta scores: opt: 1227 z-score: 1384.6 E(): 0; 79.0% identity in 238 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold and match to Prosite entry PS00120 Lipases, serine active site. (239 aa)
SCO7205Putative hydrolase; SC2H12.04, possible hydrolase, len: 286 aa. Highly similar to many including: Moraxella sp. SW:DEH1_MORSP(EMBL:D90422) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa), fasta scores opt: 556 z-score: 678.4 E(): 2.6e-30 35.6% identity in 292 aa overlap and Streptomyces coelicolor: TR:Q9RD12(EMBL:AL133422) putative hydrolase, SCM1.32 (298 aa), fasta scores opt: 653 z-score: 795.7 E(): 0 42.2% identity in 287 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (286 aa)
SCO7233Putative secreted protein; SC2H12.32, possible secreted protein, len: 934 aa. Note the product of this CDS is rich in the amino acid proline. Contains a possible N-terminal signal sequence. Contains a TTA /leucine codon, possible target for bldA regulation. (934 aa)
SCO7245Putative hydrolase; SC7A12.12, possible hydrolase, len: 301 aa. Similar to Lactobacillus helveticus SW:PIP_LACHE(EMBL:Z56283) proline iminopeptidase (EC 3.4.11.5) (294 aa), fasta scores opt: 254 z-score: 284.0 E(): 2.4e-08 27.5% identity in 262 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (301 aa)
SCO7256SC5H1.36, probable protease (putative secreted protein), len: 543 aa; similar to many e.g. TR:Q54398 (EMBL:L42758), SlpD, Streptomyces lividans protease, (539 aa), fasta scores; opt: 697 z-score: 769.7 E(): 0,35.8% identity in 545 aa overlap. Similar to other S.coelicolor proteases e.g. SlpD, SCH5.02c (EMBL:AL03563) proteinase (539 aa) (35.8% identity in 545 aa overlap). Contains possible N-terminal signal sequence. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold, score 55.00, E-value 1.6e-12. (543 aa)
SCO7359Putative hydrolase; SC9H11.13c, possible hydrolase, len: 251 aa. Weakly similar to several members of the Dienelactone hydrolase family e.g. Pseudomonas putida SW:CLCD_PSEPU(EMBL:M16964) carboxymethylenebutenolidase (EC 3.1.1.45) (246 aa), fasta scores opt: 265 z-score: 312.9 E(): 5.7e-10 27.1% identity in 255 aa overlap and Mycobacterium tuberculosis TR:O33307(EMBL:AL008967) hypothetical 26.2 kd protein (245 aa), fasta scores opt: 630 z-score: 731.0 E(): 0 43.1% identity in 246 aa overlap. Contains a Pfam match to entry PF01738 DLH, Dienelactone hydrolase family. (251 aa)
SCO7396Putative secreted protein; SC10G8.24c. possible secreted protein, len: 445 aa. Weakly similar to Mycobacterium tuberculosis TR:O06598(EMBL:Z95586) hypothetical 48.0 KD protein (446 aa), fasta scores opt: 399 z-score: 416.0 E(): 9.3e-16 28.2% identity in 387 aa overlap. Contains a possible N-terminal signal sequence. (445 aa)
SCO7440SC6D11.36c, possible hydrolase, len: 314 aa. Similar to several including Moraxella sp. SW:DEH1_MORSP (EMBL:D90422) haloacetate dehalogenase H-1 (EC 3.8.1.3) (294 aa). fasta scores opt: 356 z-score: 414.9 E(): 1.1e-15 27.9% identity in 297 aa overlap and Streptomyces coelicolor TR:O86546 (EMBL:AL031350) putative hydrolase, SC1F2.09C (309 aa), fasta scores opt: 498 z-score: 577.2 E(): 9.9e-25 35.2% identity in 307 aa overlap. Contains a Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (314 aa)
SCO7477SCBAC17A6.10, possible membrane protein, len: 497 aa: no significant database matches. Contains a possible hydrophobic membrane spanning region and Prosite match to PS00216 Sugar transport proteins signature 1. (497 aa)
SCO7609SC2H2.07c, possible esterase, len: 228 aa; low similarity to TR:Q9K3V2 (EMBL:AL359988) Streptomyces coelicolor putative esterase SCD10.24, 241 aa; fasta scores: opt: 169 z-score: 195.6 E(): 0.0023; 28.0% identity in 236 aa overlap. (228 aa)
SCO7650SC10F4.23, possible secreted hydrolase, len: 490 aa; similar to TR:Q9ZBJ5 (EMBL:AL035161) Streptomyces coelicolor putative secreted peptidase SC9C7.15c, 529 aa; fasta scores: opt: 678 z-score: 721.7 E(): 1.2e-32; 36.6% identity in 514 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold and possible N-terminal region signal peptide sequence. (490 aa)
SCO7683SC4C2.18, probable non-ribosomal peptide synthase, len: 1842 aa; similar to C-terminal domain of TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2514 z-score: 2613.8 E(): 0; 40.7% identity in 1287 aa overlap, to TR:Q9RFM7 (EMBL:AF184622) Pseudomonas aeruginosa pyochelin synthetase PchF, 1809 aa; fasta scores: opt: 2279 z-score: 2370.9 E(): 0; 39.7% identity in 1887 aa overlap, to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1826 z-score: 1476.6 E(): [...] (1842 aa)
SCO7687SC4C2.22, probable thioesterase, len: 277 aa; similar to SW:PABT_STRGR (EMBL:M93058) Streptomyces griseus probable cadicidin biosynthesis thioesterase (EC 3.1.2.-), 361 aa; fasta scores: opt: 638 z-score: 760.5 E(): 0; 40.4% identity in 277 aa overlap. Contains Pfam match to entry PF00975 Thioesterase, Thioesterase domain. (277 aa)
SCO7739SC8D11.30c, possible hydrolase, len: 235 aa; similar to C-terminal region of SW:PCD_ARTOX (EMBL:M94965) Arthrobacter oxidans phemedipham hydrolase (EC 3.1.1.-) Pcd, 493 aa; fasta scores: opt: 219 z-score: 259.2 E(): 6.7e-07; 28.1% identity in 199 aa overlap. Contains 2x Pfam matches to entry PF00135 COesterase, Carboxylesterases. (235 aa)
SCO7777SC5E9.25c, possible hydrolase, len: 309aa; weakly similar to many eg. TR:O69356 (EMBL:D88016) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase from Rhodococcus erythropolis (281 aa) fasta scores; opt: 206, z-score: 247.2, E(): 2.7e-06, 26.3% identity in 281 aa overlap. (309 aa)
SCO7787Hypothetical protein; SC5E9.35c, unknown, len: 122 aa. (122 aa)
mmyTSCP1.241c, mmyT, possible thioesterase, len: 269aa; previously sequenced and annotated as TR:Q9JN88 (EMBL:AJ276673) - note difference in predicted translational start site. Similar to many others eg. SW:P14686 (GRST_BACBR) gramicidin S biosynthesis GrsT protein (EC 3.1.2.-) from Bacillus brevis (256 aa) fasta scores; opt: 289, z-score: 338.3, E(): 2.2e-11, 29.7% identity in 256 aa overlap. Contains Pfam match to entry PF00975 Thioesterase, Thioesterase domain. (269 aa)
SCO3690SCH35.34c, possible hydrolase, len: 269 aa; similar to TR: O07015 (EMBL:Z94043) hypothetical protein from Bacillus subtilis (269 aa) fasta scores; opt: 907, z-score: 1096.7, E(): 0, (47.7% identity in 262 aa overlap). Also weakly similar to TR:BAA34263 (EMBL:AB014348) 2-hydroxy-6-oxo-6-phenylehexa-2,4-dienoate hydrolase from Rhodococcus erythropolis TA421 (297 aa) fasta scores; opt: 227, z-score: 278.9, E(): 3.3e-08, (27.1% identity in 277 aa overlap). Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (269 aa)
SCO3644SCH10.22c, possible lipase/esterase, len: 301 aa; weakly similar to many esterases e.g. SW:EST1_CAEEL (EMBL:M96145) Caenorhabditis elegans gut esterase precursor (562 aa), fasta scores; opt: 150 z-score: 166.4 E(): 0.059, 29.3% identity in 280 aa overlap. Contains PS00120 Lipases, serine active site. (301 aa)
SCO3643SCH10.21c, hypothetical protein, len: 329 aa; unknown function, weakly similar to SW:YT11_MYCTU (EMBL:Z79700) Mycobacterium tuberculosis hypothetical protein (266 aa), fasta scores; opt: 183 z-score: 199.4 E(): 0.00086, 30.7% identity in 225 aa overlap. (329 aa)
SCO3610SC66T3.21c, probable peptide hydrolase, len: 606 aa; similar to many peptidases e.g. (EMBL:AB01029) Sphingomonas capsulata prolyl oligopeptidase (723 aa), fasta scores; opt: 333 z-score: 359.1 E(): 1.1e-12, 25.8% identity in 620 aa overlap (dissimilar at N-terminus). Also weakly similar to eukaryotic peptidases e.g. TR:P70479 (EMBL:X14915) Rattus norvegicus acyl-peptide hydrolase (729 aa) (26.6% identity in 395 aa overlap). Contains Pfam match to entry PF00326 Prolyl_oligopep, Prolyl oligopeptidase family. (606 aa)
SCO3599SC66T3.10c, hypothetical protein, len: 318 aa; unknown function, similar to hypothetical proteins e.g. TR:O54025 (EMBL:AJ000884), ORF2, Paracoccus denitrificans hypothetical protein (281 aa), fasta scores; opt: 244 z-score: 272.8 E(): 7.2e-08, 31.5% identity in 295 aa overlap. (318 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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