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SCO7112 SCO7112 SCO7105 SCO7105 SCO7104 SCO7104 SCO7099 SCO7099 SCO6239 SCO6239 SCO5071 SCO5071 SCO4938 SCO4938 SCO7641 SCO7641 SCO0803 SCO0803 SCO0858 SCO0858 SCO7768 SCO7768 SCO1002 SCO1002 SCO1178 SCO1178 SCO1263 SCO1263 SCO1677 SCO1677 SCO2288 SCO2288 SCO2411 SCO2411 SCO2742 SCO2742 SCO3399 SCO3399 SCO3626 SCO3626 SCO3715 SCO3715 SCO4364 SCO4364 SCO0771 SCO0771 SCO0744 SCO0744 mmyY mmyY SCO0220 SCO0220 SCO0414 SCO0414 SCO0159 SCO0159 SCO7053 SCO7053 SCO0139 SCO0139 SCO0037 SCO0037 SCO7621 SCO7621 SCO4895 SCO4895 SCO7272 SCO7272
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO7112SC4B10.13c, probable ECF-family RNA polymerase sigma factor, len: 298 aa; similar to TR:Q9S1V5 (EMBL:AL109950) Streptomyces coelicolor putative sigma factor SCJ24.18c, 250 aa; fasta scores: opt: 1127 z-score: 1362.0 E(): 0; 72.8% identity in 243 aa overlap and to Streptomyces coelicolor SC4B10.06c, 301 aa; fasta scores: opt: 1112 z-score: 1158.1 E(): 0; 57.3% identity in 288 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (298 aa)
SCO7105SC4B10.06c, possible RNA polymerase sigma factor, len: 301 aa; similar to TR:Q9S1V5 (EMBL:AL109950) Streptomyces coelicolor putative sigma factor SCJ24.18c, 250 aa; fasta scores: opt: 877 z-score: 1049.7 E(): 0; 54.7% identity in 236 aa overlap and to Streptomyces coelicolor St4B10.13c, 298; fasta scores: opt: 1112 z-score: 1131.2 E(): 0; 57.3% identity in 288 aa overlap. Also contains a possible helix-turn-helix motif at residues 133..154 (+3.38 SD); Belongs to the sigma-70 factor family. (301 aa)
SCO7104SC4B10.05, possible RNA polymerase sigma factor, len: 292 aa; similar to TR:CAB89771 (EMBL:AL354616) Streptomyces coelicolor putative RNA polymerase sigma factor SC3A4.25c, 300 aa; fasta scores: opt: 901 z-score: 941.4 E(): 0; 51.7% identity in 290 aa overlap. (292 aa)
SCO7099SC3A4.25c, possible RNA polymerase sigma factor, len: 300 aa. Similar to many putative sigma factors from Streptomyces coelicolor e.g. TR:CAB60158 (EMBL:AL132824) SCAH10.04C (322 aa), fasta scores opt: 427 z-score: 505.7 E(): 1e-20 36.5% identity in 307 aa overlap and TR:CAB59711 (EMBL:AL132707) SCF51.13C (298 aa), fasta scores opt: 445 z-score: 527.2 E(): 6.6e-22 38.6% identity in 298 aa overlap. (300 aa)
SCO6239SCAH10.04c, possible sigma factor, len: 322 aa; similar to TR:CAB42013 (EMBL:AL049754) Streptomyces coelicolor putative sigma factor, SCH10.04c, 294 aa; fasta scores: opt: 379 z-score: 438.7 E(): 4.6e-17; 34.7% identity in 291 aa overlap and to (EMBL:AL132707) Streptomyces coelicolor SCF51.13c, 298 aa; fasta scores: opt: 833 z-score: 802.7 E(): 0; 44.9% identity in 305 aa overlap; Belongs to the sigma-70 factor family. (322 aa)
SCO5071SCBAC20F6.14c, ORFA hydroxylacyl-CoA dehydrogenase, len: 146 aa; identical to previously sequenced TR:Q53925 (EMBL:X62373) Streptomyces coelicolor hydroxylacyl-CoA dehydrogenase ORFA, 146 aa. (146 aa)
SCO4938SCK13.30, possible ECF-sigma factor, len: 304 aa; similar to TR:Q9RJS2 (EMBL:AL132707) Streptomyces coelicolor putative RNA polymerase sigma factor SCF51.13c, 298 aa; fasta scores: opt: 1110 z-score: 1299.2 E(): 0; 58.4% identity in 296 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 144..165 (+2.59 SD). (304 aa)
SCO7641SC10F4.14, possible dehydrogenase, len: 398 aa; similar to many other Streptomyces coelicolor putative dehydrogenases, e.g. TR:Q9RD04 (EMBL:AL133422) putative dehydrogenase SCM1.40c, 296 aa; fasta scores: opt: 352 z-score: 383.2 E(): 8.2e-14; 33.5% identity in 260 aa overlap. (398 aa)
SCO0803SCF43.14c, possible RNA polymerase sigma factor, len: 330 aa. Similar to Mycobacterium smegmatis TR:O05767 (EMBL:U87307) extracytoplasmic function alternative sigma factor SigE (204 aa), fasta scores opt: 234 z-score: 278.1 E(): 4.1e-08 29.1% identity in 175 aa overlap. Also highly similar to many other putative sigma factors e.g. Streptomyces coelicolor TR:Q9X8P3 (EMBL:AL049754) putative RNA polymerase sigma factor SCH10.04C (294 aa), fasta scores opt: 915 z-score: 1056.2 E():0 52.9% identity in 293 aa overlap. (324 aa)
SCO0858Hypothetical protein SCM2.11c; SCM2.11c, unknown, len: 125 aa. (125 aa)
SCO7768SC5E9.16, conserved hypothetical protein, len: 146aa; similar to SW:O31511 (YESE_BACSU) hypothetical protein from Bacillus subtilis (147 aa) fasta scores; opt: 317, z-score: 427.2, E(): 2.5e-16, 35.7% identity in 126 aa overlap. (146 aa)
SCO1002Hypothetical protein 2SCG2.15c; 2SCG2.15c, unknown, len: 128 aa. (128 aa)
SCO1178Hypothetical protein SCG11A.09c; SCG11A.09c, unknown, len: 149 aa. (149 aa)
SCO12632SCG18.10c, probable ECF-sigma factor, len: 295 aa; similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor putative sigma factor SCC57A.13c, 315 aa; fasta scores: opt: 887 z-score: 1027.2 E(): 0; 50.5% identity in 285 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (295 aa)
SCO1677SCI52.19, conserved hypothetical protein, len: 124 aa; similar to TR:BAB35158 (EMBL:AP002556) Escherichia coli O157:H7 hypothetical 17.0 kDa protein ECS1735, 152 aa; fasta scores: opt: 397 Z-score: 489.0 bits: 96.3 E(): 1.2e-19; 52.033% identity in 123 aa overlap; Belongs to the UPF0225 family. (124 aa)
SCO2288Hypothetical protein SCC75A.34c; SCC75A.34c, unknown, len: 108 aa. Similar to Streptomyces coelicolor TR:CAB58302(EMBL:AL121854) hypothetical 11.8 KD protein (106 aa), fasta scores opt:99 z-score: 145.3 E():0.96 31.2% identity in 93 aa overlap. (108 aa)
SCO2411SC4A7.39c, possible membrane protein, len: 184 aa; similar to various hypothetical proteins, e.g. SW:Y07R_MYCTU (EMBL:Z75555) Mycobacterium tuberculosis hypothetical 28.3 kD protein, 261 aa; fasta scores: opt: 188 z-score: 223.5 E(): 4.6e-05; 28.7% identity in 164 aa overlap and to S/ coelicolor SC4A7.41c, >165 aa; fasta scores: opt: 240 z-score: 255.3 E(): 7.9e-09; 36.0% identity in 161 aa overlap. Contains possible hydrophobic membrane spanning region. (184 aa)
SCO2742SCC57A.13c, possible sigma factor, len: 315 aa. Similar to many putative Streptomyces coelicolor ECF sigma factors e.g. TR:CAB53126 (EMBL:AL109962) SCJ1.08 (322 aa), fasta scores opt: 506 z-score: 595.6 E(): 8.7e-26 34.5% identity in 290 aa overlap. Also similar to Mycobacterium tuberculosis TR:O53378 (EMBL:AL021841) putative sigma factor (fragment)(312 aa), fasta scores opt: 525 z-score: 617.9 E(): 5e-27 33.7% identity in 291 aa overlap. Contains a putative helix-turn-helix motif situated between residues 152..173 (+2.66 SD); Belongs to the sigma-70 factor family. (315 aa)
SCO3399SCE9.06, hypothetical protein, len: 167 aa; probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. (167 aa)
SCO3626SCH10.04c, probable RNA polymerase sigma factor, len: 294 aa; similar to many e.g. TR:O05735 (EMBL:U87308) SigE, Mycobacterium avium extracytoplasmic function alternative sigma factor (251 aa), fasta scores; opt: 226 z-score: 266.2 E(): 1.6e-07, 29.8% identity in 168 aa overlap; Belongs to the sigma-70 factor family. (294 aa)
SCO3715SCH35.09, possible ECF sigma factor, len: 223aa; similar to many egs. TR:O53378 (EMBL:AL021841) putative sigma factor from Mycobacterium tuberculosis (312 aa) fasta scores; opt: 357, z-score: 418.3, E(): 5.7e-16, (33.2% identity in 226 aa overlap) and SW:RPOE_STRCO sigma factor E from Streptomyces coelicolor (176 aa) fasta scores; opt: 131, z-score: 162.5, E(): 0.1, (33.3% identity in 114 aa overlap). NB. Overlaps with downstream CDS. (223 aa)
SCO4364Hypothetical protein SCD19.19; SCD19.19, unknown, len: 125 aa. (125 aa)
SCO07713SCF60.03c, conserved hypothetical protein, len: 145 aa; identical to TR:O85694 (EMBL:AF072709) Streptomyces lividans hypothetical 17.2 kDa protein, 145 aa. (145 aa)
SCO0744Conserved hypothetical protein SCF81.03; SCF81.03, unknown, len: 121 aa; similar to TR:Q98BX4 (EMBL:AP003006) MLL5389 protein from Rhizobium loti (Mesorhizobium loti) (124 aa) fasta scores; opt: 363, Z-score: 452.3, E(): 1.5e-17, 43.750% identity (43.750% ungapped) in 112 aa overlap. (121 aa)
mmyYSCP1.229c, mmyY, hypothetical protein, len: 153aa; previously partially sequenced and annotated as TR:Q9JN76 (EMBL:AJ276673). (153 aa)
SCO0220Hypothetical protein SCJ12.32; SCJ12.32, unknown, len: 147 aa. (147 aa)
SCO0414SCF51.13c, possible RNA polymerase sigma factor, len: 298 aa; similar to TR:CAB42013 (EMBL:AL049754) Streptomyces coelicolor putative RNA polymerase sigma factor SCH10.4c, 294aa; fasta scores: opt: 614 z-score: 721.0 E(): 8.7e-33; 41.4% identity in 285 aa overlap and to TR:O86856 (EMBL:AJ007313) Streptomyces coelicolor sigma factor, SigT, 236aa; fasta scores: opt: 160 z-score: 194.6 E(): 0.0018; 31.0% identity in 158 aa overlap; Belongs to the sigma-70 factor family. (298 aa)
SCO0159SCJ1.08 putative ECF sigma factor, len: 322 aa, similar to many e.g. S. coelicolor TR:CAB44418 (EMBL:AL078610) putative ECF sigma factor SCH35.09 (223 aa) fasta scores, opt: 656 z-score: 777.0 E(): 0 64.6% identity in 175 aa overlap and Mycobacterium tuberculosis SIGI protein TR:O50445 (EMBL; AL010186)(290 aa), fasta scores opt: 385 z-score: 458.0 E(): 3.7e-18 30.0% identity in 290 aa overlap. Contains a Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Possible helix-turn-helix motif between 142-163 aa, score +4.11 SD. (322 aa)
SCO7053SC4G1.19c, hypothetical protein, len: 139 aa; similar to TR:O33283 (EMBL:AL008967) Mycobacterium tuberculosis hypothetical 16.6 kD protein, 149 aa; fasta scores: opt: 118 z-score: 161.0 E(): 0.17; 34.2% identity in 79 aa overlap. (139 aa)
SCO0139Hypothetical protein SCJ33.03; SCJ33.03, unknown, len: 106 aa. (106 aa)
SCO0037SCJ4.18c, possible sigma factor, len: 250 aa; similar to many proposed sigma factors e.g. TR:CAB44418 (EMBL:AL078610) putative sigma factor from Streptomyces coelicolor (223 aa) fasta scores; opt: 419, z-score: 506.3, E(): 7.7e-21, (44.3% identity in 183 aa overlap) and SW:SIGY_BACSU RNA polymerase sigma factor, SigY from Bacillus subtilis (178 aa) fasta scores; opt: 111, z-score: 142.5, E(): 1.4, (23.9% identity in 117 aa overlap). Note possible framshift from previous CDS as similar to all but the N-terminus of TR:CAB42013 (EMBL:AL049754) putative RNA polymerase sigma factor from Str [...] (250 aa)
SCO7621SC2H2.19, conserved hypothetical protein, len: 147 aa; low similarity to TR:AAG05206 (EMBL:AE004608) Pseudomonas aeruginosa hypothetical 14.4 kDa protein PA1817, 129 aa; fasta scores: opt: 142 z-score: 193.7 E(): 0.0029; 30.5% identity in 131 aa overlap. (147 aa)
SCO48952SCK8.21c, possible ECF sigma factor, len: 334 aa; similar to TR:O07426 (EMBL:Z97050) Mycobacterium tuberculosis RNA polymerase sigma subunit MTCI28.22c, 370 aa; fasta scores: opt: 818 z-score: 941.2 E(): 0; 44.7% identity in 318 aa overlap and to TR:Q9K3H7 (EMBL:AL390188) Streptomyces coelicolor putative ECF-sigma factor 2SCG18.10c, 295 aa; fasta scores: opt: 219 z-score: 257.6 E(): 8.8e-07; 31.8% identity in 314 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 159..180 (+4.07 SD). (334 aa)
SCO7272SC5H1.20, possible isomerase, len: 127 aa; weakly similar to SW:SDIS_PSEPU (EMBL:L13127), ksI, Pseudomonas putida steroid delta-isomerase (131 aa), fasta scores; opt: 109 z-score: 150.4 E(): 0.47, 26.0% identity in 131 aa overlap. (127 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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