STRINGSTRING
SCO4864 SCO4864 SCO4866 SCO4866 SCO4895 SCO4895 SCO4908 SCO4908 SCO5147 SCO5147 SCO4996 SCO4996 SCO5216 SCO5216 SCO5934 SCO5934 SCO6996 SCO6996 SCP1.116 SCP1.116 SCP1.151c SCP1.151c SCP1.161c SCP1.161c SCO3356 SCO3356 SCO3613 SCO3613 SCO3736 SCO3736 SCO3709 SCO3709 SCO0194 SCO0194 SCO0632 SCO0632 SCO0864 SCO0864 SCO0866 SCO0866 SCO0942 SCO0942 SCO1276 SCO1276 SCO1332 SCO1332 SCO1564 SCO1564 SCO1723 SCO1723 SCO1876 SCO1876 SCO2639 SCO2639 SCO2954 SCO2954 SCO3323 SCO3323 SCO3450 SCO3450 SCO3892 SCO3892 SCO4005 SCO4005 SCO4117 SCO4117 SCO4146 SCO4146 SCO4409 SCO4409 SCO4769 SCO4769 SCO4810 SCO4810
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO4864SCK20.05, possible ECF sigma factor, len: 225 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 296 z-score: 342.7 E(): 1.5e-11; 34.0% identity in 212 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.07, 220 aa; fasta scores: opt: 671 z-score: 656.4 E(): 6.9e-31; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (225 aa)
SCO4866SCK20.07, possible ECF sigma factor, len: 220 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 280 z-score: 329.1 E(): 8.5e-11; 31.9% identity in 182 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.05, 225 aa; fasta scores: opt: 671 z-score: 614.8 E(): 1.4e-28; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (220 aa)
SCO48952SCK8.21c, possible ECF sigma factor, len: 334 aa; similar to TR:O07426 (EMBL:Z97050) Mycobacterium tuberculosis RNA polymerase sigma subunit MTCI28.22c, 370 aa; fasta scores: opt: 818 z-score: 941.2 E(): 0; 44.7% identity in 318 aa overlap and to TR:Q9K3H7 (EMBL:AL390188) Streptomyces coelicolor putative ECF-sigma factor 2SCG18.10c, 295 aa; fasta scores: opt: 219 z-score: 257.6 E(): 8.8e-07; 31.8% identity in 314 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 159..180 (+4.07 SD). (334 aa)
SCO49082SCK8.34, probable RNA polymerase sigma factor (fragment), len: 196 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma factor SigE, 176 aa; fasta scores: opt: 377 z-score: 396.4 E(): 1.7e-14; 44.6% identity in 148 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 148..169 (+3.34 SD). (196 aa)
SCO5147SCP8.10, probable ECF-subfamily sigma factor, len: 223 aa; similar to TR:O05735 (EMBL:U87308) Mycobacterium avium extracytoplasmic function alternative sigma factor SigE, 251 aa; fasta scores: opt: 852 z-score: 1013.1 E(): 0; 62.5% identity in 216 aa overlap and to SW:CARQ_MYXXA (EMBL:X71062) Myxococcus xanthus RNA polymerase sigma factor CarQ, 174 aa; fasta scores: opt: 285 z-score: 347.6 E(): 6.8e-12; 36.5% identity in 159 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Also contains a possible helix-turn-helix motif at residues 164..185 [...] (223 aa)
SCO49962SCK36.19c, probable RNA polymerase ECF sigma factor, len: 169 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE or SCE94.07, 176 aa; fasta scores: opt: 278 Z-score: 347.2 bits: 70.7 E(): 9.9e-12; 36.527% identity in 167 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (169 aa)
SCO5216RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor (RsrA) until released. Responds to thiol-oxidative stress, involved in regulation of about 30 genes and operons, including the thioredoxin system (trxB-trxA, trxC), ribosomal protein L31, RNA polymerase-binding protein RbpA and mycothiol (MSH) biosynthetic (mshA) and recycling genes (mca). In conjunction with its cognate anti-s [...] (227 aa)
SCO5934SC7H1.04, possible sigma factor, len: 200 aa; some similarity to sigma factors (ECF subfamily) from diverse organisms e.g. Alcaligenes eutrophus CNRH_ALCEU P37978 rna polymerase sigma factor cnrh (191 aa), fasta scores; opt: 230 z-score: 337.3 E(): 1.4e-11, 29.5% identity in 183 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa)
SCO6996SC8F11.22, possible RNA polymerase sigma factor, len: 191 aa. Weakly similar to Streptomyces coelicolor sigma factor TR:CAB76082 (EMBL:AL157953) putative RNA polymerase sigma factor, SCL11.20C (166 aa), fasta scores opt: 206 z-score: 259.9 E(): 4.8e-07 30.4% identity in 161 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
SCP1.116SCP1.116, possible ECF-family sigma factor, len: 380aa; region similar to many eg. TR:Q9RIT1 (EMBL:AJ010584) ECF sigma factor from Streptomyces coelicolor (264 aa) fasta scores; opt: 485, z-score: 519.3, E(): 1.9e-21, 39.0% identity in 223 aa overlap and SW:P35165 (SIGX_BACSU) RNA polymerase sigma factor SigX from Bacillus subtilis (194 aa) fasta scores; opt: 215, z-score: 237.7, E(): 9e-06, 29.0% identity in 162 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains a TTA encoded leucine at residue 31, possible target for bldA regulation. (380 aa)
SCP1.151cSCP1.151c, possible sigma factor, len: 174aa; weakly similar to many eg. TR:Q9X8Z1 (EMBL:AL078610) putative ECF sigma factor from Streptomyces coelicolor (184 aa) fasta scores; .opt: 187, z-score: 235.0, E(): 1.3e-05, 28.0% identity in 164 aa overlap and TR:O05767 (EMBL:U87307) SigE, extracytoplasmic function alternative sigma factor from Mycobacterium smegmatis (204 aa) fasta scores; opt: 160, z-score: 202.2, E(): 0.00085, 27.8% identity in 187 aa overlap; Belongs to the sigma-70 factor family. (174 aa)
SCP1.161cPutative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. Belongs to the sigma-70 factor family. ECF subfamily. (268 aa)
SCO3356ECF sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is required for normal cell wall integrity; it is recruited by RNA polymerase to transcribe genes with cell wall- related functions. It is also involved in the transcription of the dagA gene coding for an extracellular agar-degrading enzyme. (177 aa)
SCO3613SC66T3.24c, possible RNA polymerase sigma factor, len: 190 aa; weakly similar to many e.g. SW:RPOE_STRCO (EMBL:L29636), AigE, S.coelicolor RNA polymerase sigma-E factor (176 aa), fasta scores; opt: 236 z-score: 274.0 E(): 6.1e-08, 30.9% identity in 162 aa overlap. The start site is uncertain as there is a second possible start site at codon 7; Belongs to the sigma-70 factor family. ECF subfamily. (190 aa)
SCO3736SCH22A.14c, probable RNA polymerase ECF sigma factor, len: 163 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE, 176 aa; fasta scores: opt: 214 z-score: 282.2 E(): 2.7e-08; 32.7% identity in 159 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (163 aa)
SCO3709SCH35.15, possible ECF sigma factor, len: 184 aa; similar to many e.g. SW:RPOE_STRCO sigma E from Streptomyces coelicolor (176 aa) fasta scores; opt: 216, z-score: 250.5, E(): 1.3e-06, (29.2% identity in 161 aa overlap); Belongs to the sigma-70 factor family. (184 aa)
SCO0194SCJ12.06, possible sigma factor, len: 202 aa. Similar to many including: Rhodobacter sphaeroide TR:O33546 (EMBL; U11283) RpoE homologue (168 aa), fasta scores opt: 291 z-score: 373.4 E(): 1.9e-13 35.4% identity in 161 aa overlap and Streptomyces coelicolor TR:O54163 (EMBL; AL021411) putative sigma factor SC7H1.04 (200 aa), fasta scores opt: 255 z-score: 327.4 E(): 7.1e-11 33.7% identity in 184 aa overlap. Contains a PS01063 Sigma-70 factors ECF subfamily signature and a Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains a possible helix-turn-helix motif [...] (202 aa)
SCO0632SCF56.16, probable RNA polymerase sigma factor, len: 194 aa; similar to TR:CAB50938 (EMBL:AL096849) Streptomyces coelicolor SCI11.12c, 185 aa; fasta scores: opt: 710 z-score: 848.0 E(): 0; 62.4% identity in 173 aa overlap and to SW:SIGW_BACSU (EMBL:AB002150) Bacillus subtilis RNA polymerase sigma factor SigW, 187 aa; fasta scores: opt: 209 z-score: 258.8 E(): 4.9e-07; 24.9% identity in 181 aa overlap. Contains a possible helix-turn-helix motif at residues 159..180 (+2.77 SD); Belongs to the sigma-70 factor family. ECF subfamily. (194 aa)
SCO0864SCM2.17c, probable ECF-family sigma factor, len: 198 aa. Highly similar to many sigma factors including: Streptomyces coelicolor TR:O86856 (EMBL:AJ007313) sigma factor SigT (236 aa), fasta scores opt: 268 z-score: 337.2 E(): 2.1e-11 34.3% identity in 181 aa overlap and Mycobacterium tuberculosis SW:RPSC_MYCTU (EMBL:Z73966) probable RNA polymerase sigma-C factor SigC (185 aa), fasta scores opt: 517 z-score: 643.3 E(): 1.9e-28 50.8% identity in 177 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 68.5 % identity, in 197 aa overlap, with the downstream gene, [...] (198 aa)
SCO0866SCM2.19c, probable ECF-family sigma factor, len: 213 aa. Highly similar to many sigma factors including: Streptomyces coelicolor TR:O86856 (EMBL:AJ007313) sigma factor SigT (236 aa), fasta scores opt: 292 z-score: 354.1 E(): 2.4e-12 35.7% identity in 185 aa overlap and Mycobacterium tuberculosis SW:RPSC_MYCTU(EMBL:Z73966) probable RNA polymerase sigma-C factor SigC (185 aa), fasta scores opt: 530 z-score: 636.2 E(): 4.6e-28 51.7% identity in 178 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 68.5 % identity, in 197 aa overlap, with the upstream gene, SCM [...] (213 aa)
SCO0942SCM10.30, possible RNA polymerase sigma factor, len: 184 aa; similar to various sigma factors, e.g. TR:O53798 (EMBL:AL021958) Mycobacterium tuberculosis, and Mycobacterium bovis RNA polymerase sigma factor SigJ, 177 aa; fasta scores: opt: 364 z-score: 454.2 E(): 6.6e-18; 42.0% identity in 174 aa overlap, to TR:O86856 (EMBL:AJ007313) Streptomyces coelicolor sigma factor SigT, 236 aa; fasta scores: opt: 235 z-score: 295.6 E(): 4.5e-09; 35.4% identity in 161 aa overlap, to SW:RPSC_MYCTU (EMBL:Z73966) Mycobacterium tuberculosis probable RNA polymerase sigma-C factor SigC, 185 aa; fasta sco [...] (184 aa)
SCO12762SCG18.23, sigJ, RNA polymerase ECF sigma factor, len: 198 aa; identical to previously sequenced TR:AAF35371 (EMBL:AF225460) Streptomyces coelicolor RNA polymerase ECF sigma factor SigJ, 198 aa. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (198 aa)
SCO1332Conserved hypothetical protein; 2SCG61.14c, unknown, len: 290 aa; similar to TR:Q9Z9I2 (EMBL:AB024056) unknown protein from Streptomyces fradiae (306 aa) fasta scores; opt: 705, z-score: 786.1, E(): 0, 45.9% identity in 259 aa overlap and TR:CAB92673 (EMBL:AL356832) hypothetical protein from Streptomyces coelicolor (342 aa) fasta scores; opt: 577, z-score: 644.3, E(): 2.1e-28, 43.6% identity in 280 aa overlap. (290 aa)
SCO1564SCL11.20c, possible RNA polymerase sigma factor ECF subfamily, len: 166 aa; similar to SW:RFAY_XANCP (EMBL:U19896) Xanthomonas campestris probable RNA polymerase sigma factor RfaY, 217 aa; fasta scores: opt: 135 z-score: 168.4 E(): 0.058; 30.9% identity in 136 aa overlap. (166 aa)
SCO1723SCI11.12c, possible RNA polymerase sigma factor, len: 185 aa; weakly similar to RNA polymerase sigma factors e.g. SW:CARQ_MYXXA (EMBL:X71062), CarQ, Myxococcus xanthus RNA polymerase sigma factor (174 aa), fasta scores; opt: 233 z-score: 295.7 E(): 3.9e-09, 29.3% identity in 167 aa overlap. Similar to many putative sigma factors e.g. TR:O53730 (EMBL:AL021932), SigK, Mycobacterium tuberculosis probable RNA polymerase sigma factor (187 aa) (51.4% identity in 173 aa overlap). Similar to others from S.coelicolor e.g. TR:O54163 (EMBL:AL021411) S. coelicolor possible sigma factor (200 aa) (3 [...] (185 aa)
SCO1876SCI39.23, possible RNA polymerase sigma factor, len: 190 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE, 176 aa; fasta scores: opt: 210 Z-score: 262.1 bits: 55.1 E(): 5.2e-07; 34.177% identity in 158 aa overlap. Contains possible helix-turn-helix motif at residues 132..153 (+3.59 SD); Belongs to the sigma-70 factor family. ECF subfamily. (190 aa)
SCO2639SC8E4A.09c, possible RNA polymerase sigma factor, len: 208 aa; similar to TR:O53798 (EMBL:AL021958) Mycobacterium tuberculosis RNA polymerase sigma factor SigJ, 177 aa; fasta scores: opt: 221 z-score: 269.6 E(): 1.3e-07; 34.9% identity in 146 aa overlap and to SW:SIGV_BACSU (EMBL:U93874) Bacillus subtilis RNA polymerase sigma factor SigV, 166 aa; fasta scores: opt: 177 z-score: 218.8 E(): 8.9e-05; 28.2% identity in 142 aa overlap. Contains possible helix-turn-helix motif at residues 171..192 (+2.79 SD); Belongs to the sigma-70 factor family. ECF subfamily. (208 aa)
SCO2954SCE59.13c, probable RNA polymerase sigma factor, len: 194 aa; similar to TR:CAB63191 (EMBL:AL133469) Streptomyces coelicolor putative RNA polymerase sigma factor SCM10.30, 184 aa; fasta scores: opt: 522 z-score: 641.7 E(): 2.5e-28; 54.7% identity in 161 aa overlap and to SW:SIGY_BACSU (EMBL:D83026) Bacillus subtilis RNA polymerase sigma factor SigY, 178 aa; fasta scores: opt: 211 z-score: 266.1 E(): 2.1e-07; 27.2% identity in 169 aa overlap Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) PS01063 Sigma-70 factors ECF subfamily signature. (194 aa)
SCO3323SCE68.21, probable RNA polymerase sigma factor, len: 177 aa; similar to many members of the extracytoplasmic function sigma factor family e.g. SW:CARQ_MYXXA (EMBL:X71062), CarQ, Myxococcus xanthus RNA polymerase sigma factor (174 aa), fasta scores; opt: 237 z-score: 281.3 E(): 2.4e-08, 32.0% identity in 169 aa overlap. Similar to others from S. coelicolor e.g. TR:O54163 (EMBL:AL021411), SC7H1.04, possible sigma factor (200 aa) (30.8% identity in 172 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (177 aa)
SCO3450SCE46.07c, probable RNA polymerase sigma factor (ECF subfamily), len: 201 aa; similar to TR:O87834 (EMBL:AJ010320) Streptomyces coelicolor RNA polymerase sigma factor SigR, 227 aa; fasta scores: opt: 337 z-score: 413.7 E(): 1.1e-15; 34.1% identity in 208 aa overlap and to SW:RPOE_MYCTU (EMBL:Z95120) Mycobacterium tuberculosis RNA polymerase sigma-E factor (sigma-24), 216 aa; fasta socres: opt: 339 z-score: 416.4 E(): 7.5e-16; 35.4% identity in 189 aa overlap. Contains match to Pfam entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and match to PS01063 Sigma-70 factors ECF subf [...] (201 aa)
SCO3892SCH24.14c, sigT, probable RNA polymerase sigma factor, len: 236 aa; previously sequenced as TR:O86856 (EMBL:AJ007313), SigT. Similar to other S.coelicolor putative sigma factors TR:O54163 (EMBL:AL021411) possible sigma factor (200 aa) (32.2% identity in 199 aa overlap) and SCH10.35 putative RNA polymerase sigma factor from cosmid StH10 (294 aa) (37.7% identity in 159 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 57.10, E-value 3.8e-13. (236 aa)
SCO40052SC10A7.09, probable RNA polymerase sigma factor, len: 157 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE, 176 aa; fasta scores: opt: 451 z-score: 556.7 E(): 1.7e-23; 48.7% identity in 150 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 120..141 (+3.36 SD). (157 aa)
SCO4117SCD72A.03, possible membrane protein, len: 687aa; contains possible membrane-spanning hydrophobic region (358-453aa) and proline-rich region (495-540aa); Belongs to the sigma-70 factor family. ECF subfamily. (687 aa)
SCO4146SCD84.13, probable ECF subfamily sigma factor, len: 180 aa; similar to TR:Q9WWP4 (EMBL:AF121850) Synechococcus sp. SigH, 199 aa; fasta scores: opt: 273 z-score: 333.6 E(): 4e-11; 37.4% identity in 163 aa overlap and to TR:O05767 (EMBL:U87307) Mycobacterium smegmatis extracytoplasmic function alternative sigma factor, SigE, 204 aa; fasta scores: opt: 261 z-score: 319.3 E(): 2.5e-10; 33.5% identity in 188 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (180 aa)
SCO4409SC6F11.07c, possible RNA polymerase sigma factor, len: 197 aa; similar to SW:SIGZ_BACSU (EMBL:U93875) Bacillus subtilis RNA polymerase sigma factor SigZ, 176 aa; fasta scores: opt: 166 z-score: 208.5 E(): 0.00041; 27.0% identity in 148 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (197 aa)
SCO4769SCD63.01, ECF sigma factor, len: 195 aa; identical to previously sequenced TR:O86843 (EMBL:AJ010601) Streptomyces coelicolor ECF sigma factor, 195 aa; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa)
SCO4810SCD63A.21c, hypothetical protein, len: 342 aa; similar to TR:Q9Z9I2 (EMBL:AB024056) Streptomyces fradiae unknown protein, 306 aa; fasta scores: opt: 645 z-score: 632.8 E(): 8.7e-28; 44.5% identity in 281 aa overlap. (342 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.