STRINGSTRING
SCO1242 SCO1242 SCP1.186 SCP1.186 SCP1.60 SCP1.60 SCO7615 SCO7615 SCO7579 SCO7579 SCO6629 SCO6629 SCO6537 SCO6537 SCO6236 SCO6236 SCO6129 SCO6129 SCO6003 SCO6003 SCO5125 SCO5125 SCO4998 SCO4998 SCO4678 SCO4678 SCO4543 SCO4543 SCO4441 SCO4441 SCO4301 SCO4301 SCO4176 SCO4176 SCO3421 SCO3421 SCO3365 SCO3365 SCO2869 SCO2869 SCO2865 SCO2865 SCO2513 SCO2513 SCO2381 SCO2381 SCO2253 SCO2253 SCO2246 SCO2246 SCO1979 SCO1979
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO12422SCG1.17, probable DNA-binding protein, len: 286 aa; similar to TR:CAB8844 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 626 z-score: 747.0 E(): 0; 40.0% identity in 280 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 25..46 (+4.46 SD). Also contains a TTA leucine codon (58), possible target for bldA regulation. (286 aa)
SCP1.186SCP1.186, conserved hypothetical protein, len: 282aa; similar to other hypothetical proteins from streptomycetes eg. SCE6.06 (TR:Q9KZT2 EMBL:AL353832) from Streptomyces coelicolor (281 aa) fasta scores; opt: 882, z-score: 1083.5, E(): 0, 47.9% identity in 280 aa overlap. Note possible alternative downstream translational start site. (282 aa)
SCP1.60SCP1.60, possible conserved DNA-binding protein, len: 290aa; similar to many from streptomycetes eg. TR:Q9RHR7 (EMBL:AB025200) ORF312 protein from plasmid pNO33 of Streptomyces albulus (285 aa) fasta scores; opt: 857, z-score: 1027.5, E(): 0, and TR:Q9KZY5 (EMBL:AL353815) putative DNA-binding protein from Streptomyces coelicolor (295 aa) fasta scores; opt: 706, z-score: 847.4, E(): 0, 40.8% identity in 282 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (290 aa)
SCO7615SC2H2.13, possible DNA-binding protein, len: 290 aa; similar to many Streptomyces coelicolor putative DNA-binding proteins, e.g. TR:CAC01466 (EMBL:AL391014) putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 613 z-score: 722.6 E(): 1e-32; 41.8% identity in 261 aa overlap and TR:CAA20634 (EMBL:AL031515) hypothetical protein SC5C7.22c, 287 aa; fasta scores: opt: 917 z-score: 1027.9 E(): 0; 50.0% identity in 292 aa overlap. Contains possible helix-turn-helix motif at residues 33..54 (+4.70 SD). (290 aa)
SCO7579SC5F1.33, possible DNA-binding protein, len: 291 aa; similar to TR:Q9KZY5 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 643 z-score: 787.2 E(): 0; 37.0% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. Also contains possible helix-turn-helix motif at residues 31..52 (+6.28 SD). (291 aa)
SCO6629SC4G2.03, hypothetical protein, len: 277 aa; similar to TR:Q9F345 (EMBL:AL391751) Streptomyces coelicolor hypothetical protein SC9E12.10c, 287 aa; fasta scores: opt: 769 Z-score: 890.8 E(): 5.5e-42; 48.736% identity in 277 aa overlap. (277 aa)
SCO6537SC5C7.22c, unknown, len: 287 aa; similar to S. coelicolor hypothetical protein SC4G2.03 (E(): 2.2e-08, 29.2% identity in 257 aa overlap). Contains possible helix-turn-helix motif at aa 29-50 (Score 1251, +3.45 SD). (287 aa)
SCO6236SCAH10.01c, possible DNA-binding protein, len: >270 aa; similar to TR:Q9Z543 (EMBL:AL035212) Streptomyces coelicolor putative binding protein, SC9B2.16c, len: 303 aa; fasta scores: opt: 466 z-score: 574.2 E(): 1.3e-24; 34.1% identity in 252 aa overlap. Contains a possible helix-turn-helix motif between residues 612..677 (+3.39 SD); SC2H4.18c, unknown, partial CDS, len: >55 aa; some similarity to the C-terminus of S. coelicolor hypothetical protein SC4G2.03, fasta scores; (E(): 0.018, 32.7% identity in 52 aa overlap). (291 aa)
SCO6129SC9B2.16c, possible DNA-binding protein, len: 303aa; similar to proteins of unknown function egs. TR:O86676 (EMBL:AL031371) hypothetical 30.7 kD protein from Streptomyces coelicolor (277 aa) fasta scores; opt: 552, z-score: 663.3, E(): 1.2e-29, (37.7% identity in 257 aa overlap) and SW:ENTD_SALTY EntD, a protein from Salmonella typhimurium with undefined involvement in enterobactin biosynthesis (232 aa) fasta scores; opt: 102, z-score: 129.9, E(): 6, (26.7% identity in 191 aa overlap). Contains a probable helix-turn-helix (+3.37 SD) at residues 60 to 81. (303 aa)
SCO6003SCBAC1C11.06c, possible DNA-binding protein, len: 286 aa; similar to TR:CAC01466 (EMBL:AL391014) Streptomyces coelicolor putative DNA-binding protein 2SCG1.17, 286 aa; fasta scores: opt: 528 z-score: 639.9 E(): 4.2e-28; 37.4% identity in 281 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and possible helix-turn-helix motif at residues 27..48 (+4.04 SD). (286 aa)
SCO5125SC9E12.10c, hypothetical protein, len: 287 aa; similar to TR:Q9RDR4 (EMBL:AL136500) Streptomyces coelicolor hypothetical 31.7 kDa protein SC1G2.15c, 284 aa; fasta scores: opt: 1240 z-score: 1466.1 E(): 0; 67.2% identity in 287 aa overlap. (287 aa)
SCO49982SCK36.21c, hypothetical protein, len: 283 aa; similar to TR:Q9XD96 (EMBL:AF106004) Streptomyces coelicolor hypothetical 31.8 kDa protein ORF3, 283 aa; fasta scores: opt: 815 Z-score: 959.3 bits: 185.4 E(): 8e-46; 45.230% identity in 283 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (283 aa)
SCO4678SCD31.03, conserved hypothetical protein, len: 282 aa; similar to various hypothetical proteins, e.g. TR:CAB66187 (EMBL:AL136500) Streptomyces coelicolor hypothetical 31.7 kD protein SC1G2.15c, 284 aa; fasta scores: opt: 1359 z-score: 1611.1 E(): 0; 71.7% identity in 279 aa overlap. (282 aa)
SCO45432SCD4.14c, hypothetical protein, len: 283 aa; identical to previously sequenced TR:Q9XD96 (EMBL:AF106004) Streptomyces coelicolor hypothetical 31.8 kDa protein, 283 aa. (283 aa)
SCO4441SCD6.19, possible DNA-binding protein, len: 295 aa; similar to many other S. coelicolor hypothetical proteins, e.g. TR:Q9X8K0 (EMBL:AL049841) Streptomyces coelicolor hypothetical 30.9 kD protein SCE9.28c, 274 aa; fasta scores: opt: 717 z-score: 834.5 E(): 0; 42.6% identity in 263 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 37..58 (+5.84 SD). (295 aa)
SCO4301SCD95A.34c, possible DNA-binding protein, len: 279 aa; similar to various S. coelicolor hypothetical proteins, e.g. TR:CAB69734 (EMBL:AL137166) Streptomyces coelicolor hypothetical 30.4 kD protein SCC121.16, 277 aa; fasta scores: opt: 731 z-score: 897.3 E(): 0; 45.2% identity in 259 aa overlap and to TR:CAB88448 (EMBL:AL353815) Streptomyces coelicolor putative DNA-binding protein SCD6.19, 295 aa; fasta scores: opt: 388 z-score: 478.8 E(): 3.3e-19; 34.3% identity in 286 aa overlap. Contains TTA leucine codon, possible target for bldA regulation and a possible helix-turn-helix motif at r [...] (279 aa)
SCO4176SCD66.13, conserved hypothetical protein, len: 280 aa; similar to TR:O86676 (EMBL:AL031371) Streptomyces coelicolor hypothetical 30.7 kD protein SC4G2.03, 277 aa; fasta scores: opt: 378 z-score: 466.2 E(): 1.7e-18; 31.7% identity in 262 aa overlap. (280 aa)
SCO3421SCE9.28c, hypothetical protein, len: 274 aa; similar others from S.coelicolor e.g. TR:O86719 (EMBL:AL031515), SC5C7.22C, hypothetical protein (287 aa), fasta scores; opt: 727 z-score: 871.9 E(): 0, 44.7% identity in 273 aa overlap. (274 aa)
SCO3365Conserved hypothetical protein; SCE94.16c, unknown, len: aa; similar to others from Streptomyces coelicolor eg. TR:E1370777 (EMBL:AL035212) possible DNA binding protein (303 aa) fasta scores; opt: 420, z-score: 512.3, E(): 3.2e-21, (32.5% identity in 265 aa overlap). (280 aa)
SCO2869Putative regulatory protein; SCE6.06, possible regulatory protein, len: 281 aa. Similar to several proteins of undefined function e.g. Streptomyces albulus TR:BAA89264(EMBL: AB025200) plasmid pNO33 protein ORF312 (285 aa), fasta scores opt: 356 z-score: 441.0 E(): 3.9e-17 30.9% identity in 282 aa overlap. Also weakly similar to SCE6.02, also located on this cosmid, fasta scores opt: 269 z-score: 293.0 E(): 8.1e-11 27.5% identity in 265 aa overlap. Contains a putative helix-turn-helix motif situated between residues 27..48 (+4.07 SD). (281 aa)
SCO2865Putative regulatory protein; SCE6.02, possible regulatory protein, len: 280 aa. Similar to several proteins of undefined function including: Streptomyces albulus TR:BAA89264 (EMBL:AB025200) hypothetical protein ORF312 (285 aa), fasta scores opt: 585 z-score: 728.2 E():0 38.2% identity in 280 aa overlap and Streptomyces coelicolor TR:Q9Z543 (EMBL:AL035212) putative DNA binding protein, SC9B2.16C (303 aa), fasta scores opt: 313 z-score: 391.9 E(): 2.1e-14 31.0% identity in 284 aa overlap. Also weakly similar to SCE6.06, also located on this cosmid, fasta scores opt: 269 z-score: 293.0 E( [...] (280 aa)
SCO2513SCC121.16, hypothetical protein, len: 277 aa; similar to various hypothetical proteins, e.g. TR:Q9X8M2 (EMBL:AL049628) Streptomyces coelicolor hypothetical 31.5 kD protein SCE94.16c, 280 aa; fasta scores: opt: 538 z-score: 655.5 E(): 4.1e-29; 37.1% identity in 259 aa overlap. (277 aa)
SCO2381SC4A7.09, hypothetical protein, len: 278 aa; simialr to various hypothetical proteins, e.g. TR:Q9X8M2 (EMBL:AL049628) Streptomyces coelicolor hypothetical 31.5 kD protein SCE94.16c, 280 aa; fasta scores: opt: 1333 z-score: 1595.1 E(): 0; 76.4% identity in 271 aa overlap. (278 aa)
SCO2253Conserved hypothetical protein SC1G2.15c; SC1G2.15c, unknown, len: 258 aa. Similar to several proteins of undefined function from Streptomyces coelicolor including: TR:O86676(EMBL:AL031371) SC4G2.03 (277 aa), fasta scores opt: 758 z-score: 919.8 E():0 46.7% identity in 276 aa overlap and TR:Q9X8M2(EMBL:AL049628) SCE94.16C (280 aa), fasta scores opt: 476 z-score: 580.1 E(): 6.2e-25 32.7% identity in 260 aa overlap. This gene is duplicated on this cosmid and shares 76.1 % identity, in 259 aa overlap, with the upstream gene, SC1G2.08c. (284 aa)
SCO2246Conserved hypothetical protein SC1G2.08c; SC1G2.08c, unknown, len: 258 aa. Similar to several proteins of undefined function from Streptomyces coelicolor including: TR:O86676(EMBL:AL031371) SC4G2.03 (277 aa), fasta scores opt: 604 z-score: 734.8 E():0 46.3% identity in 229 aa overlap and TR:Q9X8M2(EMBL:AL049628) SCE94.16C (280 aa), fasta scores opt: 469 z-score: 572.0 E(): 1.8e-24 35.2% identity in 230 aa overlap. This gene is duplicated on this cosmid and shares 76.1 % identity, in 259 aa overlap, with the downstream gene, SC1G2.15c. (258 aa)
SCO1979SC3C9.14c, probable DNA-binding protein, len: 286 aa; similar to many Streptomyces DNA-binding proteins e.g. TR:Q9F3E2 (EMBL:AL450289) Streptomyces coelicolor putative DNA-binding proteins SC2H2.13, 290 aa; fasta scores: opt: 1019 Z-score: 1178.0 bits: 225.9 E(): 5.2e-58; 55.000% identity in 280 aa overlap and TR:O86719 (EMBL:AL031515) SC5C7.22c, 287 aa; fasta scores: opt: 1360 Z-score: 1390.2 bits: 265.1 E(): 1e-71; 69.338% identity in 287 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and a possible helix-turn-helix motif at residues 28..49 (+4.23 SD). (286 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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