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SCO3460 SCO3460 SCO3092 SCO3092 SCO2487 SCO2487 SCO2486 SCO2486 SCO2180 SCO2180 SCO2106 SCO2106 SCO0158 SCO0158 SCO7319 SCO7319 SCO6762 SCO6762 SCO6496 SCO6496 SCO7117 SCO7117 SCO7101 SCO7101 SCO4119 SCO4119
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO3460SCE46.17, probable oxidoreductase, len: 505 aa; similar to SW:MERA_STAAU (EMBL:L29436) Staphylococcus aureus mercuric reductase (EC 1.16.1.1) MerA, 547 aa; fasta scores: opt: 891 z-score: 971.7 E(): 0; 37.4% identity in 452 aa overlap. Contains match to Prosite entry PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. (505 aa)
SCO3092SCE41.01c, probable oxidoreductase (fragment), len: >317 aa; similar to SW:DHNA_ECOLI (EMBL:V00306) Escherichia coli NADH dehydrogenase (EC 1.6.99.3) Ndh, 433 aa; fasta scores: opt: 361 z-score: 417.8 E(): 9.1e-16; 27.6% identity in 330 aa overlap and to TR:CAB92372 (EMBL:AL356612) Streptomyces coelicolor putative NADH dehydrogenase SCD72A.05, 442 aa; fasta scores: opt: 1185 z-score: 1267.3 E(): 0; 57.0% identity in 321 aa overlap. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase; SCE25.33c, possible dehydrogenase (fragment), len: >162 aa; s [...] (446 aa)
SCO2487SC7A8.26, nirB, probable nitrite reductase large subunit, len: 871 aa; similar to TR:Q00943 (EMBL:Z68122) Pichia angusta nitrite reductase Yni1, 1044 aa; fasta scores: opt: 1960 z-score: 2117.6 E(): 0; 43.2% identity in 868 aa overlap and SW:NIRB_ECOLI (EMBL:X14202) Escherichia coli nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4) NirB 847 aa; fasta scores:opt: 1609 z-score: 1739.1 E(): 0; 52.1% identity in 845 aa overlap. Contains Pfam match to entry PF01077 NIR_SIR, Nitrite and sulphite reductase and two matches to Prosite entries PS00136 Serine proteases, subtilase family, asp [...] (871 aa)
SCO2486SC7A8.25, nirB, probable nitrite reductase, len: 410 aa; similar to N-terminal region of TR:O53674 (EMBL:AL021929) Mycobacterium tuberculosis nitrite reductase large subunit NirB, 853 aa; fasta scores: opt: 657 z-score: 711.6 E(): 3e-32; 37.8% identity in 431 aa overlap and to SW:NIRB_KLEPN (EMBL:L06800) Klebsiella pneumoniae nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4) NasB, 957 aa; fasta scores: opt: 636 z-score: 688.3 E(): 6e-3; 35.4% identity in 412 aa overlap. Contains possible N-terminal region signal peptide sequence. (410 aa)
SCO2180SC5F7.21, pdhL, probable dihydrolipoamide dehydrogenase, len: 486 aa; note possible downstream translational start sites. Similar to many prokaryote and eukaryote egs. TR:Q9Z6I5 (EMBL: AF047034) dihydrolipoamide dehydrogenase from Streptomyces seoulensis (462 aa) fasta scores; opt: 2780, z-score: 3088.0, E(): 0, (90.3% identity in 462 aa overlap), TR:Q54101 (EMBL:L38646) NADH ferredoxin oxidoreductase from Saccharopolyspora erythraea (456 aa) fasta scores; opt: 1918, z-score: 2131.8, E(): 0, (64.2% identity in 452 aa overlap) and SW:DLDH_PEA dihydrolipoamide dehydrogenase from Pisum sa [...] (486 aa)
SCO2106SC2C1A.02c, possible oxidoreductase, len: 407 aa. Highly similar to several reductases including: Rhodococcus sp. (strain NI86/21) SW:THCD_RHOSN(EMBL:U17130) rhodocoxin reductase (EC 1.18.1.-) (426 aa), fasta scores opt: 792 z-score: 833.9 E():0 36.9% identity in 412 aa overlap and Sphingomonas sp. TR:O65946(EMBL:AJ002606) reductase, RedA2, protein (409 aa), fasta scores opt:794 z-score: 836.2 E():0 40.1% identity in 409 aa overlap. (407 aa)
SCO0158SCJ1.07, probable oxidoreductase, len: 409 aa; similar to e.g. Synechocystis sp. (strain PCC 6803) TR:P73735 (EMBL:D90909) NADH dehydrogenase (404 aa), fasta scores opt: 358 z-score: 399.1 E(): 7.1e-15 28.9% identity in 353 aa overlap and Rhodococcus globerulus TR:Q57031(EMBL:X80041) ferredoxin reductase BPH (412 aa), fasta scores opt:294 z-score: 328.8 E(): 5.9e-11 31.3% identity in 358 aa overlap. (409 aa)
SCO7319Putative oxidoreductase; SC5F8.29c, possible oxidoreductase, len: 481 aa. Similar to many dehydrogenases including: Escherichia coli SW:DHNA_ECOLI(EMBL:V00306) NADH dehydrogenase (EC 1.6.99.3) (433 aa), fasta scores opt: 438 z-score: 509.8 E(): 6.4e-21 26.3% identity in 384 aa overlap and Streptomyces coelicolor TR:Q9ZC17(EMBL:AL033505) putative dehydrogenase, SC1E6.05 (629 aa), fasta scores opt: 1148 z-score: 1329.8 E(): 0 44.3% identity in 420 aa overlap. Contains a Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Note codon 27 may offer an altern [...] (481 aa)
SCO6762SC6A5.11, possible phytoene dehydrogenase, len: 478aa; similar to many from eukaryotes eg. SW:CRTI_CAPAN phytoene dehydrogenase precursor from Capsicum annuum (bell pepper) (582 aa) fasta scores; opt: 276, z-score: 302.1, E(): 1.6e-09, (24.0% identity in 459 aa overlap). Also similar to prokaryotes eg. TR:P72449 (EMBL:X95596) proposed dehydrogenase from a cryptic carotenoid biosynthesis cluster in Streptomyces griseus (517 aa) fasta scores; opt: 206, z-score: 226.8, E(): 2.5e-05, (29.7% identity in 512 aa overlap). (478 aa)
SCO6496SC1E6.05, probable dehydrogenase, len: 629 aa; similar to e.g. Mycobacterium smegmatis TR:O52473 (EMBL:AF038423) NADH dehydrogenase (457 aa), fasta scores; opt: 499 z-score: 263.3 E(): 2.2e-07, 31.2% identity in 417 aa overlap. Contains 6x degenerate repeats of the sequence KNQPGGEP(A /G)= (P-loop). (629 aa)
SCO7117SC4B10.18c, probable ferredoxin reductase, len: 420 aa; similar to TR:BAA94714 (EMBL:AB031319) Nocardioides sp. ferredoxin reductase PhdD, 414 aa; fasta scores: opt: 928 z-score: 1051.4 E(): 0; 40.0% identity in 420 aa overlap, to SW:THCD_RHOER (EMBL:U17130) Rhodococcus erythropolis rhodocoxin reductase (EC 1.18.1.-) ThcD, 426aa; fasta scores: opt: 853 z-score: 966.6 E(): 0; 39.5% identity in 370 aa overlap and to TR:CAB69757 (EMBL:AL137187) Streptomyces coelicolor putative reductase SC7A8.08c, 421 aa; fasta scores: opt: 830 z-score: 732.2 E(): 0; 50.8% identity in 415 aa overlap. Cont [...] (420 aa)
SCO7101SC4B10.02, probable dehydrogenase, len: 451 aa; similar to SW:DHNA_ECOLI (EMBL:V00306) Escherichia coli NADH dehydrogenase (EC 1.6.99.3) Ndh, 433 aa; fasta scores: opt: 472 z-score: 552.4 E(): 2.7e-23; 31.6% identity in 377 aa overlap. (451 aa)
SCO4119SCD72A.05, possible NADH dehydrogenase, len: 442aa; similar to many eg. TR:Q9ZC17 (EMBL:AL033505) putative dehydrogenase from Streptomyces coelicolor SC1E6.05 (629 aa) fasta scores; opt: 893, z-score: 1049.2, E(): 0, 38.5% identity in 452 aa overlap and SW:P00393 (DHNA_ECOLI) NADH dehydrogenase Ndh (EC 1.6.99.3) from Escherichia coli (433 aa) fasta scores; opt: 404, z-score: 477.0, E(): 4.2e-19, 27.0% identity in 389 aa overlap. (442 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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