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SCO4146 SCO4146 SCO3736 SCO3736 SCO3715 SCO3715 SCO4452 SCO4452 SCO0942 SCO0942 SCO4757 SCO4757 SCO4769 SCO4769 SCO0866 SCO0866 SCO0864 SCO0864 SCO0803 SCO0803 SCO1723 SCO1723 SCO4938 SCO4938 SCO6239 SCO6239 SCO7105 SCO7105 SCO7112 SCO7112 SCO7192 SCO7192 SCO7278 SCO7278 SCO3626 SCO3626 SCP1.151c SCP1.151c SCO0159 SCO0159 SCO0037 SCO0037 SCO3323 SCO3323 SCO4409 SCO4409 SCO3892 SCO3892 SCO0600 SCO0600 SCO4864 SCO4864 SCO4866 SCO4866 SCO0414 SCO0414 SCO4895 SCO4895
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO4146SCD84.13, probable ECF subfamily sigma factor, len: 180 aa; similar to TR:Q9WWP4 (EMBL:AF121850) Synechococcus sp. SigH, 199 aa; fasta scores: opt: 273 z-score: 333.6 E(): 4e-11; 37.4% identity in 163 aa overlap and to TR:O05767 (EMBL:U87307) Mycobacterium smegmatis extracytoplasmic function alternative sigma factor, SigE, 204 aa; fasta scores: opt: 261 z-score: 319.3 E(): 2.5e-10; 33.5% identity in 188 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (180 aa)
SCO3736SCH22A.14c, probable RNA polymerase ECF sigma factor, len: 163 aa; similar to SW:RPOE_STRCO (EMBL:L29636) Streptomyces coelicolor RNA polymerase sigma-E factor SigE, 176 aa; fasta scores: opt: 214 z-score: 282.2 E(): 2.7e-08; 32.7% identity in 159 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (163 aa)
SCO3715SCH35.09, possible ECF sigma factor, len: 223aa; similar to many egs. TR:O53378 (EMBL:AL021841) putative sigma factor from Mycobacterium tuberculosis (312 aa) fasta scores; opt: 357, z-score: 418.3, E(): 5.7e-16, (33.2% identity in 226 aa overlap) and SW:RPOE_STRCO sigma factor E from Streptomyces coelicolor (176 aa) fasta scores; opt: 131, z-score: 162.5, E(): 0.1, (33.3% identity in 114 aa overlap). NB. Overlaps with downstream CDS. (223 aa)
SCO4452Putative RNA polymerase sigma factor; SCD6.30c, hypothetical protein, len: 383 aa; similar to TR:O86798 (EMBL:AL031317) Streptomyces coelicolor hypothetical 45.7 kD protein SC6G4.35, 419 aa; fasta scores: opt: 312 z-score: 358.2 E(): 1.7e-12; 42.3% identity in 404 aa overlap and to many putative RNA polymerase sigma facotrs, e.g. TR:Q984U6 (EMBL:AP003012) Rhizobium loti (Mesorhizobium loti) sigma-70 factor, ECF subfamily MLL7837 417 aa; fasta scores: opt: 535 Z-score: 594.4 E(): 1.8e-25; 43.325% identity in 397 aa overlap. (383 aa)
SCO0942SCM10.30, possible RNA polymerase sigma factor, len: 184 aa; similar to various sigma factors, e.g. TR:O53798 (EMBL:AL021958) Mycobacterium tuberculosis, and Mycobacterium bovis RNA polymerase sigma factor SigJ, 177 aa; fasta scores: opt: 364 z-score: 454.2 E(): 6.6e-18; 42.0% identity in 174 aa overlap, to TR:O86856 (EMBL:AJ007313) Streptomyces coelicolor sigma factor SigT, 236 aa; fasta scores: opt: 235 z-score: 295.6 E(): 4.5e-09; 35.4% identity in 161 aa overlap, to SW:RPSC_MYCTU (EMBL:Z73966) Mycobacterium tuberculosis probable RNA polymerase sigma-C factor SigC, 185 aa; fasta sco [...] (184 aa)
SCO4757Conserved hypothetical protein; SC6G4.35, unknown, len: 419 aa; similar to hypotheti cal protein from Rhizobium meliloti TR:Q52997 (EMBL:L39265) (66 aa, partial) opt: 154 z-score: 162.6 E(): 0.086, 40.0% identity in 50 aa overlap. N-terminus is weakly similar to several sigma factors e.g. CARQ_MYXXA RNA polymerase sigma factor carQ (174 aa), fasta scores; opt: 153 z-score: 172. 4 E(): 0.024, 29.8% identity in 161 aa overlap. (419 aa)
SCO4769SCD63.01, ECF sigma factor, len: 195 aa; identical to previously sequenced TR:O86843 (EMBL:AJ010601) Streptomyces coelicolor ECF sigma factor, 195 aa; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa)
SCO0866SCM2.19c, probable ECF-family sigma factor, len: 213 aa. Highly similar to many sigma factors including: Streptomyces coelicolor TR:O86856 (EMBL:AJ007313) sigma factor SigT (236 aa), fasta scores opt: 292 z-score: 354.1 E(): 2.4e-12 35.7% identity in 185 aa overlap and Mycobacterium tuberculosis SW:RPSC_MYCTU(EMBL:Z73966) probable RNA polymerase sigma-C factor SigC (185 aa), fasta scores opt: 530 z-score: 636.2 E(): 4.6e-28 51.7% identity in 178 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 68.5 % identity, in 197 aa overlap, with the upstream gene, SCM [...] (213 aa)
SCO0864SCM2.17c, probable ECF-family sigma factor, len: 198 aa. Highly similar to many sigma factors including: Streptomyces coelicolor TR:O86856 (EMBL:AJ007313) sigma factor SigT (236 aa), fasta scores opt: 268 z-score: 337.2 E(): 2.1e-11 34.3% identity in 181 aa overlap and Mycobacterium tuberculosis SW:RPSC_MYCTU (EMBL:Z73966) probable RNA polymerase sigma-C factor SigC (185 aa), fasta scores opt: 517 z-score: 643.3 E(): 1.9e-28 50.8% identity in 177 aa overlap. Note this CDS appears to be a duplicated on this cosmid and shares 68.5 % identity, in 197 aa overlap, with the downstream gene, [...] (198 aa)
SCO0803SCF43.14c, possible RNA polymerase sigma factor, len: 330 aa. Similar to Mycobacterium smegmatis TR:O05767 (EMBL:U87307) extracytoplasmic function alternative sigma factor SigE (204 aa), fasta scores opt: 234 z-score: 278.1 E(): 4.1e-08 29.1% identity in 175 aa overlap. Also highly similar to many other putative sigma factors e.g. Streptomyces coelicolor TR:Q9X8P3 (EMBL:AL049754) putative RNA polymerase sigma factor SCH10.04C (294 aa), fasta scores opt: 915 z-score: 1056.2 E():0 52.9% identity in 293 aa overlap. (324 aa)
SCO1723SCI11.12c, possible RNA polymerase sigma factor, len: 185 aa; weakly similar to RNA polymerase sigma factors e.g. SW:CARQ_MYXXA (EMBL:X71062), CarQ, Myxococcus xanthus RNA polymerase sigma factor (174 aa), fasta scores; opt: 233 z-score: 295.7 E(): 3.9e-09, 29.3% identity in 167 aa overlap. Similar to many putative sigma factors e.g. TR:O53730 (EMBL:AL021932), SigK, Mycobacterium tuberculosis probable RNA polymerase sigma factor (187 aa) (51.4% identity in 173 aa overlap). Similar to others from S.coelicolor e.g. TR:O54163 (EMBL:AL021411) S. coelicolor possible sigma factor (200 aa) (3 [...] (185 aa)
SCO4938SCK13.30, possible ECF-sigma factor, len: 304 aa; similar to TR:Q9RJS2 (EMBL:AL132707) Streptomyces coelicolor putative RNA polymerase sigma factor SCF51.13c, 298 aa; fasta scores: opt: 1110 z-score: 1299.2 E(): 0; 58.4% identity in 296 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 144..165 (+2.59 SD). (304 aa)
SCO6239SCAH10.04c, possible sigma factor, len: 322 aa; similar to TR:CAB42013 (EMBL:AL049754) Streptomyces coelicolor putative sigma factor, SCH10.04c, 294 aa; fasta scores: opt: 379 z-score: 438.7 E(): 4.6e-17; 34.7% identity in 291 aa overlap and to (EMBL:AL132707) Streptomyces coelicolor SCF51.13c, 298 aa; fasta scores: opt: 833 z-score: 802.7 E(): 0; 44.9% identity in 305 aa overlap; Belongs to the sigma-70 factor family. (322 aa)
SCO7105SC4B10.06c, possible RNA polymerase sigma factor, len: 301 aa; similar to TR:Q9S1V5 (EMBL:AL109950) Streptomyces coelicolor putative sigma factor SCJ24.18c, 250 aa; fasta scores: opt: 877 z-score: 1049.7 E(): 0; 54.7% identity in 236 aa overlap and to Streptomyces coelicolor St4B10.13c, 298; fasta scores: opt: 1112 z-score: 1131.2 E(): 0; 57.3% identity in 288 aa overlap. Also contains a possible helix-turn-helix motif at residues 133..154 (+3.38 SD); Belongs to the sigma-70 factor family. (301 aa)
SCO7112SC4B10.13c, probable ECF-family RNA polymerase sigma factor, len: 298 aa; similar to TR:Q9S1V5 (EMBL:AL109950) Streptomyces coelicolor putative sigma factor SCJ24.18c, 250 aa; fasta scores: opt: 1127 z-score: 1362.0 E(): 0; 72.8% identity in 243 aa overlap and to Streptomyces coelicolor SC4B10.06c, 301 aa; fasta scores: opt: 1112 z-score: 1158.1 E(): 0; 57.3% identity in 288 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (298 aa)
SCO7192SC8A11.20, possible sigma factor, len: 221 aa; similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor putative sigma factor SCC57A.13c, 315 aa; fasta scores: opt: 381 z-score: 442.9 E(): 3.4e-17; 39.9% identity in 178 aa overlap; Belongs to the sigma-70 factor family. (221 aa)
SCO7278SC5H1.14, probable RNA polymerase sigma factor, len: 295 aa; similar to many e.g. SW:RPOF_STRCO (EMBL:L11648), SigF, RpoX, Streptomyces coelicolor RNA polymerase sigma-F factor (287 aa), fasta scores; opt: 707 z-score: 817.4 E(): 0, 43.6% identity in 282 aa overlap. Contains probable helix-turn-helix motif at aa 258-279 (Score 2096, +6.33 SD). Contains Pfam match to entry PF00140 sigma70, Sigma-70 factors, score 230.40, E-value 2.6e-65 and PS00715 Sigma-70 factors family signature 1. (295 aa)
SCO3626SCH10.04c, probable RNA polymerase sigma factor, len: 294 aa; similar to many e.g. TR:O05735 (EMBL:U87308) SigE, Mycobacterium avium extracytoplasmic function alternative sigma factor (251 aa), fasta scores; opt: 226 z-score: 266.2 E(): 1.6e-07, 29.8% identity in 168 aa overlap; Belongs to the sigma-70 factor family. (294 aa)
SCP1.151cSCP1.151c, possible sigma factor, len: 174aa; weakly similar to many eg. TR:Q9X8Z1 (EMBL:AL078610) putative ECF sigma factor from Streptomyces coelicolor (184 aa) fasta scores; .opt: 187, z-score: 235.0, E(): 1.3e-05, 28.0% identity in 164 aa overlap and TR:O05767 (EMBL:U87307) SigE, extracytoplasmic function alternative sigma factor from Mycobacterium smegmatis (204 aa) fasta scores; opt: 160, z-score: 202.2, E(): 0.00085, 27.8% identity in 187 aa overlap; Belongs to the sigma-70 factor family. (174 aa)
SCO0159SCJ1.08 putative ECF sigma factor, len: 322 aa, similar to many e.g. S. coelicolor TR:CAB44418 (EMBL:AL078610) putative ECF sigma factor SCH35.09 (223 aa) fasta scores, opt: 656 z-score: 777.0 E(): 0 64.6% identity in 175 aa overlap and Mycobacterium tuberculosis SIGI protein TR:O50445 (EMBL; AL010186)(290 aa), fasta scores opt: 385 z-score: 458.0 E(): 3.7e-18 30.0% identity in 290 aa overlap. Contains a Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Possible helix-turn-helix motif between 142-163 aa, score +4.11 SD. (322 aa)
SCO0037SCJ4.18c, possible sigma factor, len: 250 aa; similar to many proposed sigma factors e.g. TR:CAB44418 (EMBL:AL078610) putative sigma factor from Streptomyces coelicolor (223 aa) fasta scores; opt: 419, z-score: 506.3, E(): 7.7e-21, (44.3% identity in 183 aa overlap) and SW:SIGY_BACSU RNA polymerase sigma factor, SigY from Bacillus subtilis (178 aa) fasta scores; opt: 111, z-score: 142.5, E(): 1.4, (23.9% identity in 117 aa overlap). Note possible framshift from previous CDS as similar to all but the N-terminus of TR:CAB42013 (EMBL:AL049754) putative RNA polymerase sigma factor from Str [...] (250 aa)
SCO3323SCE68.21, probable RNA polymerase sigma factor, len: 177 aa; similar to many members of the extracytoplasmic function sigma factor family e.g. SW:CARQ_MYXXA (EMBL:X71062), CarQ, Myxococcus xanthus RNA polymerase sigma factor (174 aa), fasta scores; opt: 237 z-score: 281.3 E(): 2.4e-08, 32.0% identity in 169 aa overlap. Similar to others from S. coelicolor e.g. TR:O54163 (EMBL:AL021411), SC7H1.04, possible sigma factor (200 aa) (30.8% identity in 172 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (177 aa)
SCO4409SC6F11.07c, possible RNA polymerase sigma factor, len: 197 aa; similar to SW:SIGZ_BACSU (EMBL:U93875) Bacillus subtilis RNA polymerase sigma factor SigZ, 176 aa; fasta scores: opt: 166 z-score: 208.5 E(): 0.00041; 27.0% identity in 148 aa overlap; Belongs to the sigma-70 factor family. ECF subfamily. (197 aa)
SCO3892SCH24.14c, sigT, probable RNA polymerase sigma factor, len: 236 aa; previously sequenced as TR:O86856 (EMBL:AJ007313), SigT. Similar to other S.coelicolor putative sigma factors TR:O54163 (EMBL:AL021411) possible sigma factor (200 aa) (32.2% identity in 199 aa overlap) and SCH10.35 putative RNA polymerase sigma factor from cosmid StH10 (294 aa) (37.7% identity in 159 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 57.10, E-value 3.8e-13. (236 aa)
SCO0600RNA polymerase sigma factor sig8; SCF55.24, sig8, len: 266 aa; identical to previously sequenced TR:CAB55833 (EMBL:AJ249580) Streptomyces coelicolor Sig8 protein, 266 aa and similar to SW:RPOF_STRCO (EMBL:L11648) Streptomyces coelicolor RNA polymerase sigma-F factor, SigF, 287 aa; fasta scores: opt: 759 z-score: 872.2 E(): 0; 47.6% identity in 269 aa overlap and to Streptomyces coelicolor putative RNA polymerase sigma factor SC5H1.14, 295 aa; fasta scores: opt: 1265 z-score: 1335.0 E(): 0; 73.8% identity in 263 aa overlap. Contains match to Pfam entry PF00140 sigma70, Sigma-70 factor a [...] (281 aa)
SCO4864SCK20.05, possible ECF sigma factor, len: 225 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 296 z-score: 342.7 E(): 1.5e-11; 34.0% identity in 212 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.07, 220 aa; fasta scores: opt: 671 z-score: 656.4 E(): 6.9e-31; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (225 aa)
SCO4866SCK20.07, possible ECF sigma factor, len: 220 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 280 z-score: 329.1 E(): 8.5e-11; 31.9% identity in 182 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.05, 225 aa; fasta scores: opt: 671 z-score: 614.8 E(): 1.4e-28; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (220 aa)
SCO0414SCF51.13c, possible RNA polymerase sigma factor, len: 298 aa; similar to TR:CAB42013 (EMBL:AL049754) Streptomyces coelicolor putative RNA polymerase sigma factor SCH10.4c, 294aa; fasta scores: opt: 614 z-score: 721.0 E(): 8.7e-33; 41.4% identity in 285 aa overlap and to TR:O86856 (EMBL:AJ007313) Streptomyces coelicolor sigma factor, SigT, 236aa; fasta scores: opt: 160 z-score: 194.6 E(): 0.0018; 31.0% identity in 158 aa overlap; Belongs to the sigma-70 factor family. (298 aa)
SCO48952SCK8.21c, possible ECF sigma factor, len: 334 aa; similar to TR:O07426 (EMBL:Z97050) Mycobacterium tuberculosis RNA polymerase sigma subunit MTCI28.22c, 370 aa; fasta scores: opt: 818 z-score: 941.2 E(): 0; 44.7% identity in 318 aa overlap and to TR:Q9K3H7 (EMBL:AL390188) Streptomyces coelicolor putative ECF-sigma factor 2SCG18.10c, 295 aa; fasta scores: opt: 219 z-score: 257.6 E(): 8.8e-07; 31.8% identity in 314 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 159..180 (+4.07 SD). (334 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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