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SCO2378 SCO2378 SCO0140 SCO0140 SCO0159 SCO0159 SCO0557 SCO0557 SCO1263 SCO1263 SCO1697 SCO1697 SCO2875 SCO2875 SCO3173 SCO3173 SCO3275 SCO3275 SCO3356 SCO3356 SCO3709 SCO3709 SCO3715 SCO3715 SCO4102 SCO4102 SCO4443 SCO4443 SCO4477 SCO4477 SCO4769 SCO4769 SCO4864 SCO4864 SCO4866 SCO4866 SCO4938 SCO4938 SCO5437 SCO5437 SCO5463 SCO5463 SCO7086 SCO7086 SCO7144 SCO7144 SCO7585 SCO7585 SCO7698 SCO7698
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO2378SC4A7.06c, possible merR-family transciptional regulator, len: 196 aa; similar to SW:TIPA_STRLI (EMBL:S64314) Streptomyces lividans transcriptional activator TipA, 253 aa; fasta scores: opt: 187 z-score: 225.2 E(): 3.7e-05; 32.7% identity in 110 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and a possible helix-turn-helix motif at residues 72..93 (+3.19 SD). (196 aa)
SCO0140SCJ33.04, possible merR-family transcriptional regulator, len: 275 aa. Similar to several e.g. Streptomyces coelicolor TR:CAB56383 (EMBL; AL118515) putative merR family transcriptional regulator SCD17.06C (319 aa), fasta scores opt: 164 z-score: 194.6 E(): 0.0018 28.9% identity in 298 aa overlap and Bacillus subtilis SW:BLTR_BACSU (EMBL; L32599) multidrug-efflux transporter 2 regulator (273 aa), fasta scores opt: 154 z-score: 184.2 E(): 0.0069 21.3% identity in 253 aa overlap. Contains a Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family. Contains a possible h [...] (275 aa)
SCO0159SCJ1.08 putative ECF sigma factor, len: 322 aa, similar to many e.g. S. coelicolor TR:CAB44418 (EMBL:AL078610) putative ECF sigma factor SCH35.09 (223 aa) fasta scores, opt: 656 z-score: 777.0 E(): 0 64.6% identity in 175 aa overlap and Mycobacterium tuberculosis SIGI protein TR:O50445 (EMBL; AL010186)(290 aa), fasta scores opt: 385 z-score: 458.0 E(): 3.7e-18 30.0% identity in 290 aa overlap. Contains a Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Possible helix-turn-helix motif between 142-163 aa, score +4.11 SD. (322 aa)
SCO0557SCF73.04, probable transcriptional regulator, len: 340 aa; similar in N-terminus to members of the MerR family e.g. NOLA_BRASN nodulation protein NOLA (237 aa), fasta scores; opt: 211 z-score: 233.9 E(): 1.2e-05, 48.5% identity in 68 aa overlap. Also similar to SCD17.06c (34.8% identity in 322 aa overlap). Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family. (340 aa)
SCO12632SCG18.10c, probable ECF-sigma factor, len: 295 aa; similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor putative sigma factor SCC57A.13c, 315 aa; fasta scores: opt: 887 z-score: 1027.2 E(): 0; 50.5% identity in 285 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (295 aa)
SCO1697SCI30A.18c, probable merR-family transcriptional regulator, len: 175aa; similar to many egs. TR:CAA09641 (EMBL:AJ011500) from Streptomyces violaceoruber Tu22 (196 aa) fasta scores; opt: 698, z-score: 833.1, E(): 0, (64.1% identity in 167 aa overlap) and SW:SOXR_ECOLI SoxR transcriptional regulator from Escherichia coli (154 aa) fasta scores; opt: 575, z-score: 689.9, E(): 4.3e-31, (60.3% identity in 146 aa overlap). Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family. (175 aa)
SCO2875SCE6.12, possible MerR-family transcriptional regulator, len: 135 aa. Similar to many regulators e.g. Haemophilus influenzae SW:Y186_HAEIN(EMBL:U32704) hypothetical transcriptional regulator (135 aa), fasta scores opt: 233 z-score: 315.6 E(): 3.8e-10 33.9% identity in 121 aa overlap. Also similar to Streptomyces coelicolor TR:CAB62710(EMBL:AL133423) putative MerR-family transcriptional regulator, SC4A7.06C (196 aa), fasta scores opt: 295 z-score: 393.5 E(): 1.7e-14 41.2% identity in 119 aa overlap. Contains a Prosite hit to PS00552 Bacterial regulatory proteins, merR family signature a [...] (135 aa)
SCO3173SCE87.24, possible merR-family transcriptional regulator, len: 215 aa. Similar to two other putative transcriptional regulators from Streptomyces coelicolor TR:CAB40683 (EMBL:AL049587) SC5F2A.16C (251 aa), fasta scores opt: 210 z-score: 257.9 E(): 5.4e-07 32.3% identity in 217 aa overlap and TR:O86531 (EMBL:AL031124) SC1C2.31C (214 aa), fasta scores opt: 176 z-score: 218.8 E(): 8.2e-05 30.4% identity in 191 aa overlap. Contains a Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family with the putative helix-turn-helix motif situated between residues 8..29 (+3.90 SD). (215 aa)
SCO3275SCE39.25c, possible merR-family transcriptional regulator, len: 150 aa; similar to many e.g. SW:MERR_BACSR MerR, mercury resistance operon transcriptional regulator from Bacillus subtilis (132 aa) fasta scores; opt: 201, z-score: 245.2, E(): 2.4e-06, (40.3% identity in 77 aa overlap) and SW:TIPA_STRLI TipA, transcriptional activator of a thiostrepton-induced gene in Streptomyces lividans (253 aa) fasta scores; opt: 196, z-score: 235.4, E(): 8.4e-06, (35.5% identity in 107 aa overlap). Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and Prosite matc [...] (150 aa)
SCO3356ECF sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is required for normal cell wall integrity; it is recruited by RNA polymerase to transcribe genes with cell wall- related functions. It is also involved in the transcription of the dagA gene coding for an extracellular agar-degrading enzyme. (177 aa)
SCO3709SCH35.15, possible ECF sigma factor, len: 184 aa; similar to many e.g. SW:RPOE_STRCO sigma E from Streptomyces coelicolor (176 aa) fasta scores; opt: 216, z-score: 250.5, E(): 1.3e-06, (29.2% identity in 161 aa overlap); Belongs to the sigma-70 factor family. (184 aa)
SCO3715SCH35.09, possible ECF sigma factor, len: 223aa; similar to many egs. TR:O53378 (EMBL:AL021841) putative sigma factor from Mycobacterium tuberculosis (312 aa) fasta scores; opt: 357, z-score: 418.3, E(): 5.7e-16, (33.2% identity in 226 aa overlap) and SW:RPOE_STRCO sigma factor E from Streptomyces coelicolor (176 aa) fasta scores; opt: 131, z-score: 162.5, E(): 0.1, (33.3% identity in 114 aa overlap). NB. Overlaps with downstream CDS. (223 aa)
SCO4102SCD17.06c, possible MerR family transcriptional regulator, len:319 aa. Similar to many other MerR family regulators e.g. Bradyrhizobium sp. (strain NC92) SW:NOLA_BRASN (EMBL; U33192) nodulation protein NolA (237 aa), fasta scores opt: 251 z-score: 286.3 E(): 1.4e-08 28.9% identity in 225 aa overlap. Contains a Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and a probable helix-turn-helix motif between residues 9..30 (+3.43 SD). (319 aa)
SCO4443SCD6.21c, possible merR-family transcriptional regulator, len: 294 aa; similar to TR:AAF11989 (EMBL:AE002074) Deinococcus radiodurans transcriptional regulator, merR-family DR2448, 280 aa; fasta scores: opt: 465 z-score: 562.4 E(): 7.3e-24; 43.0% identity in 286 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and match to Prosite entry PS00552 Bacterial regulatory proteins, merR family signature. (294 aa)
SCO4477SCD65.20c, probable merR-family transcriptional regulatory protein, len: 238 aa; presents two hits to TR:Q9RKM5 (EMBL:AL138978) Streptomyces coelicolor putative merR family transcriptional regulator SCD17.06c, 319 aa; blastp scores for N-terminal domain: Score= 143 (50.3 bits), Expect= 7.3e-08, P= 7.3e-08; Identities= 42/108 (38%), Positives= 57/108 (52%) and blastp scores for C-terminal domain: Score= 102 (35.9 bits), Expect= 0.0052, P= 0.0052; Identities= 33/96 (34%), Positives= 45/96 (46%). Contains 2x Pfam matches to entry PF00376 merR, Bacterial regulatory proteins, merR family an [...] (238 aa)
SCO4769SCD63.01, ECF sigma factor, len: 195 aa; identical to previously sequenced TR:O86843 (EMBL:AJ010601) Streptomyces coelicolor ECF sigma factor, 195 aa; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa)
SCO4864SCK20.05, possible ECF sigma factor, len: 225 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 296 z-score: 342.7 E(): 1.5e-11; 34.0% identity in 212 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.07, 220 aa; fasta scores: opt: 671 z-score: 656.4 E(): 6.9e-31; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (225 aa)
SCO4866SCK20.07, possible ECF sigma factor, len: 220 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 280 z-score: 329.1 E(): 8.5e-11; 31.9% identity in 182 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.05, 225 aa; fasta scores: opt: 671 z-score: 614.8 E(): 1.4e-28; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (220 aa)
SCO4938SCK13.30, possible ECF-sigma factor, len: 304 aa; similar to TR:Q9RJS2 (EMBL:AL132707) Streptomyces coelicolor putative RNA polymerase sigma factor SCF51.13c, 298 aa; fasta scores: opt: 1110 z-score: 1299.2 E(): 0; 58.4% identity in 296 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 144..165 (+2.59 SD). (304 aa)
SCO5437SC6A11.13, possible MerR-family transcriptional regulator, len: 132 aa; similar to many e.g. TR:Q9X5V4 (EMBL:AF127795) heavy metal regulator HmrR from Rhizobium leguminosarum (biovar viciae) (129 aa) fasta scores; opt: 228, z-score: 295.1, E(): 5e-09, 35.7% identity in 129 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and possible helix-turn-helix motif score 1747 (+5.14 SD) in ID at residue 1. (132 aa)
SCO5463SC3D11.20, possible MerR-family transcriptional regulator, len: 304 aa; similar to many e.g. TRNEW:CAB56383 (EMBL:AL118515) putative MerR-family transcriptional regulator from Streptomyces coelicolor (319 aa) fasta scores; opt: 622, z-score: 719.6, E(): 1.2e-32, 41.3% identity in 310 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family. (304 aa)
SCO7086SC3A4.12c, possible MerR-family transcriptional regulator, len: 115 aa. Similar to many regulators including: Thiobacillus ferrooxidans SW:MERR_THIFE (EMBL:M57717) mercuric resistance operon regulatory protein (fragment) (122 aa), fasta scores opt: 166 z-score: 229.9 E(): 2.4e-05 33.0% identity in 106 aa overlap. Conatins a Prosite hit to PS00552 Bacterial regulatory proteins, merR family signature and a Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family with a putative helix-turn-helix motif situated between residues 4..25 (+4.59 SD). (115 aa)
SCO7144SC9A4.06, possible ECF sigma factor, len: 245 aa; similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor putative sigma factor SCC57A.13c, 315 aa; fasta scores: opt: 395 z-score: 475.1 E(): 5.3e-19; 35.0% identity in 197 aa overlap and to SW:RPSH_PSEAE (EMBL:L14760) Pseudomonas aeruginosa RNA polymerase sigma-H factor AlgU, 193 aa; fasta scores: opt: 143 z-score: 180.2 E(): 0.014; 26.0% identity in 177 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (245 aa)
SCO7585SC5F1.39c, probable merR-family transcriptional regulator, len: 132 aa; similar to SW:SOXR_PSEAE (EMBL:X95517) Pseudomonas aeruginosa SoxR protein, 156 aa; fasta scores: opt: 205 z-score: 264.7 E(): 3.3e-07; 36.8% identity in 117 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and match to Prosite entry PS00552 Bacterial regulatory proteins, merR family signature and possible helix-turn-helix at residues 12..33 (+4.37 SD). (132 aa)
SCO7698SC1A4.06c, probable merR-family transcriptional regulator, len: 380 aa; N-terminal region similar to SW:TIPA_STRLI (EMBL:S64314) Streptomyces lividans transcriptional activator TipA, 253 aa; fasta scores: opt: 404 z-score: 467.3 E(): 1.7e-18; 40.0% identity in 185 aa overlap and C-terminal region similar to TR:O87011 (EMBL:U93274) Pseudomonas aeruginosa hypothetical protein YafE, 187 aa; blastp scores: Score= 121 (42.6 bits), Expect= 1.6e-05, P= 1.6e-05; Identities= 51/144 (35%), Positives= 72/144 (50%). Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR fam [...] (380 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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