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SCO6924 SCO6924 SCO7774 SCO7774 SCO7791 SCO7791 SCO0098 SCO0098 SCO3356 SCO3356 SCO3404 SCO3404 SCO3466 SCO3466 SCO3709 SCO3709 SCO3715 SCO3715 SCO3892 SCO3892 SCO3926 SCO3926 SCO4035 SCO4035 SCO4423 SCO4423 SCO4426 SCO4426 SCO4722 SCO4722 SCO4769 SCO4769 SCO4777 SCO4777 SCO4864 SCO4864 SCO4866 SCO4866 SCO4938 SCO4938 SCO5587 SCO5587 SCO5621 SCO5621 SCO5663 SCO5663 SCO5750 SCO5750 SCO5820 SCO5820 SCO6266 SCO6266 SCO7144 SCO7144 SCO0159 SCO0159 SCO0445 SCO0445 SCO0734 SCO0734 SCO1060 SCO1060 SCO1263 SCO1263 SCO1489 SCO1489 SCO1513 SCO1513 SCO1632 SCO1632 SCO1633 SCO1633 SCO1857 SCO1857 SCO1864 SCO1864 SCO1867 SCO1867 SCO1950 SCO1950 SCO2082 SCO2082 SCO2083 SCO2083 SCO2085 SCO2085 SCO2611 SCO2611 SCO2792 SCO2792 SCO2906 SCO2906 SCO2927 SCO2927 SCO3005 SCO3005 SCO3229 SCO3229 SCO3255 SCO3255
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO6924SC1B2.30c, possible DNA-binding protein, len: 298 aa. Contains a helix-turn-helix motif situated between residues 66..87 (+2.59 SD). (298 aa)
SCO7774SC5E9.22, possible secreted protein, len: 213aa; region similar to many eg. SW:P96463 (ABFB_STRLI) alpha-L-arabinofuranosidase precursor from Streptomyces lividans (475 aa) fasta scores; opt: 171, z-score: 209.1, E(): 0.00036, 32.2% identity in 177 aa overlap. Contains a possible N-terminal signal sequence. Similar to neighbouring CDS SC5E9.23 fasta scores; opt: 371, z-score: 401.0, E(): 1.1e-16, 42.2% identity in 173 aa overlap. (213 aa)
SCO7791SC5E9.38c, possible secreted oxidoreductase, len: 401 aa; similar to many e.g. TR:O53772 (EMBL:AL021942) putative oxidoreductase from Mycobacterium tuberculosis (388 aa) fasta scores; opt: 524, z-score: 584.4, E(): 4.4e-25, 32.4% identity in 373 aa overlap. Contains Pfam match to entry PF01360 Monooxygenase, Monooxygenase. (401 aa)
SCO0098SCJ11.27c, possible transposase, len: 279 aa; previously sequenced therefore identical to TR:Q9Z9H3 (EMBL:AB024596) putative transposase from Streptomyces coelicolor (279 aa) fasta scores; opt: 1839, z-score: 2190.6, E(): 0, (99.6% identity in 279 aa overlap). Also similar to many others eg. TR:Q48339 (EMBL:M80805) from IS1031 of Acetobacter xylinum (278 aa) fasta scores; opt: 611, z-score: 732.8, E(): 0, (38.9% identity in 262 aa overlap). (279 aa)
SCO3356ECF sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is required for normal cell wall integrity; it is recruited by RNA polymerase to transcribe genes with cell wall- related functions. It is also involved in the transcription of the dagA gene coding for an extracellular agar-degrading enzyme. (177 aa)
SCO3404Cell division protein ftsH homolog; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (668 aa)
SCO3466Transposase; SCE65.02, IS468B, transposase, len: 279 aa; identical to previously sequenced TR:BAA84088 (EMB:AB032065) Streptomyces coelicolor transposase IS468B-ORF, to Streptomyces coelicolor SCE65.03 and to Streptomyces coelicolor SCJ11.27c. Contains Pfam matches to entry PF01675 Transposase_13, Transposase and to entry PF01511 Transposase_6, Transposase. (279 aa)
SCO3709SCH35.15, possible ECF sigma factor, len: 184 aa; similar to many e.g. SW:RPOE_STRCO sigma E from Streptomyces coelicolor (176 aa) fasta scores; opt: 216, z-score: 250.5, E(): 1.3e-06, (29.2% identity in 161 aa overlap); Belongs to the sigma-70 factor family. (184 aa)
SCO3715SCH35.09, possible ECF sigma factor, len: 223aa; similar to many egs. TR:O53378 (EMBL:AL021841) putative sigma factor from Mycobacterium tuberculosis (312 aa) fasta scores; opt: 357, z-score: 418.3, E(): 5.7e-16, (33.2% identity in 226 aa overlap) and SW:RPOE_STRCO sigma factor E from Streptomyces coelicolor (176 aa) fasta scores; opt: 131, z-score: 162.5, E(): 0.1, (33.3% identity in 114 aa overlap). NB. Overlaps with downstream CDS. (223 aa)
SCO3892SCH24.14c, sigT, probable RNA polymerase sigma factor, len: 236 aa; previously sequenced as TR:O86856 (EMBL:AJ007313), SigT. Similar to other S.coelicolor putative sigma factors TR:O54163 (EMBL:AL021411) possible sigma factor (200 aa) (32.2% identity in 199 aa overlap) and SCH10.35 putative RNA polymerase sigma factor from cosmid StH10 (294 aa) (37.7% identity in 159 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 57.10, E-value 3.8e-13. (236 aa)
SCO3926SCQ11.09, ssgA, probable regulator, len: 136 aa; highly similar to TR:P95753 (EMBL:D50051), SsgA, Streptomyces griseus protein associated with sporulation and cell division (136 aa), fasta scores; opt: 715 z-score: 896.6 E(): 0, 77.9% identity in 136 aa overlap and similar to others from S.coelicolor e.g. SC5F2A.05c (EMBL:AL049587) possible regulator (138 aa) (35.7% identity in 115 aa overlap) and SC5H1.03 (EMBL:AL049863) possible regulator (142 aa) (2.5% identity in 114 aa overlap), both annotated by similarity to Streptomyces griseus SsgA. The start codon was selected by similarity t [...] (136 aa)
SCO4035RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is required for normal spore maturation. (287 aa)
SCO4423Serine/threonine protein kinase (fragment); Involved in the regulation of secondary metabolism by phosphorylating, on both Ser and Thr, the AfsR global regulatory protein involved in the control of secondary metabolism. (799 aa)
SCO4426Regulatory protein; Global regulatory protein for secondary metabolite formation. (993 aa)
SCO4722Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (437 aa)
SCO4769SCD63.01, ECF sigma factor, len: 195 aa; identical to previously sequenced TR:O86843 (EMBL:AJ010601) Streptomyces coelicolor ECF sigma factor, 195 aa; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa)
SCO4777SCD63.09, pkaD, protein serine/threonine kinase, len: 599 aa; identical to previously sequenced TR:O83032 (EMBL:AB016932) Streptomyces coelicolor protein serine/threonine kinase PkaD. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Serine/Threonine protein kinases active-site signature and possible hydrophobic membrane spanning region. (599 aa)
SCO4864SCK20.05, possible ECF sigma factor, len: 225 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 296 z-score: 342.7 E(): 1.5e-11; 34.0% identity in 212 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.07, 220 aa; fasta scores: opt: 671 z-score: 656.4 E(): 6.9e-31; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (225 aa)
SCO4866SCK20.07, possible ECF sigma factor, len: 220 aa; similar to TR:Q9RIT1 (EMBL:AJ010584) Streptomyces coelicolor ECF sigma factor, 264 aa; fasta scores: opt: 280 z-score: 329.1 E(): 8.5e-11; 31.9% identity in 182 aa overlap and to Streptomyces coelicolor putative ECF sigma factor SCK20.05, 225 aa; fasta scores: opt: 671 z-score: 614.8 E(): 1.4e-28; 59.5% identity in 185 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (220 aa)
SCO4938SCK13.30, possible ECF-sigma factor, len: 304 aa; similar to TR:Q9RJS2 (EMBL:AL132707) Streptomyces coelicolor putative RNA polymerase sigma factor SCF51.13c, 298 aa; fasta scores: opt: 1110 z-score: 1299.2 E(): 0; 58.4% identity in 296 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily) and possible helix-turn-helix motif at residues 144..165 (+2.59 SD). (304 aa)
SCO5587Cell division protein FtsH homolog; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (648 aa)
SCO5621RNA polymerase sigma factor WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (280 aa)
SCO5663SC3A9.04c, probable integral membrane protein, len: 226 aa; has highly proline-rich N-terminus and two possible transmembrane domains in the C-terminus. Similar to downstream ORF SC3A9.03c, fasta scores; E(): 6.5e-06, 41.0% identity in 134 aa overlap. (226 aa)
SCO5750ftsK homolog; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Belongs to the FtsK/SpoIIIE/SftA family. (929 aa)
SCO5820Major vegetative sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Its activity is stimulated by RbpA. (511 aa)
SCO6266SCAH10.31, scbA, len: 314 aa; identical to previously sequenced TR:O86851 (EMBL:AJ007731) Streptomyces coelicolor ScbA protein, 314 aa and to SW:AFSA_STRGR (EMBL:M24250) Streptomyces griseus possible A-factor biosynthesis enzyme AfsA, 301 aa; fasta scores: opt: 1345 z-score: 1570.4 E(): 0; 66.1% identity in 292 aa overlap. (314 aa)
SCO7144SC9A4.06, possible ECF sigma factor, len: 245 aa; similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor putative sigma factor SCC57A.13c, 315 aa; fasta scores: opt: 395 z-score: 475.1 E(): 5.3e-19; 35.0% identity in 197 aa overlap and to SW:RPSH_PSEAE (EMBL:L14760) Pseudomonas aeruginosa RNA polymerase sigma-H factor AlgU, 193 aa; fasta scores: opt: 143 z-score: 180.2 E(): 0.014; 26.0% identity in 177 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (245 aa)
SCO0159SCJ1.08 putative ECF sigma factor, len: 322 aa, similar to many e.g. S. coelicolor TR:CAB44418 (EMBL:AL078610) putative ECF sigma factor SCH35.09 (223 aa) fasta scores, opt: 656 z-score: 777.0 E(): 0 64.6% identity in 175 aa overlap and Mycobacterium tuberculosis SIGI protein TR:O50445 (EMBL; AL010186)(290 aa), fasta scores opt: 385 z-score: 458.0 E(): 3.7e-18 30.0% identity in 290 aa overlap. Contains a Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Possible helix-turn-helix motif between 142-163 aa, score +4.11 SD. (322 aa)
SCO0445SCF51A.23c, possible secreted protein, len: 405 aa. Contains a possible N-terminal signal sequence. (431 aa)
SCO07343SC5B7.12c, probable transcriptional repressor, len: 424 aa; similar to SW:MLC_ECOLI (EMBL:D32222) Escherichia coli transcriptional regulator Mlc protein, 406 aa; fasta scores: opt: 387 z-score: 414.7 E(): 1.4e-15; 24.1% identity in 344 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and possible helix-turn-helix motif at residues 64..85 (+6.19 SD). (424 aa)
SCO1060SCG22.06, probable transcriptional repressor, len: 413 aa; similar to TR:O05180 (EMBL:Z71474) Bacillus megaterium Xyl repressor XylR, 388 aa; fasta scores: opt: 382 z-score: 417.8 E(): 8.5e-16; 31.3% identity in 386 aa overlap and to TR:CAB61583 (EMBL:AL133210) Streptomyces coelicolor possible xylose repressor SCF37.02, 402 aa; fasta scores: opt: 586 z-score: 523.0 E(): 1.5e-23; 48.0% identity in 396 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and a possible helix-turn-helix motif at residues 35..56 (+3.03 SD). (413 aa)
SCO12632SCG18.10c, probable ECF-sigma factor, len: 295 aa; similar to TR:Q9RDI5 (EMBL:AL136519) Streptomyces coelicolor putative sigma factor SCC57A.13c, 315 aa; fasta scores: opt: 887 z-score: 1027.2 E(): 0; 50.5% identity in 285 aa overlap. Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). (295 aa)
SCO1489SC9C5.13, bldD, putative DNA-binding protein, len: 167 aa; identical to previously sequenced TR:O52732 (EMBL:AF045549) Streptomyces coelicolor putative DNA binding protein BldD, 167 aa. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (167 aa)
SCO1513GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. PppGpp could play an essential role in triggering antibiotic production under some nutritional conditions; Belongs to the RelA/SpoT family. (847 aa)
SCO1632Putative integral membrane protein SCI41.15c; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (316 aa)
SCO1633Putative secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (95 aa)
SCO1857SCI39.04, probable bifunctional protein (CbiGH), len: 583 aa; N-terminal region similar to SW:CBIG_SALTY (EMBL:L12006) Salmonella typhimurium involved in cobalamin synthesis CbiG protein, 351 aa; fasta scores: opt: 312 Z-score: 304.6 bits: 65.6 E(): 2.2e-09; 32.986% identity in 288 aa overlap and C-terminal region similar to SW:CBIH_SALTY (EMBL:L12006) Salmonella typhimurium precorrin-3B C17-methyltransferase (EC 2.1.1.131) CbiH, 241 aa; fasta scores: opt: 684 Z-score: 658.7 bits: 130.6 E(): 4.3e-29; 46.862% identity in 239 aa overlap. Contains Pfam match to entry PF01890 CbiG, CbiG an [...] (583 aa)
SCO1864Putative acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (170 aa)
SCO1867Putative hydroxylase; Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2- oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. (280 aa)
SCO1950Hypothetical protein; Involved in cell division and chromosome segregation (By similarity). Involved in sporulation. May coordinate the cessation of aerial hyphae growth and subsequent chromosome segregation and/or septation. Required for expression of the ParB partioning protein during sporogenesis. Activates its own transcription and represses WhiB. Binds with low affinity to its own promoter and to the Parp2 sporulation-specific promoter. Also binds directly to the RNA polymerase sigma factor WhiG, leading to inhibition of WhiG-dependent transcription in a dose-dependent manner ; Be [...] (328 aa)
SCO2082Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (399 aa)
SCO2083Sporulation protein; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily. (264 aa)
SCO2085SC4A10.18c, ftsW, probable cell division protein, len; 456 aa; previously sequenced as TR:Q9ZBA6 (EMBL:U10879), ftsW, Streptomyces coelicolor ftsW protein (456 aa) and identical to that sequence. Similar to many members of the ftsW/rodA/spoVE family e.g. SW:SP5E_BACSU (EMBL:X51419), spoVE, Bacillus subtilis stage V sporulation protein (366 aa), fasta scores; opt: 745 z-score: 788.4 E(): 0, 36.9% identity in 350 aa overlap. Shows similarity to SC6G9.31 (EMBL:AL079356) S.coelicolor probable integral membrane cell-cycle protein (446 aa) (30.0% identity in 416 aa overlap) and SCH69.16 (EMB [...] (456 aa)
SCO2611SCC88.22c mreB, rod shape-determining protein, len: 343 aa; identical to previously sequenced TR:O33619 (EMBL:Y14206) Streptomyces coelicolor MreB protein, 342 aa and similar to SW:MREB_BACSU (EMBL:M95582) Bacillus subtilis rod shape-determining protein MreB, 337 aa; fasta scores: opt: 1346 z-score: 1516.0 E(): 0; 63.0% identity in 330 aa overlap. (343 aa)
SCO2792SCC105.23, adpA, araC-family transcriptional regulator, len: 398 aa; highly similar to TR:BAA86265 (EMBL:AB023785) Streptomyces griseus AdpA, 405 aa; fasta scores: opt: 2219 z-score: 2270.5 E(): 0; 84.4% identity in 410 aa overlap and to TR:Q9XA73 (EMBL:AL096822) Streptomyces coelicolor putative araC-family transcriptional regulator SCGD3.05, 334 aa; fasta scores: opt: 878 z-score: 904.2 E(): 0; 45.7% identity in 313 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family and match to Prosite entry PS00041 Bacterial regulat [...] (398 aa)
SCO2906SCE19A.06, possible PTS transmembrane component, len: 431 aa; similar to many PTS (phosphoenolpyruvate-dependent sugar phosphotransferase system) transmembrane and sugar-binding components e.g. TR:Q57071 (EMBL:X93360), GlcA, PtsG, Staphylococcus carnosus PTS system, glucose-specific IIABC component (675 aa), fasta scores; opt: 1120 z-score: 1260.6 E(): 0, 43.4% identity in 431 aa overlap. Similar to the adjacent CDS SCE19A.07, possible PTS transmembrane component (416 aa) (4.1% identity in 429 aa overlap).The homologous PTS family proteins have a C-terminal extension not present in thi [...] (431 aa)
SCO2927SCE19A.27c, probable 4-hydroxyphenylpyruvate dioxygenase, len: 381 aa; highly similar to many e.g. SW:HPPD_STRAW (EMBL:U11864) Streptomyces avermitilis 4-hydroxyphenylpyruvate dioxygenase (380 aa), fasta scores; opt: 2347 z-score: 2634.5 E(): 0, 91.9% identity in 381 aa overlap. Similar to TR:Q9Z4X7 (EMBL:AL035640) S. coelicolor probable 4-hydroxyphenylpyruvic acid dioxygenase (325 aa) (36.4% identity in 330 aa overlap); Belongs to the 4HPPD family. (381 aa)
SCO3005Preprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (947 aa)
SCO3229SCE63.04, probable 4-hydroxyphenylpyruvic acid dioxygenase, len: 371 aa; similar to many both prokaryotic and eukaryotic e.g. TR:O52791 (EMBL:AJ223998) similar to hydroxyphenyl pyruvate dioxygenase from a cluster of genes involved in the biosynthesis of a vancomycin group antibiotic in Amycolatopsis orientalis (Actinomycete) (357 aa) fasta scores; opt: 989, z-score: 1130.3, E(): 0, (48.7% identity in 355 aa overlap) and SW:HPPD_MOUSE hpd, 4-hydroxyphenylpyruvic acid dioxygenase from Mus musculus (mouse) (392 aa) fasta scores; opt: 610, z-score: 698.5, E(): 1.3e-31, (31.6% identity in 3 [...] (371 aa)
SCO3255SCE39.05c, SpdB protein, len: 53 aa; highly similar to TR:Q07194 (EMBL:AJ005260) SpdB protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (58 aa) fasta scores; opt: 291, z-score: 448.0, E(): 1.2e-17, (83.3% identity in 48 aa overlap). (53 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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