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SCO2474 SCO2474 SCO0863 SCO0863 SCO0987 SCO0987 SCO1226 SCO1226 SCO1489 SCO1489 SCO1541 SCO1541 SCO2074 SCO2074 SCO2082 SCO2082 SCO2085 SCO2085 SCO2090 SCO2090 SCO2097 SCO2097 SCO2611 SCO2611 SCO3124 SCO3124 SCO3854 SCO3854 SCO3901 SCO3901 SCO3926 SCO3926 SCO4035 SCO4035 SCO4677 SCO4677 SCO5321 SCO5321 SCO5402 SCO5402 SCO5621 SCO5621 SCO7434 SCO7434
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SCO2474Putative metalloproteinase (putative secreted protein); Extracellular zinc metalloprotease. (547 aa)
SCO0863SCM2.16c, possible integral membrane protein, len: 485 aa. Weakly similar to Pseudomonas aeruginosa TR:P72122(EMBL:D28119) OprC outer membrane protein C (471 aa), fasta scores opt: 256 z-score: 271.9 E(): 9.1e-08 28.5% identity in 466 aa overlap and to TR:CAC44337 (EMBL:AL596102) Streptomyces coelicolor putative integral membrane protein SCBAC19F3.14, 517 aa; fasta scores: opt: 581 Z-score: 603.9 E(): 5.2e-26; 46.076% identity in 497 aa overlap. Contains possible membrane spanning hydrophobic domains. (485 aa)
SCO0987SCBAC19F3.14, possible integral membrane protein, len: 517aa: similar to many eg. TR:Q9RCU8 (EMBL:AL136149) putative integral membrane protein from Streptomyces coelicolor (485 aa) fasta scores; opt: 581, Z-score: 572.1, 46.076% identity (48.211% ungapped) in 497 aa overlap. Contains possible membrane-spanning hydrophobic regions. (517 aa)
SCO1226Putative bifunctional protein; 2SCG1.01c, possible secreted metallopeptidase (fragment), len: >385 aa; similar to TR:CAB76001 (EMBL:AL157916) Streptomyces coelicolor putative neutral zinc metallopeptidase SC3D11.04c, 684 aa; fasta scores: opt: 504 z-score: 545.2 E(): 6.7e-23; 35.2% identity in 406 aa overlap. Contains match to Prosite entry PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. Also contains possible N-terminal region signal peptide sequence; 2SCG58.26c, possible bifunctional protein (fragment), len: >713 aa; middle region highly similar to SW:APX_STRGR [...] (1066 aa)
SCO1489SC9C5.13, bldD, putative DNA-binding protein, len: 167 aa; identical to previously sequenced TR:O52732 (EMBL:AF045549) Streptomyces coelicolor putative DNA binding protein BldD, 167 aa. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (167 aa)
SCO1541Putative regulator; Involved in sporulation-specific cell division. Required for early stages of sporulation. Important in the process of growth cessation prior to sporulation-specific cell division. Recruits cell division protein FtsZ to the future septum sites and tethers the contractile ring structure (Z ring) to the cytoplasmic membrane during sporulation. Stimulates polymerization and filament length of FtsZ in vitro (By similarity). Belongs to the SsgA family. (159 aa)
SCO2074Putative signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (204 aa)
SCO2082Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (399 aa)
SCO2085SC4A10.18c, ftsW, probable cell division protein, len; 456 aa; previously sequenced as TR:Q9ZBA6 (EMBL:U10879), ftsW, Streptomyces coelicolor ftsW protein (456 aa) and identical to that sequence. Similar to many members of the ftsW/rodA/spoVE family e.g. SW:SP5E_BACSU (EMBL:X51419), spoVE, Bacillus subtilis stage V sporulation protein (366 aa), fasta scores; opt: 745 z-score: 788.4 E(): 0, 36.9% identity in 350 aa overlap. Shows similarity to SC6G9.31 (EMBL:AL079356) S.coelicolor probable integral membrane cell-cycle protein (446 aa) (30.0% identity in 416 aa overlap) and SCH69.16 (EMB [...] (456 aa)
SCO2090SC4A10.23c, ftsI, cell division protein, len: 654 aa; previously sequenced as TR:Q9Z5V7 (EMBL:AF123319), FtsI, Streptomyces coelicolor cell division protein (651 aa) and identical to that sequence, but with a different putative start codon. C-terminal end shares weak similarity with others from S.coelicolor e.g. SC6G9.32 (EMBL:AL079356) S.coelicolor possible penicillin-binding protein (485 aa) (29.3% identity in 447 aa overlap). Contains a hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domai [...] (654 aa)
SCO2097SC4A10.30c, possible membrane protein, len: 135 aa; unknown function, similar to mycobacterial hypothetical proteins TR:O53503 (EMBL:AL021957) Mycobacterium tuberculosis (134 aa), fasta scores; opt: 349 z-score: 414.6 E(): 9e-16, 44.1% identity in 136 aa overlap and its homologue in Mycobacterium leprae TR:O69562 (EMBL:AL022602) Mycobacterium leprae hypothetical protein (134 aa) (42.6% identity in 136 aa overlap). Contains hydrophobic, possible membrane-spanning regions. (135 aa)
SCO2611SCC88.22c mreB, rod shape-determining protein, len: 343 aa; identical to previously sequenced TR:O33619 (EMBL:Y14206) Streptomyces coelicolor MreB protein, 342 aa and similar to SW:MREB_BACSU (EMBL:M95582) Bacillus subtilis rod shape-determining protein MreB, 337 aa; fasta scores: opt: 1346 z-score: 1516.0 E(): 0; 63.0% identity in 330 aa overlap. (343 aa)
SCO3124Ribosomal L25p family protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (198 aa)
SCO3854Cputative membrane protein; Involved in cell division. Coordinates growth and cell division. May act as an inhibitor of Z-ring formation. Belongs to the CrgA family. (84 aa)
SCO3901SCH24.23, probable secreted penicillin-binding protein, len: 795 aa; similar to many e.g. SW:PBPF_BACSU (EMBL:Y14083), PbpF, Bacillus subtilis penicillin-binding protein 1A (714 aa), fasta scores; opt: 439 z-score: 369.7 E(): 2.8e-13, 31.2% identity in 683 aa overlap. Contains hydrophobic, possible membrane-spanning region at N-terminus. Contains Pfam matches to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain, score 49.60, E-value 2.8e-11 and entry PF00912 Transglycosyl, Transglycosylase, score 172.40, E-value 7.3e-48. Contains PS00017 ATP/GTP-binding sit [...] (795 aa)
SCO3926SCQ11.09, ssgA, probable regulator, len: 136 aa; highly similar to TR:P95753 (EMBL:D50051), SsgA, Streptomyces griseus protein associated with sporulation and cell division (136 aa), fasta scores; opt: 715 z-score: 896.6 E(): 0, 77.9% identity in 136 aa overlap and similar to others from S.coelicolor e.g. SC5F2A.05c (EMBL:AL049587) possible regulator (138 aa) (35.7% identity in 115 aa overlap) and SC5H1.03 (EMBL:AL049863) possible regulator (142 aa) (2.5% identity in 114 aa overlap), both annotated by similarity to Streptomyces griseus SsgA. The start codon was selected by similarity t [...] (136 aa)
SCO4035RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is required for normal spore maturation. (287 aa)
SCO4677SCD31.02c, possible regulatory protein, len: 144 aa; similar to TR:CAB60156 (EMBL:AL132824) Streptomyces coelicolor putative regulatory protein SCAH10.02, 160 aa; fasta scores: opt: 396 z-score: 500.7 E(): 1.9e-20; 51.7% identity in 143 aa overlap. (144 aa)
SCO5321Polyketide hydroxylase; Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptococcus coelicolor; Belongs to the PheA/TfdB FAD monooxygenase family. (627 aa)
SCO5402SC8F4.06c, Asp-rich hydrophilic protein (putative membrane protein), len: 257 aa. Contains possible hydrophobic membrane spanning region. (257 aa)
SCO5621RNA polymerase sigma factor WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (280 aa)
SCO7434Putative lipoprotein; SC6D11.30, possible lipoprotein, len: 253 aa. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (253 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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