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SCO6963 SCO6963 SCO6964 SCO6964 SCO6965 SCO6965 SCO7035 SCO7035 SCO5658 SCO5658 SCO1223 SCO1223 SCO5657 SCO5657 SCO1284 SCO1284 SCO1281 SCO1281 SCO5655 SCO5655 SCO5057 SCO5057 SCO2210 SCO2210 SCO5667 SCO5667 SCO5671 SCO5671 SCO5676 SCO5676 SCO5820 SCO5820 SCO6051 SCO6051 SCO6960 SCO6960 SCO6961 SCO6961 SCO5666 SCO5666
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO6963SC6F7.16c, possible lipoprotein, len: 281 aa. Weakly similar to Streptomyces coelicolor TR:Q54398 (EMBL:L42758) proteinase, SlpD or SCH5.02C (539 aa), fasta scores opt: 137 z-score: 151.5 E(): 0.54 29.5% identity in 295 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (281 aa)
SCO6964Conservedhypothetical protein; SC6F7.17c, unknown, len: 216 aa. Similar to Mycobacterium tuberculosis TR:P95145(EMBL:Z83859) hypothetical 23.1 kd protein (211 aa), fasta scores opt: 519 z-score: 613.8 E(): 9.4e-27 46.6% identity in 193 aa overlap. (216 aa)
SCO6965Hypothetical protein SC6F7.18c; SC6F7.18c, unknown, len: 110 aa. Similar to Streptomyces coelicolor TR:Q9XA81(EMBL:AL096837) possible DNA-binding protein, SCF43A.34C (113 aa), fasta scores opt: 235 z-score: 310.8 E(): 7.5e-10 40.4% identity in 109 aa overlap. (110 aa)
SCO7035SC2C3.02, gabD, succinate-semialdehyde dehydrogenase (fragment), len: >422 aa; highly similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) GabD, 482 aa; fasta scores: opt: 1329 z-score: 1466.8 E(): 0; 48.9% identity in 415 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family and match to Prosite entry PS00687 Aldehyde dehydrogenases glutamic acid active site; SC4G1.01, gabD, succinate-semialdehyde dehydrogenase (fragment), len: >90 aa; similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli [...] (479 aa)
SCO5658SC6A9.09c, possible polyamine-binding lipoprotein, len: 399 aa; some similarity to several spermidine. (399 aa)
SCO12232SCG58.23, rocD, ornithine aminotransferase, len: 407 aa; highly similar to SW:OAT_BACSU (EMBL:X81802) Bacillus subtilis ornithine aminotransferase (EC 2.6.1.13) RocD, 401 aa; fasta scores: opt: 1356 z-score: 1462.1 E(): 0; 50.4% identity in 395 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (407 aa)
SCO5657SC6A9.10c, probable aldehyde dehydrogenase, len: 479 aa; similar to many e.g. DHAB_BACSU betaine aldehyde dehydrogenase (EC 1.2.1.8) (490 aa), fasta scores; opt: 1131 z-score: 1242.7 E(): 0, 39.2% identity in 472 aa overlap. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site, PS00070 Aldehyde dehydrogenases cysteine active site and Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenases, score 598.80, E-value 3.2e-176. (479 aa)
SCO12842SCG18.31c, probable aminotransferase (putative secreted protein), len: 461 aa; similar to TR:CAB76097 (EMBL:AL157956) Streptomyces coelicolor acetonitrile amonitransferase ArgD, 402 aa; fasta scores: opt: 783 z-score: 776.7 E(): 0; 41.6% identity in 385 aa overlap and to SW:OAT_BACSU (EMBL:X81802) Bacillus subtilis ornithine amonitransferase (EC 2.6.1.13) RocD, 401 aa; fasta scores: opt: 692 z-score: 687.5 E(): 8.3e-31; 32.4% identity in 380 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 [...] (461 aa)
SCO12812SCG18.28c, possible oxidoreductase, len: 440 aa; similar to SW:ORDL_ECOLI (EMBL:U38543) Escherichia coli probable oxidoreductase OrdL, 426 aa; fasta scores: opt: 273 z-score: 283.9 E(): 2.5e-08; 27.7% identity in 433 aa overlap. (440 aa)
SCO5655SC6A9.12, probable aminotransferase, len: 457 aa; similar to many e.g. BIOA_BACSU adenosylmethionine-8-amino-7-oxononanoate aminotransferase (448 aa), fasta scores; opt: 895 z-score: 881.6 E(): 0, 35.6% identity in 449 aa overlap. Also highly similar to M. tuberculosis putative aminotransferase TR:O53379 (EMBL:AL021841) MTV016.29; 70.3% identity in 438 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate, score 355.70, E-value 3.5e-123; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
SCO5057SCK7.30c, possible amino acid permease, len: 460 aa; similar to SW:MMUP_ECOLI (EMBL:D83536) Escherichia coli probable S-methylmethionine permease MmuP, 475 aa; fasta scores: opt: 345 z-score: 390.5 E(): 2.8e-14; 23.3% identity in 408 aa overlap and to TR:P74848 (EMBL:X99945) Salmonella typhimurium amino acid permease YeeF like protein, 448 aa; fasta scores: opt: 705 z-score: 792.4 E(): 0; 32.0% identity in 416 aa overlap. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease and possible hydrophobic membrane spanning regions. (460 aa)
SCO2210SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...] (343 aa)
SCO5667SC8B7.11c, probable ABC-transporter polyamine-binding lipoprotein, len: 399 aa; similar to e.g. POTF_ECOLI putrescine-binding periplasmic protein precursor (370 aa), fasta scores; opt: 327 z-score: 259.5 E(): 3.4e-07, 28.5% identity in 365 aa overlap. Also similar to upstream gene SC6A9.09c (E(): 0, 46.8% identity in 391 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site and PS00017 ATP/GTP-binding site motif A (P-loop). Contains possible N-terminal region signal sequence peptide. (399 aa)
SCO5671SC8B7.07c, possible oxidoreductase, len: 475 aa; some similarity to e.g. ORDL_ECOLI probable oxidoreductase ord L (426 aa), fasta scores; opt: 413 z-score: 280.3 E(): 2.4 e-08, 32.1% identity in 436 aa overlap. (475 aa)
SCO5676SC8B7.02, gabT, probable 4-aminobutyrate aminotransferase, len: 444 aa; highly similar to e.g. GABT_ECOLI 4-aminobutyrate aminotransferase (EC 2.6.1.19) (426 aa), fasta s cores; opt: 1194 z-score: 1404.8 E(): 0, 45.5% identity in 424 aa overlap. Contains PS00600 Aminotransferases class-II I pyridoxal-phosphate attachment site and Pfam match to ent ry PF00202 aminotran_3, Aminotransferases class-III pyridox al-phosphate, score 516.20, E-value 5e-179; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
SCO5820Major vegetative sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Its activity is stimulated by RbpA. (511 aa)
SCO6051SC1B5.11c, probable iron-sulfur binding oxidoreductase, len: 513 aa; similar to e.g. ORDL_ECOLI P37906 escherichia coli. probable oxidoreductase (426 aa), fasta scores; opt: 303 z-score: 334.4 E(): 2.1e-11, 25.4% identity in 389 aa overlap. Contains PS00199 and PS00200 Rieske iron-sulfur protein signatures 1 and 2, and Pfam match to entry Rieske PF00355, Rieske iron-sulfur protein, score 49.39. (513 aa)
SCO6960Hypothetical protein SC6F7.13c; SC6F7.13c, unknown, len: 178 aa. (178 aa)
SCO6961SC6F7.14c, unknown, len: 382 aa. Similar to several proteins of undefined function e.g. Streptomyces coelicolor TR:Q9XAC4 (EMBL:AL096839) SCC22.14C (368 aa), fasta scores opt: 945 z-score: 1101.8 E():0 47.7% identity in 369 aa overlap. (382 aa)
SCO5666SC8B7.12c, probable aldehyde dehydrogenase, partial CDS, len: >315 aa; similar to many e.g. DHAB_ECOLI betaine aldehyde dehydrogenase (489 aa), fasta scores; opt: 861 z-s core: 1174.4 E(): 0, 44.2% identity in 301 aa overlap. Also similar to upstream ORF SC6A9.10c (E(): 0, 45.6% identity in 281 aa overlap). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site, PS00070 Aldehyde dehydrogenases cysteine active site and Pfam match to entry PF00171 alde dh, Aldehyde dehydrogenases, score 153.00, E-value 5.3e-42. Overlaps and extends SC6A9.01c; SC6A9.01c, probable aldehyde dehy [...] (511 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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