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SCO0920 SCO0920 SCO0921 SCO0921 SCO1102 SCO1102 SCO1389 SCO1389 SCO1489 SCO1489 SCO1526 SCO1526 SCO1527 SCO1527 SCO3322 SCO3322 SCO3549 SCO3549 SCO3879 SCO3879 SCO5431 SCO5431 SCO5621 SCO5621 SCO5628 SCO5628 SCO5723 SCO5723 SCO5753 SCO5753 SCO6467 SCO6467 SCO6468 SCO6468 SCO6760 SCO6760 SCO6763 SCO6763 SCO6764 SCO6764 SCO6765 SCO6765 SCO6771 SCO6771
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO0920SCM10.08c, probable acyltransferase, len: 260 aa; similar to SW:PLSC_NEIGO (EMBL:U21806) Neisseria gonorrhoeae 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51)PlsC, 255aa; fasta scores: opt: 384 z-score: 454.1 E(): 6.7e-18; 38.9% identity in 185 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. Contains possible hydrophobic membrane spanning region. (275 aa)
SCO0921SCM10.09c, hypothetical protein, len: 256 aa; similar to TR:O53274 (EMBL:AL021287) Mycobacterium tuberculosis hypothetical 27.0 kD protein, 246 aa; fasta scores: opt: 498 z-score: 593.9 E(): 1.1e-25; 47.7% identity in 237 aa overlap. (256 aa)
SCO11022SCG4.18, possible integral membrane protein, len: 223 aa; similar to TR:Q06074 (EMBL:Z21972) Bacillus megaterium hypothetical 24.9 kD protein in cytochrome P450MEG gene 3' region, 216 aa; fasta scores: opt: 298 z-score: 353.5 E(): 3.3e-12; 27.5% identity in 207 aa overlap. Contains Pfam match to entry PF01569 PAP2, PAP2 superfamily. Also contains possible hydrophobic membrane spanning regions. (223 aa)
SCO1389SC1A8A.09c, possible CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase, len: 206 aa; similar to many eg. SW:Q50611 (PGSA_MYCTU) putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Mycobacterium tuberculosis (209 aa) fasta scores; opt: 504, z-score: 637.7, E(): 4.3e-28, 43.5% identity in 193 aa overlap and SW:P06978 (PGSA_ECOLI) CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase from Escherichia coli (181 aa) fasta scores; opt: 232, z-score: 299.4 E(): 3e-09, 29.3% identity in 174 aa overlap. Contains Pfam match to entry P [...] (215 aa)
SCO1489SC9C5.13, bldD, putative DNA-binding protein, len: 167 aa; identical to previously sequenced TR:O52732 (EMBL:AF045549) Streptomyces coelicolor putative DNA binding protein BldD, 167 aa. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix. (167 aa)
SCO1526SCL2.16c, possible acyltransferase, len: 311 aa; similar to TR:Q9Z983 (EMBL:AE001596) Chlamydia pneumoniae acyltransferase HtrB, 467 aa; fasta scores: opt: 243 z-score: 289.8 E(): 9.4e-09; 29.0% identity in 238 aa overlap and to SW:HTRB_ECOLI (EMBL:X61000) Escherichia coli lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) HtrB, 306 aa; fasta scores: opt: 130 z-score: 159.2 E(): 0.18; 23.4% identity in 286 aa overlap. (311 aa)
SCO1527SCL2.17c, possible membrane transferase, len: 241 aa; similar to TR:CAB50482 (EMBL:AJ248288) Pyrococcus abyssi CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA, 186 aa; fasta scores: opt: 286 z-score: 350.3 E(): 4e-12; 33.0% identity in 203 aa overlap and to TR:O06202 (EMBL:Z95387) Mycobacterium tuberculosis hypothetical 23.3 kD protein MTCY1A10.21, 217 aa; fasta scores: opt: 564 z-score: 679.1 E(): 2e-30; 43.4% identity in 212 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase and match to Prosite entry PS00379 [...] (241 aa)
SCO3322SCE68.20, putative membrane protein, len: 298 aa; unknown function, similar to TR:O33611 (EMBL:AB004855) Streptomyces cyaneus hypothetical protein (277 aa), fasta scores; opt: 463 z-score: 536.3 E(): 1.5e-22, 34.2% identity in 269 aa overlap. C-terminus similar to other hypothetical proteins e.g. SW:YV32_MYCTU (EMBL:Z77162) from Mycobacterium tuberculosis (373 aa) (57.8% identity in 256 aa overlap) and SCH5.21 (EMBL:AL035636) S.coelicolor hypothetical protein (268 aa) (36.3% identity in 267 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain. (298 aa)
SCO3549Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity). (113 aa)
SCO3879Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). (656 aa)
SCO5431SC6A11.07c, possible secreted nucleosidase, len: 287 aa; similar to many e.g. SW:P24247 (PFS_ECOLI) MTA/SAH nucleosidase (P46) from Escherichia coli (232 aa) fasta scores: opt: 211, z-score: 251.7, E(): 1.3e-06, 27.1% identity in 210 aa overlap. Contains Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase family (which includes some nucleosidases) and possible N-terminal signal sequence. (287 aa)
SCO5621RNA polymerase sigma factor WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (280 aa)
SCO5628SC6A9.39c, probable integral membrane protein, len: 391 aa; C-terminus is similar to many phosphatidate cytidylyltransferases e.g. SW:CDSA_ECOLI (EMBL:M11330) phosphatidate cytidylyltransferase (249 aa), fasta scores; opt: 379 z-score: 384.3 E(): 3.6e-14, 38.8% identity in 196 aa overlap; Belongs to the CDS family. (391 aa)
SCO5723SC3C3.09c, possible regulator, BldB, len: 98 aa; identical to TR:Q53842 (EMBL:U28930) bldB (98 aa) and similar to S. coelicolor TR:Q53896 (EMBL:X60316) AbaA ORFD (75 aa), fasta scores; opt: 150 z-score: 201.9 E(): 0.00055, 47.4% identity in 57 aa overlap. (98 aa)
SCO5753SC7C7.08, pgsA, probable phosphatidylglycerophosphate synthase, len: 263 aa; integral membrane protein similar to many e.g. PGSA_BACSU CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (193 aa), fasta scores; opt: 304 z-score: 312.1 E(): 3.8e-10, 38.0% identity in 187 aa overlap. Contains PS00379 CDP-alcohol phosphatidyltransferases signature. FramePlot suggests start site at V40, similarities start downstream of this. Upstream start site chosen by HMM, corroborated by RBS. Contains possible hydrophobic membrane spanning regions; Belongs to the CDP-alcohol phosphatidyl [...] (263 aa)
SCO6467Putative phosphatidylserine synthase; SC9C7.03c, probable integral membrane protein, possible phosphatidylserine synthase, len: 260 aa; similar to many from prokaryotes (all putative) and eukaryotes eg. SW:PSS_YEAST phosphatidylserine synthase from Saccharomyces cerevisiae (275 aa) fasta scores; opt: 187, z-score: 254.6, E(): 6.8e-07, (35.9% identity in 170 aa overlap). Contains possible membrane spanning regions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (260 aa)
SCO6468Conserved hypothetical protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (218 aa)
SCO6760SC6A5.09, probable phytoene synthase, len: 312aa; similar to many egs. SW:CRTB_MYCTU probable phytoene synthase from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 791, z-score: 925.6, E(): 0, (48.3% identity in 286 aa overlap) and SW:PSY_ARATH phytoene synthase precusor from Arabidopsis thaliana (mouse ear cress) (423 aa) fasta scores; opt: 493, z-score: 577.3, E(): 7.4e-25, (34.4% identity in 282 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 168.70, E-value 9.4e-47 and Prosite matches to PS01044 Squalene and phytoene synthas [...] (312 aa)
SCO6763SC6A5.12, probable polyprenyl synthatase, len: 378aa; similar to many eg. SW:GGPP_MYCTU probable geranylgeranyl pyrophosphate synthatase from Mycobacterium tuberculosis (359 aa) fasta scores; opt: 1103, z-score: 1231.0, E(): 0, (49.3% identity in 355 aa overlap) and SW:IDSA_METTM short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrophicum (324 aa) fasta scores; opt: 547, z-score: 614.0, E(): 6.7e-27, (38.2% identity in 293 aa overlap). Contains Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetases, score 176.70, E-value 3.9e-49 and Prosite matches [...] (378 aa)
SCO6764SC6A5.13, probable squalene-hopene cyclase, len: 680 aa; similar to many e.g. SW:SQHC_ALIAC squalene-hopene cyclase A key enzyme in triterpenoid metabolism in Bacillus acidocaldarius (630 aa) fasta scores; opt: 2153, z-score: 2386.3, E(): 0, (51.8% identity in 620 aa overlap). Contains two Pfam matches to entry PF00432 prenyltrans, Prenyltransferase and squalene oxidase repeats and a Prosite match to PS01074 Terpene synthases signature. (680 aa)
SCO6765SC6A5.14, possible lipoprotein, len: 213 aa; similar to SW:TYRT_STRLN proposed tyrosinase co-factor from the melanin biosynthesis in Streptomyces lincolnensis (140 aa) fasta scores; opt: 115, z-score: 142.8, E(): 1.2, (29.2% identity in 120 aa overlap). Contains Prosite match to PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (213 aa)
SCO6771SC6A5.20, possible small hydrophobic secreted protein, len: 39 aa; contains possible N-terminal signal sequence. (39 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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