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SCO1660 SCO1660 SCO0400 SCO0400 SCO0509 SCO0509 SCO0883 SCO0883 SCO1211 SCO1211 SCO3879 SCO3879 SCO3926 SCO3926 SCO4560 SCO4560 SCO5221 SCO5221 SCO5627 SCO5627 SCO5820 SCO5820 SCO7682 SCO7682 SCO7683 SCO7683
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
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SCO1660Putative glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (512 aa)
SCO0400SCF62.26, possible epimerase, len: 178 aa. Similar to many including: Streptomyces griseus SW:STRM_STRGR (EMBL; X62567) dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (DTDP-4-keto-6-deoxyglucose 3,5-epimerase) (DTDP-l-rhamnose synthetase) (200 aa), fasta scores opt: 340 z-score:0.0 E(): 0.0 37.78% identity in 180 aa overlap and Leptospira borgpetersenii TR:Q9ZGK0 (EMBL; AF078135) RmlC (186 aa), fasta scores pt: 432 z-score: 524.9 E(): 7.2e-22 42.3% identity in 175 aa overlap. Contains a Pfam match to entry PF00908 dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. (183 aa)
SCO0509Glycerol kinase 2 (ATP:glycerol 3-phosphotransferase) (EC 2.7.1.30); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (507 aa)
SCO0883Polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (218 aa)
SCO1211Putative polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (217 aa)
SCO3879Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). (656 aa)
SCO3926SCQ11.09, ssgA, probable regulator, len: 136 aa; highly similar to TR:P95753 (EMBL:D50051), SsgA, Streptomyces griseus protein associated with sporulation and cell division (136 aa), fasta scores; opt: 715 z-score: 896.6 E(): 0, 77.9% identity in 136 aa overlap and similar to others from S.coelicolor e.g. SC5F2A.05c (EMBL:AL049587) possible regulator (138 aa) (35.7% identity in 115 aa overlap) and SC5H1.03 (EMBL:AL049863) possible regulator (142 aa) (2.5% identity in 114 aa overlap), both annotated by similarity to Streptomyces griseus SsgA. The start codon was selected by similarity t [...] (136 aa)
SCO4560Putative polypetide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). (208 aa)
SCO5221Putative polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (216 aa)
SCO5627Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
SCO5820Major vegetative sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Its activity is stimulated by RbpA. (511 aa)
SCO7682SC4C2.17, probable non-ribosomal peptide synthase, len: 2229 aa; similar to TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2485 z-score: 2429.3 E(): 0; 37.9% identity in 2203 aa overlap, to SW:HMP2_YEREN (EMBL:L18881) Yersinia enterocolitica high-molecular-weight protein 2 Irp2, 2035 aa; fasta scores: opt: 2251 z-score: 2201.3 E(): 0; 33.3% identity in 2022 aa overlap to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1764 z-score: 1430.4 E(): 0; 40.0% [...] (2229 aa)
SCO7683SC4C2.18, probable non-ribosomal peptide synthase, len: 1842 aa; similar to C-terminal domain of TR:AAG02364 (EMBL:AF210249) Streptomyces verticillus peptide synthetase NRPS2-1 BlmIV, 2626 aa; fasta scores: opt: 2514 z-score: 2613.8 E(): 0; 40.7% identity in 1287 aa overlap, to TR:Q9RFM7 (EMBL:AF184622) Pseudomonas aeruginosa pyochelin synthetase PchF, 1809 aa; fasta scores: opt: 2279 z-score: 2370.9 E(): 0; 39.7% identity in 1887 aa overlap, to TR:CAA18919 (EMBL:AL023496) Streptomyces coelicolor probable peptide synthase SC1A6.21, 1407 aa; fasta scores: opt: 1826 z-score: 1476.6 E(): [...] (1842 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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