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SCO2043 SCO2043 SCO0122 SCO0122 SCO1494 SCO1494 SCO1496 SCO1496 SCO1937 SCO1937 SCO2036 SCO2036 SCO2039 SCO2039 SCO7638 SCO7638 SCO6662 SCO6662 SCO6661 SCO6661 SCO6585 SCO6585 SCO6277 SCO6277 SCO5841 SCO5841 SCO5042 SCO5042 SCO4808 SCO4808 SCO4762 SCO4762 SCO4761 SCO4761 SCO4645 SCO4645 SCO4296 SCO4296 SCO3770 SCO3770 SCO3574 SCO3574 SCO3563 SCO3563 SCO3403 SCO3403 SCO3214 SCO3214 SCO3096 SCO3096 SCO2390 SCO2390 SCO2387 SCO2387 SCO2147 SCO2147 SCO2126 SCO2126 SCO2115 SCO2115
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SCO2043Putative anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (502 aa)
SCO0122SCJ21.03, probable flavin-containing monooxygenase (putative secreted protein), len: 458 aa; similar to many eukaryotic monooxygenases, e.g. FMO5_RABIT dimethylaniline monooxygenase [N-oxide forming] (532 aa), fasta scores; opt: 938 z-score: 1016.9 E(): 0, 38.7% identity in 432 aa overlap. Also similar to S. coelicolor putative oxidoreductase SCH35.27 E(): 3.4e-07, 34.8% identity in 282 aa overlap. Contains Pfam match to entry PF00743 FMO-like, Flavin-binding monooxygenase-like. (458 aa)
SCO14943-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (363 aa)
SCO1496Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
SCO1937Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa)
SCO2036Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa)
SCO2039SC4G6.08c, trpC1, indoleglycerol phosphate synthase, len: 269 aa; previously sequenced therefore identical to TR:O68814 (EMBL:AF054585). Also similar to many others eg. SW:TRPC_AZOBR trpC, indoleglycerol phosphate synthase from Azospirillum brasilense (262 aa) fasta scores; opt: 589, z-score: 655.0, E(): 3.7e-29, (44.4% identity in 259 aa overlap). Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases and Prosite match to PS00614 Indole-3-glycerol phosphate synthase signature. (269 aa)
SCO7638Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
SCO6662Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (381 aa)
SCO6661Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (592 aa)
SCO6585Succinyl-coa synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa)
SCO6277SC1G7.03, possible epoxide hydrolase, len: 286 aa; similar to TR:Q42566 (EMBL:D16628) Arabidopsis thaliana epoxide hydrolase (EC 3.3.2.3) Seh or F18A8.11, 321 aa; fasta scores: opt: 351 Z-score: 406.4 bits: 83.3 E(): 4.8e-15; 29.560% identity in 318 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (286 aa)
SCO5841Phosphocarrier protein hpr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (93 aa)
SCO5042Fumarate hydratase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
SCO4808succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
SCO476260 kD chaperonin cpn60; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
SCO476110 kD chaperonin cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (102 aa)
SCO4645SCD82.16c, aspC, aspartate aminotransferase, len: 408 aa; highly similar to SW:AAT_STRVG (EMBL:D50624) Streptomyces virginiae aspartate aminotransferase AspC, 397 aa; fasta scores: opt: 2346 z-score: 2655.6 E(): 0; 89.4% identity in 396 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. (408 aa)
SCO4296Chaperonin 2; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
SCO3770SCH63.17, probable cytochrome P450 oxidoreductase, len: 394 aa; similar to SW:CPXK_SACER (EMBL:M83110) Saccharopolyspora erythraea cytochrome P450 107B1 (EC 1.14.-.-) (P450CVIIB1) Cyp107B1, 405 aa; fasta scores: opt: 1038 z-score: 1154.8 E(): 0; 46.9% identity in 373 aa overlap. Contains Pfam match to entry PF00067 p450, Cytochrome P450 and match to Prosite entry PS00211 ABC transporters family signature and PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Also contains a TTA leucine codon, possible target for bldA regulation. (394 aa)
SCO3574SCH17.08c, possible epoxide hydrolase, len: 354 aa; similar to eukaryotic epoxide hydrolases e.g. TR:Q42566 (EMBL:D16628), atseH, Arabidopsis thaliana epoxide hydrolase (321 aa), fasta scores; opt: 501 z-score: 542.6 E(): 6.8e-23, 37.7% identity in 332 aa overlap. Similar to others from S.coelicolor e.g. SCH5.29 (EMBL:AL035636) putative hydrolase (324 aa) (33.6% identity in 348 aa overlap). Alternative start codons are present at codons 6 and 30, but these have no apparent RBS. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold. (354 aa)
SCO3563Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
SCO3403SCE9.10c, folE, probable GTP cyclohydrolase I, len: 201 aa; similar to many e.g. SW:GCH1_BACSU (EMBL:M37320), MtrA, Bacillus subtilis GTP cyclohydrolase I (190 aa), fasta scores; opt: 728 z-score: 880.0 E(): 0, 58.9% identity in 185 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I, score 351.80, E-value 7.2e-102, PS00859 GTP cyclohydrolase I signature 1 and PS00860 GTP cyclohydrolase I signature 2. (201 aa)
SCO3214Probable anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (511 aa)
SCO3096Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SCO23903-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (429 aa)
SCO2387SC4A7.15, fabD, malonyl CoA:acyl carrier protein malonyltransferase, len: 316 aa; identical to previously sequenced TR:P72391 (EMBL:X86475) Streptomyces coelicolor malonyl CoA:acyl carrier protein malonyltransferase, FabD, 316 aa and similar to SW:FABD_ECOLI (EMBL:M87040) Escherichia coli malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) FabD, 308 aa; fasta scores: opt: 524 z-score: 551.4 E(): 2.5e-23; 36.8% identity in 315 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. (316 aa)
SCO2147Phosphoribosylanthranilate transferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa)
SCO2126Glucokinase; Required for glucose repression of many different genes; Belongs to the ROK (NagC/XylR) family. (317 aa)
SCO2115SC6E10.09c, aroH, probable 2-dehydro-3-deoxyphosphoheptonate aldolase, len: 450 aa; highly similar to many, especially those from plants e.g. SW:AROF_ARATH (EMBL:M74819), Dhs1, Arabidopsis thaliana phospho-2-dehydro-3-deoxyheptonate aldolase 1 precursor (525 aa), fasta scores; opt: 1633 z-score: 1839.4 E(): 0, 53.8% identity in 437 aa overlap. The N-terminus is similar (but not identical) to the SW:AROF_STRCO, AroH, Streptomyces coelicolor 2-dehydro-3-deoxyphosphoheptonate aldolase N-terminal sequence determined from purified protein (TVNAKTSPSA GNTDDPLQAP S). Similar to TR:O52308 (EMB [...] (450 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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