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SCO0560 SCO0560 SCO0982 SCO0982 SCO1443 SCO1443 SCO1494 SCO1494 SCO1495 SCO1495 SCO1496 SCO1496 SCO3403 SCO3403 SCO3400 SCO3400 SCO3051 SCO3051 SCO2390 SCO2390 SCO2054 SCO2054 SCO2053 SCO2053 SCO1996 SCO1996 SCO1498 SCO1498 SCO5568 SCO5568 SCO6186 SCO6186 SCO0506 SCO0506
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SCO0560Catalase/peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. (740 aa)
SCO0982SCBAC19F3.09, aceA, isocitrate lyase, len: 426 aa: strongly similar to many e.g. SW:O53752 (ACEA_MYCTU) isocitrate lyase from Mycobacterium tuberculosis (428 aa) fasta scores; opt: 2144, Z-score: 2405.5, 74.822% identity (75.000% ungapped) in 421 aa overlap. Contains Pfam matches to entry PF00463 ICL, Isocitrate lyase family and Prosite match to PS00161 Isocitrate lyase signature. (426 aa)
SCO1443SC6D7A.06c, probable riboflavin synthase, len: 200 aa; similar to SW:RISA_ACTPL (EMBL:U27202) Actinobacillus pleuropneumoniae riboflavin synthase alpha chain (EC 2.5.1.9) RibE or RibB, 215 aa; fasta scores: opt: 607 z-score: 734.5 E(): 0; 50.3% identity in 193 aa overlap. Contains 2x Pfam matches to entry PF00677 Lum_binding, Lumazine binding domain and match to Prosite entry PS00693 Riboflavin synthase alpha chain family signature. (200 aa)
SCO14943-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (363 aa)
SCO1495Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa)
SCO1496Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)
SCO3403SCE9.10c, folE, probable GTP cyclohydrolase I, len: 201 aa; similar to many e.g. SW:GCH1_BACSU (EMBL:M37320), MtrA, Bacillus subtilis GTP cyclohydrolase I (190 aa), fasta scores; opt: 728 z-score: 880.0 E(): 0, 58.9% identity in 185 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I, score 351.80, E-value 7.2e-102, PS00859 GTP cyclohydrolase I signature 1 and PS00860 GTP cyclohydrolase I signature 2. (201 aa)
SCO3400Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
SCO3051SCBAC19G2.06c, fadE, acyl-CoA dehydrogenase, len: 385 aa: similar to many e.g. TR:Q9RIQ5 (EMBL:AJ250495) fatty acid acyl CoA dehydrogenase FadE from Streptomyces lividans (385 aa) fasta scores; opt: 2480, Z-score: 2753.5, 99.740% identity (99.740% ungapped) in 385 aa overlap and SW:P45867 (ACDA_BACSU) acyl CoA dehydrogenase from Bacillus subtilis (379 aa) fasta scores; opt: 1214, Z-score: 1351.1, 53.600% identity (54.472% ungapped) in 375 aa overlap. Also similar to TR:Q9RKY7 (EMBL:AL133213) SC6D7.11 Acd acyl CoA dehydrogenase from Streptomyces coelicolor (391 aa) fasta scores; opt: 10 [...] (385 aa)
SCO23903-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (429 aa)
SCO2054Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa)
SCO2053SC4G6.22c, hisC1, histidinol-phosphate aminotransferase, len: 369aa; previously sequenced therefore identical to SW:HIS8_STRCO. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II and Prosite match to PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. (369 aa)
SCO1996dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa)
SCO1498SC9C5.22c, aroE, shikimate 5-dehydrogenase, len: 255 aa; similar to SW:AROE_PSEAE (EMBL:X85015) Pseudomonas aeruginosa shikimate 5-dehydrogenase (EC 1.1.1.25) AroE, 274 aa; fasta scores: opt: 294 z-score: 335.8 E(): 3.1e-11; 31.3% identity in 259 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. (255 aa)
SCO5568Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
SCO6186Putative phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (231 aa)
SCO0506NH(3)-dependent NAD(+)synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (276 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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