(3 nodes) (2020) Facets of Autophagy Based Unconventional Protein Secretion-The Road Less Traveled. network (Streptomyces coelicolor)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCO3556	SCH5.19c, possible secretory protein, len: 523 aa; similar to many of undefined function eg. TR:O69627 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (352 aa) fasta scores; opt: 1287, z-score: 1191.3, E(): 0, (59.8% identity in 351 aa overlap) and SW:TRBB_AGRT6 conjugal transfer protein from Agrobacterium tumefaciens (323 aa) fasta scores; opt: 469, z-score: 441.4, E(): 2.8e-17, (31.4% identity in 287 aa overlap). Contains Pfam match to entry PF00437 GSPII_E, Bacterial type II secretion system protein, score 41.30, E-value 1.6e-11. Also contains PS00017 ATP/GTP-bi [...] (523 aa)
	SCO5009	SCK15.11, probable secretory protein, len: 445 aa; similar to TR:P94647 (EMBL:U77780) Chlorobium limicola secretory protein kinase Kbh, 474 aa; fasta scores: opt: 1192 z-score: 1311.8 E(): 0; 47.7% identity in 396 aa overlap, to SW:TRBB_AGRT6 (EMBL:U43675) Agrobacterium tumefaciens conjugal transfer protein TrbB, 323 aa; fasta scores: opt: 512 z-score: 568.9 E(): 3.2e-24; 30.4% identity in 326 aa overlap and to TR:Q9X921 (EMBL:AL035636) Streptomyces coelicolor putative secretory protein SCH5.19c, 523 aa; fasta scores: opt: 878 z-score: 847.4 E(): 0; 40.3% identity in 365 aa overlap. Co [...] (445 aa)
	SCO2643	SC8E4A.13, pepN, aminopeptidase N, len: 857 aa; identical to SW:AMPN_STRLI (EMBL:L23172) Streptomyces lividans aminopeptidase N (EC 3.4.11.2) PepN, 857 aa and similar to SW:AMPN_LACLA (EMBL:D38040) Lactococcus lactis aminopeptidase N (EC 3.4.11.2) PepN, 848 aa; fasta scores: opt: 738 z-score: 846.7 E(): 0; 33.4% identity in 440 aa overlap and to S. coelicolor SC8E4A.05, 833 aa; fasta scores: opt: 2998 z-score: 2943.4 E(): 0; 55.8% identity in 842 aa overlap. Contains Pfam match to entry PF01433 Peptidase_M1, Peptidase family M1 and match ot Prosite entry PS00142 Neutral zinc metallopep [...] (857 aa)