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SCO6661 SCO6661 SCO0324 SCO0324 SCO0381 SCO0381 SCO0390 SCO0390 SCO0401 SCO0401 SCO0578 SCO0578 SCO0782 SCO0782 SCO0923 SCO0923 SCO0983 SCO0983 SCO1090 SCO1090 SCO1214 SCO1214 SCO1293 SCO1293 SCO1335 SCO1335 SCO1419 SCO1419 SCO1566 SCO1566 SCO1781 SCO1781 SCO1845 SCO1845 SCO1936 SCO1936 SCO1937 SCO1937 SCO1939 SCO1939 SCO1942 SCO1942 SCO1945 SCO1945 SCO1946 SCO1946 SCO1947 SCO1947 SCO1957 SCO1957 SCO2119 SCO2119 SCO2126 SCO2126 SCO2198 SCO2198 SCO2234 SCO2234 SCO2366 SCO2366 SCO2393 SCO2393 SCO2494 SCO2494 SCO2620 SCO2620 SCO2736 SCO2736 SCO2917 SCO2917 SCO2951 SCO2951 SCO2958 SCO2958 SCO3096 SCO3096 SCO3216 SCO3216 SCO3219 SCO3219 SCO3223 SCO3223 SCO3225 SCO3225 SCO3226 SCO3226 SCO3232 SCO3232 SCO3234 SCO3234 SCO3237 SCO3237 SCO3249 SCO3249 SCO3317 SCO3317 SCO3320 SCO3320 SCO3381 SCO3381 SCO3409 SCO3409 SCO3547 SCO3547 SCO3649 SCO3649 SCO3877 SCO3877 SCO3976 SCO3976 SCO4138 SCO4138 SCO4141 SCO4141 SCO4144 SCO4144 SCO4145 SCO4145 SCO4209 SCO4209 SCO4388 SCO4388 SCO4470 SCO4470 SCO4472 SCO4472 SCO4562 SCO4562 SCO4594 SCO4594 SCO4595 SCO4595 SCO4723 SCO4723 SCO4808 SCO4808 SCO4809 SCO4809 SCO4827 SCO4827 SCO4855 SCO4855 SCO5047 SCO5047 SCO5261 SCO5261 SCO5366 SCO5366 SCO5374 SCO5374 SCO5426 SCO5426 SCO5831 SCO5831 SCO5999 SCO5999 SCO6243 SCO6243 SCO6260 SCO6260 SCO6288 SCO6288 SCO6429 SCO6429 SCO6466 SCO6466 SCO6471 SCO6471 SCO6659 SCO6659 SCO6662 SCO6662 SCO6811 SCO6811 SCO6837 SCO6837 SCO7035 SCO7035 SCO7040 SCO7040 SCO7511 SCO7511 SCO7622 SCO7622 SCO7623 SCO7623 SCO7638 SCO7638 SCO7681 SCO7681 SCO7691 SCO7691
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proteins of unknown 3D structure
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SCO6661Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (592 aa)
SCO0324SCF12.03c, possible secreted protein, len: 799 aa; similar to TR:CAC45838 (EMBL:AL591786) Rhizobium meliloti (Sinorhizobium meliloti) hypothetical transmembrane protein (fragment) SMC01907, 729 aa; fasta scores: opt: 492 Z-score: 517.1 E(): 3.6e-21; 42.318% identity in 742 aa overlap. Contains possible cleavable N-terminal signal sequence. (792 aa)
SCO0381SCF62.07, possible glycosyl transferase, len: 491 aa. Similar to many other glycosyl transferases e.g. Erwinia amylovora SW: AMSG_ERWAM (EMBL; X77921) UDP-galactose-lipid carrier transferase (EC 2.-.-.-) (477 aa), fasta scores opt: 599 z-score: 695.6 E(): 2.2e-31 33.0% identity in 403 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. (491 aa)
SCO0390SCF62.16, possible membrane protein, len: 410 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains. (410 aa)
SCO0401SCF62.27, possible aminotransferase, len: 441 aa. Similar to many including Pseudomonas aeruginosa SW:GSA_PSEAE (EMBL:X82072) glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) (glutamate-1-semialdehyde aminotransferase) (427 aa), fasta scores opt: 475 z-score: 540.8 E(): 9.5e-23 34.8% identity in 434 aa overlap and Streptomyces coelicolor TR:CAB39702 (EMBL: AL049485) probable aminotransferase SC6A5.18 (461 aa), fasta scores opt: 464 z-score: 527.9 E(): 4.9e-22 32.4% identity in 407 aa overlap. Contains 2x Pfam matches to entry PF00202 aminotran_3, Aminotransferases class-III pyrido [...] (441 aa)
SCO0578SCF55.02c, possible triosephosphate isomerase, len: 259 aa; similar to SW:TPIS_MYCTU (EMBL:Z95844) Mycobacterium tuberculosis triosephosphate isomerase (EC 5.3.1.1) TpiA, 261 aa; fasta scores: opt: 437 z-score: 490.8 E(): 5.8e-20; 38.9% identity in 221 aa overlap. Contains match to Pfam entry PF00121 TIM, Triosephosphate isomerase. (259 aa)
SCO07823SCF60.14c, prsA, ribose-phosphate pyrophosphokinase, len: 317 aa; similar to SW:KPRS_SYNP7 (EMBL:D14994) Synechococcus sp. ribose-phosphate pyrophosphokinase (EC 2.7.6.1) PrsA, 331 aa; fasta scores: opt: 795 z-score: 931.4 E(): 0; 42.7% identity in 307 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain. (317 aa)
SCO0923SCM10.11c, probable reductase flavoprotein subunit, len: 649 aa; similar to SW:DHSA_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) SdhA, 585 aa;fasta scores: opt: 580 z-score: 658.7 E(): 2.7e-29; 36.8% identity in 609 aa overlap and to SW:FRDA_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase flavoprotein subunit FrdA, 583 aa; fasta scores: opt: 443 z-score: 503.1 E(): 1.2e-20; 32.2% identity in 574 aa overlap. Contains three Pfam matches to entry Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. (649 aa)
SCO0983SCBAC19F3.10, aceB2, malate synthase, len: 530 aa; strongly similar to many e.g. SW:Q9ZH77 (MASY_STRCL) malate synthase AceB from Streptomyces clavuligerus (541 aa) fasta scores; opt: 1923, Z-score: 2204.2, 58.889% identity (61.390% ungapped) in 540 aa overlap and TR:Q9RKU9 (EMBL:AL132824) malate synthase AceB1 (StAH10.08c) from Streptomyces coelicolor (540 aa) fasta scores; opt: 1930, Z-score: 2212.2, 61.895% identity (63.090% ungapped) in 475 aa overlap. Contains Pfam match to entry PF01274 Malate_synthase, Malate synthase and Prosite match to PS00510 Malate synthase signature. (530 aa)
SCO10902SCG4.06, possible phosphodiesterase, len: 227 aa; similar to TR:Q9RKX8 (EMBL:AL133213) Streptomyces coelicolor putative phosphodiesterase SC6D7.20c, 255 aa; fasta scores: opt: 287 z-score: 341.1 E(): 1.6e-11; 33.9% identity in 230 aa overlap and to SW:GLPQ_BACSU (EMBL:Z26522) Bacillus subtilis glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) GlpQ, 293 aa; fasta scores: opt: 268 z-score: 318.3 E(): 3e-10; 30.8% identity in 247 aa overlap. (227 aa)
SCO12146-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (341 aa)
SCO1293SCBAC36F5.04, hypothetical protein, len: 452 aa; C-terminal part similar to TR:Q9FC64 (EMBL:AL391515) Streptomyces coelicolor putative acetyltransferase SC4B10.23, 163 aa; fasta scores: opt: 287 Z-score: 300.0 bits: 63.3 E(): 4.2e-09; 42.857% identity in 133 aa overlap. Contains Pfam match to entry PF01842 ACT, ACT domain and PF00583 Acetyltransf, Acetyltransferase (GNAT) family. (452 aa)
SCO13352SCG61.17c, probable oxidoreductase, len: 246 aa; similar to many eg. SW:P40288 (DHG_BACME) glucose 1-dehydrogenase (EC 1.1.1.47) from Bacillus megaterium (261 aa) fasta scores; opt: 511, z-score: 535.5, E(): 2.4e-22, 36.6% identity in 243 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus. (246 aa)
SCO1419SC6D7.20c, putative phosphodiesterase, len: 255 aa. Similar to several including Escherichia coli SW:UGPQ_ECOLI(EMBL:X14437) glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) (247 aa), fasta scores opt: 215 z-score: 267.5 E(): 1.6e-07 27.0% identity in 252 aa overlap and Mycobacterium tuberculosis TR:O07244(EMBL:Z96800) hypothetical 28.3 KD protein (256 aa), fasta scores opt: 632 z-score: 771.7 E(): 0 44.2% identity in 251 aa overlap. (255 aa)
SCO1566SCL24.02, possible acyltransferase, len: 223 aa; similar to TR:Q9ZBS1 (EMBL:AL034447) Streptomyces coelicolor putative acyltransferase SC7A1.02, 264 aa; fasta scores: opt: 277 z-score: 327.1 E(): 8.5e-11; 30.7% identity in 202 aa overlap and to TR:CAB51970 (EMBL:AL109661) Streptomyces coelicolor hypothetical 28.2 kD protein SC6E10.16c, 262 aa; fasta scores: opt: 858 z-score: 879.9 E(): 0; 59.0% identity in 217 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase. (223 aa)
SCO1781Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (301 aa)
SCO1845SCI8.30, possible low-affinity phosphate transport protein, len: 423 aa. Highly similar to many possible transporters, including: Streptomyces halstedii SW: PITH_STRHA (EMBL: L05390) putative low-affinity inorganic phosphate transporter (fragment) (>213 aa), fasta scores opt: 505 z-score: 517.8 E(): 1.8e-21 45.9% identity in 194 aa overlap and Mycobacterium tuberculosis TR:O06411 (EMBL: Z95558) hypothetical 42.7 KD protein (417 aa), fasta scores opt: 1286 z-score: 1295.4 E():0 50.8% identity in 421 aa overlap. Contains a Pfam match to entry PF01384 PHO4, Phosphate transporter family. A [...] (423 aa)
SCO1936Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa)
SCO1937Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa)
SCO1939Putative 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (261 aa)
SCO1942SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...] (551 aa)
SCO1945Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P). (258 aa)
SCO1946SCC54.06c, pgk, phosphoglycerate kinase, len: 403 aa; member of a family of proteins highly conserved across prokaryotes and eukaryotes, e.g. SW:PGK_BACSU Pgk, phosphoglycerate kinase from Bacillus subtilis (394 aa) fasta scores; opt: 1263, z-score: 1322.3, E(): 0, (51.2% identity in 404 aa overlap) and SW:PGKH_SPIOL phosphoglycerate kinase from Spinacia oleracea (Spinach) (433 aa) fasta scores; opt: 1200, z-score: 1256.1, E(): 0, (49.9% identity in 407 aa overlap). Contains PS00111 Phosphoglycerate kinase signature and Pfam match to entry PF00162 PGK, Phosphoglycerate kinases, score 6 [...] (403 aa)
SCO1947Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] (336 aa)
SCO1957SCC54.17, probable fructokinase, len: 302 aa; similar to many e.g. SW:SCRK_RHILT Frk, fructokinase from Rhizobium leguminosarum biovar trifolii (326 aa) fasta scores; opt: 617, z-score: 682.4, E(): 1.1e-30, (41.0% identity in 288 aa overlap). Contains PS00584 pfkB family of carbohydrate kinases signature 2 and Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 132.90, E-value 9.6e-41. (302 aa)
SCO21196-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (342 aa)
SCO2126Glucokinase; Required for glucose repression of many different genes; Belongs to the ROK (NagC/XylR) family. (317 aa)
SCO2198Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
SCO2234Glutamate-ammonia-ligase adenylyltransferase; Adenylation and deadenylation of glutamate--ammonia ligase. (999 aa)
SCO2366SCC8A.24c, possible integral membrane protein, len: 380aa; similar to other eg. TR:Q9Z654 (EMBL:AF102543) hypothetical protein from Zymomonas mobilis (339 aa) fasta scores; opt: 428, z-score: 504.2, E(): 1.3e-20, 43.3% identity in 374 aa overlap and TR:CAB57414 (EMBL:AL121746) putative integral membrane protein from Streptomyces coelicolor (370 aa) fasta scores; opt: 2038, z-score: 2376.3, E(): 0, 85.6% identity in 369 aa overlap. Contains possible membrane-spanning hydrophobic regions. (380 aa)
SCO2393Putative aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (323 aa)
SCO2494SC7A8.33c, probable pyruvate phosphate dikinase, len: 909 aa; similar to TR:CAB53432 (EMBL:AL109989) Streptomyces coelicolor pyruvate phosphate dikinase SCJ12.20, 898 aa; fasta scores: opt: 3956 z-score: 4354.7 E(): 0; 66.7% identity in 889 aa overlap and to SW:PODK_CLOSY (EMBL:M60920) Clostridium symbiosum pyruvate, phosphate dikinase (EC 2.7.9.1) (pyruvate,orthophosphate dikinase) PpdK, 873 aa; fasta scores: opt: 1765 z-score: 1941.1 E():; 51.7% identity in 899 aa overlap. Contains Pfam match to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain, two [...] (909 aa)
SCO2620Putative cell division trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (468 aa)
SCO2736SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. (429 aa)
SCO2917Conserved hypothetical protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (448 aa)
SCO2951SCE59.10c, probable malate oxidoreductase, len: 471 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38) (NAD-ME) 478 aa; fasta scores: opt: 1778 z-score: 1887.0 E(): 0; 58.8% identity in 471 aa overlap and to SW:MAO2_ECOLI (EMBL:AE000333) Escherichia coli NADP-dependent malic enzyme (EC 1.1.1.40) MaeB, 759 aa; fasta scores: opt: 1092 z-score: 1158.4 E(): 0; 46.4% identity in 394 aa overlap Contains two Pfam matches to entry PF00390 malic, Malic enzyme. (471 aa)
SCO2958SCE59.17c, possible transcriptional regulator, len: 395 aa; similar to TR:P95217 (EMBL:Z86089) Mycobacterium tuberculosis hypothetical 40.7 kD protein MCTY0A4.04c, 381 aa; fasta scores: opt: 1224 z-score: 1335.3 E(): 0; 52.3% identity in 377 aa overlap and C-terminal region similar to SW:CUTR_STRCO (EMBL:X58793) Streptomyces coelicolor transcriptional regulatory protein CutR, 217 aa; fasta scores: opt: 130 z-score: 151.1 E(): 0.53; 30.3% identity in 132 aa overlap. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal. (395 aa)
SCO3096Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SCO3216SCE8.09, probable integral membrane ATPase, len: 796 aa; member of a large family including SW:Y1B2_MYCTU putative cation-transporting ATPase from Mycobacterium tuberculosis (797 aa) fasta scores; opt: 2741, z-score: 2896.9, E(): 0, (56.8% identity in 791 aa overlap). Contains two Pfam matches to entry PF00122 E1-E2_ATPase, E1-E2 ATPases, score 109.40, E-value 9.7e-30 and score 155.80, E-value 7.3e-43, and Prosite match to PS00154 E1-E2 ATPases phosphorylation site. (796 aa)
SCO3219SCE8.12c, possible lipase (putative secreted protein), len: 391 aa; weak similarity to many eukaryotic lipases e.g. SW:PAFA_CAVPO platelet-activating factor-acetylhydrolase from guinea pig (Cavia porcellus) (436 aa) fasta scores; opt: 153, z-score: 161.7, E(): 0.11, (22.9% identity in 319 aa overlap). Contains PS00120 Lipases, serine active site. Contains possible N-terminal region signal peptide sequence. (391 aa)
SCO3223SCE8.16c, probable ABC transporter integral membrane protein, len: 266aa; located directly downstream of a probable ABC transporter ATP-binding protein (6bp gap). Similar to many particularly TR:O86630 (EMBL:AL031155) an integral membrane protein located directly downstream of a probable ABC transporter ATP-binding protein (2bp gap) from Streptomyces coelicolor (279 aa) fasta scores; opt: 460, z-score: 539.7, E(): 9.4e-23, (37.0% identity in 273 aa overlap). Contains several probable membrane spanning hydrophobic regions. (264 aa)
SCO3225SCE8.18, absA1, two component sensor kinase, len: 571aa; sequenced previously therefore identical to TR:Q53893 (EMBL:U51332) AbsA1, predicted sensor histidine kinase which acts as part of a two component signal transduction system in the global regulation of antibiotic synthesis in Streptomyces coelicolor (571 aa) fasta scores; opt: 3782, z-score: 3585.7, E(): 0, (100.0% identity in 571 aa overlap). (571 aa)
SCO3226SCE8.19, absA2, two component system response regulator, len: 222aa; sequenced previously therefore identical to TR:Q53894 (EMBL:U51332) AbsA2, predicted response regulator which acts as part of a two component signal transduction system in the global regulation of antibiotic synthesis in Streptomyces coelicolor (222 aa) fasta scores; opt: 1376, z-score: 1584.1, E(): 0, (100.0% identity in 222 aa overlap). Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain, score 138.20, E-value 1.5e-37 and PF00196 GerE, Bacterial regulatory proteins, luxR family, [...] (222 aa)
SCO3232SCE63.01, partial CDS, cdaPS3, CDA peptide synthetase III, len: >332 aa; Constitutes the N-terminus of cdaPS3, CDA peptide synthetase III, part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This partial CDS encodes the N-terminus of a subunit of this enzyme suspected to be responsible for the addition of 2 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSII) by one base indicating possible tra [...] (2417 aa)
SCO3234Putative phosphotransferase; Phosphotransferase that is responsible for the production of the 3-phosphohydroxyasparaginyl residues found at position 9 in the non-ribosomally synthesized calcium-dependent antibiotic (CDA) derivatives CDA1b and CDA2a/b. It is not known whether the phosphorylation reaction takes place before, during or after peptide assembly. (300 aa)
SCO3237Conserved hypothetical protein; SCE29.06c, unknown, len: 462 aa; similar to TR:O69954 (EMBL:AL023862) hypothetical protein from Streptomyces coelicolor (465 aa) fasta scores; opt: 2210, z-score: 2646.8, E(): 0, (70.8% identity in 452 aa overlap). (462 aa)
SCO3249SCE29.18c, probable acyl carrier protein, len: 81 aa; member of a large family including SW:ACP_HELPY acyl carrier protein from Helicobacter pylori (78 aa) fasta scores; opt: 121, z-score: 179.0, E(): 0.012, (37.5% identity in 64 aa overlap). Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site, score 31.20, E-value 5.3e-07. (81 aa)
SCO3317SCE68.15c, possible uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, len: 565 aa; similar to many e.g. SW:HEM4_CLOJO (EMBL:D28503), hemD, Clostridium josui porphyrin biosynthesis probable bifunctional protein (504 aa), fasta scores; opt: 519 z-score: 562.5 E(): 5.2e-24, 29.8% identity in 533 aa overlap. The C-terminal half is similar to the monofunctional SW:HEM4_SYNP7 (EMBL:X70966) Synechococcus sp. uroporphyrinogen-III synthase (264 aa) (29.7% identity in 263 aa overlap). May be involved in cysteine biosynthesis and/or porphyrin biosynthesis. Contains Pfam match to [...] (565 aa)
SCO3320Conserved hypothetical protein; Modulates transcription of respiratory genes in response to changes in cellular NADH/NAD(+) redox state. May play a general role as a sensor of cellular redox balance; Belongs to the transcriptional regulatory Rex family. (258 aa)
SCO3381SCE94.32c, nadC, nicotinate-nucleotide pyrophophorylase, len: 329 aa; similar to many e.g. SW:NADC_MYCTU NadC, nicotinate-nucleotide pyrophophorylase from Mycobacterium tuberculosis (285 aa) fasta scores; opt: 909, z-score: 1017.8, E(): 0, (57.3% identity in 267 aa overlap); Belongs to the NadC/ModD family. (329 aa)
SCO3409Putative inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (163 aa)
SCO3547Putative pyrophosphate synthase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. (794 aa)
SCO3649Putative fructose 1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
SCO3877SCH18.14c, probable 6-phosphogluconate dehydrogenase, len: 291 aa; identical to previously sequenced TR:Q53917 (EMBL:L27063) Streptomyces coelicolor 6-phosphogluconate dehydrogenase, 291 aa and highly similar to TR:O88014 (EMBL:AL031107) S. coelicolor SC5A7.08c probable 6-phosphogluconate dehydrogenase, 293 aa; fasta scores: opt: 1654 z-score: 1688.1 E(): 0; 83.4% identity in 289 aa overlap. Contains Pfam match to entry PF00393 6PGD, 6-phosphogluconate dehydrogenasesand match to Prosite entry. (291 aa)
SCO3976SCBAC25E3.13c, possible phosphodiesterase, len: 275aa: similar to many eg. TR:Q9CDC5 (EMBL:AL583917) putative glycerophosphoryl diester phosphodiesterase from Mycobacterium leprae (271 aa) fasta scores; opt: 416, Z-score: 496.0, 46.269% identity (49.012% ungapped) in 268 aa overlap and SW:P37965 (GLPQ_BACSU) glycerophosphoryl diester phosphodiesterase from Bacillus subtilis (293 aa) fasta scores; opt: 233, Z-score: 281.0, 33.712% identity (36.777% ungapped) in 264 aa overlap. (275 aa)
SCO4138SCD84.05, pitH, phosphate transport protein, len: 332 aa; similar to N-terminal region of SW:PITH_STRHA (EMBL:L05390) Streptomyces halstedii putative low-affinity inorganic phosphate transporter (fragment), 213 aa; fasta scores: opt: 768 z-score: 850.1 E(): 0; 59.8% identity in 189 aa overlap, to TR:O30499 (EMBL:AF008187) Sinorhizobium meliloti phosphate transport protein, Pit, 334 aa; fasta scores: opt: 988 z-score: 1087.8 E(): 0; 48.3% identity in 327 aa overlap and to TR:CAB59459 (EMBL:AL132644) Streptomyces coelicolor putative secreted protein SCI8.28, 423 aa; fasta scores: opt: 99 [...] (332 aa)
SCO4141Phosphate ABC transport system permease protein; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (336 aa)
SCO4144Conserved hypothetical protein SCD84.12c; SCD84.11c, unknown, len: 388 aa; similar to TR:Q9EUS7 (EMBL:AJ243674) MutT Protein from Streptomyces griseus subsp. griseus (337 aa) fasta scores; opt: 357, Z-score: 350.5, E(): 6.9e-12, 53.403% identity (68.227% ungapped) in 382 aa overlap. Contains TTA leucine codon, possible target for bldA regulation. High % of G+C content. (388 aa)
SCO4145Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (774 aa)
SCO4209Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
SCO4388SCD10.20, probable citrate synthase, len: 387 aa; similar to SW:CISY_BACSU (EMBL:U05256) Bacillus subtilis citrate synthase I (EC 4.1.3.7) CitA, 366 aa; fasta scores: opt: 615 z-score: 685.9 E(): 9.9e-31; 36.7% identity in 360 aa overlap and to TR:O70008 (EMBL:AL022374) Streptomyces coelicolor citrate synthase (EC 4.1.3.7) SC5B8.22, 390 aa; fasta scores: opt: 780 z-score: 867.9 E(): 0; 41.0% identity in 371 aa overlap. Contains 2 Pfam matches to entry PF00285 citrate_synt, Citrate synthase and match to Prosite entry PS00480 Citrate synthase signature. (387 aa)
SCO4470SCD65.13, probable phosphoglycerate mutase, len: 233 aa; similar to SW:PMG2_ECOLI (EMBL:M97495) Escherichia coli probable phosphoglycerate mutase 2 (EC 5.4.2.1) GpmB, 215 aa; fasta scores: opt: 182 z-score: 227.1 E(): 3.5e-05; 26.5% identity in 215 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. (233 aa)
SCO4472SCD65.15, possible secreted protein, len: 223 aa; similar to TR:O06392 (EMBL:Z95558) Mycobacterium tuberculosis hypothetical 23.2 kDa protein MTCY25D10.05, 216 aa; fasta scores: opt: 431 z-score: 460.1 E(): 3.7e-18; 39.2% identity in 204 aa overlap. Contains possible N-terminal region signal peptide sequence. (223 aa)
SCO4562NuoA, NADH dehydrogenase subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (119 aa)
SCO4594SCD20.12c, probable oxidoreductase, len: 352 aa; highly similar to TR:Q9RKS5 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase beta-subunit SCAH10.34c, 350 aa; fasta scores: opt: 2267 z-score: 2567.5 E(): 0; 98.0% identity in 349 aa overlap and to SW:KORB_ARCFU (EMBL:AE001072) Archaeoglobus fulgidus 2-oxoglutarate synthase subunit KorB (EC 1.2.7.3), 267 aa; fasta scores: opt: 529 z-score: 605.9 E(): 2.8e-26; 37.6% identity in 221 aa overlap. (352 aa)
SCO4595SCD20.13c, probable oxidoreductase, len: 645 aa; highly similar to TR:Q9RKS4 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase alpha-subunit SCAH10.35c, 630 aa; fasta scores: opt: 4069 z-score: 4338.6 E(): 0; 98.7% identity in 627 aa overlap and C-terminal domain similar to TR:O68228 (EMBL:AF021094) Helicobacter pylori OorA subunit of 2-oxoglutarate:acceptor oxidoreductase, 371 aa; fasta scores: opt: 495 z-score: 532.2 E(): 3.6e-22; 31.0% identity in 352 aa overlap. Contains Pfam match to entry PF01855 POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase (N terminus). (645 aa)
SCO4723Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
SCO4808succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
SCO4809Succinyl CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SCO4827Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H). (329 aa)
SCO4855SC5G8.23c, dhsB, probable succinate dehydrogenase iron-sulfur subunit, len: 257aa; strongly similar to many eg. SW:P07014 (DHSB_ECOLI) succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa) fasta scores; opt: 729, z-score: 839.1, E(): 0, 44.3% identity in 237 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Belongs to the succinate [...] (257 aa)
SCO5047SCK7.20c, conserved hypothetical protein, len: 343 aa; similar to SW:GLPX_ECOLI (EMBL:Z11767) Escherichia coli hypothetical protein GlpX, 336 aa; fasta scores: opt: 789 z-score: 868.1 E(): 0; 46.5% identity in 325 aa overlap. (343 aa)
SCO52612SC7G11.23, probable malate oxidoreductase, len: 409 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38), 478 aa; fasta scores: opt: 1385 z-score: 1470.9 E(): 0; 55.0% identity in 391 aa overlap. Contains 2x Pfam matches to entry PF00390 malic, Malic enzyme. (409 aa)
SCO5366ATP synthase protein I; A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex; Belongs to the bacterial AtpI family. (144 aa)
SCO5374ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (124 aa)
SCO54266-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (341 aa)
SCO5831SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap. (421 aa)
SCO5999Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SCO6243SCAH10.08c, aceB1, malate synthase, len: 540 aa; highly similar to SW:MASY_STAE (EMBL:U63518) Streptomyces arenae, malate synthase (EC 4.1.3.2) AceB, 543 aa; fasta scores: opt: 2625 z-score: 3156.2 E(): 0; 78.2% identity in 551 aa overlap. Contains match to Pfam entry PF01274 Malate_synthase, Malate synthase and to Prosite entry PS00510 Malate synthase signature. (540 aa)
SCO6260SCAH10.25, possible sugar kinase, len: 382 aa; similar to SW:GLK_STRCO (EMBL:X65932) Streptomyces coelicolor glucokinase (EC 2.7.1.2) (glucose kinase) Glk, 317 aa; fasta scores: opt: 1022 z-score: 1142.9 E(): 0; 46.6% identity in 311 aa overlap and to TR:CAB51974 EMBL:SC6E10 Streptomyces coelicolor SC6E10.20c, 317 aa; fasta scores: opt: 1022 z-score: 1035.4 E(): 0; 46.6% identity in 311 aa overlap. Contains a match to Pfam entry PF00480 ROK, ROK family and Prosite entry PS01125 ROK family signature. (382 aa)
SCO6288SCBAC8D1.01, probable regulatory protein, len: 276 aa; similar to SW:AC24_STRCO (EMBL:M64683) Streptomyces coelicolor probable actinorhodin operon activatory protein actII-4, 255 aa; fasta scores: opt: 707 Z-score: 815.0 bits: 158.5 E(): 8.3e-38; 45.306% identity in 245 aa overlap; SC1G7.14, possible regulatory protein (fragment), len: >35 aa; similar to TR:Q54494 (EMBL:AJ224512) Streptomyces nogalater activator SnoA, 665 aa; fasta scores: opt: 86 Z-score: 144.4 bits: 32.8 E(): 1.9; 45.455% identity in 33 aa overlap. (276 aa)
SCO6429Hypothetical protein; SC1A6.18, unknown, len: 462 aa; some similarity to a hypothetical proteins from Streptomyces hygroscopicus TR:Q54310 (EMBL:X86780) ORFE from gene cluster for polyketide immunosuppressant rapamycin (465 aa), fatsa scores; opt: 306 z-score: 225.9 E(): 1.8e-05, 28.3% identity in 441 aa overlap. (462 aa)
SCO6466Putative transferase; SC9C7.02, conserved hypothetical protein, len: 380 aa; similar to many e.g. SW:YXAA_BACSU hypothetical protein from Bacillus subtilis (382 aa) fasta scores; opt: 1045, z-score: 998.9, E(): 0, (46.3% identity in 374 aa overlap) and to SW:GRK_BACSU (EMBL:AB005554) Bacillus subtilis glycerate kinase (EC 2.7.1.31) GlxK, 382 aa; fasta scores: opt: 1045 Z-score: 991.1 E(): 1.4e-47; 46.257% identity in 374 aa overlap. (380 aa)
SCO6471SC9C7.07c, probable citratelyase, len: 339 aa; similar to many e.g. SW:CILB_KLEPN citrate lyase beta chain from Klebsiella pneumoniae (289 aa) fasta scores; opt: 187, z-score: 643.3, E(): 1.5e-28, (30.5% identity in 298 aa overlap); Belongs to the HpcH/HpaI aldolase family. (339 aa)
SCO6659SC5A7.09c, pgi, glucose-6-phosphate isomerase, len: 550 aa; highly similar to many e.g. G6PI_ECOLI glucose-6-phosphate isomerase (EC 5.3.1.9) (549 aa), fasta sores; opt: 1878 z-score: 1900.7 E(): 0, 53.6% identity in 545 aa overlap. Contains PS00174 Phosphoglucose isomerase signature 2 and Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 897.30, E-value 4.4e-266. (550 aa)
SCO6662Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (381 aa)
SCO6811Putative secreted protein; SC1A2.20c, possible secreted protein, len: 464 aa. The N-terminus is highly similar to Streptomyces coelicolor TR:Q9X8X7 (EMBL:AL078610) putative secreted protein, SCH35.29 (162 aa), fasta scores opt: 753 z-score: 813.4 E(): 0 71.2% identity in 146 aa overlap. Contains a possible N-terminal signal sequence. (464 aa)
SCO6837SC3D9.05, possible arsenic resistance membrane transport protein, len: 368 aa. Highly similar to Streptomyces coelicolor TR:Q9X8Y0(EMBL:AL078610) putative heavy metal resistance membrane protein, SCH35.26 (369 aa), fasta scores opt: 2304 z-score: 2675.9 E(): 0 95.4% identity in 369 aa overlap and Sinorhizobium sp. As4. TR:AAD51846(EMBL:AF178758) membrane subunit of arsenic oxyanion-translocation pump, ArsB (351 aa), fasta scores opt: 1263 z-score: 1469.8 E():0 53.8% identity in 344 aa overlap. Contains possible membrane spanning hydrophobic domains and a Pfam match to entry PF01758 SBF [...] (368 aa)
SCO7035SC2C3.02, gabD, succinate-semialdehyde dehydrogenase (fragment), len: >422 aa; highly similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) GabD, 482 aa; fasta scores: opt: 1329 z-score: 1466.8 E(): 0; 48.9% identity in 415 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family and match to Prosite entry PS00687 Aldehyde dehydrogenases glutamic acid active site; SC4G1.01, gabD, succinate-semialdehyde dehydrogenase (fragment), len: >90 aa; similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli [...] (479 aa)
SCO7040SC4G1.06c, gap2, glyceraldehyde-3-phosphate dehydrogenase, len: 481 aa; highly similar to TR:O68923 (EMBL:AF058302) Streptomyces roseofulvus glyceraldehyde-3-phosphate dehydrogenase homolog GapX, 461 aa; fasta scores: opt: 2562 z-score: 2921.8 E(): 0; 84.5% identity in 459 aa overlap and to many eukaryotic homologos, e.g. SW:G3PA_MAIZE (EMBL:X15408) Zea mays glyceraldehyde-3-phosphate dehydrogenase A, chloroplast precursor (EC 1.2.1.12) GapA, 403 aa; fasta scores: opt: 793 z-score: 907.5 E(): 0; 39.6% identity in 366 aa overlap. Contains Pfam match to entry PF00044 gpdh, glyceraldehyde [...] (481 aa)
SCO7511SCBAC25F8.03, gap2, glyceraldehyde 3-phosphate dehydrogenase, len: 332 aa; highly similar to SW:G3P_STRAU (EMBL:U21191) Streptomyces aureofaciens glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) Gap, 332 aa; fasta scores: opt: 1898 Z-score: 2070.6 bits: 391.5 E(): 1e-107; 88.855% identity in 332 aa overlap and to TR:CAB38137 (EMBL:AL035591) Streptomyces coelicolor glyceraldehyde 3-phosphate dehydrogenase Gap or SCC54.07c, 337 aa; fasta scores: opt: 1272 Z-score: 1174.4 bits: 225.7 E(): 1.1e-59; 57.831% identity in 332 aa overlap. Contains Pfam matches to entries PF00044 gpdh, Gly [...] (332 aa)
SCO7622NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (483 aa)
SCO7623SC2H2.21c, pntA, NAD(P) transhydrogenase alpha subunit, len: 524 aa; similar to SW:PNTA_ECOLI (EMBL:X04195) Escherichia coli NAD(P) transhydrogenase subunit alpha (EC 1.6.1.1) PntA, 510 aa; fasta scores: opt: 1907 z-score: 1729.3 E(): 0; 58.4% identity in 514 aa overlap. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. Also contains possible hydrophobic membrane spanning regions. (524 aa)
SCO7638Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
SCO7681SC4C2.16c, probable AMP-binding ligase, len: 553 aa; similar to SW:DHBE_BACSU (EMBL:U26444) Bacillus subtilis 2,3-dihydroxybenzoate-AMP ligase (EC 6.3.2.-) DhbE, 539 aa; fasta scores: opt: 1324 z-score: 1411.8 E(): 0; 51.6% identity in 539 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme and match to Prosite entry PS00455 Putative AMP-binding domain signature. (553 aa)
SCO7691SC4C2.26, possible lyase, len: 471 aa; C-terminal region similar to C-terminal region of SW:TRPE_HALVO (EMBL:M83788) Halobacterium volcanii anthranilate synthase component I(EC 4.1.3.27) TrpE, 523 aa; fasta scores: opt: 545 z-score: 624.2 E(): 3.1e-27; 38.7% identity in 300 aa overlap. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme. (471 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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