STRINGSTRING
SCO2465 SCO2465 SCO0509 SCO0509 SCO5820 SCO5820 SCO3202 SCO3202 SCO2119 SCO2119 SCO6661 SCO6661 SCO1658 SCO1658 SCO1659 SCO1659 SCO1660 SCO1660 SCO1937 SCO1937 SCO6246 SCO6246
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SCO2465RNA polymerase principal sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (396 aa)
SCO0509Glycerol kinase 2 (ATP:glycerol 3-phosphotransferase) (EC 2.7.1.30); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (507 aa)
SCO5820Major vegetative sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Its activity is stimulated by RbpA. (511 aa)
SCO3202RNA polymerase principal sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (332 aa)
SCO21196-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (342 aa)
SCO6661Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (592 aa)
SCO1658Glycerol operon regulatory protein; May be an activator protein for the gylABX operon. (254 aa)
SCO1659Putative glycerol uptake facilitator protein; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)
SCO1660Putative glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (512 aa)
SCO1937Putative glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa)
SCO6246SCAH10.11c, iclR, transcriptional regulator for glyoxylate bypass, len: 270 aa; highly similar to SW:ICLR_ECOLI (EMBL:M31761) Escherichia coli acetate operon repressor IclR, 274 aa; fasta scores: opt: 538 Z-score: 603.9 E(): 5.5e-26; 40.234% identity in 256 aa overlap and to SW:GYLR_STRCO (EMBL:X14188) Streptomyces coelicolor glycerol operon regulatory protein, 254 aa; fasta scores: opt: 333 z-score: 389.8 E(): 2.4e-14; 32.8% identity in 250 aa overlap. Contains match to Pfam entry PF01614 IclR, Bacterial transcriptional regulator and a possible helix-turn-helix motif at residues 39..6 [...] (270 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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