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SCO6748 SCO6748 SCO6586 SCO6586 SCO6585 SCO6585 SCO6178 SCO6178 SCO5979 SCO5979 SCO4388 SCO4388 SCO4722 SCO4722 SCO4808 SCO4808 SCO4384 SCO4384 SCO3096 SCO3096 SCO3005 SCO3005 SCO2736 SCO2736 SCO2014 SCO2014 SCO1947 SCO1947 SCO1852 SCO1852 SCO1129 SCO1129 SCO0923 SCO0923 SCO0560 SCO0560 SCO0364 SCO0364 SCO4809 SCO4809 SCO4827 SCO4827 SCO4837 SCO4837 SCO4856 SCO4856 SCO4930 SCO4930 SCO5042 SCO5042 SCO5107 SCO5107 SCO5254 SCO5254 SCO5364 SCO5364 SCO5423 SCO5423 SCO5459 SCO5459 SCO5470 SCO5470 SCO5831 SCO5831 SCO5832 SCO5832
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
SCO6748SC5F2A.31c, possible enoyl coA hydratase, len: 257aa; similar to many proposed to be enoyl coA hydratase based on Pfam match eg. TR:P97087 (EMBL:Z92974) from Clostridium thermosaccharolyticum (259 aa) fasta scores; opt: 426, z-score: 496.6, E(): 2.4e-20, (31.2% identity in 247 aa overlap). Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. (257 aa)
SCO6586Succinyl-coa synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (308 aa)
SCO6585Succinyl-coa synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa)
SCO6178SC6C5.14c, possible deacetylase (putative secreted protein), len: 260 aa; similar to many e.g. SW:NODB_RHILT NodB, chitooligosaccharide deacetylase, nodulation protein B, from Rhizobium leguminosarum (215 aa) fasta scores; opt: 321, z-score: 420.9, E(): 3.7e-16, (35.0% identity in 197 aa overlap). Contains possible N-terminal region signal peptide sequence. (260 aa)
SCO5979SCBAC16H6.14, possible enoyl-CoA hydratase, len: 275 aa: similar to many e.g. SW:P77467 (PAAG_ECOLI) probable enoyl-CoA hydratase from Escherichia coli (262 aa) fasta scores; opt: 488, Z-score: 554.6, 36.434% identity (37.450% ungapped) in 258 aa overlap and TR:Q9AJT1 (EMBL:AJ278289) hypothetical protein from Thauera aromatica (272 aa) fasta scores; opt: 780, Z-score: 880.5, 44.318% identity (44.656% ungapped) in 264 aa overlap. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family and Prosite match to PS00166 Enoyl-CoA hydratase/isomerase signature. (275 aa)
SCO4388SCD10.20, probable citrate synthase, len: 387 aa; similar to SW:CISY_BACSU (EMBL:U05256) Bacillus subtilis citrate synthase I (EC 4.1.3.7) CitA, 366 aa; fasta scores: opt: 615 z-score: 685.9 E(): 9.9e-31; 36.7% identity in 360 aa overlap and to TR:O70008 (EMBL:AL022374) Streptomyces coelicolor citrate synthase (EC 4.1.3.7) SC5B8.22, 390 aa; fasta scores: opt: 780 z-score: 867.9 E(): 0; 41.0% identity in 371 aa overlap. Contains 2 Pfam matches to entry PF00285 citrate_synt, Citrate synthase and match to Prosite entry PS00480 Citrate synthase signature. (387 aa)
SCO4722Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (437 aa)
SCO4808succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
SCO4384SCD10.16, possible enoyl CoA hydratase, len: 247 aa; similar to TR:Q9X7Q4 (EMBL:AL049587) Streptomyces coelicolor putative enoyl CoA hydratase SC5F2A.31c, 257 aa; fasta scores: opt: 364 z-score: 425.2 E(): 3.3e-16; 36.1% identity in 252 aa overlap and to SW:ECHH_RHIME (EMBL:L39265) Rhizobium meliloti probable enoyl-CoA hydratase (EC 4.2.1.17) FadB1, 257 aa; fasta scores: opt: 334 z-score: 390.9 E(): 2.7e-14; 34.0% identity in 247 aa overla. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. (247 aa)
SCO3096Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
SCO3005Preprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (947 aa)
SCO2736SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. (429 aa)
SCO2014SC7H2.28c, pyk1, pyruvate kinase, len: 478 aa; strongly similar to many e.g. SW:KPYK_CORGL pyruvate kinase from Corynebacterium glutamicum (475 aa) fasta scores; opt: 1800, z-score: 2008.1, E(): 0, (59.6% identity in 473 aa overlap). Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature. (478 aa)
SCO1947Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] (336 aa)
SCO1852Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (486 aa)
SCO11292SCG38.22, probable secreted deacetylase, len: 282 aa; similar to SW:NODB_RHIME (EMBL:X01649) Rhizobium meliloti chitooligosaccharide deacetylase (EC 3.5.1.-) NodB, 217 aa; fasta scores: opt: 363 z-score: 383.5 E(): 6.5e-14; 38.5% identity in 195 aa overlap. Contains Pfam match to entry PF01522 Polysac_deacet, Polysaccharide deacetylase and possible N-terminal region signal peptide sequence. (282 aa)
SCO0923SCM10.11c, probable reductase flavoprotein subunit, len: 649 aa; similar to SW:DHSA_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) SdhA, 585 aa;fasta scores: opt: 580 z-score: 658.7 E(): 2.7e-29; 36.8% identity in 609 aa overlap and to SW:FRDA_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase flavoprotein subunit FrdA, 583 aa; fasta scores: opt: 443 z-score: 503.1 E(): 1.2e-20; 32.2% identity in 574 aa overlap. Contains three Pfam matches to entry Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. (649 aa)
SCO0560Catalase/peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. (740 aa)
SCO0364SCF41.23, possible enoyl-CoA hydratase, len: 268 aa. Shares a high level of similarity with Mycobacterium tuberculosis TR:O53418 (EMBL; AL021897) enoyl-CoA hydratase MTV017.23C (EMBL; AL021897), fasta scores opt: 554 z-score: 635.0 E(): 5.1e-28 40.9% identity in 257 aa overlap. Contains a Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. (268 aa)
SCO4809Succinyl CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SCO4827Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H). (329 aa)
SCO4837Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (481 aa)
SCO4856SC5G8.24c, dhsA, probable succinate dehydrogenase flavoprotein subunit, len: 584aa; strongly similar to many eg. SW:P10444 (DHSA_ECOLI) succinate dehydrogenase flavoprotein subunit from Escherichia coli (588 aa) fasta scores; opt: 1842, z-score: 2076.6, E(): 0, 48.4% identity in 591 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain and Prosite match to PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. (584 aa)
SCO4930SCK13.22, probable enoyl-CoA hydratase, len: 266 aa; similar to SW:PAAF_ECOLI (EMBL:AE000236) Escherichia coli probable enoyl-CoA hydratase PaaF (EC 4.2.1.17), 255 aa; fasta scores: opt: 562 z-score: 664.6 E(): 1.8e-29; 40.2% identity in 259 aa overlap. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family and match to Prosite entry PS00166 Enoyl-CoA hydratase/isomerase signature. (266 aa)
SCO5042Fumarate hydratase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
SCO5107SCBAC31E11.03c, shdA2, probable succinate dehydrogenase flavoprotein subunit, len: 653 aa; highly similar to TR:AAK44480 (EMBL:AE006934) Mycobacterium tuberculosis CDC1551 FAD flavoprotein oxidase, putative MT0262, 646 aa; fasta scores: opt: 2941 Z-score: 3164.4 bits: 595.8 E(): 1.2e-168; 70.416% identity in 649 aa overlap and to SW:DHSA_RICPR (EMBL:M88696) Rickettsia prowazekii succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) SdhA, 596 aa; fasta scores: opt: 643 Z-score: 693.1 bits: 138.4 E(): 5.4e-31; 35.218% identity; in 619 aa overlap. Contains Pfam matches to entries PF0 [...] (653 aa)
SCO52542SC7G11.16c, sodN, superoxide dismutase, len: 131 aa; previously sequenced as TR:O51921 (EMBL:AF104994) Streptomyces coelicolor superoxide dismutase (EC 1.15.1.1) SodN, 131 aa; Belongs to the nickel superoxide dismutase family. (131 aa)
SCO5364Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
SCO5423SC8F4.27c, pyk2, pyruvate kinase, len: 476 aa; strongly similar to many e.g. SW:Q46078 (KPYK_CORGL) pyruvate kinase from Corynebacterium glutamicum (Brevibacterium flavum) (475 aa) fasta scores; opt: 1693, z-score: 1907.7, E(): 0, 55.3% identity in 474 aa overlap and TRNEW:CAB52070 (EMBL:AL109732) pyruvate kinase from Streptomyces coelicolor (478 aa) fasta scores; opt: 2185, z-score: 2461.2, E(): 0, 69.3% identity in 473 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature. (476 aa)
SCO5459SC3D11.16, probable enoyl-coA hydratase, len: 255aa; similar to many eg. SW:P52046 (CRT_CLOAB) 3-hydroxybutyryl-coa dehydratase from Clostridium acetobutylicum (261 aa) fasta scores; opt: 637, z-score: 725.4, E(): 5.4e-33, 43.4% identity in 249 aa overlap. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family and Prosite match to PS00166 Enoyl-CoA hydratase/isomerase signature. (255 aa)
SCO5470Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
SCO5831SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap. (421 aa)
SCO5832SC5B8.22, putative citrate synthase, len: 390 aa; similar to citrate synthase from many organisms e.g. CISZ _BACSU P39120 bacillus subtilis. citrate synthase i (372 aa), fasta scores; opt: 729 z-score: 877.4 E(): 0, 35.5% iden tity in 372 aa overlap. Contains PS00480 Citrate synthase s ignature and Pfam match to entry citrate_synt PF00285, Citr ate synthase, score 314.55. Also similar to downstream gene SC5B8.21c (421 aa) E(): 2.6e-14, 32.4% identity in 352 aa overlap. (390 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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