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SCO0812 SCO0812 SCO0814 SCO0814 SCO1110 SCO1110 SCO1169 SCO1169 SCO1170 SCO1170 SCO1464 SCO1464 SCO1879 SCO1879 SCO1880 SCO1880 SCO1888 SCO1888 SCO2439 SCO2439 SCO2462 SCO2462 SCO2821 SCO2821 SCO3052 SCO3052 SCO3182 SCO3182 SCO3476 SCO3476 SCO6147 SCO6147 SCO7629 SCO7629
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO0812SCF43A.02, possible sugar isomerase, len: 386 aa; weakly similar to many xylose isomerases (divergent at N-and C-termini) e.g. SW:XYLA_AMPSP (EMBL:M15050), XylA, Ampullariella sp. xylose isomerase (394 aa), fasta scores; opt: 189 z-score: 229.6 E(): 1.8e-05, 26.9% identity in 219 aa overlap. (386 aa)
SCO0814SCF43A.04, probable rhamnose kinase, len: 484 aa; similar to rhamnose kinases e.g. SW:RHAB_ECOLI (EMBL:L19201), rhaB, Escherichia coli rhamnulokinase (489 aa), fasta scores; opt: 1136 z-score: 1280.7 E(): 0, 41.5% identity in 468 aa overlap. Also similar to many other carbohydrate kinases e.g. SW:FUCK_ECOLI (EMBL:X15025), fucK, Escherichia coli L-fuculokinase (482 aa) (27.7% identity in 411 aa overlap). Contains Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases. (484 aa)
SCO11102SCG38.03, probable secreted lyase, len: 266 aa; similar to TR:Q04701 (EMBL:M94691) Fusarium solani pectate lyase A precursor (EC 4.2.2.2) PelA, 242 aa; fasta scores: opt: 605 z-score: 664.1 E(): 1.5e-29; 43.6% identity in 236 aa overlap. Contains possible N-terminal region signal peptide sequence. (266 aa)
SCO11692SCG11.03c, xylA, xylose isomerase, len: 387 aa; identical to SW:XYLA_STRRU (EMBL:M73789) Streptomyces rubiginosus xylose isomerase XylA, 387 aa. Contains Pfam match to entry PF00259 Xylose_isom, Xylose isomerase and matches to Prosite entries PS00172 Xylose isomerase signature 1 and PS00173 Xylose isomerase signature 2. (387 aa)
SCO1170Xylulose kinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate; Belongs to the FGGY kinase family. (481 aa)
SCO1464Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
SCO1879SCI39.26c, probable secreted pectinesterase, len: 381 aa; similar to SW:PME_BURSO (EMBL:M62803) Burkholderia solanacearum pectinesterase precursor (EC 3.1.1.11) Pme, 396 aa; fasta scores: opt: 350 Z-score: 372.6 bits: 77.7 E(): 3.7e-13; 32.036% identity in 334 aa overlap. Contains Pfam match to entry PF01095 Pectinesterase, Pectinesterase and match to Prosite entry PS00503 Pectinesterase signature 2. Contains also possible N-terminal region signal peptide sequence. (381 aa)
SCO1880SCI39.27c, probable secreted pectate lyase, len: 444 aa; similar to SW:PEL_BACS (EMBL:X74880) Bacillus subtilis pectate lyase precursor (EC 4.2.2.2) Pel, 420 aa; fasta scores: opt: 1127 Z-score: 1249.8 bits: 240.3 E(): 5e-62; 42.431% identity in 436 aa overlap. Contains 2x Pfam matches to entry PF00544 pec_lyase, Pectate lyase. Contains also possible N-terminal region signal peptide sequence. (444 aa)
SCO1888SCI7.06c, probable dihydroxy-acid dehydratase, len: 576aa; similar to many eg. SW:ILVD_BACSU dihydroxy-acid dehydratase from Bacillus subtilis (557 aa) fasta scores; opt: 1153, z-score: 1290.1, E(): 0, (37.0% identity in 560 aa overlap). Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family and Prosite match to PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. Also contains a helix-turn-helix motif (+3.32 SD) 207-228aa; Belongs to the IlvD/Edd family. (576 aa)
SCO2439SCC24.10c, possible calcium-binding protein, len: 286 aa; similar to TR:BAA90694 (EMBL:AB037936) Xenopus laevis regucalcin, 299 aa; fasta scores: opt: 449 z-score: 514.7 E(): 3.1e-21; 33.8% identity in 293 aa overlap. (286 aa)
SCO2462SC7A8.01, probable sugar kinase (fragment), len: >434 aa; similar to TR:CAB61582 (EMBL:AL133210) Streptomyces coelicolor xylulose kinase (fragment) XylB, 432 aa; fasta scores: opt: 822 z-score: 871.9 E(): 0; 38.8% identity in 418 aa overlap and to SW:XYLB_STRRU (EMBL:M73789) Streptomyces rubiginosus xylulose kinase (EC 2.7.1.17) XylB, 481 aa; fasta scores: opt: 814 z-score: 862.8 E(): 0; 39.5% identity in 423 aa overlap. Contains Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases and PS00445 FGGY family of carbohydrate kinases signature 2; SCC24.33, probable sugar ki [...] (482 aa)
SCO2821SCBAC17F8.12c, possible secreted pectate lyase, len: 521 aa: similar to many e.g. TR:Q9KGY6 (EMBL:AF278705) pectate lyase B from Alteromonas haloplanktis (658 aa) fasta scores; opt: 1744, Z-score: 1590.1, 63.301% identity (65.859% ungapped) in 515 aa overlap and SW:P04959 (PELB_ERWCH) pectate lyase B from Erwinia chrysanthemi (375 aa) fasta scores; opt: 413, Z-score: 386.2, 29.167% identity (32.464% ungapped) in 384 aa overlap. Contains Pfam match to entry PF00544 pec_lyase, Pectate lyase and a probable N-terminal signal sequence. (521 aa)
SCO3052SCBAC19G2.07, probable UDP-glucose 6-dehydrogenase, len: 447aa: similar to many eg. SW:O54068 (UDG_RHIME) UDP-glucose 6-dehydrogenase RkpK from Rhizobium meliloti EC:1.1.1.22 (437 aa) fasta scores; opt: 1101, Z-score: 1198.1, 43.080% identity (44.780% ungapped) in 448 aa overlap. Contains Pfam match to entry PF00984 UDPG_MGDP_dh, UDP-glucose/GDP-mannose dehydrogenase family. (447 aa)
SCO3182SCE87.33c, gtaB, UTP-glucose-1-phosphate uridylyltransferase, len: 303 aa. Highly similar to many proteins belonging to the prokaryotic UDPGP family e.g. Bacillus subtilis SW:GTAB_BACSU (EMBL:L12272) UTP-glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (292 aa), fasta scores opt: 907 z-score: 1054.0 E(): 0 47.1% identity in 293 aa overlap. Contains a Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. (303 aa)
SCO3476Putative short-chain dehydrogenase; SCE65.12c, probable dehydrogenase, len: 251 aa; similar to SW:KDUD_BACSU (EMBL:L47838) Bacillus subtilis 2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) KduD, 254 aa; fasta scores: opt: 833 z-score: 937.8 E(): 0; 52.0% identity in 248 aa overlap and to Streptomyces coelicolor SCI30A.02, 253 aa; fasta scores: opt: 605 z-score: 622.2 E(): 2.7e-29; 44.1% identity in 245 aa overlap. Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and match to [...] (251 aa)
SCO6147Putative oxidoreductase; Catalyzes the oxidation of xylitol to xylose, also acts on D- sorbitol. (418 aa)
SCO7629SC10F4.02, spaA, probable starvation sensing protein, len: 413 aa; identical to previously sequenced TR:P95726 (EMBL:X94190) Streptomyces coelicolor spaA gene, 413 aa. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family and match to Prosite entry PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. (413 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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