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SCO3137 SCO3137 SCO3138 SCO3138 SCO3182 SCO3182 SCO3326 SCO3326 SCO3475 SCO3475 SCO3479 SCO3479 SCO3651 SCO3651 SCO3780 SCO3780 SCO4283 SCO4283 SCO4285 SCO4285 SCO5426 SCO5426 SCO5689 SCO5689 SCO5848 SCO5848 SCO6110 SCO6110 SCO6260 SCO6260 SCO6347 SCO6347 SCO7010 SCO7010 SCO6457 SCO6457 SCO7407 SCO7407 SCO7443 SCO7443 SCO0063 SCO0063 SCO0274 SCO0274 SCO0284 SCO0284 SCO0541 SCO0541 SCO0766 SCO0766 SCO1077 SCO1077 SCO1214 SCO1214 SCO1394 SCO1394 SCO2119 SCO2119 SCO2126 SCO2126 SCO2228 SCO2228 SCO2393 SCO2393 SCO2401 SCO2401 SCO2407 SCO2407 SCO2988 SCO2988 SCO3136 SCO3136
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO3137SCE66.16c, galE1, UDP-glucose 4-epimerase (EC 5.1.3.2), len: 321aa; strongly similar to many eg. SW:P13226 (GALE_STRLI) UDP-glucose 4-epimerase from Streptomyces lividans (329 aa) fasta scores; opt: 1791, z-score: 2020.5, E(): 0, 89.4% identity in 321 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. (321 aa)
SCO3138SCE66.17c, galT, galactose-1-phosphate uridylyltransferase (EC 2.7.7.10), len: 353aa; similar to many especially SW:P13212 (GAL7_STRLI) galactose-1-phosphate uridylyltransferase from Streptomyces lividans (354 aa) fasta scores; opt: 1998, z-score: 2363.0, E(): 0, 87.2% identity in 352 aa overlap. Contains Pfam match to entry PF01087 GalP_UDP_transf, Galactose-1-phosphate uridyl transferase and Prosite match to PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. (353 aa)
SCO3182SCE87.33c, gtaB, UTP-glucose-1-phosphate uridylyltransferase, len: 303 aa. Highly similar to many proteins belonging to the prokaryotic UDPGP family e.g. Bacillus subtilis SW:GTAB_BACSU (EMBL:L12272) UTP-glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (292 aa), fasta scores opt: 907 z-score: 1054.0 E(): 0 47.1% identity in 293 aa overlap. Contains a Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. (303 aa)
SCO3326SCE68.24c, possible epimerase, len: 353 aa; similar to many e.g. SW:GALE_SALT (EMBL:M33681), galE, Salmonella typhimurium UDP-glucose 4-epimerase (337 aa), fasta scores; opt: 209 z-score: 250.6 E(): 1.2e-06, 32.1% identity in 193 aa overlap. Similar to hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. SW:YV28_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis putative UDP-glucose 4-epimerase (376 aa) (45.0% identity in 353 aa overlap). N-terminal half weakly similar to the corresponding region of TR:O54156 (EMBL:AL021409), SC3F7.13, S.coelicolor probable o [...] (353 aa)
SCO3475SCE65.11c, possible isomerase, len: 377 aa; similar to SW:ATB_RHOOP (EMBL:X99622) Rhodococcus opacus muconate cycloisomerase I (EC 5.5.1.1) CatB, 373 aa; fasta scores: opt: 390 z-score: 443.3 E(): 2.6e-17; 31.1% identity in 357 aa overlap. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. (377 aa)
SCO3479SCE65.15c, possible beta-galatosidase, len: 995 aa; similar to SW:BGAL_ECOLI (EMBL:J01636) Escherichia coli beta-galactosidase (EC 3.2.1.23) (lactase) lacZ, 1023 aa; fasta scores: opt: 1594 z-score: 1693.3 E(): 0; 33.6% identity in 1039 aa overlap. Contains Pfam match to entry PF00703 Glyco_hydro_2, Glycosyl hydrolases family and match to Prosite entry PS00719 Glycosyl hydrolases family 2 signature 1. (995 aa)
SCO3651SCH10.29c, hypothetical protein, len: 262 aa; unknown function, weakly similar to SW:YPHB_ECOLI (EMBL:AE000340), YphB, Escherichia coli hypothetical protein (290 aa), fasta scores; opt: 225 z-score: 270.0 E(): 1e-07, 26.4% identity in 239 aa overlap and SW:YIHR_ECOLI (EMBL:L19201), YihR, Escherichia coli hypothetical protein (308 aa) (26.3% identity in 270 aa overlap). (262 aa)
SCO3780SCH63.27, probable sugar hydrolase, len: 556 aa; similar to SW:TREC_ECOLI (EMBL:U06195) Escherichia coli trehalose-6-phosphate hydrolase (EC 3.2.1.93) TreC, 551 aa; fasta scores: opt: 833 z-score: 927.7 E(): 0; 35.4% identity in 557 aa overlap and to TR:CAB90876 (EMBL:AL355753) Streptomyces coelicolor aglA, alpha-glucosidase SC10B7.23c, 577 aa; fasta scores: opt: 1146 z-score: 1084.7 E(): 0; 56.8% identity in 572 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase. (556 aa)
SCO4283SCD95A.16c, probable sugar kinase, len: 310 aa; similar to SW:LACC_LACLA (EMBL:M60447) Lactococcus lactis tagatose-6-phosphate kinase (EC 2.7.1.144) (phosphotagatokinase) LacC, 310 aa; fasta scores: opt: 559 z-score: 579.1 E(): 8.5e-25; 35.9% identity in 304 aa overlap. Contains Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase and match to Prosite entry PS00583 pfkB family of carbohydrate kinases signature 1 and PS00584 pfkB family of carbohydrate kinases signature 2. (310 aa)
SCO4285SCD95A.18, possible sugar kinase, len: 326 aa; similar to TR:CAB60179 (EMBL:AL132824) Streptomyces coelicolor putative sugar kinase SCAH10.25, 382 aa; fasta scores: opt: 449 z-score: 453.3 E(): 8.7e-18; 37.2% identity in 301 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and 5x degenerate repeat: (S/A)AP. (326 aa)
SCO54266-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (341 aa)
SCO5689SC5H4.13, probable beta-galactosidase, len: 656 aa; similar to SW:BGAL_BACST (EMBL:M13466) Bacillus stearothermophilus beta-galactosidase I (EC 3.2.1.23) (lactase) BgaB, 672 aa; fasta scores: opt: 1761 z-score: 2065.7 E(): 0; 41.3% identity in 634 aa overlap and to TR:CAB76326 (EMBL:AL158061) Streptomyces coelicolor probable beta-galactosidase SC6D11.03c, 681 aa; fasta scores: opt: 1739 z-score: 1719.0 E(): 0; 46.0% identity in 670 aa overlap. (656 aa)
SCO5848SC9B10.15, agaZ, possible tagatose 6-phosphate kinase, len: 435; highly similar to AGAZ_ECOLI P42903 putative tagatose 6-phosphate kinase (426 aa), fasta scores; opt: 1637 z-score: 2100.1 E(): 0, 57.5% identity in 421 aa overlap. (435 aa)
SCO6110SCBAC1A6.34c, probable sugar kinase, len: 308 aa; similar to SW:GLK_STRCO (EMBL:X65932) Streptomyces coelicolor glucokinase (EC 2.7.1.2) Glk or SC6E10.20c, 317 aa; fasta scores: opt: 391 z-score: 407.0 E(): 4.3e-15; 34.4% identity in 314 aa overlap. Contains Pfam match to entry PF00480 ROK, ROK family and match to Prosite entry PS01125 ROK family signature. (308 aa)
SCO6260SCAH10.25, possible sugar kinase, len: 382 aa; similar to SW:GLK_STRCO (EMBL:X65932) Streptomyces coelicolor glucokinase (EC 2.7.1.2) (glucose kinase) Glk, 317 aa; fasta scores: opt: 1022 z-score: 1142.9 E(): 0; 46.6% identity in 311 aa overlap and to TR:CAB51974 EMBL:SC6E10 Streptomyces coelicolor SC6E10.20c, 317 aa; fasta scores: opt: 1022 z-score: 1035.4 E(): 0; 46.6% identity in 311 aa overlap. Contains a match to Pfam entry PF00480 ROK, ROK family and Prosite entry PS01125 ROK family signature. (382 aa)
SCO6347Beta-galactosidase; SC3A7.15, probable beta-galactosidase, len: 595; similar to many e.g. TR:O31341 (EMBL:D88750) beta-galactosidase (EC 3.2.1.23) (lactase) from Bacillus circulans (586 aa), fasta scores; opt: 1648 z-score: 1500.8 E(): 0, 43.0% identity in 584 aa overlap., Contains PS01182 Glycosyl hydrolases family 35 putative active site. (595 aa)
SCO7010SC8F11.36c, aglA, alpha glucosidase, len: 534 aa. Identical to Streptomyces lividans TR:O86874(EMBL:U22894) alpha glucosidase, AglA (534 aa), fasta scores opt: 3764 z-score: 4189.4 E(): 0 99.6% identity in 534 aa overlap. Also highly similar to many other glycosyl hydrolases e.g. Escherichia coli SW:TREC_ECOLI(EMBL:U06195) trehalose-6-phosphate hydrolase (EC 3.2.1.93) (551 aa), fasta scores opt: 882 z-score: 982.3 E():0 36.1% identity in 523 aa overlap and Streptomyces coelicolor SC10B7.07 (577 aa), fasta scores opt: 1026 z-score: 1004.4 E():0 55.0% identity in 565 aa overlap. Contains [...] (534 aa)
SCO6457SC9B5.24, lacZ*, beta-galactosidase, len: 1307 aa; similar to many e.g. TR:O85167 (EMBL:AF047824) beta-galactosidase from Bacillus megaterium (1034 aa) fasta scores: opt: 1750, z-score: 2221.6, E(): 0, (37.4% identity in 1256 aa overlap). Note that this CDS is approx. 300 residues longer than the homologues due to an extra region around residues 600 to 900. Contains PS00719 Glycosyl hydrolases family 2 signature 1 and PS00608 Glycosyl hydrolases family 2 acid /base catalyst. Also contains Pfam match to entry PF00703 glycosyl_hydro7, Glycosyl hydrolases family 2. (1307 aa)
SCO7407SC6D11.03c, probable beta-galactosidase, len: 681 aa. Similar to many beta-galactosidases e.g. Bacillus stearothermophilus SW:BGAL_BACST(EMBL:M13466) beta-galactosidase I (EC 3.2.1.23), BgaB, (672 aa), fasta scores opt: 1816 z-score: 2079.7 E(): 0 43.2% identity in 666 aa overlap. (681 aa)
SCO7443Phosphoglucomutase; SC6D11.39, pgm, phosphoglucomutase (EC 5.4.2.2), len: 546 aa. Highly similar to many phosphoglucomutases e.g. Escherichia coli SW:PGMU_ECOLI(EMBL:U08369) phosphoglucomutase (EC 5.4.2.2) (546 aa), fasta scores opt: 2216 z-score: 2396.0 E():0 60.8% identity in 538 aa overlap. Contains a Prosite hit to PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature and a Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase. (546 aa)
SCO0063SCJ4.44c, possible glucokinase, len: 311 aa; similar to many eg. SW:GLK_STRCO glucokinase from Streptomyces coelicolor (317 aa) fasta scores; opt: 175, z-score: 195.7, E(): 0.0015, (28.2% identity in 326 aa overlap). Contains Pfam match to entry PF00480 ROK, ROK family. (311 aa)
SCO0274SCF85.02, possible alpha-galactosidase, len: 499 aa. Similar to many alpha galactosidases e.g. Thermus aquaticus TR:AAD32628(EMBL; AF135399) alpha-galactosidase (476 aa), fasta scores opt: 1329 z-score: 1530.0 E(): 0 45.8% identity in 487 aa overlap. (499 aa)
SCO0284SCF85.12, possible secreted alpha-galactosidase, len: 680 aa. Highly similar to many Eukaryotic alpha-galactosidases over the first 415 aa, e.g. Coffea arabica (Coffee) alpha-galactosidase precursor (EC 3.2.1.22) (melibiase) (378 aa),opt: 1323 z-score: 1416.9 E(): 0; 54.5% identity in 354 aa overlap, in addition to Saccharopolyspora erythraea (Streptomyces erythraeus)alpha galactosidase precursor MelA (428 aa),fasta scores opt: 623 z-score: 668.6 E(): 6.9e-30 50.6% identity in 427 aa overlap. Contains a PS00512 Alpha-galactosidase signature, a PS00599 Aminotransferases class-II pyridox [...] (680 aa)
SCO0541SCF11.21, probable alpha-galactosidase, len: 441 aa; similar to SW:AGAL_BACSU (EMBL:AF008220) Bacillus subtilis alpha-galactosidase (EC 3.2.1.22) (Melibiase) MelA, 432 aa; fasta scores: opt: 1068 z-score: 1240.5 E(): 0; 39.3% identity in 427 aa overlap. (441 aa)
SCO0766SCF81.25c, possible secreted beta-galactosidase, len: 1028 aa; similar to SW:BGA2_ECOLI (EMBL:M64441) Escherichia coli evolved beta-galactosidase alpha-subunit (EC 3.2.1.23) (lactase) 1031 aa; fasta scores: opt: 482 z-score: 519.9 E(): 1.4e-21; 30.6% identity in 464 aa overlap. Contains N-terminal signal peptide sequence; Belongs to the glycosyl hydrolase 2 family. (1028 aa)
SCO1077SCG22.23c, probable sugar kinase, len: 317 aa; similar to SW:GLK_BACSU (EMBL:D84432) Bacillus subtilis glucokinase (EC 2.7.1.2) GlcK, 321 aa; fasta scores: opt: 495 z-score: 504.0 E(): 1.3e-20; 31.4% identity in 312 aa overlap. Contains match to Prosite entry PS01125 ROK family signature. (317 aa)
SCO12146-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (341 aa)
SCO1394SC1A8A.14, possible glycosyl hydrolase, len: 795 aa; similar to many e.g. SW:O59645 (AGLU_SULSO) alpha-glucosidase from Sulfolobus solfataricus (693 aa) fasta scores; opt: 535, z-score: 568.6, E(): 3e-24, 32.4% identity in 463 aa overlap. Contains Pfam match to entry PF01055 Glyco_hydro_31, Glycosyl hydrolases family 31. (795 aa)
SCO21196-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (342 aa)
SCO2126Glucokinase; Required for glucose repression of many different genes; Belongs to the ROK (NagC/XylR) family. (317 aa)
SCO2228Alpha-glucosidase; SC10B7.23c, aglA, alpha-glucosidase, len: 577 aa; highly similar to TR:P72463 (EMBL:Y08304) Streptomyces limosus alpha-glucosidase AglA, 391 aa; fasta scores: opt: 1453 z-score: 1607.1 E(): 0; 72.0% identity in 347 aa overlap, to TR:AAD50603 (EMBL:AF096282) Thermus aquaticus alpha-glucosidase, 529 aa; fasta scores: opt: 925 z-score: 1022.3 E(): 0; 40.2% identity in 567 aa overlap and to SW:MAL2_DROVI (EMBL:AF006573) Drosophila virilis maltase 2 precursor (EC 3.2.1.20) Mal2, 524 aa; fasta scores: opt: 870 z-score: 961.6 E(): 0; 36.2% identity in 516 aa overlap. Contai [...] (577 aa)
SCO2393Putative aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (323 aa)
SCO2401SC4A7.29, possible dehydratase, len: 388 aa; similar to C-terminal region of SW:DGOA_ECOLI (EMBL:L10328) Escherichia coli galactonate dehydratase (EC 4.2.1.6) GdoA, 587 aa; fasta scores: opt: 751 z-score: 864.7 E(): 0; 35.0% identity in 383 aa overlap. Contains Pfam match to entry PF01188 MR_MLE, Mandelate racemase / muconate lactonizing enzyme family. (388 aa)
SCO2407Putative aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (366 aa)
SCO2988SCE50.16, galE2, UDP-glucose 4-epimerase, len: 326 aa; highly similar to SW:EXOB_AZOBR (EMBL:Z25478) Azospirillum brasilense UDP-glucose 4-epimerase (EC 5.1.3.2) ExoB, 348 aa; fasta scores: opt: 885 z-score: 970.7 E(): 0; 46.4% identity in 319 aa overlap and to SW:GALE_STRLI (EMBL:M18953) Streptomyces lividans UDP-glucose 4-epimerase (EC 5.1.3.2) GalE, 329 aa; fasta scores: opt: 793 z-score: 870.9 E(): 0;42.7% identity in 328 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family. (326 aa)
SCO3136Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (387 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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