STRINGSTRING
SCO4326 SCO4326 SCO4327 SCO4327 SCO4490 SCO4490 SCO4491 SCO4491 SCO4492 SCO4492 SCO4494 SCO4494 SCO4506 SCO4506 SCO4550 SCO4550 SCO4556 SCO4556 SCO4593 SCO4593 SCO5662 SCO5662 SCO6574 SCO6574 SCO2927 SCO2927 SCO3242 SCO3242
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO4326Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (282 aa)
SCO4327Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily. (209 aa)
SCO4490SCD69.10, putative decarboxylase, len: 485 aa; similar to SW:Y209_ARCFU (EMBL:AE001091) Archaeoglobus fulgidus hypothetical protein AF0209, 481 aa; fasta scores: opt: 1557 z-score: 1800.8 E(): 0; 48.6% identity in 484 aa overlap and to SW:P26615 (UBID_ECOLI) 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase from Escherichia coli (497 aa) fasta scores; opt: 1293, Z-score: 1478.5, 40.162% identity (41.336% ungapped) in 493 aa overlap. Contains Pfam match to entry PF01977 UPF0096, Protein of unknown function. (485 aa)
SCO4491SCD69.11, probable octaprenyltransferase, len: 301 aa; similar to TR:AAF10428 (EMBL:AE001939) Deinococcus radiodurans 4-hydroxybenzoate octaprenyltransferase DR0851, 313 aa; fasta scores: opt: 794 z-score: 949.5 E(): 0; 44.7% identity in 302 aa overlap and to SW:UBIA_ECOLI (EMBL:M93136) Escherichia coli 4-hydroxybenzoate octaprenyltransferase (EC 2.5.1.-) UbiA, 290 aa; fasta scores: opt: 299 z-score: 362.7 E(): 9.7e-13; 27.9% identity in 276 aa overlap. Contains Pfam match to entry PF01040 UbiA, UbiA prenyltransferase family. Contains also possible hydrophobic membrane spanning regions. (301 aa)
SCO4492Putative octaprenyl carboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (216 aa)
SCO4494Conserved hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)
SCO4506Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnA subfamily. (282 aa)
SCO4550Conserved hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (399 aa)
SCO4556Putative ubiquinone/menaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (231 aa)
SCO4593SCD20.11c, conserved hypothetical protein, len: 284 aa; similar to SW:YTFG_ECOLI (EMBL:U14003) Escherichia coli hypothetical 29,7 kDa protein in RplI-CpdB intergenic region YtfG, 286 aa; fasta scores: opt: 801 z-score: 906.2 E(): 0; 47.1% identity in 280 aa overlap. (284 aa)
SCO5662Putative adenosine deaminase; Catalyzes the deamination of aminodeoxyfutalosine (AFL) into futalosine (FL), a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (387 aa)
SCO6574SC3F9.09, putative membrane protein, len: 363 aa; similar to TR:Q9Z4Y9 (EMBL:AL035707) Streptomyces coelicolor putative transferase SCE29.11c, 291 aa; fasta scores: opt: 666 Z-score: 604.6 E(): 4.8e-26; 51.282% identity in 312 aa overlap. Contains possible hydrophobic membrane spanning regions. (363 aa)
SCO2927SCE19A.27c, probable 4-hydroxyphenylpyruvate dioxygenase, len: 381 aa; highly similar to many e.g. SW:HPPD_STRAW (EMBL:U11864) Streptomyces avermitilis 4-hydroxyphenylpyruvate dioxygenase (380 aa), fasta scores; opt: 2347 z-score: 2634.5 E(): 0, 91.9% identity in 381 aa overlap. Similar to TR:Q9Z4X7 (EMBL:AL035640) S. coelicolor probable 4-hydroxyphenylpyruvic acid dioxygenase (325 aa) (36.4% identity in 330 aa overlap); Belongs to the 4HPPD family. (381 aa)
SCO3242SCE29.11c, possible transferase, len: 291 aa; similar to TR:O69949 (EMBL:AL023862) hypothetical protein from Streptomyces coelicolor (363 aa) fasta scores; opt: 666, z-score: 682.9, E(): 9.9e-31, (51.3% identity in 312 aa overlap). Also similar to SW:UBIA_ECOLI 4-hydroxybenzoate octaprenyl transferase from Escherichia coli (290 aa) fasta scores; opt: 137, z-score: 150.2, E(): 0.47, (31.8% identity in 110 aa overlap). (291 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.