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SCO0379 SCO0379 SCO0666 SCO0666 SCO0852 SCO0852 SCO0982 SCO0982 SCO0983 SCO0983 SCO1378 SCO1378 SCO1613 SCO1613 SCO2145 SCO2145 SCO2180 SCO2180 SCO2198 SCO2198 SCO2210 SCO2210 SCO2241 SCO2241 SCO2298 SCO2298 SCO2736 SCO2736 SCO2777 SCO2777 SCO2925 SCO2925 SCO3079 SCO3079 SCO3473 SCO3473 SCO3486 SCO3486 SCO3495 SCO3495 SCO3563 SCO3563 SCO4323 SCO4323 SCO4381 SCO4381 SCO4388 SCO4388 SCO4403 SCO4403 SCO4502 SCO4502 SCO4800 SCO4800 SCO4827 SCO4827 SCO4837 SCO4837 SCO4869 SCO4869 SCO4921 SCO4921 SCO4926 SCO4926 SCO5364 SCO5364 SCO5398 SCO5398 SCO5399 SCO5399 SCO5415 SCO5415 SCO5470 SCO5470 SCO5471 SCO5471 SCO5472 SCO5472 SCO5831 SCO5831 SCO5832 SCO5832 SCO5999 SCO5999 SCO6195 SCO6195 SCO6201 SCO6201 SCO6204 SCO6204 SCO6205 SCO6205 SCO6206 SCO6206 SCO6243 SCO6243 SCO6466 SCO6466 SCO6472 SCO6472 SCO6561 SCO6561 SCO6731 SCO6731 SCO6788 SCO6788 SCO6832 SCO6832 SCO6833 SCO6833 SCO6962 SCO6962 SCO7590 SCO7590
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query proteins and first shell of interactors
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proteins of unknown 3D structure
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SCO0379SCF62.05, katA, catalase (EC 1.11.1.6) len: 487 aa. Has been previously sequenced and characterised from Streptomyces coelicolor strain ATCC10147 TR:P77948 (EMBL; X96981) catalase (EC 1.11.1.6) (488 aa), fasta scores opt: 3300 z-score: 3768.6 E():0 98.2% identity in 488 aa overlap. Also similar to another proposed Streptomyces coelicolor catalase (EC 1.11.1.6) TR:Q9Z598 (EMBL; AL035478) SC2G5.25C (487 aa), fasta scores opt: 1704 z-score: 1896.1 E():0 53.8% identity in 483 aa overlap. Contains Prosite hits to PS00437 Catalase proximal heme-ligand signature and to PS00438 Catalase proxim [...] (487 aa)
SCO0666Catalase (EC 1.11.1.6); Serves to protect cells from the toxic effects of hydrogen peroxide. (759 aa)
SCO0852SCM2.05c, possible aldolase, len: 210 aa. Similar to Bacillus subtilis SW:ALKH_BACSU (EMBL:L47838) 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) (196 aa), fasta scores opt: 383 z-score: 406.3 E(): 3e-15 38.5% identity in 179 aa overlap. Contains a Pfam match to entry PF01081 Aldolase, KDPG and KHG aldolase. (210 aa)
SCO0982SCBAC19F3.09, aceA, isocitrate lyase, len: 426 aa: strongly similar to many e.g. SW:O53752 (ACEA_MYCTU) isocitrate lyase from Mycobacterium tuberculosis (428 aa) fasta scores; opt: 2144, Z-score: 2405.5, 74.822% identity (75.000% ungapped) in 421 aa overlap. Contains Pfam matches to entry PF00463 ICL, Isocitrate lyase family and Prosite match to PS00161 Isocitrate lyase signature. (426 aa)
SCO0983SCBAC19F3.10, aceB2, malate synthase, len: 530 aa; strongly similar to many e.g. SW:Q9ZH77 (MASY_STRCL) malate synthase AceB from Streptomyces clavuligerus (541 aa) fasta scores; opt: 1923, Z-score: 2204.2, 58.889% identity (61.390% ungapped) in 540 aa overlap and TR:Q9RKU9 (EMBL:AL132824) malate synthase AceB1 (StAH10.08c) from Streptomyces coelicolor (540 aa) fasta scores; opt: 1930, Z-score: 2212.2, 61.895% identity (63.090% ungapped) in 475 aa overlap. Contains Pfam match to entry PF01274 Malate_synthase, Malate synthase and Prosite match to PS00510 Malate synthase signature. (530 aa)
SCO1378Putative glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
SCO1613SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39. (462 aa)
SCO2145Putative glycerate kinase; SC6G10.18, unknown, len: 432aa; similar to many hypothetical proteins eg. SW:YXAA_BACSU hypothetical protein from Bacillus subtilis (382 aa) fasta scores; opt: 1005, z-score: 1049.9, E(): 0, (44.1% identity in 381 aa overlap). Note predicted C-terminal overlap with downstream CDS. Simialr also to SW:GRK_BACSU (EMBL:AB005554) Bacillus subtilis glycerate kinase (EC 2.7.1.31) GlxK or S14A, 382 aa; fasta scores: opt: 1005 Z-score:1015.2 E(): 6.5e-49; 44.094% identity in 381 aa overlap. (432 aa)
SCO2180SC5F7.21, pdhL, probable dihydrolipoamide dehydrogenase, len: 486 aa; note possible downstream translational start sites. Similar to many prokaryote and eukaryote egs. TR:Q9Z6I5 (EMBL: AF047034) dihydrolipoamide dehydrogenase from Streptomyces seoulensis (462 aa) fasta scores; opt: 2780, z-score: 3088.0, E(): 0, (90.3% identity in 462 aa overlap), TR:Q54101 (EMBL:L38646) NADH ferredoxin oxidoreductase from Saccharopolyspora erythraea (456 aa) fasta scores; opt: 1918, z-score: 2131.8, E(): 0, (64.2% identity in 452 aa overlap) and SW:DLDH_PEA dihydrolipoamide dehydrogenase from Pisum sa [...] (486 aa)
SCO2198Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
SCO2210SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...] (343 aa)
SCO2241SC1G2.03, probable glutamine synthetase (EC 6.3.1.2), len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa), fasta scores opt: 1017 z-score: 1188.9 E():0 44.4% identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa), fasta scores opt: 2114 z-score: 2469.2 E():0 70.2% identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase putative ATP-binding region signature. (453 aa)
SCO2298SCC30.06, kdgA, KHG/KDPG aldolase, len: 219 aa; highly similar to SW:ALKH_ECOLI (EMBL:X68871) Escherichia coli KHG/KDPG aldolase [includes: 4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) (2-keto-4-hydroxyglutarate aldolase) (KHG-aldolase); 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) (phospho-2-dehydro-3-deoxygluconate aldolase) (phospho-2-keto-3-deoxygluconate aldolase) (2-keto-3-deoxy-6-phosphogluconate aldolase) (KDPG-aldolase)] KdgA, 213 aa; fasta scores: opt: 757 z-score: 811.9 E(): 0; 55.0% identity in 202 aa overlap. Contains Pfam match to entry PF01081 Aldolase, KD [...] (219 aa)
SCO2736SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. (429 aa)
SCO2777SCC105.08, accC, acetyl/propionyl CoA carboxylase alpha subunit, len: 646 aa; similar to SW:PCCA_HUMAN (EMBL:X14608) Homo sapiens propionyl-CoA carboxylase alpha chain precursor (EC 6.4.1.3) PccA, 703 aa; fasta scores: opt: 1539 z-score: 1630.1 E(): 0; 43.0% identity in 665 aa overlap and to SW:ACCC_ECOLI (EMBL:M79446) Escherichia coli biotin carboxylase (EC 6.3.4.14), alpha subunit of acetyl CoA carboxylase (EC 6.4.1.2) AccC or FabG, 449 aa; fasta scores: opt: 1439 z-score: 1527.1 E(): 0; 47.9% identity in 451 aa overlap and to N-terminal region of TR:CAB59603 (EMBL:AL132662) Streptom [...] (646 aa)
SCO2925SCE19A.25c, probable oxidoreductase subunit, len: 488 aa; similar to many e.g. SW:GLCD_ECOLI (EMBL:L43490), GlcD, Escherichia coli glycolate oxidase subunit (499 aa), fasta scores; opt: 1033 z-score: 1172.9 E(): 0, 38.9% identity in 460 aa overlap. Also similar to SW:DLD1_YEAST (EMBL:X66052), dld, Saccharomyces cerevisiae D-lactate dehydrogenase [cytochrome] precursor (587 aa) (29.4% identity in 435 aa overlap). The N-terminus differs from its homologues and an alternative start codon is present at codon 3. (488 aa)
SCO3079SCE25.20, probable thiolase, len: 406 aa; similar to SW:CATF_ACICA (EMBL:AF009224) Acinetobacter calcoaceticus beta-ketoadipyl CoA thiolase (EC 2.3.1.-) CatF, 401 aa; fasta scores: opt: 957 z-score: 1066.1 E(): 0; 40.0% identity in 415 aa overlap and to TR:CAB45575 (EMBL:AL079355) Streptomyces coelicolor PcaF, beta-ketoadipyl CoA thiolase SC4C6.11c, 400 aa; fasta scores: opt: 895 z-score: 916.7 E(): 0; 38.9% identity in 409 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase and match to Prosite entry PS00737 Thiolases signature 2; Belongs to the thiolase-like superfami [...] (406 aa)
SCO3473SCE65.09c, probable aldolase, len: 215 aa; similar to SW:ALKH_BACSU (EMBL:L47838) Bacillus subtilis KHG/KDPG aldolase AlkH, 347 aa; fasta scores: opt: 457 z-score: 523.2 E(): 9.1e-22; 39.5% identity in 200 aa overlap and to Streptomyces coelicolor SCE65.31c, 225 aa; fasta scores: opt: 424 z-score: 429.4 E(): 1.5e-18; 37.7% identity in 215 aa overlap. Contains Pfam match to entry PF01081 Aldolase, KDPG and KHG aldolase and match to Prosite entry PS00160 KDPG and KHG aldolases Schiff-base forming residue. (215 aa)
SCO3486SCE65.22, probable aldehyde dehydrogenase, len: 492 aa; similar to SW:ALDA_ECOLI (EBML:M64541) Escherichia coli aldehyde dehydrogenase A (EC 1.2.1.22) aldA, 478 aa; fasta scores: opt: 1189 z-score: 1347.0 E(): 0; 39.1% identity in 473 aa overlap and to Streptomyces coelicolor SCI35.34c, 483 aa; fasta scores: opt: 1014 z-score: 940.7 E(): 0; 40.2% identity in 455 aa overlap. Contains match to Pfam entry PF00171 aldedh, Aldehyde dehydrogenase and two matches to Prosite entries PS00687 Aldehyde dehydrogenases glutamic acid active site PS00070 Aldehyde dehydrogenases cysteine active site. (492 aa)
SCO3495SCE65.31c probable aldolase, len: 225 aa; similar to TR:AAD35160 (EMBL:AE001693) Thermotoga maritima 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase TM0066, 205 aa; fasta scores: opt: 437 z-score: 460.7 E(): 2.8e-18; 39.1% identity in 174 aa overlap and to SW:ALKH_BACSU (EMBL:L47838) Bacillus subtilis Khg/KdpG aldolase KdgA, 196 aa; fasta scores: opt: 379 z-score: 401.8 E(): 5.3e-15; 37.9% identity in 177 aa overlap. Contains match to Pfam entry PF01081 Aldolase, KDPG and KHG aldolase. (225 aa)
SCO3563Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
SCO4323SCD12A.06, possible hydrolase, len: 220 aa; similar to TR:O86530 (EMBL:AL031124) Streptomyces coelicolor putative hydrolase SC1C2.30, 244 aa; fasta scores: opt: 128 z-score: 155.4 E(): 0.34; 32.9% identity in 167 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. (220 aa)
SCO4381SCD10.13, probable acetyl/propionyl CoA carboxylase, alpha subunit, len: 614 aa; similar to TR:CAB87214 (EMBL:AL163641) Streptomyces coelicolor acetyl/propionyl CoA carboxylase, alpha subunit AccC, 646 aa; fasta scores: opt: 1088 z-score: 1184.1 E(): 0; 46.6% identity in 644 aa overlap and to SW:BCCA_MYCTU (EMBL:Z19549) Mycobacterium tuberculosis acetyl/propionyl-coenzyme A carboxylase alpha chain AccA1, 654 aa; fasta scores: opt: 939 z-score: 1022.0 E(): 0; 43.2% identity in 655 aa overlap. Contains 2x Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) [...] (614 aa)
SCO4388SCD10.20, probable citrate synthase, len: 387 aa; similar to SW:CISY_BACSU (EMBL:U05256) Bacillus subtilis citrate synthase I (EC 4.1.3.7) CitA, 366 aa; fasta scores: opt: 615 z-score: 685.9 E(): 9.9e-31; 36.7% identity in 360 aa overlap and to TR:O70008 (EMBL:AL022374) Streptomyces coelicolor citrate synthase (EC 4.1.3.7) SC5B8.22, 390 aa; fasta scores: opt: 780 z-score: 867.9 E(): 0; 41.0% identity in 371 aa overlap. Contains 2 Pfam matches to entry PF00285 citrate_synt, Citrate synthase and match to Prosite entry PS00480 Citrate synthase signature. (387 aa)
SCO4403Putative formyltetrahydrofolate deformylase (fragment); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (297 aa)
SCO4502SCD35.09, probable ketoacyl CoA thiolase, len: 428 aa; similar to TR:O86361 (EMBL:AL021929) Mycobacterium tuberculosis FadA2, 440 aa; fasta scores: opt: 1585 z-score: 1791.9 E(): 0; 63.0% identity in 446 aa overlap and to SW:THIK_ECOLI (EMBL:M87049) Escherichia coli 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (fatty oxidation complex beta subunit) (beta-ketothiolase) (acetyl-CoA acyltransferase) FadA, 387 aa; fasta scores: opt: 453 z-score: 515.8 E(): 2.7e-21; 30.9% identity in 430 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase; Belongs to the thiolase-like superfamily. [...] (428 aa)
SCO4800SCD63A.11, icmB, isobutyryl CoA mutase, small subunit, len: 138 aa; almost identical to TR:CAB59633 (EMBL:AJ246005) Streptomyces cinnamonensis isobutyryl CoA mutase, small subunit (EC 5.4.99.13) IcmB, 136 aa; fasta scores: opt: 803 z-score: 972.5 E(): 0; 92.5% identity in 134 aa overlap and highly similar to TR:CAB71846 (EMBL:138667) Streptomyces coelicolor probable isobutyryl-CoA mutase, small subunit SC3D9.01, 159 aa; fasta scores: opt: 594 z-score: 628.1 E(): 2e-29; 70.6% identity in 126 aa overlap. (138 aa)
SCO4827Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H). (329 aa)
SCO4837Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (481 aa)
SCO4869SCK20.10, mutA2, methylmalonyl CoA mutase, len: 534 aa; highly similar to SW:MUTA_HUMAN (EMBL:M65131) Homo sapiens methylmalonyl CoA mutase mitochondrial precursor (EC 5.4.99.2) Mut, 750 aa; fasta scores: opt: 1707 z-score: 1912.4 E(): 0; 49.6% identity in 534 aa overlap and almost identical to TR:Q9L1V3 (EMBL:AL138668) Streptomyces coelicolor methylmalonyl CoA mutase mutA SC4A9.09, 531 aa; fasta scores: opt: 3319 z-score: 3721.0 E(): 0; 97.0% identity in 528 aa overlap. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. (534 aa)
SCO4921SCK13.13c, accA2, putative acyl-CoA carboxylase complex A subunit, len: 590 aa; identical to previously sequenced TR:Q9X4K6 (EMBL:AF113603) Streptomyces coelicolor putative acyl-CoA carboxylase complex A subunit AccA2, 590 aa. Contains Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and PF00364 biotin_lipoyl, Biotin-requiring enzymes and match to Prosite entry PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site. (590 aa)
SCO4926SCK13.18c, pccB, propionyl-CoA carboxylase complex B subunit, len: 530 aa; identical to previously sequenced TR:Q9X4K7 (EMBL:AF113605) Streptomyces coelicolor propionyl-CoA carboxylase complex B subunit PccB, 530 aa and similar to TR:O86517 (EMBL:AL031124) Streptomyces coelicolor putative carboxyl transferase SC1C2.16, 527 aa; fasta scores: opt: 1958 z-score: 2071.4 E(): 0; 57.4% identity in 526 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. (530 aa)
SCO5364Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
SCO5398SC8F4.02c, conserved hypothetical protein, len: 146aa; similar to several of undefined function eg. TR:O28065 (EMBL:AE000952) conserved hypothetical protein from Archaeoglobus fulgidus (131 aa) fasta scores; opt: 346 z-score: 449.3 E(): 1.3e-17 40.4% identity in 136 aa overlap. (146 aa)
SCO5399SC8F4.03, thiL, probable acetoacetyl-coA thiolase, len: 401aa; similar to many eg. SW:P14611 (THIL_ALCEU) acetoacetyl-coA thiolase from Alcaligenes eutrophus (393 aa) fasta scores; opt: 1272, z-score: 1344.2, E(): 0, 53.6% identity in 390 aa overlap. Also similar to TR:Q9XAM9 (EMBL:AL079355) beta-ketoadipyl-coA thiolase from Streptomyces coelicolor (cosmid 4C6) (400 aa) fasta scores; opt: 949, z-score: 919.8, E(): 0, 42.0% identity in 393 aa overlap. Contains Pfam match to entry PF00108 thiolase and Prosite matches to PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiola [...] (401 aa)
SCO5415SC8F4.19, icmA, isobutyryl-CoA mutase A, len: 566 aa; previously sequenced and characterised as TR:Q9X949 (EMBL:AJ237976). Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. (566 aa)
SCO5470Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
SCO5471Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
SCO5472Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
SCO5831SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap. (421 aa)
SCO5832SC5B8.22, putative citrate synthase, len: 390 aa; similar to citrate synthase from many organisms e.g. CISZ _BACSU P39120 bacillus subtilis. citrate synthase i (372 aa), fasta scores; opt: 729 z-score: 877.4 E(): 0, 35.5% iden tity in 372 aa overlap. Contains PS00480 Citrate synthase s ignature and Pfam match to entry citrate_synt PF00285, Citr ate synthase, score 314.55. Also similar to downstream gene SC5B8.21c (421 aa) E(): 2.6e-14, 32.4% identity in 352 aa overlap. (390 aa)
SCO5999Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SCO6195SC2G5.16, probable acetyl-coenzyme A synthetase, len:558 aa; similar to many e.g. SW:ACSA_BACSU from Bacillus subtilis (572 aa) fasta scores; opt: 798, z-score: 878.3,E():0, (31.8% identity in 537 aa overlap). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 116.90, E-value 3.8e-31. Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 116.90, E-value 3.8e-31. (558 aa)
SCO6201SC2G5.22, gcl, probable glyoxylate carboligase, acetohydroxy acid synthase-pyruvate oxidase family,len:594aa; highly similar to SW:GCL_ECOLI glyoxylate carboligase from Escherichia coli (592 aa) fasta scores;opt: 2905, z-score: 3262. 8,E(): 0, (72.7% identity in 586aa overlap). Contains Pfam match to entry PF00205TPP_enzymes, Thiamine pyrophosphate enzymes, score 427.80, E-value 4.7e-132. Note: as with the Escherichia coli homologue, this CDS is located close to a glyoxylate induced protein of unknown function. (594 aa)
SCO6204Putative catalase; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. (487 aa)
SCO6205SC2G5.26c, probable dehydrogenase, len: 296aa; similar to many eg. TR:D1035162 (EMBL:AB015439) D-threonine dehydrogenase (292 aa) fasta scores; opt: 628, z-score:702.7, E(): 7.4e-32, (37.6% identity in 290 aa overlap). (296 aa)
SCO6206Putative oxidoreductase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. (279 aa)
SCO6243SCAH10.08c, aceB1, malate synthase, len: 540 aa; highly similar to SW:MASY_STAE (EMBL:U63518) Streptomyces arenae, malate synthase (EC 4.1.3.2) AceB, 543 aa; fasta scores: opt: 2625 z-score: 3156.2 E(): 0; 78.2% identity in 551 aa overlap. Contains match to Pfam entry PF01274 Malate_synthase, Malate synthase and to Prosite entry PS00510 Malate synthase signature. (540 aa)
SCO6466Putative transferase; SC9C7.02, conserved hypothetical protein, len: 380 aa; similar to many e.g. SW:YXAA_BACSU hypothetical protein from Bacillus subtilis (382 aa) fasta scores; opt: 1045, z-score: 998.9, E(): 0, (46.3% identity in 374 aa overlap) and to SW:GRK_BACSU (EMBL:AB005554) Bacillus subtilis glycerate kinase (EC 2.7.1.31) GlxK, 382 aa; fasta scores: opt: 1045 Z-score: 991.1 E(): 1.4e-47; 46.257% identity in 374 aa overlap. (380 aa)
SCO6472SC9C7.08c, meaA, coenzyme B12-dependent mutase, len: 675aa; similar to many, very similar to TR:O33614 (EMBL:AF008569) coenzyme B12-dependent mutase from Streptomyces collinus (674 aa) fasta scores; opt: 4085, z-score: 5046.6, E(): 0, (91.7% identity in 675 aa overlap). (675 aa)
SCO6561SC4B5.11c, respiratory chain oxidoreductase, len: 642 aa; similar to the C-terminal region of many proteins involved in electron transfer e.g. TR:P77908 (EMBL:U73807) FdhA formate dehydrogenase alpha subunit from Moorella thermoacetica (893 aa) fasta scores; opt: 1532, z-score: 1338.5, E(): 0, (43.1% identity in 619 aa overlap). Contains Pfam match to entry PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases, score 95.80, E-value 6.2e-30. Considering the corresponding homolgies, this CDS may have previously been located directly downsteam of SC4B5.09c. (642 aa)
SCO6731SC5F2A.14, probable thiolase, len: 404aa; similar to many egs. TR:O53871 (EMBL:AL022004) putative beta-ketoadypyl coA tiolase from Mycobacterium tuberculosis (403 aa) fasta scores; opt: 1842, z-score: 1989.2, E(): 0, (67.6% identity in 404 aa overlap) and TR:O53017 (EMBL:X97452) acetyl coA thiolase from Escherichia coli (401 aa) fasta scores; opt: 819, z-score: 887.9, E(): 0, (41.7% identity in 424 aa overlap). Also similar to SC6A5.37 (EMBL:AL049485) probable acetyl coA acetyltransferase from Streptomyces coelicolor (404 aa) fasta scores; opt: 2480, z-score: 2352.6, E(): 0, (95.0% ide [...] (404 aa)
SCO6788SC6A5.37, probable acetyl coA acetyltransferase (thiolase), len: 404aa; similar to many eg. TR:O53017 (EMBL:X97452) acetyl coA acetyltransferase (thiolase) from Escherichia coli (401 aa) fasta scores; opt: 831, z-score: 891.0, E(): 0, (41.9% identity in 422 aa overlap). Contains Pfam match to entry PF00108 thiolase, Thiolase and Prosite matches to PS00737 Thiolases signature 2 and PS00099 Thiolases active site; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
SCO6832SC4A9.09, mutA, methylmalonyl-CoA mutase (EC 5.4.99.2), len: 531 aa. Highly similar to many members of the methylmalonyll-CoA mutase family including: Sinorhizobium meliloti TR:O86028(EMBL:AF080073) methylmalonyll-CoA mutase (EC 5.4.99.2) (712 aa), fasta scores opt: 1720 z-score: 1946.7 E(): 0 52.2% identity in 515 aa overlap and Pyrococcus abyssi TR:CAB49756(EMBL:AJ248285) methylmalonyl-CoA mutase, subunit alpha, N-terminus (562 aa), fasta scores opt: 2180 z-score: 2469.0 E():0 62.7% identity in 518 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9X949(EMBL:AJ237976) is [...] (531 aa)
SCO6833SC3D9.01, probable isobutyryl-CoA mutase, small subunit (EC 5.4.99.13), len: 159 aa. Highly similar to Streptomyces cinnamonensis TR:CAB59633 (EMBL:AJ246005) isobutyryl-CoA mutase, small subunit (EC 5.4.99.13) (136 aa), fasta scores opt: 580 z-score: 685.3 E(): 9.2e-31 68.3% identity in 126 aa overlap and to the C-terminus of Streptomyces cinnamonensis SW:MUTB_STRCM (EMBL:L10064) methylmalonyl-CoA mutase alpha-subunit (EC 5.4.99.2) (733 aa), fasta scores opt: 291 z-score: 341.2 E(): 1.4e-11 40.5% identity in 111 aa overlap. (159 aa)
SCO6962Putative glutamine synthetase; SC6F7.15c, possible glutamine synthetase (EC 6.3.1.2), len: 466 aa. Similar to many glutamine synthetases e.g. Bacillus subtilis SW:GLNA_BACSU(EMBL:M22811) GlnA (443 aa), fasta scores opt: 540 z-score: 593.0 E(): 1.4e-25 28.5% identity in 421 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase. (466 aa)
SCO7590Catalase; SC7H9.02c, katA2, catalase, len: 487 aa; similar to SW:CATA_MICLU (PIR:S27264) Micrococcus luteus catalase (EC 1.11.1.6) KatA, 497 aa; fasta scores: opt: 1791 z-score: 2040.9 E(): 0; 54.8% identity in 484 aa overlap and to SW:CATA_STRCO (EMBL:AL035478) Streptomyces coelicolor catalase KatA or SC2G5.25c, 487 aa; fasta scores: opt: 1699 z-score: 1936.3 E(): 0; 53.8% identity in 483 aa overlap. Contains Pfam match to entry PF00199 catalase, Catalase and matches to Prosite entries PS00438 Catalase proximal active site signature and PS00437 Catalase proximal heme-ligand signature; [...] (506 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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