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SCO0179 SCO0179 SCO0259 SCO0259 SCO2180 SCO2180 SCO2726 SCO2726 SCO2777 SCO2777 SCO3079 SCO3079 SCO3247 SCO3247 SCO3563 SCO3563 SCO4381 SCO4381 SCO4384 SCO4384 SCO4502 SCO4502 SCO4800 SCO4800 SCO4808 SCO4808 SCO4809 SCO4809 SCO4869 SCO4869 SCO4921 SCO4921 SCO4926 SCO4926 SCO5398 SCO5398 SCO5399 SCO5399 SCO5415 SCO5415 SCO5424 SCO5424 SCO5425 SCO5425 SCO5676 SCO5676 SCO6195 SCO6195 SCO6412 SCO6412 SCO6585 SCO6585 SCO6586 SCO6586 SCO6731 SCO6731 SCO6732 SCO6732 SCO6788 SCO6788 SCO6832 SCO6832 SCO6833 SCO6833 SCO7034 SCO7034
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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SCO0179SCJ1.28c,possible zinc-containing dehydrogenase, len: 356 aa. Similar to many including: Thermoanaerobacter brockii SW:ADH_THEBR (EMBL; X64841) NADP-dependent alcohol dehydrogenase (EC 1.1.1.2) (352 aa), fasta scores opt: 556 z-score: 601.1 E(): 4e-26 33.7% identity in 338 aa overlap and Halobacterium volcanii TR:O34179 (EMBL; U95372) dehydrogenase (389 aa), fasta scores opt: 715 z-score: 770.1 E(): 0 37.0% identity in 351 aa overlap. Contains a Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases and a PS00059 Zinc-containing alcohol dehydrogenases signature. (356 aa)
SCO0259SCF1.01, partial CDS, probable alcohol dehydrogenase, len: >167aa; similar the C-terminal region of many eg. SW:ADH3_SULSO NAD-dependent alcohol dehydrogenase from Sulfolobus solfataricus (347 aa) fasta scores; opt: 274, z-score: 304.7, E(): 1.3e-09, (31.8% identity in 170 aa overlap). Also similar to C-terminal region of TR:BAA82700 (EMBL:AB017438) from Streptomyces coelicolor (346 aa) fasta scores; opt: 372, z-score: 409.3, E(): 2e-15, (40.7% identity in 167 aa overlap); SCF20.05, probable alcohol dehydrogenase (zinc-binding), len: >236aa; similar to many eg. alcohol dehydrogenases e [...] (341 aa)
SCO2180SC5F7.21, pdhL, probable dihydrolipoamide dehydrogenase, len: 486 aa; note possible downstream translational start sites. Similar to many prokaryote and eukaryote egs. TR:Q9Z6I5 (EMBL: AF047034) dihydrolipoamide dehydrogenase from Streptomyces seoulensis (462 aa) fasta scores; opt: 2780, z-score: 3088.0, E(): 0, (90.3% identity in 462 aa overlap), TR:Q54101 (EMBL:L38646) NADH ferredoxin oxidoreductase from Saccharopolyspora erythraea (456 aa) fasta scores; opt: 1918, z-score: 2131.8, E(): 0, (64.2% identity in 452 aa overlap) and SW:DLDH_PEA dihydrolipoamide dehydrogenase from Pisum sa [...] (486 aa)
SCO2726SCC46.11c, msdA, methylmalonic acid semialdehyde dehydrogenase, 500 aa; identical to previously sequenced TR:Q53935 (EMBL:L48550) Streptomyces coelicolor methylmalonic acid semialdehyde dehydrogenase MsdA and highly similar to SW:MMSA_PSEAE (EMBL:M84911) Pseudomonas aeruginosa methylmalonate-semialdehyde dehydrogenase [acylating] (EC 1.2.1.27) MmsA, 496 aa; fasta scores: opt: 1652 z-score: 1799.5 E(): 0; 48.0% identity in 490 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family and match to Prosite entry PS00070 Aldehyde dehydrogenases cysteine active site. (500 aa)
SCO2777SCC105.08, accC, acetyl/propionyl CoA carboxylase alpha subunit, len: 646 aa; similar to SW:PCCA_HUMAN (EMBL:X14608) Homo sapiens propionyl-CoA carboxylase alpha chain precursor (EC 6.4.1.3) PccA, 703 aa; fasta scores: opt: 1539 z-score: 1630.1 E(): 0; 43.0% identity in 665 aa overlap and to SW:ACCC_ECOLI (EMBL:M79446) Escherichia coli biotin carboxylase (EC 6.3.4.14), alpha subunit of acetyl CoA carboxylase (EC 6.4.1.2) AccC or FabG, 449 aa; fasta scores: opt: 1439 z-score: 1527.1 E(): 0; 47.9% identity in 451 aa overlap and to N-terminal region of TR:CAB59603 (EMBL:AL132662) Streptom [...] (646 aa)
SCO3079SCE25.20, probable thiolase, len: 406 aa; similar to SW:CATF_ACICA (EMBL:AF009224) Acinetobacter calcoaceticus beta-ketoadipyl CoA thiolase (EC 2.3.1.-) CatF, 401 aa; fasta scores: opt: 957 z-score: 1066.1 E(): 0; 40.0% identity in 415 aa overlap and to TR:CAB45575 (EMBL:AL079355) Streptomyces coelicolor PcaF, beta-ketoadipyl CoA thiolase SC4C6.11c, 400 aa; fasta scores: opt: 895 z-score: 916.7 E(): 0; 38.9% identity in 409 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase and match to Prosite entry PS00737 Thiolases signature 2; Belongs to the thiolase-like superfami [...] (406 aa)
SCO3247SCE29.16c, possible acyl CoA oxidase, len: 600 aa; similar to many acyl CoA oxidases, especially from eukaryotes e.g. SW:CAOP_RAT acyl CoA oxidase from Rattus norvegicus (rat) (661 aa) fasta scores; opt: 462, z-score: 477.6, E(): 2.7e-19, (27.8% identity in 425 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). (600 aa)
SCO3563Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
SCO4381SCD10.13, probable acetyl/propionyl CoA carboxylase, alpha subunit, len: 614 aa; similar to TR:CAB87214 (EMBL:AL163641) Streptomyces coelicolor acetyl/propionyl CoA carboxylase, alpha subunit AccC, 646 aa; fasta scores: opt: 1088 z-score: 1184.1 E(): 0; 46.6% identity in 644 aa overlap and to SW:BCCA_MYCTU (EMBL:Z19549) Mycobacterium tuberculosis acetyl/propionyl-coenzyme A carboxylase alpha chain AccA1, 654 aa; fasta scores: opt: 939 z-score: 1022.0 E(): 0; 43.2% identity in 655 aa overlap. Contains 2x Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) [...] (614 aa)
SCO4384SCD10.16, possible enoyl CoA hydratase, len: 247 aa; similar to TR:Q9X7Q4 (EMBL:AL049587) Streptomyces coelicolor putative enoyl CoA hydratase SC5F2A.31c, 257 aa; fasta scores: opt: 364 z-score: 425.2 E(): 3.3e-16; 36.1% identity in 252 aa overlap and to SW:ECHH_RHIME (EMBL:L39265) Rhizobium meliloti probable enoyl-CoA hydratase (EC 4.2.1.17) FadB1, 257 aa; fasta scores: opt: 334 z-score: 390.9 E(): 2.7e-14; 34.0% identity in 247 aa overla. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. (247 aa)
SCO4502SCD35.09, probable ketoacyl CoA thiolase, len: 428 aa; similar to TR:O86361 (EMBL:AL021929) Mycobacterium tuberculosis FadA2, 440 aa; fasta scores: opt: 1585 z-score: 1791.9 E(): 0; 63.0% identity in 446 aa overlap and to SW:THIK_ECOLI (EMBL:M87049) Escherichia coli 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (fatty oxidation complex beta subunit) (beta-ketothiolase) (acetyl-CoA acyltransferase) FadA, 387 aa; fasta scores: opt: 453 z-score: 515.8 E(): 2.7e-21; 30.9% identity in 430 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase; Belongs to the thiolase-like superfamily. [...] (428 aa)
SCO4800SCD63A.11, icmB, isobutyryl CoA mutase, small subunit, len: 138 aa; almost identical to TR:CAB59633 (EMBL:AJ246005) Streptomyces cinnamonensis isobutyryl CoA mutase, small subunit (EC 5.4.99.13) IcmB, 136 aa; fasta scores: opt: 803 z-score: 972.5 E(): 0; 92.5% identity in 134 aa overlap and highly similar to TR:CAB71846 (EMBL:138667) Streptomyces coelicolor probable isobutyryl-CoA mutase, small subunit SC3D9.01, 159 aa; fasta scores: opt: 594 z-score: 628.1 E(): 2e-29; 70.6% identity in 126 aa overlap. (138 aa)
SCO4808succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
SCO4809Succinyl CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SCO4869SCK20.10, mutA2, methylmalonyl CoA mutase, len: 534 aa; highly similar to SW:MUTA_HUMAN (EMBL:M65131) Homo sapiens methylmalonyl CoA mutase mitochondrial precursor (EC 5.4.99.2) Mut, 750 aa; fasta scores: opt: 1707 z-score: 1912.4 E(): 0; 49.6% identity in 534 aa overlap and almost identical to TR:Q9L1V3 (EMBL:AL138668) Streptomyces coelicolor methylmalonyl CoA mutase mutA SC4A9.09, 531 aa; fasta scores: opt: 3319 z-score: 3721.0 E(): 0; 97.0% identity in 528 aa overlap. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. (534 aa)
SCO4921SCK13.13c, accA2, putative acyl-CoA carboxylase complex A subunit, len: 590 aa; identical to previously sequenced TR:Q9X4K6 (EMBL:AF113603) Streptomyces coelicolor putative acyl-CoA carboxylase complex A subunit AccA2, 590 aa. Contains Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and PF00364 biotin_lipoyl, Biotin-requiring enzymes and match to Prosite entry PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site. (590 aa)
SCO4926SCK13.18c, pccB, propionyl-CoA carboxylase complex B subunit, len: 530 aa; identical to previously sequenced TR:Q9X4K7 (EMBL:AF113605) Streptomyces coelicolor propionyl-CoA carboxylase complex B subunit PccB, 530 aa and similar to TR:O86517 (EMBL:AL031124) Streptomyces coelicolor putative carboxyl transferase SC1C2.16, 527 aa; fasta scores: opt: 1958 z-score: 2071.4 E(): 0; 57.4% identity in 526 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. (530 aa)
SCO5398SC8F4.02c, conserved hypothetical protein, len: 146aa; similar to several of undefined function eg. TR:O28065 (EMBL:AE000952) conserved hypothetical protein from Archaeoglobus fulgidus (131 aa) fasta scores; opt: 346 z-score: 449.3 E(): 1.3e-17 40.4% identity in 136 aa overlap. (146 aa)
SCO5399SC8F4.03, thiL, probable acetoacetyl-coA thiolase, len: 401aa; similar to many eg. SW:P14611 (THIL_ALCEU) acetoacetyl-coA thiolase from Alcaligenes eutrophus (393 aa) fasta scores; opt: 1272, z-score: 1344.2, E(): 0, 53.6% identity in 390 aa overlap. Also similar to TR:Q9XAM9 (EMBL:AL079355) beta-ketoadipyl-coA thiolase from Streptomyces coelicolor (cosmid 4C6) (400 aa) fasta scores; opt: 949, z-score: 919.8, E(): 0, 42.0% identity in 393 aa overlap. Contains Pfam match to entry PF00108 thiolase and Prosite matches to PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiola [...] (401 aa)
SCO5415SC8F4.19, icmA, isobutyryl-CoA mutase A, len: 566 aa; previously sequenced and characterised as TR:Q9X949 (EMBL:AJ237976). Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. (566 aa)
SCO5424Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (407 aa)
SCO5425Phosphate acetyltransferase (fragment); Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. (697 aa)
SCO5676SC8B7.02, gabT, probable 4-aminobutyrate aminotransferase, len: 444 aa; highly similar to e.g. GABT_ECOLI 4-aminobutyrate aminotransferase (EC 2.6.1.19) (426 aa), fasta s cores; opt: 1194 z-score: 1404.8 E(): 0, 45.5% identity in 424 aa overlap. Contains PS00600 Aminotransferases class-II I pyridoxal-phosphate attachment site and Pfam match to ent ry PF00202 aminotran_3, Aminotransferases class-III pyridox al-phosphate, score 516.20, E-value 5e-179; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
SCO6195SC2G5.16, probable acetyl-coenzyme A synthetase, len:558 aa; similar to many e.g. SW:ACSA_BACSU from Bacillus subtilis (572 aa) fasta scores; opt: 798, z-score: 878.3,E():0, (31.8% identity in 537 aa overlap). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 116.90, E-value 3.8e-31. Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 116.90, E-value 3.8e-31. (558 aa)
SCO6412SC1A6.01, probable aminotransferase, partial CDS, len: 190 aa; similar to many members of the class-III family of pyridoxal-phosphate-dependent aminotransferases e.g. ARGD_ANASP P54752 anabaena sp. acetylornithine aminotransferase (427 aa), fasta scores; opt: 315 z-score: 402.3 E(): 2.8e-15, 36.0% identity in 189 aa overlap. Contains Pfam matchto entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, score 147.18; SC3C8.31, probable aminotransferase, partial CDS, len: > 270 aa; similar to many members of the class-III pyridoxal-phosphate-dependent aminotransferase [...] (427 aa)
SCO6585Succinyl-coa synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa)
SCO6586Succinyl-coa synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (308 aa)
SCO6731SC5F2A.14, probable thiolase, len: 404aa; similar to many egs. TR:O53871 (EMBL:AL022004) putative beta-ketoadypyl coA tiolase from Mycobacterium tuberculosis (403 aa) fasta scores; opt: 1842, z-score: 1989.2, E(): 0, (67.6% identity in 404 aa overlap) and TR:O53017 (EMBL:X97452) acetyl coA thiolase from Escherichia coli (401 aa) fasta scores; opt: 819, z-score: 887.9, E(): 0, (41.7% identity in 424 aa overlap). Also similar to SC6A5.37 (EMBL:AL049485) probable acetyl coA acetyltransferase from Streptomyces coelicolor (404 aa) fasta scores; opt: 2480, z-score: 2352.6, E(): 0, (95.0% ide [...] (404 aa)
SCO6732SC5F2A.15, possible fatty acid oxidative multifunctional enzyme, len: 726aa; similar to SW:FAOB_PSEFR fatty oxidation complex alpha subunit from Pseudomonas fragi (715 aa) fasta scores; opt: 1174, z-score: 1211.3, E(): 0, (33.2% identity in 717 aa overlap). Also similar to TR:O53872 (EMBL:AL022004) hypothetical protein from Mycobacterium tuberculosis (720 aa) fasta scores; opt: 3034, z-score: 3128.4, E(): 0, (64.3% identity in 717 aa overlap). Also similar to SC6A5.38 (EMBL:AL049485) possible fatty oxidation protein from Streptomyces coelicolor (733 aa) fasta scores; opt: 4069, z-score [...] (726 aa)
SCO6788SC6A5.37, probable acetyl coA acetyltransferase (thiolase), len: 404aa; similar to many eg. TR:O53017 (EMBL:X97452) acetyl coA acetyltransferase (thiolase) from Escherichia coli (401 aa) fasta scores; opt: 831, z-score: 891.0, E(): 0, (41.9% identity in 422 aa overlap). Contains Pfam match to entry PF00108 thiolase, Thiolase and Prosite matches to PS00737 Thiolases signature 2 and PS00099 Thiolases active site; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
SCO6832SC4A9.09, mutA, methylmalonyl-CoA mutase (EC 5.4.99.2), len: 531 aa. Highly similar to many members of the methylmalonyll-CoA mutase family including: Sinorhizobium meliloti TR:O86028(EMBL:AF080073) methylmalonyll-CoA mutase (EC 5.4.99.2) (712 aa), fasta scores opt: 1720 z-score: 1946.7 E(): 0 52.2% identity in 515 aa overlap and Pyrococcus abyssi TR:CAB49756(EMBL:AJ248285) methylmalonyl-CoA mutase, subunit alpha, N-terminus (562 aa), fasta scores opt: 2180 z-score: 2469.0 E():0 62.7% identity in 518 aa overlap. Also highly similar to Streptomyces coelicolor TR:Q9X949(EMBL:AJ237976) is [...] (531 aa)
SCO6833SC3D9.01, probable isobutyryl-CoA mutase, small subunit (EC 5.4.99.13), len: 159 aa. Highly similar to Streptomyces cinnamonensis TR:CAB59633 (EMBL:AJ246005) isobutyryl-CoA mutase, small subunit (EC 5.4.99.13) (136 aa), fasta scores opt: 580 z-score: 685.3 E(): 9.2e-31 68.3% identity in 126 aa overlap and to the C-terminus of Streptomyces cinnamonensis SW:MUTB_STRCM (EMBL:L10064) methylmalonyl-CoA mutase alpha-subunit (EC 5.4.99.2) (733 aa), fasta scores opt: 291 z-score: 341.2 E(): 1.4e-11 40.5% identity in 111 aa overlap. (159 aa)
SCO7034SC2C3.01, probable aminotransferase (fragment), len: >275 aa; similar to SW:GABT_ECOL (EMBL:M88334) Escherichia coli 4-aminobutyrate aminotransferase (EC 2.6.1.19) GabT, 426 aa; fasta scores: opt: 634 z-score: 729.2 E(): 0; 40.8% identity in 233 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; SC1H10.23, possible aminotransferase, partial CDS len: > 187 aa. Similar to Escherichia coli SW:ARGD_ECOLI (EMBL:M32796) acetylornithine [...] (422 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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