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SCO0256 SCO0256 SCO0922 SCO0922 SCO0923 SCO0923 SCO0924 SCO0924 SCO0984 SCO0984 SCO1012 SCO1012 SCO1204 SCO1204 SCO1393 SCO1393 SCO1591 SCO1591 SCO2769 SCO2769 SCO2778 SCO2778 SCO2823 SCO2823 SCO3079 SCO3079 SCO3416 SCO3416 SCO3834 SCO3834 SCO4384 SCO4384 SCO4502 SCO4502 SCO4594 SCO4594 SCO4595 SCO4595 SCO4780 SCO4780 SCO4855 SCO4855 SCO4856 SCO4856 SCO4857 SCO4857 SCO4858 SCO4858 SCO5106 SCO5106 SCO5107 SCO5107 SCO5385 SCO5385 SCO5399 SCO5399 SCO5512 SCO5512 SCO5513 SCO5513 SCO5676 SCO5676 SCO6269 SCO6269 SCO6270 SCO6270 SCO6412 SCO6412 SCO6473 SCO6473 SCO6475 SCO6475 SCO6584 SCO6584 SCO6702 SCO6702 SCO6703 SCO6703 SCO6731 SCO6731 SCO6732 SCO6732 SCO6788 SCO6788 SCO7034 SCO7034 SCO7035 SCO7035 SCO7109 SCO7109 SCP1.54c SCP1.54c
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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co-expression
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Your Input:
SCO0256SCF20.02, possible short chain oxidoreductase, len: 265aa; similar to many oxidoreductases e.g. TR:Q9ZNN8 (EMBL:AB009078) L-2,3-butanediol dehydrogenase from Corynebacterium glutamicum (258 aa) fasta scores; opt: 784, z-score: 848.0, E(): 0, (49.4% identity in 255 aa overlap). Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature. (265 aa)
SCO0922SCM10.10c, probable reductase iron-sulfur protein, len: 248 aa; similar to SW:FRDB_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase iron-sulfur protein (EC 1.3.99.1) FrdB, 247 aa; fasta scores: opt: 288 z-score: 321.7 E(): 1.6e-10; 28.9% identity in 239 aa overlap. Contains Pfam matches to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains and entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and to Prosite entries PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature and PS00198 4Fe-4S ferredoxins, iron-sulfu [...] (248 aa)
SCO0923SCM10.11c, probable reductase flavoprotein subunit, len: 649 aa; similar to SW:DHSA_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) SdhA, 585 aa;fasta scores: opt: 580 z-score: 658.7 E(): 2.7e-29; 36.8% identity in 609 aa overlap and to SW:FRDA_MYCTU (EMBL:Z74020) Mycobacterium tuberculosis fumarate reductase flavoprotein subunit FrdA, 583 aa; fasta scores: opt: 443 z-score: 503.1 E(): 1.2e-20; 32.2% identity in 574 aa overlap. Contains three Pfam matches to entry Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. (649 aa)
SCO0924SCM10.12c, possible cytochrome B subunit subunit, len: 243 aa; similar to SW:FRDC_HELPY (EMBL:U78101) Helicobacter pylori fumarate reductase cytochrome B subunit FrdC, 255aa; fasta scores: opt: 106 z-score: 139.5 E(): 2.2; 22.1% identity in 181 aa overlap. (243 aa)
SCO0984SCBAC19F3.11, possible 3-hydroxyacyl-CoA dehydrogenase, len: 289 aa; similar to many e.g. SW:P52041 (HBD_CLOAB) 3-hydroxybutyryl-CoA dehydrogenase from Clostridium acetobutylicum (282 aa) fasta scores; opt: 697, Z-score: 765.4, 40.702% identity (41.281% ungapped) in 285 aa overlap and TR:O88051 (EMBL:AL031541) putative 3-hydroxyacyl-CoA dehydrogenase SCI35.13 from Streptomyces coelicolor (303 aa) fasta scores; opt: 1134, Z-score: 1238.6, 61.538% identity (61.538% ungapped) in 286 aa overlap. Contains Pfam match to entry PF02737 3HCDH_N, 3-hydroxyacyl-CoA dehydrogenase, NAD binding doma [...] (289 aa)
SCO10122SCG2.25c, probable oxidoreductase, len: 266 aa; similar to SW:BDHA_ALCEU (EMBL:AF145230) Alcaligenes eutrophus D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30) HbdH1, 258 aa; fasta scores: opt: 586 z-score: 655.1 E(): 5.8e-29; 39.3% identity in 257 aa overlap. Contains Pfam matches to entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
SCO12042SCG58.04, probable aldehyde dehydrogenase, len: 461 aa; similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) GabD, 482 aa; fasta scores: opt: 1006 z-score: 1146.9 E(): 0; 36.5% identity in 455 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. (461 aa)
SCO1393SC1A8A.13, acsA, acetoacetyl-CoA synthetase, len: 658 aa; similar to many eg. TR:BAA90828 (EMBL:AB026291) acetoacetyl-CoA synthetase from Rattus norvegicus (Rat) (672 aa) fasta scores; opt: 1133, z-score: 1295.8, E(): 0, 39.9% identity in 667 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme and Prosite match to PS00455 Putative AMP-binding domain signature. (658 aa)
SCO1591SCI35.13, probable 3-hydroxyacyl-CoA dehydrogenase, len: 303 aa; similar to many e.g. SW:MMGB_BACSU probable 3-hydroxybutyryl-CoA dehydrogenase (287 aa), fasta scores; opt: 764 z-score: 1162.2 E(): 0, 45.6% identity in 283 aa overlap and SW:HBD_CLOAB 3-hydroxybutyryl-CoA dehydrogenase (282 aa), fasta scores; opt: 733 z-score: 1075.7 E(): 0, 43.6% identity in 282 aa overlap. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase, score 361.30, E-value 1.1e-104. (303 aa)
SCO2769SCC57A.40c, possible acetolactate synthase, len: 564 aa. Similar to many e.g. Escherichia coli SW:ILVB_ECOLI (EMBL:J01633) acetolactate synthase isozyme I large subunit (EC 4.1.3.18) (562 aa), fasta scores opt: 732 z-score: 776.9 E(): 0 29.6% identity in 538 aa overlap. Contains a Prosite hit to PS00187 Thiamine pyrophosphate enzymes signature and a Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. (564 aa)
SCO2778SCC105.09, hmgL, hydroxymethylglutaryl-CoA lyase, len: 317 aa; similar to TR:P95639 (EMBL:U41280) Rhodospirillum rubrum hydroxymethylglutaryl-CoA lyase (EC4.1.3.4) HmgL, 303 aa; fasta scores: opt: 924 z-score: 1043.1 E(): 0; 51.2% identity in 297 aa overlap and to SW:HMGL_RAT (EMBL:Y10054) Rattus norvegicus hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) HmgCL, 325 aa; fasta scores: opt: 983 z-score: 1108.8 E(): 0; 52.7% identity in 296 aa overlap. Contains Pfam match to entry PF00682 HMGL-like, HMGL-like. (317 aa)
SCO2823SCBAC17F8.14c, possible decarboxylase, len: 300 aa: similar to many e.g. SW:Q05115 (AMDA_BORBR) arylmalonate decarboxylase from Alcaligenes bronchisepticus (240 aa) fasta scores; opt: 328, Z-score: 331.2, 33.810% identity (35.323% ungapped) in 210 aa overlap and TR:Q54412 (EMBL:X52071) hypothetical protein which close alongside transfer RNA-gly in Streptomyces lividans (195 aa) fasta scores; opt: 295, Z-score: 300.7, 36.872% identity (38.824% ungapped) in 179 aa overlap. Also similar to neighbouring CDS SCBAC17F8.13c. (300 aa)
SCO3079SCE25.20, probable thiolase, len: 406 aa; similar to SW:CATF_ACICA (EMBL:AF009224) Acinetobacter calcoaceticus beta-ketoadipyl CoA thiolase (EC 2.3.1.-) CatF, 401 aa; fasta scores: opt: 957 z-score: 1066.1 E(): 0; 40.0% identity in 415 aa overlap and to TR:CAB45575 (EMBL:AL079355) Streptomyces coelicolor PcaF, beta-ketoadipyl CoA thiolase SC4C6.11c, 400 aa; fasta scores: opt: 895 z-score: 916.7 E(): 0; 38.9% identity in 409 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase and match to Prosite entry PS00737 Thiolases signature 2; Belongs to the thiolase-like superfami [...] (406 aa)
SCO3416SCE9.23, gad, probable glutamate decarboxylase, len: 475 aa; similar to many e.g. SW:DCEA_ECOLI (EMBL:M84024), gadA, Escherichia coli glutamate decarboxylase alpha (466 aa), fasta scores; opt: 1433 z-score: 1665.2 E(): 0, 50.0% identity in 426 aa overlap. Contains Pfam match to entry PF00282 pyridoxal_deC, Pyridoxal-dependent decarboxylase conserved domain, score 276.70, E-value 1.1e-79; Belongs to the group II decarboxylase family. (475 aa)
SCO3834SCH69.04c, probable 3-Hydroxyacyl-CoA dehydrogenase, len: 504aa; similar to many eg. TR:O84980 (EMBL:AF029714) PhaC, 3-Hydroxyacyl-CoA dehydrogenase from Pseudomonas putida (505 aa) fasta scores; opt: 1512, z-score: 1634.7, E(): 0, (50.0% identity in 498 aa overlap). Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. (504 aa)
SCO4384SCD10.16, possible enoyl CoA hydratase, len: 247 aa; similar to TR:Q9X7Q4 (EMBL:AL049587) Streptomyces coelicolor putative enoyl CoA hydratase SC5F2A.31c, 257 aa; fasta scores: opt: 364 z-score: 425.2 E(): 3.3e-16; 36.1% identity in 252 aa overlap and to SW:ECHH_RHIME (EMBL:L39265) Rhizobium meliloti probable enoyl-CoA hydratase (EC 4.2.1.17) FadB1, 257 aa; fasta scores: opt: 334 z-score: 390.9 E(): 2.7e-14; 34.0% identity in 247 aa overla. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. (247 aa)
SCO4502SCD35.09, probable ketoacyl CoA thiolase, len: 428 aa; similar to TR:O86361 (EMBL:AL021929) Mycobacterium tuberculosis FadA2, 440 aa; fasta scores: opt: 1585 z-score: 1791.9 E(): 0; 63.0% identity in 446 aa overlap and to SW:THIK_ECOLI (EMBL:M87049) Escherichia coli 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (fatty oxidation complex beta subunit) (beta-ketothiolase) (acetyl-CoA acyltransferase) FadA, 387 aa; fasta scores: opt: 453 z-score: 515.8 E(): 2.7e-21; 30.9% identity in 430 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase; Belongs to the thiolase-like superfamily. [...] (428 aa)
SCO4594SCD20.12c, probable oxidoreductase, len: 352 aa; highly similar to TR:Q9RKS5 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase beta-subunit SCAH10.34c, 350 aa; fasta scores: opt: 2267 z-score: 2567.5 E(): 0; 98.0% identity in 349 aa overlap and to SW:KORB_ARCFU (EMBL:AE001072) Archaeoglobus fulgidus 2-oxoglutarate synthase subunit KorB (EC 1.2.7.3), 267 aa; fasta scores: opt: 529 z-score: 605.9 E(): 2.8e-26; 37.6% identity in 221 aa overlap. (352 aa)
SCO4595SCD20.13c, probable oxidoreductase, len: 645 aa; highly similar to TR:Q9RKS4 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase alpha-subunit SCAH10.35c, 630 aa; fasta scores: opt: 4069 z-score: 4338.6 E(): 0; 98.7% identity in 627 aa overlap and C-terminal domain similar to TR:O68228 (EMBL:AF021094) Helicobacter pylori OorA subunit of 2-oxoglutarate:acceptor oxidoreductase, 371 aa; fasta scores: opt: 495 z-score: 532.2 E(): 3.6e-22; 31.0% identity in 352 aa overlap. Contains Pfam match to entry PF01855 POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase (N terminus). (645 aa)
SCO4780SCD63.12, probable aldehyde dehydrogenase, len: 537 aa; similar to SW:DHAB_BACSU (EMBL:U47861) Bacillus subtilis betaine aldehyde dehydrogenase (EC 1.2.1.8) GbsA, 490 aa; fasta scores: opt: 950 z-score: 1089.2 E(): 0; 37.4% identity in 460 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family and match to Prosite entry PS00687 Aldehyde dehydrogenases glutamic acid active site. (537 aa)
SCO4855SC5G8.23c, dhsB, probable succinate dehydrogenase iron-sulfur subunit, len: 257aa; strongly similar to many eg. SW:P07014 (DHSB_ECOLI) succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa) fasta scores; opt: 729, z-score: 839.1, E(): 0, 44.3% identity in 237 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Belongs to the succinate [...] (257 aa)
SCO4856SC5G8.24c, dhsA, probable succinate dehydrogenase flavoprotein subunit, len: 584aa; strongly similar to many eg. SW:P10444 (DHSA_ECOLI) succinate dehydrogenase flavoprotein subunit from Escherichia coli (588 aa) fasta scores; opt: 1842, z-score: 2076.6, E(): 0, 48.4% identity in 591 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain and Prosite match to PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. (584 aa)
SCO4857SC5G8.25c, dhsD, possible succinate dehydrogenase membrane subunit, len: 160 aa; similar to TR:O53369 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (144 aa) fasta scores; opt: 553, z-score: 702.9, E(): 1.1e-31, 58.9% identity in 141 aa overlap. Also weakly similar to SW:P10445 (DHSD_ECOLI) succinate dehydrogenase hydrophobic membrane anchor protein from Escherichia coli (115 aa) fasta scores; opt: 126, z-score: 172.2, E(): 0.039, 23.5% identity in 115 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match [...] (160 aa)
SCO4858SC5G8.26c, dhsC, possible succinate dehydrogenase membrane subunit, len: 126aa; similar to many eg. TR:O53368 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (112 aa) fasta scores; opt: 484, z-score: 649.2, E(): 1e-28, 65.7% identity in 99 aa overlap. Also wealky similar to SW:P10446 (DHSC_ECOLI) succinate dehydrogenase cytochrome b-556 subunit from Escherichia coli (129 aa) fasta scores; opt: 121, z-score: 173.9, E(): 0.031, 29.6% identity in 71 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochr [...] (126 aa)
SCO5106SCBAC31E11.02c, shdB2, probable succinate dehydrogenase iron-sulfur subunit, len: 259 aa; highly similar to TR:AAK44479 (EMBL:AE006934) Mycobacterium tuberculosis ferredoxin, 2Fe-2S MT0261, 248 aa; fasta scores: opt: 1355 Z-score: 1588.1 bits: 301.4 E(): 7.7e-81; 74.900% identity in 251 aa overlap and to SW:DHSB_BACSU (EMBL:M13470) Bacillus subtilis succinate dehydrogenase iron-sulfur protein SdhB, 252 aa; fasta scores: opt: 365 Z-score: 434.1 bits: 87.9 E(): 1.4e-16; 30.603% identity in 232 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. (259 aa)
SCO5107SCBAC31E11.03c, shdA2, probable succinate dehydrogenase flavoprotein subunit, len: 653 aa; highly similar to TR:AAK44480 (EMBL:AE006934) Mycobacterium tuberculosis CDC1551 FAD flavoprotein oxidase, putative MT0262, 646 aa; fasta scores: opt: 2941 Z-score: 3164.4 bits: 595.8 E(): 1.2e-168; 70.416% identity in 649 aa overlap and to SW:DHSA_RICPR (EMBL:M88696) Rickettsia prowazekii succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) SdhA, 596 aa; fasta scores: opt: 643 Z-score: 693.1 bits: 138.4 E(): 5.4e-31; 35.218% identity; in 619 aa overlap. Contains Pfam matches to entries PF0 [...] (653 aa)
SCO53852SC6G5.29, possible 3-hydroxybutyryl-coA dehydrogenase, len: 282 aa; similar to many eg. SW:P52041 (HBD_CLOAB) 3-hydroxybutyryl-coA dehydrogenase from Clostridium acetobutylicum (282 aa) fasta scores; opt: 806, z-score: 947.0, E(): 0, 44.6% identity in 280 aa overlap. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase and Prosite match to PS00067 3-hydroxyacyl-CoA dehydrogenase signature. (282 aa)
SCO5399SC8F4.03, thiL, probable acetoacetyl-coA thiolase, len: 401aa; similar to many eg. SW:P14611 (THIL_ALCEU) acetoacetyl-coA thiolase from Alcaligenes eutrophus (393 aa) fasta scores; opt: 1272, z-score: 1344.2, E(): 0, 53.6% identity in 390 aa overlap. Also similar to TR:Q9XAM9 (EMBL:AL079355) beta-ketoadipyl-coA thiolase from Streptomyces coelicolor (cosmid 4C6) (400 aa) fasta scores; opt: 949, z-score: 919.8, E(): 0, 42.0% identity in 393 aa overlap. Contains Pfam match to entry PF00108 thiolase and Prosite matches to PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiola [...] (401 aa)
SCO5512SC8D9.24, ilvB, acetolactate synthase, len: 613aa; high level of similarity to many eg. TR:Q59816 (EMBL:L39268) ilvB, acetolactate synthase from the ilvBNC gene cluster of Streptomyces avermitilis (617 aa) fasta scores; opt: 3558, z-score: 3786.3, E(): 0, (87.2% identity in 619 aa overlap). Contains PS00187 Thiamine pyrophosphate enzymes signature and Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 899.00, E-value 3.2e-278. (613 aa)
SCO5513SC8D9.25, ilvN, acetolactate synthase small subunit, len: 174 aa; high level of similarity to many e.g. TR:Q59817 (EMBL:L39268) IlvN, acetolactate synthase small subunit from the ilvBNC gene cluster of Streptomyces avermitilis (176 aa) fasta scores; opt: 884, z-score: 1056.9, E(): 0, (86.4% identity in 176 aa overlap). (174 aa)
SCO5676SC8B7.02, gabT, probable 4-aminobutyrate aminotransferase, len: 444 aa; highly similar to e.g. GABT_ECOLI 4-aminobutyrate aminotransferase (EC 2.6.1.19) (426 aa), fasta s cores; opt: 1194 z-score: 1404.8 E(): 0, 45.5% identity in 424 aa overlap. Contains PS00600 Aminotransferases class-II I pyridoxal-phosphate attachment site and Pfam match to ent ry PF00202 aminotran_3, Aminotransferases class-III pyridox al-phosphate, score 516.20, E-value 5e-179; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
SCO6269SCAH10.34c, possible oxidoreductase beta-subunit, 350 aa; highly similar to TR:O53181 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase beta-subunit, 373 aa; fasta scores: opt: 1415 z-score: 1622.6 E(): 0; 64.0% identity in 342 aa overlap. Contains possible N-terminal region signal sequence. (350 aa)
SCO6270SCAH10.35c, possible oxidoreductase alpha-subunit, len: 630 aa; similar to TR:O53182 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase alpha-subunit, 653 aa; fasta scores: opt: 2008 z-score: 2153.9 E(): 0; 66.4% identity in 614 aa overlap. (630 aa)
SCO6412SC1A6.01, probable aminotransferase, partial CDS, len: 190 aa; similar to many members of the class-III family of pyridoxal-phosphate-dependent aminotransferases e.g. ARGD_ANASP P54752 anabaena sp. acetylornithine aminotransferase (427 aa), fasta scores; opt: 315 z-score: 402.3 E(): 2.8e-15, 36.0% identity in 189 aa overlap. Contains Pfam matchto entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, score 147.18; SC3C8.31, probable aminotransferase, partial CDS, len: > 270 aa; similar to many members of the class-III pyridoxal-phosphate-dependent aminotransferase [...] (427 aa)
SCO6473SC9C7.09c, ccr, crotonyl CoA reductase, len: 447aa; similar to many, very similar to EMBL:U37135 ccr, crotonyl CoA reductase from Streptomyces collinus (447 aa) fasta scores; opt: 2819, z-score: 3635.0, E(): 0, (92.6% identity in 447 aa overlap). Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. (447 aa)
SCO6475SC9C7.11c, probable oxidoreductase, len: 601aa; similar to many eg. TR:Q45815 (EMBL:M31799) NAD-dependent beta-hydroxybutyryl coenzyme dehydrogenase from Clostridium acetobutylicum (282 aa) fasta scores; opt: 801, z-score: 936.4, E(): 0, (41.1% identity in 280 aa overlap). Appears to be a fusion of two dehydrogesase as each half contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. (601 aa)
SCO6584SC8A6.05c, probable TPP-requiring enzyme, len: 560 a a; similar to many e.g. ILVB_MYCTU probable acetolactate synthase (EC 4.1.3.18) (547 aa), fasta scores; opt: 733 z-sco re: 1305.6 E(): 0, 36.4% identity in 557 aa overlap. Contai ns PS00187 Thiamine pyrophosphate enzymes signature and Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 343.90, E-value 5e-106. (560 aa)
SCO6702SC4C6.12c, pcaJ, probable 3-oxoadipate CoA-transferase subunit B, len: 217 aa; highly similar to many CoA transferases e.g. SW:PCAJ_PSEPU (EMBL:M88763), PcaJ, Pseudomonas putida 3-oxoadipate CoA-transferase subunit B (212 aa), fasta scores; opt: 684 z-score: 774.2 E(): 0, 52.9% identity in 206 aa overlap. Highly similar to SW:SCOB_MYCTU (EMBL:Z95556), ScoB, Mycobacterium tuberculosis probable succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B (218 aa) (73.9% identity in 207 aa overlap). Contains Pfam match to entry PF01144 CoA_trans, Coenzyme A transferase. (217 aa)
SCO6703SC4C6.13c, pcaI, probable 3-oxoadipate CoA-transferase subunit A, len: 260 aa; highly similar to many CoA transferases e.g. SW:PCAI_PSEPU (EMBL:M88763), pcaI, Pseudomonas putida 3-oxoadipate CoA-transferase subunit A (231 aa), fasta scores; opt: 337 z-score: 379.8 E(): 8e-14, 42.6% identity in 242 aa overlap. Highly similar to SW:SCOA_MYCTU (EMBL:Z95556), scoA, Mycobacterium tuberculosis probable succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A (248 aa) (69.9% identity in 249 aa overlap). Contains Pfam match to entry PF01144 CoA_trans, Coenzyme A transferase and PS01273 CoA tra [...] (260 aa)
SCO6731SC5F2A.14, probable thiolase, len: 404aa; similar to many egs. TR:O53871 (EMBL:AL022004) putative beta-ketoadypyl coA tiolase from Mycobacterium tuberculosis (403 aa) fasta scores; opt: 1842, z-score: 1989.2, E(): 0, (67.6% identity in 404 aa overlap) and TR:O53017 (EMBL:X97452) acetyl coA thiolase from Escherichia coli (401 aa) fasta scores; opt: 819, z-score: 887.9, E(): 0, (41.7% identity in 424 aa overlap). Also similar to SC6A5.37 (EMBL:AL049485) probable acetyl coA acetyltransferase from Streptomyces coelicolor (404 aa) fasta scores; opt: 2480, z-score: 2352.6, E(): 0, (95.0% ide [...] (404 aa)
SCO6732SC5F2A.15, possible fatty acid oxidative multifunctional enzyme, len: 726aa; similar to SW:FAOB_PSEFR fatty oxidation complex alpha subunit from Pseudomonas fragi (715 aa) fasta scores; opt: 1174, z-score: 1211.3, E(): 0, (33.2% identity in 717 aa overlap). Also similar to TR:O53872 (EMBL:AL022004) hypothetical protein from Mycobacterium tuberculosis (720 aa) fasta scores; opt: 3034, z-score: 3128.4, E(): 0, (64.3% identity in 717 aa overlap). Also similar to SC6A5.38 (EMBL:AL049485) possible fatty oxidation protein from Streptomyces coelicolor (733 aa) fasta scores; opt: 4069, z-score [...] (726 aa)
SCO6788SC6A5.37, probable acetyl coA acetyltransferase (thiolase), len: 404aa; similar to many eg. TR:O53017 (EMBL:X97452) acetyl coA acetyltransferase (thiolase) from Escherichia coli (401 aa) fasta scores; opt: 831, z-score: 891.0, E(): 0, (41.9% identity in 422 aa overlap). Contains Pfam match to entry PF00108 thiolase, Thiolase and Prosite matches to PS00737 Thiolases signature 2 and PS00099 Thiolases active site; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
SCO7034SC2C3.01, probable aminotransferase (fragment), len: >275 aa; similar to SW:GABT_ECOL (EMBL:M88334) Escherichia coli 4-aminobutyrate aminotransferase (EC 2.6.1.19) GabT, 426 aa; fasta scores: opt: 634 z-score: 729.2 E(): 0; 40.8% identity in 233 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate and match to Prosite entry PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; SC1H10.23, possible aminotransferase, partial CDS len: > 187 aa. Similar to Escherichia coli SW:ARGD_ECOLI (EMBL:M32796) acetylornithine [...] (422 aa)
SCO7035SC2C3.02, gabD, succinate-semialdehyde dehydrogenase (fragment), len: >422 aa; highly similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) GabD, 482 aa; fasta scores: opt: 1329 z-score: 1466.8 E(): 0; 48.9% identity in 415 aa overlap. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family and match to Prosite entry PS00687 Aldehyde dehydrogenases glutamic acid active site; SC4G1.01, gabD, succinate-semialdehyde dehydrogenase (fragment), len: >90 aa; similar to SW:GABD_ECOLI (EMBL:M88334) Escherichia coli [...] (479 aa)
SCO7109SC4B10.10c, possible oxidoreductase, len: 576 aa; similar to TR:O27546 (EMBL:AE000910) Methanobacterium thermoautotrophicum succinate dehydrogenase, flavoprotein subunit MTH1502, 558 aa; fasta scores: opt: 1262 z-score: 1392.4 E(): 0; 41.0% identity in 542 aa overlap and to TR:O53141 (EMBL:AJ000941) Methanobacterium thermoautotrophicum strain marburg, thiol:fumarate reductase subunit A Tfr, 545 aa; fasta scores: opt: 1184 z-score: 1306.6 E(): 0; 40.5% identity in 536 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. (576 aa)
SCP1.54cPutative acetaldehyde dehydrogenase (acylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (293 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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