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SCO4809 SCO4809 SCO2769 SCO2769 SCO4808 SCO4808 SCO5512 SCO5512 SCO5513 SCO5513 SCO5522 SCO5522 SCO5553 SCO5553 SCO5554 SCO5554 SCO6584 SCO6584 SCO6585 SCO6585 SCO6586 SCO6586
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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SCO4809Succinyl CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
SCO2769SCC57A.40c, possible acetolactate synthase, len: 564 aa. Similar to many e.g. Escherichia coli SW:ILVB_ECOLI (EMBL:J01633) acetolactate synthase isozyme I large subunit (EC 4.1.3.18) (562 aa), fasta scores opt: 732 z-score: 776.9 E(): 0 29.6% identity in 538 aa overlap. Contains a Prosite hit to PS00187 Thiamine pyrophosphate enzymes signature and a Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. (564 aa)
SCO4808succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
SCO5512SC8D9.24, ilvB, acetolactate synthase, len: 613aa; high level of similarity to many eg. TR:Q59816 (EMBL:L39268) ilvB, acetolactate synthase from the ilvBNC gene cluster of Streptomyces avermitilis (617 aa) fasta scores; opt: 3558, z-score: 3786.3, E(): 0, (87.2% identity in 619 aa overlap). Contains PS00187 Thiamine pyrophosphate enzymes signature and Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 899.00, E-value 3.2e-278. (613 aa)
SCO5513SC8D9.25, ilvN, acetolactate synthase small subunit, len: 174 aa; high level of similarity to many e.g. TR:Q59817 (EMBL:L39268) IlvN, acetolactate synthase small subunit from the ilvBNC gene cluster of Streptomyces avermitilis (176 aa) fasta scores; opt: 884, z-score: 1056.9, E(): 0, (86.4% identity in 176 aa overlap). (174 aa)
SCO55223-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
SCO55533-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
SCO55543-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
SCO6584SC8A6.05c, probable TPP-requiring enzyme, len: 560 a a; similar to many e.g. ILVB_MYCTU probable acetolactate synthase (EC 4.1.3.18) (547 aa), fasta scores; opt: 733 z-sco re: 1305.6 E(): 0, 36.4% identity in 557 aa overlap. Contai ns PS00187 Thiamine pyrophosphate enzymes signature and Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 343.90, E-value 5e-106. (560 aa)
SCO6585Succinyl-coa synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (383 aa)
SCO6586Succinyl-coa synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (308 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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