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SCO1865 SCO1865 SCO7154 SCO7154 SCO7000 SCO7000 SCO6584 SCO6584 SCO6222 SCO6222 SCO5999 SCO5999 SCO5832 SCO5832 SCO5831 SCO5831 SCO5799 SCO5799 SCO5554 SCO5554 SCO5553 SCO5553 SCO5529 SCO5529 SCO5523 SCO5523 SCO5522 SCO5522 SCO5514 SCO5514 SCO5513 SCO5513 SCO5512 SCO5512 SCO5134 SCO5134 SCO4984 SCO4984 SCO4645 SCO4645 SCO4388 SCO4388 SCO3615 SCO3615 SCO3614 SCO3614 SCO3376 SCO3376 SCO3345 SCO3345 SCO3306 SCO3306 SCO2769 SCO2769 SCO2736 SCO2736 SCO2640 SCO2640 SCO2528 SCO2528 SCO1546 SCO1546 SCO1577 SCO1577 SCO1578 SCO1578 SCO1579 SCO1579 SCO1580 SCO1580
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proteins of unknown 3D structure
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SCO1865Putative aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa)
SCO7154Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
SCO7000SC8F11.26c, idh, isocitrate dehydrogenase, len: 739 aa. Shares 97.8% sequence identity with that previously sequenced and characterised: Streptomyces coelicolor isocitrate dehydrogenase Idh, 741 aa TR:Q9X5M9(EMBL:AF127018); Belongs to the monomeric-type IDH family. (739 aa)
SCO6584SC8A6.05c, probable TPP-requiring enzyme, len: 560 a a; similar to many e.g. ILVB_MYCTU probable acetolactate synthase (EC 4.1.3.18) (547 aa), fasta scores; opt: 733 z-sco re: 1305.6 E(): 0, 36.4% identity in 557 aa overlap. Contai ns PS00187 Thiamine pyrophosphate enzymes signature and Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 343.90, E-value 5e-106. (560 aa)
SCO6222SC2H4.04c, probable aminotransferase, len: 402 aa; smilar to many e.g. AAT_BACST aspartate aminotransferase (EC 2.6.1.1) (393 aa), fasta scores; opt: 657 z-score: 607.8 E(): 1.3e-26, 33.9% identity in 386 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I, score 136.00, E-value 6.9e-37. (402 aa)
SCO5999Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
SCO5832SC5B8.22, putative citrate synthase, len: 390 aa; similar to citrate synthase from many organisms e.g. CISZ _BACSU P39120 bacillus subtilis. citrate synthase i (372 aa), fasta scores; opt: 729 z-score: 877.4 E(): 0, 35.5% iden tity in 372 aa overlap. Contains PS00480 Citrate synthase s ignature and Pfam match to entry citrate_synt PF00285, Citr ate synthase, score 314.55. Also similar to downstream gene SC5B8.21c (421 aa) E(): 2.6e-14, 32.4% identity in 352 aa overlap. (390 aa)
SCO5831SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap. (421 aa)
SCO5799SC4H2.20, probable aminotransferase, len: 532; similar to many e.g. GABT_ECOLI P22256 4-aminobutyrate aminotransferase (426 aa), fasta scores; opt: 355 z-score: 385.5 E(): 3e-14, 28.8% identity in 427 aa overlap. Contains two repetitive regions: GSGSGTGPGSGTGPGTGTGPGTGPGTGPG between aa 82-104, and VTVTDAVTVTDAVTDADADAD between aa 241-261, that are not present in other aminotransferases. Also contains 2x match to Pfam match to entry aminotran_3 PF00202, Aminotransferases class-III pyridoxal-phosphate, scores 72.94 and 175.90, and TTA leucine codon; a potential target for actionof bldA. (532 aa)
SCO55543-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
SCO55533-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
SCO5529Putative 2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. (534 aa)
SCO5523Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (362 aa)
SCO55223-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
SCO5514Acetolactate synthase small subunit; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
SCO5513SC8D9.25, ilvN, acetolactate synthase small subunit, len: 174 aa; high level of similarity to many e.g. TR:Q59817 (EMBL:L39268) IlvN, acetolactate synthase small subunit from the ilvBNC gene cluster of Streptomyces avermitilis (176 aa) fasta scores; opt: 884, z-score: 1056.9, E(): 0, (86.4% identity in 176 aa overlap). (174 aa)
SCO5512SC8D9.24, ilvB, acetolactate synthase, len: 613aa; high level of similarity to many eg. TR:Q59816 (EMBL:L39268) ilvB, acetolactate synthase from the ilvBNC gene cluster of Streptomyces avermitilis (617 aa) fasta scores; opt: 3558, z-score: 3786.3, E(): 0, (87.2% identity in 619 aa overlap). Contains PS00187 Thiamine pyrophosphate enzymes signature and Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 899.00, E-value 3.2e-278. (613 aa)
SCO5134SC9E12.19c, hypothetical protein, len: 344 aa; highly similar to TR:O87087 (EMBL:AB006206) Streptomyces griseus AmfR, AmfA and AmfB genes and 4 ORFS, complete CDS, ORF5, 264 aa; fasta scores: opt: 1018 z-score: 1086.7 E(): 0; 63.3% identity in 264 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. (344 aa)
SCO49842SCK36.07c, probable aminotransferase, len: 403 aa; similar to many, e.g. TR:O86587 (EMBL:AL031514) Streptomyces coelicolor putative aminotransferase SC2H4.04c, 402 aa; fasta scores: opt: 1881 Z-score: 2193.7 bits: 414.8 E(): 1.4e-114; 65.920% identity in 402 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferase class-I. (403 aa)
SCO4645SCD82.16c, aspC, aspartate aminotransferase, len: 408 aa; highly similar to SW:AAT_STRVG (EMBL:D50624) Streptomyces virginiae aspartate aminotransferase AspC, 397 aa; fasta scores: opt: 2346 z-score: 2655.6 E(): 0; 89.4% identity in 396 aa overlap. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I and match to Prosite entry PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. (408 aa)
SCO4388SCD10.20, probable citrate synthase, len: 387 aa; similar to SW:CISY_BACSU (EMBL:U05256) Bacillus subtilis citrate synthase I (EC 4.1.3.7) CitA, 366 aa; fasta scores: opt: 615 z-score: 685.9 E(): 9.9e-31; 36.7% identity in 360 aa overlap and to TR:O70008 (EMBL:AL022374) Streptomyces coelicolor citrate synthase (EC 4.1.3.7) SC5B8.22, 390 aa; fasta scores: opt: 780 z-score: 867.9 E(): 0; 41.0% identity in 371 aa overlap. Contains 2 Pfam matches to entry PF00285 citrate_synt, Citrate synthase and match to Prosite entry PS00480 Citrate synthase signature. (387 aa)
SCO3615SC66T3.26c, ask, probable aspartokinase, len: 425 aa; highly similar to many e.g. SW:AKAB_MYCSM (EMBL:Z17372), ask, Mycobacterium smegmatis aspartokinase (421 aa), fasta scores; opt: 1839 z-score: 1990.8 E(): 0, 67.4% identity in 427 aa overlap. Homologous genes encode both the alpha and beta subunits of ask by using alternative initiation codons. Codon 253 represents the equivalent position in this sequence, by similarity. Contains Pfam match to entry PF00696 aakinase, Aspartate kinases, Glutamate kinases and Gamma glutamate phospho-reductases and PS00324 Aspartokinase signature. (425 aa)
SCO3614Putative aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (362 aa)
SCO3376SCE94.27c, possible acetyltransferase, len: 169aa; similar to hypothetical proteins eg. TR:O33289 (EMBL:AL008967) from Mycobacterium tuberculosis (174 aa) fasta scores; opt: 656, z-score: 842.4, E(): 0, (60.4% identity in 164 aa overlap). Also some similarity to SW:ARGA_ECOLI ArgA, amino-acid acetyltransferase from Escherichia coli (443 aa) fasta scores; opt: 192, z-score: 248.7, E(): 1.5e-06, (29.0% identity in 138 aa overlap). Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family. (169 aa)
SCO3345SCE7.12c, ilvD, dihydroxy acid dehydratase, len: 617aa; previously sequenced therefore almost (conflict of 3 amino acids) identical to TR:O69198 (EMBL:AF068843) ilvD, dihydroxy acid dehydratase from Streptomyces coelicolor (617 aa) fasta scores; opt: 4019, z-score: 4363.1, E(): 0, (99.2% identity in 617 aa overlap). Also similar to SW:ILVD_ECOLI ilvD, dihydroxy acid dehydratase from Escherichia coli (605 aa) fasta scores; opt: 2644, z-score: 2871.0, E(): 0, (66.5% identity in 606 aa overlap). Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family and Prosite matches to PS008 [...] (617 aa)
SCO3306SCE68.04c, possible aminotransferase, len: 404 aa; similar to TR:Q56232 (EMBL:D38459), aspC, Thermus aquaticus aspartate aminotransferase (385 aa), fasta scores; opt: 379 z-score: 433.6 E(): 7.9e-17, 28.9% identity in 370 aa overlap and to many hypothetical aminotransferases. Similar to many from S.coelicolor e.g. SCH10.36 (EMBL:AL049754) probable aspartate aminotransferase (396 aa) (33.2% identity in 404 aa overlap). Alternative start codons are present at codons 3 and 7. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. (404 aa)
SCO2769SCC57A.40c, possible acetolactate synthase, len: 564 aa. Similar to many e.g. Escherichia coli SW:ILVB_ECOLI (EMBL:J01633) acetolactate synthase isozyme I large subunit (EC 4.1.3.18) (562 aa), fasta scores opt: 732 z-score: 776.9 E(): 0 29.6% identity in 538 aa overlap. Contains a Prosite hit to PS00187 Thiamine pyrophosphate enzymes signature and a Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. (564 aa)
SCO2736SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. (429 aa)
SCO2640Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa)
SCO25282-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
SCO1546SCL11.02c, probable aminotransferase, len: 273 aa; similar to SW:DAAA_BACSU (EMBL:)Y14082 Bacillus subtilis D-alanine aminotransferase (EC 2.6.1.21) Dat, 282 aa; fasta scores: opt: 347 z-score: 415.1 E(): 1.1e-15; 28.5% identity in 274 aa overlap. Contains Pfam match to entry PF01063 aminotran_4, Aminotransferase class IV and match to Prosite entry PS00770 Aminotransferases class-IV signature. (273 aa)
SCO1577SCL24.13c, argD, acetonitrile aminotransferase, len: 402 aa; highly similar to SW:ARGD_CORGL (EMBL:X86157) Corynebacterium glutamicum acetylornithine aminotransferase (EC 2.6.1.11) ArgD, 389 aa; fasta scores: opt: 1247 z-score: 1362.1 E(): 0; 52.0% identity in 379 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (402 aa)
SCO1578Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (306 aa)
SCO1579Putative glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa)
SCO1580N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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