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SCO0216 SCO0216 SCO0217 SCO0217 SCO0218 SCO0218 SCO0219 SCO0219 SCO0269 SCO0269 SCO0270 SCO0270 SCO0382 SCO0382 SCO0765 SCO0765 SCO0828 SCO0828 SCO1138 SCO1138 SCO1139 SCO1139 SCO1140 SCO1140 SCO1290 SCO1290 SCO1396 SCO1396 SCO1451 SCO1451 SCO1613 SCO1613 SCO1879 SCO1879 SCO1930 SCO1930 SCO2033 SCO2033 SCO2068 SCO2068 SCO2198 SCO2198 SCO2210 SCO2210 SCO2241 SCO2241 SCO2255 SCO2255 SCO2286 SCO2286 SCO2307 SCO2307 SCO2308 SCO2308 SCO2328 SCO2328 SCO2838 SCO2838 SCO2951 SCO2951 SCO3012 SCO3012 SCO3013 SCO3013 SCO3079 SCO3079 SCO3571 SCO3571 SCO3589 SCO3589 SCO3590 SCO3590 SCO3592 SCO3592 SCO3593 SCO3593 SCO3594 SCO3594 SCO3595 SCO3595 SCO3596 SCO3596 SCO3716 SCO3716 SCO3717 SCO3717 SCO3718 SCO3718 SCO3818 SCO3818 SCO3879 SCO3879 SCO3921 SCO3921 SCO3945 SCO3945 SCO3946 SCO3946 SCO3977 SCO3977 SCO4072 SCO4072 SCO4073 SCO4073 SCO4142 SCO4142 SCO4155 SCO4155 SCO4156 SCO4156 SCO4157 SCO4157 SCO4229 SCO4229 SCO4230 SCO4230 SCO4502 SCO4502 SCO4906 SCO4906 SCO4947 SCO4947 SCO4948 SCO4948 SCO4949 SCO4949 SCO4950 SCO4950 SCO5131 SCO5131 SCO5132 SCO5132 SCO5149 SCO5149 SCO5261 SCO5261 SCO5363 SCO5363 SCO5399 SCO5399 SCO5436 SCO5436 SCO5584 SCO5584 SCO5585 SCO5585 SCO5621 SCO5621 SCO5784 SCO5784 SCO5871 SCO5871 SCO5872 SCO5872 SCO6163 SCO6163 SCO6424 SCO6424 SCO6471 SCO6471 SCO6532 SCO6532 SCO6533 SCO6533 SCO6534 SCO6534 SCO6535 SCO6535 SCO6548 SCO6548 SCO6731 SCO6731 SCO6772 SCO6772 SCO6788 SCO6788 SCO6816 SCO6816 SCO6929 SCO6929 SCO6930 SCO6930 SCO6962 SCO6962 SCO7049 SCO7049 SCO7076 SCO7076 SCO7231 SCO7231 SCO7534 SCO7534 SCO7637 SCO7637 SCP1.52c SCP1.52c
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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gene neighborhood
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SCO0216SCJ12.28, narG2, probable nitrate reductase alpha chain, len: 1233 aa. Highly similar to Streptomyces coelicolor TR:O86717 (EMBL; AL031515) putative nitrate reductase alpha chain NarG SC5C7.20c (1231 aa), fasta scores: opt: 5792 z-score: 6544.7 E(): 0 67.6% identity in 1230 aa overlap and Bacillus subtilis SW:NARG_BACSU (EMBL; Z49884) nitrate reductase alpha chain (EC 1.7.99.4) NarG (1228 aa), fasta scores: opt: 4331 z-score: 4891.8 E(): 0 52.9% identity in 1201 aa overlap. Contains a PS00551 Prokaryotic molybdopterin oxidoreductases signature 1, a Pfam match to entry PF00384 molybdopt [...] (1233 aa)
SCO0217SCJ12.29, narH2, probable nitrate reductase beta chain, len: 522 aa. Highly similar to many e.g. Streptomyces coelicolor TR:O86716 (EMBL; AL031515) putative nitrate reductase beta chain NarH SC5C7.19c (531 aa), fasta scores: opt: 2348 z-score: 2413.0 E(): opt: 2348 z-score: 2413.0 E(): 0 65.3% identity in 496 aa overlap and Bacillus subtilis SW:NARH_BACSU (EMBL; Z49884) nitrate reductase beta chain (EC 1.7.99.4) NarH (487 aa), fasta scores: opt: 2081 z-score: 2139.7 E(): 0 57.1% identity in 485 aa overlap. Contains a PS00190 Cytochrome c family heme-binding site signature, a Pfam match [...] (522 aa)
SCO0218SCJ12.30, narJ2, probable nitrate reductase delta chain, len: 267 aa. Similar to many e.g. Bacillus subtilis SW:NARJ_BACSU (EMBL:Z49884) nitrate reductase delta chain NarJ (EC 1.7.99.4) SC5C7.18c (184 aa), fasta scores: opt: 287 z-score: 314.9 E(): 3.5e-10 32.9% identity in 164 aa overlap and Streptomyces coelicolor TR:O86715 (EMBL:AL031515) nitrate reductase delta chain SC5C7.18c (164 aa), fasta scores: opt: 309 z-score: 338.8 E(): 1.6e-11 40.1% identity in 172 aa overlap. (267 aa)
SCO0219SCJ12.31, narI2, possible nitrate reductase gamma chain, len: 256 aa. Similar to many including: Streptomyces coelicolor TR:O86714 (EMBL:AL031515) putative nitrate reductase gamma chain NarI SC5C7.17c (240 aa), fasta scores: opt: 755 z-score: 891.5 E(): 0 46.8% identity in 235 aa overlap and Bacillus subtilis SW:NARI_BACSU (EMBL:Z49884) nitrate reductase gamma chain (EC 1.7.99.4) (223 aa), fasta scores: opt: 668 z-score: 790.4 E(): 0 43.6% identity in 225 aa overlap. Contains possible membrane spanning hydrophobic domains. (256 aa)
SCO0269Hypothetical protein; SCF1.11, unknown, len: 1053aa; similar to large proteins thought to be involved in the post-translational modification of lantibiotics eg. SW:SPAB_BACSU subtilin modification protein from Bacillus subtilis (1030 aa) fasta scores; opt: 346, z-score: 367.5, E(): 4.2e-13, (22.6% identity in 1041 aa overlap). (1053 aa)
SCO0270Conserved hypothetical protein; SCF1.12, unknown, len: 466 aa; similar to proteins predicted to be involved in lantibiotic biosynthesis eg. SW:SPAC_BACSU subtilin biosynthesis protein from Bacillus subtilis (441 aa) fasta scores; opt: 502, z-score: 549.2, E(): 3.2e-23, (28.9% identity in 405 aa overlap). (466 aa)
SCO0382SCF62.08, probable UDP-glucose/GDP-mannose family dehydrogenase (putative secreted protein), len: 441 aa. Highly similar to many e.g. Pseudomonas syringae (pv. phaseolicola) SW: ALGD_PSESH (EMBL; AF001555) GDP-mannose 6-dehydrogenase (EC 1.1.1.132) (438 aa), fasta scores opt: 1453 z-score: 1666.9 E(): 0 49.2% identity in 445 aa overlap. Contains a Pfam match to entry PF00984 UDPG_MGDP_dh, UDP-glucose/GDP-mannose dehydrogenase family. (441 aa)
SCO0765SCF81.24c, cel1, secreted endoglucanase, len: 747 aa; highly similar to SW:GUN1_STRRE (EMBL:X65616) Streptomyces reticulii cellulase 1 precursor (EC 3.2.1.4) (endoglucanase) (endo-1,4-beta-glucanase) (avicelase) Cel1, 746 aa; fasta scores: opt: 4213 z-score: 4621.9 E(): 0; 80.3% identity in 747 aa overlap. Contains two matches to Pfam entries PF00759 Glyco_hydro_9, Glycosyl hydrolase family 9 and to Prosite entry PS00698 Glycosyl hydrolases family 9 active sites signature 2. Also contains N-terminal region signal peptide sequence and a possible helix-turn-helix motif at residues 119..1 [...] (747 aa)
SCO0828SCF43A.18, probable alkaline phosphatase, len: 553 aa; similar to SW:PPBD_BACSU (EMBL:U49060), PhoD, Bacillus subtilis alkaline phosphatase D precursor (556 aa), fasta scores; opt: 1512 z-score: 1782.1 E(): 0, 47.8% identity in 485 aa overlap. (553 aa)
SCO11382SCG38.31, possible secreted protein, len: 332 aa; similar to TR:AAG04143 (EMBL:AE004510) Pseudomonas aeruginosa hypothetical 34.9 kD protein PA0754, 327 aa; fasta scores: opt: 503 z-score: 536.4 E(): 2e-22; 29.0% identity in 328 aa overlap. Contains possible N-terminal region signal peptide sequence. (332 aa)
SCO11392SCG38.32, possible integral membrane protein, len: 181 aa. Contains possible hydrophobic membrane spanning regions. (181 aa)
SCO11402SCG38.33, possible integral membrane protein, len: 499 aa; similar to SW:YZ2R_AGRVI (EMBL:U32375) Agrobacterium vitis hypothetical 52.8 kDa protein, 502 aa; fasta scores: opt: 1419 z-score: 1523.5 E(): 0; 44.1% identity in 479 aa overlap. Contains Pfam match to entry PF01970 DUF112, Integral membrane protein DUF112. Also contains possible hydrophobic membrane spanning regions. (499 aa)
SCO1290SCBAC36F5.01, possible secreted phosphatase (fragment), len: >296 aa; similar to C-terminal region of SW:PPBD_BACSU (EMBL:U49060) Bacillus subtilis alkaline phosphatase D precursor (EC 3.1.3.1) PhoD, 556 aa; fasta scores: opt: 277 Z-score: 319.4 bits: 68.0 E(): 3.5e-10; 30.258% identity in 271 aa overlap; 2SCG18.37, possible secreted alkaline phosphatase (fragment), len: >266 aa; similar to SW:PPBD_BACSU (EMBL:U49060) Bacillus subtilis alkaline phosphatase D precursor (EC 3.1.3.1) PhoD, 556 aa; fasta scores: opt: 148 z-score: 173.1 E(): 0.037; 25.2% identity in 270 aa overlap. Contains [...] (529 aa)
SCO1396Putative D-alanyl-D-alanine dipeptidase (putative secreted protein); Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (274 aa)
SCO1451SCL6.08c, probable endoglucanase precursor, len: 383 aa; similar to SW:GUN1_STRSQ (EMBL:L03218) Streptomyces sp. endoglucanase 1 precursor (EC 3.2.1.4) CasA, 359 aa; fasta scores: opt: 1042 z-score: 1000.3 E(): 0; 50.6% identity in 324 aa overlap. Contains Pfam match to entry PF01341 Glyco_hydro_6, Glycosyl hydrolases family 6 and possible N-terminal region signal peptide sequence. (383 aa)
SCO1613SCI35.35c, possible glutamine synthetase, len: 462 aa; similar to many e.g. GLNA_PYRWO glutamine synthetase I (EC 6.3.1.2) (439 aa), fasta scores; opt: 536 z-score: 653.9 E(): 3.6e-29, 31.6% identity in 450 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase, score 123.40, E-value 9.4e-39. (462 aa)
SCO1879SCI39.26c, probable secreted pectinesterase, len: 381 aa; similar to SW:PME_BURSO (EMBL:M62803) Burkholderia solanacearum pectinesterase precursor (EC 3.1.1.11) Pme, 396 aa; fasta scores: opt: 350 Z-score: 372.6 bits: 77.7 E(): 3.7e-13; 32.036% identity in 334 aa overlap. Contains Pfam match to entry PF01095 Pectinesterase, Pectinesterase and match to Prosite entry PS00503 Pectinesterase signature 2. Contains also possible N-terminal region signal peptide sequence. (381 aa)
SCO1930SCC22.12, possible integral membrane transport protein, len: 356aa; function predicted as it contains possible membrane spanning hydrophobic regions and is located alongside a possible ABC transport ATP-binding protein (SCC22.10). Similar to TR:O53148 (EMBL:AL021184) hypothetical protein from Mycobacterium tuberculosis (310 aa) fasta scores; opt: 527, z-score: 648.1, E(): 9.2e-29, (35.0% identity in 300 aa overlap). (356 aa)
SCO2033SC4G6.02, possible citrate lyase beta chain, len: 274 aa; similar to SW:CILB_KLEPN citrate lyase beta chain from Klebsiella pneumoniae (289 aa) fasta scores; opt: 293, z-score: 325.3, E(): 8.5e-11, (33.5% identity in 284 aa overlap); Belongs to the HpcH/HpaI aldolase family. (274 aa)
SCO2068Putative secreted alkaline phosphatase; SC4A10.01, hypothetical protein, partial CDS, len: >67 aa; unknown function, probable CDS suggested by GC frameplot and positional base preference. Continues in cosmid 4G6 as SC4G6.39; SC4G6.37, possible secreted alkaline phosphatase, len: >517aa; similar to SW:PPBD_BACSU alkaline phosphatase D from Bacillus subtilis (556 aa) fasta scores; opt: 837, z-score: 915.3, E(): 0, (34.3% identity in 539 aa overlap). Contains possible N-terminal region signal sequence peptide. (551 aa)
SCO2198Glutamine synthetase I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
SCO2210SC10B7.05, glnII, glutamine synthetase, len: 343 aa; identical to previously sequenced TR:Q9X958 (EMBL:Y13833) Streptomyces coelicolor glutamine synthetase (EC 6.3.1.2) (glutamate-ammonia ligase) GlnII, 343 aa and highly similar to SW:GLN2_STRVR (EMBL:X52842) Streptomyces viridochromogenes glutamine synthetase II (EC 6.3.1.2) (glutamate-ammonia ligase II) GlnII, 343 aa; fasta scores: opt: 2196 z-score: 2572.0 E(): 0; 91.0% identity in 343 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase and two matches to Prosite entries PS00180 Glutamine synthetase signa [...] (343 aa)
SCO2241SC1G2.03, probable glutamine synthetase (EC 6.3.1.2), len: 453 aa. Highly similar to many other glutamine synthetases e.g. from Clostridium acetobutylicum SW:GLNA_CLOAB(EMBL:M18966) (443 aa), fasta scores opt: 1017 z-score: 1188.9 E():0 44.4% identity in 446 aa overlap and Mycobacterium tuberculosis SW:GLN2_MYCTU(EMBL:Z70692) (446 aa), fasta scores opt: 2114 z-score: 2469.2 E():0 70.2% identity in 453 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase and a Prosite hit to PS00181 Glutamine synthetase putative ATP-binding region signature. (453 aa)
SCO2255SCC75A.01c, possible membrane protein, partial CDS, len: > 268 aa. Highly similar to another putative membrane protein from Streptomyces coelicolor TR:CAB45459(EMBL:AL079348) SC66T3.03 (330 aa), fasta scores opt: 695 z-score: 823.4 E():0 54.8% identity in 241 aa overlap. Contains possible membrane spanning hydrophobic domains; SC1G2.17c, unknown, partial CDS, len: > 116 aa. Highly similar to the C-terminus of Streptomyces coelicolor TR:Q9XAL0(EMBL:AL079348) putative membrane protein SC66T3.03 (330 aa), fasta scores opt: 472 z-score: 600.5 E(): 4.6e-26 66.1% identity in 109 aa overlap. (350 aa)
SCO2286SCC75A.32c, possible alkaline phosphatase, len: 558 aa. Highly similar to alkaline phosphatases from Bacillus subtilis SW:PPBD_BACSU (EMBL:U49060) alkaline phosphatase D precursor (EC 3.1.3.1) (556 aa), fasta scores opt: 1652 z-score: 1864.2 E():0 49.6% identity in 488 aa overlap. Also similar to several from Streptomyces coelicolor: EMBL:AL096837 putative alkaline phosphatase SCF43A.18 (553 aa), fasta scores opt: 2452 z-score: 2273.5 E():0 65.0% identity in 552 aa overlap and TR:CAB51460 (EMBL:AL096884) putative secreted alkaline phosphatase (551 aa), fasta scores opt: 928 z-score: 10 [...] (558 aa)
SCO2307SCC30.15, possible two-component sensor kinase, len: 409 aa; similar to TR:Q9ZA46 (EMBL:AJ011500) Streptomyces violaceoruber putative two-component sensor kinase GRA-ORF11, 406 aa; fasta scores: opt: 460 z-score: 493.4 E(): 4.9e-20; 33.3% identity in 402 aa overlap. Contains possible hydrophobic membrane spanning regions. (409 aa)
SCO2308SCC30.16, probable two-component system response regulator, len: 235 aa; similar to TR:Q9ZA47 (EMBL:AJ011500) Streptomyces violaceoruber putative two-component response regulator GRA-ORF10, 202 aa; fasta scores: opt: 711 z-score: 821.6 E(): 0; 55.0% identity in 200 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain and PF00196 GerE, Bacterial regulatory proteins, luxR family and match to Prosite entry PS00622 Bacterial regulatory proteins, luxR family signature. Contains also possible helix-turn-helix motif at residues 190..211 (+4.76 SD). (210 aa)
SCO2328Putative dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (218 aa)
SCO2838Putative secreted endoglucanase; SCE20.12c, possible secreted endoglucanase, len: 332 aa. Similar to many including: Streptomyces halstedii SW:GUN1_STRHA(EMBL:Z12157) endoglucanase 1 precursor (EC 3.2.1.4) (321 aa), fasta scores opt: 613 z-score: 677.4 E(): 2.4e-30 37.6% identity in 343 aa overlap and Mycobacterium tuberculosis TR:O53607(EMBL:AL021428) putative cellulase (380 aa), fasta scores opt: 796 z-score: 876.5 E():0 44.3% identity in 298 aa overlap. Note that codon 10 maybe the true initiation codon. Contains a Pfam match to entry PF01341 Glyco_hydro_6, Glycosyl hydrolases and a [...] (332 aa)
SCO2951SCE59.10c, probable malate oxidoreductase, len: 471 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38) (NAD-ME) 478 aa; fasta scores: opt: 1778 z-score: 1887.0 E(): 0; 58.8% identity in 471 aa overlap and to SW:MAO2_ECOLI (EMBL:AE000333) Escherichia coli NADP-dependent malic enzyme (EC 1.1.1.40) MaeB, 759 aa; fasta scores: opt: 1092 z-score: 1158.4 E(): 0; 46.4% identity in 394 aa overlap Contains two Pfam matches to entry PF00390 malic, Malic enzyme. (471 aa)
SCO3012SCE33.14c, probable two-component system histidine kinase, len: 688 aa; similar to TR:O05890 (EMBL:Z95121) Mycobacterium tuberculosis MtrB, 567 aa; fasta scores: opt: 1355 z-score: 1302.5 E(): 0; 48.9% identity in 515 aa overlap and to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-) fasta scores: opt: 560 z-score: 542.0 E(): 9.8e-23; 31.1% identity in 460 aa overlap. Contains Pfam matches to entries PF00672 DUF5, Domain found in bacterial signal proteins and PF00512 signal, Histidine kinase. Contains possible hydrophobic membrane spanning regions. (688 aa)
SCO3013SCE33.15c, probable two-component system response regulator, len: 229 aa; similar to TR:Q50447 (EMBL:Z95121) Mycobacterium tuberculosis MtrA, 228 aa; fasta scores: opt: 1141 z-score: 1397.7 E(): 0; 74.9% identity in 227 aa overlap, to SW:AFQ1_STRCO (EMBL:D10654) Streptomyces coelicolor transcriptional regulatory protein AfsQ1, 225 aa; fasta scores: opt: 698 z-score: 858.5 E(): 0; 47.7% identity in 220 aa overlap and to many other S. coelicolor two-component system response regulators, e.g. TR: CAB77324(EMBL:AL160331) putative response regulator SCD8A.03, 223 aa; fasta scores: opt: 695 [...] (229 aa)
SCO3079SCE25.20, probable thiolase, len: 406 aa; similar to SW:CATF_ACICA (EMBL:AF009224) Acinetobacter calcoaceticus beta-ketoadipyl CoA thiolase (EC 2.3.1.-) CatF, 401 aa; fasta scores: opt: 957 z-score: 1066.1 E(): 0; 40.0% identity in 415 aa overlap and to TR:CAB45575 (EMBL:AL079355) Streptomyces coelicolor PcaF, beta-ketoadipyl CoA thiolase SC4C6.11c, 400 aa; fasta scores: opt: 895 z-score: 916.7 E(): 0; 38.9% identity in 409 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase and match to Prosite entry PS00737 Thiolases signature 2; Belongs to the thiolase-like superfami [...] (406 aa)
SCO3571SCH17.05, probable transcriptional regulator, len: 224 aa; similar to many, especially cAMP-binding receptors, e.g. TR:O34015 (EMBL:U87623), Crp, Vibrio cholerae cyclic AMP receptor protein (210 aa), fasta scores; opt: 314 z-score: 381.1 E(): 6.7e-14, 30.6% identity in 180 aa overlap. Highly similar to TR:O69644 (EMBL:AL022121) Mycobacterium tuberculosis putative transcriptional regulator (224 aa) (54.5% identity in 224 aa overlap). Contains probable helix-turn-helix motif at aa 176-197 (Score 1923, +5.74 SD). Contains Pfam matches to entry PF00027 cNMP_binding, Cyclic nucleotide-bindi [...] (224 aa)
SCO3589SCH66.10c, probable two component sensor kinase, len: 364 aa; similar to many e.g. SW:CUTS_STRCO two component sensor kinase involved in the regulation of copper uptake in Streptomyces coelicolor (414 aa) fasta scores; opt: 659, z-score: 768.1, E(): 0, (35.6% identity in 390 aa overlap). Contains Pfam matches to entry PF00512 signal, Signal carboxyl-terminal domain and to entry PF00672 DUF5, Domain found in bacterial signal proteins. Contains possible hydrophobic membrane spanning regions. (364 aa)
SCO3590SC66T3.01c, probable two-component system response regulator, partial CDS, len: >62 aa; similar to many e.g. SW:CUTR_STRCO (EMBL:X58793), CutR, S.coelicolor two component response regulator involved in regulation of copper metabolism (217 aa), fasta scores; opt: 231 z-score: 316.5 E(): 2.7e-10, 56.5% identity in 62 aa overlap. The CDS continues as SCH66.11c in cosmid H66 (EMBL:AL049731); SCH66.11c, probable two component response regulator, len: 213 aa; similar to many e.g. SW:CUTR_STRCO two component response regulator involved in regulation of copper uptake in Streptomyces coelicolor [...] (231 aa)
SCO3592SC66T3.03, possible membrane protein, len: 330 aa; similar to TR:Q9L038 (EMBL:AL352956) Streptomyces coelicolor putative membrane protein SC1H10.06c, 301 aa; fasta scores: opt: 557 Z-score: 630.1 E(): 1.8e-27; 50.968% identity in 310 aa overlap. Contains hydrophobic, possible membrane-spanning regions at the N-terminus region. (330 aa)
SCO3593SC66T3.04, hypothetical protein, len: 397 aa; unknown function, weakly similar to many femA proteins e.g. SW:FEMA_STAAU (EMBL:M23918), FemA, Staphylococcus aureus factor essential for expression of methicillin resistance (433 aa), fasta scores; opt: 184 z-score: 218.4 E(): 7.7e-05, 23.3% identity in 434 aa overlap. Similar to SCH24.26c (EMBL:AL049826) S.coelicolor hypothetical protein (373 aa) (50.4% identity in 387 aa overlap). (397 aa)
SCO3594SC66T3.05, dldh, probable D-lactate dehydrogenase, len: 337 aa; highly similar to many e.g. TR:O33805 (EMBL:U8296) Streptomyces toyocaensis D-lactate dehydrogenase (330 aa), fasta scores; opt: 1470 z-score: 1711.8 E(): 0,71.4% identity in 318 aa overlap. Also similar to D-specific alpha-keto acid dehydrogenases from vancomycin-resistant bacteria e.g. SW:VANH_ENTFC (EMBL:M64304), VanH, Enterococcus faecium alpha-keto acid dehydrogenase (322 aa) (61.4% identity in 316 aa overlap). Similar to other S.coelicolor putative dehydrogenases e.g. part of SerA (EMBL:AL035569) S.coelicolor probabl [...] (337 aa)
SCO3595Putative D-alanine:D-lactate ligase; Required for resistance to glycopeptides antibiotics. D-Ala-- D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; producing a peptidoglycan which does not terminate by D-alanine but by D-lactate, thus preventing vancomycin binding (By similarity); Belongs to the D-alanine--D-alanine ligase family. (346 aa)
SCO3596Putative D-alanine:D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. May play a role in immunity or defense against glycopeptide antibiotics (perhaps at a moderate level) in the soil environment. Might confer vancomycin resistance to S.coelicolor. (202 aa)
SCO3716Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (225 aa)
SCO3717Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (707 aa)
SCO3718Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (554 aa)
SCO3818SCGD3.19, probable two-component system transcriptional regulator, len: 218 aa; similar to many two-component system regulators e.g. TR:O85372 (EMBL:AF064700), CprR, Rhodococcus sp. two-component system component controlling expression of an emulsion-stabilizing capsule (212 aa), fasta scores; opt: 807 z-score: 938.9 E(): 0, 60.7% identity in 211 aa overlap, but doesn't have a directly adjacent sensor kinase. Similar to many from S.coelicolor e.g. (EMBL:AL049754), SCH10.18c, probable two-component system regulator (228 aa) (42.2% identity in 211 aa overlap). Contains probable helix-tur [...] (218 aa)
SCO3879Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). (656 aa)
SCO3921Low molecular weight protein-tyrosine-phosphatase; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (164 aa)
SCO3945SCD78.12, cydA, cytochrome oxidase subunit I len: 501 aa; similar to e.g. APPC_ECOLI (EMBL:S63811) cytochrome BD-II oxidase subunit I from Escherichia coli (485 aa), fasta scores opt: 1099 z-score: 1869.0 E():0 (48.6% identity in 510 aa overlap) and CYDA_BACSU (EMBL:D83026) cytochrome D ubiquinol oxidase subunit I from Bacillus subtilis (468 aa), fasta scores opt: 1178 z-score: 1729.6(43.9% identity in 472 aa overlap). Contains possible hydrophobic membrane spanning regions. (501 aa)
SCO3946SCD78.13, cydB, cytochrome oxidase subunit II, len: 334 aa; similar to CYDB_ECOLI (EMBL:J03939) cytochrome D ubiquinol oxidase subunit II from Escherichia coli (379 aa) fasta scores: opt: 674, z-score: 1092.0, E():0 (37.3% identity in 367 aa overlap) and CYDB_BACSU (EMBL:D83026) cytochrome D ubiquinol oxidase subunit II from Bacillus subtilis (338 aa), fasta scores; opt: 1041, z-score: 1431.1, E():0, (47.1% identity in 329 aa overlap). Contains possible membrane spanning regions. (334 aa)
SCO3977SCBAC25E3.14, possible protease (putative secreted protein), len: 519aa: similar to many eg. TR:Q9FBK9 (EMBL:AL390975) putative protease SCP8.12 from Streptomyces coelicolor (542 aa) fasta scores; opt: 1265, Z-score: 796.4, 43.636% identity (47.431% ungapped) in 550 aa overlap and TR:O06291 (EMBL:Z98260) HtrA from Mycobacterium tuberculosis (549 aa) fasta scores; opt: 614, Z-score: 396.6, 34.870% identity (37.826% ungapped) in 499 aa overlap. Contains Pfam match to entry PF00089 trypsin, Trypsin and Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Contains possi [...] (519 aa)
SCO4072SCD25.08c, luxR family two component system response regulator, len: 200. Highly similar to many e.g. Bacillus subtilis TR:O34723 (EMBL; AF027868), fasta scores opt: 538 z-score: 609.7 E(): 1.3e-26 41.2% identity in 199 aa overlap and Streptomyces coelicolor TR:CAB46973 (EMBL; AL096825) putative two-component system response regulator SC6G3.01C (fragment) (202 aa), fasta scores opt: 413 z-score: 356.7 E(): 1.3e-14 38.6% identity in 202 aa overlap. Contains a Pfam match to entry PF00072 response_reg, Response regulator receiver domain and a Pfam match to entry PF00196 GerE, Bacterial re [...] (200 aa)
SCO4073SCD25.09c, possible sensor kinase, len: 415 aa. Identical to Streptomyces lividans TR:Q04390 (EMBL:X65556) hypothetical protein in tRNA-glyU beta gene region (fragment) (>64 aa), fasta scores opt: 436 z-score: 463.7 E(): 1.8e-18 100.0% identity in 64 aa overlap. Also similar to Streptomyces coelicolor TR:O70000 (EMBL:AL022374) putative two-component sensor SC5B8.14 (384 aa), fasta scores opt: 303 z-score: 317.3 E(): 2.5e-10 26.8% identity in 400 aa overlap. Contains possible membrane spanning hydrophobic domains. (415 aa)
SCO4142Phosphate-binding protein precursor; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (370 aa)
SCO4155SCD84.22c, probable two-component system sensor, len: 481 aa; similar to TR:O53895 (EMBL:AL021999) Mycobacterium tuberculosis putative two-component sensor, MTV044.10, 504 aa; fasta scores: opt: 884 z-score: 949.8 E(): 0; 39.4% identity in 482 aa overlap and to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-), 535 aa; fasta scores: opt: 404 z-score: 435.9 E(): 8e-17; 31.4% identity in 526 aa overlap. Contains Pfam matches to entries PF00672 DUF5, Domain found in bacterial signal proteins and PF00512 signal, Histidine kinase and correctly situated ma [...] (481 aa)
SCO4156SCD84.23c, probable two-component systen response regulator, len: 248 aa; similar to SW:COPR_PSESM (EMBL:L05176) Pseudomonas syringae transcriptional activator protein CopR, 227 aa; fasta scores: opt: 610 z-score: 735.3 E(): 0; 42.7% identity in 227 aa overlap and to TR:O53894 (EMBL:AL021999) Mycobacterium tuberculosis putative two-component response regulator MTV044.09, 230 aa; fasta scores: opt: 933 z-score: 1119.0 E(): 0; 62.9% identity in 229 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain and PF00486 trans_reg_C, Transcriptiona [...] (248 aa)
SCO4157SCD84.24c, probable protease, len: 347 aa; similar to C-terminal region of TR:O06291(EMBL:Z98260) Mycobacterium tuberculosis HtrA, 549 aa; fasta scores: opt: 426 z-score: 370.9 E(): 3.4e-13; 38.4% identity in 328 aa overlap and C-terminal region similar to C-terminal region of SW:HTRA_ECOLI (EMBL:M36536) Escherichia coli protease do precursor HtrA, 474 aa; fasta scores: opt: 329 z-score: 290.0 E(): 1.1e-08; 42.7% identity in 199 aa overlap. Contains 2x Pfam match to entry PF00089 trypsin, Trypsin. Contains possible hydrophobic membrane spanning region. (347 aa)
SCO4229SCD8A.02, possible sensor kinase, len: 426 aa; similar to SW:SEX3_MYCTU (EMBL:Y13628) Mycobacterium tuberculosis sensor-like histidine kinase SenX3 (EC 2.7.3.-), 410 aa; fasta scores: opt: 874 z-score: 939.7 E(): 0; 43.6% identity in 406 aa overlap and to C-terminal region of SW:PHOR_ECOLI (EMBL:X04704) Escherichia coli phosphate regulon sensor protein PhoR, 431 aa; fasta scores: opt: 521 z-score: 562.5 E(): 6.7e-24; 36.8% identity in 261 aa overlap; also similar to various S. coelicolor sensor proteins, e.g. SCH22A.18c, 370 aa; fasta scores: opt: 415 z-score: 388.1 E(): 3.9e-16; 31.1% [...] (426 aa)
SCO4230SCD8A.03, probable response regulator, len: 223 aa; similar to TR:O86269 (EMBL:AJ001103) Lactococcus lactis ArcA protein, 233 aa; fasta scores: opt: 700 z-score: 810.0 E(): 0; 49.3% identity in 223 aa overlap and to TR:Q56180 (EMBL:U38917) Synechococcus sp. response regulator PhoB, 234 aa; fasta scores: opt: 687 z-score: 795.1 E(): 0; 48.0% identity in 229 aa overlap, and similar to many S. coelicolor response regulators, e.g. SCH22A.19c, 256 aa; fasta scores: opt: 687 z-score: 696.9 E(): 2.5e-33; 49.1% identity in 224 aa overlap. Contains Pfam matches to entries PF00072 response_reg, [...] (223 aa)
SCO4502SCD35.09, probable ketoacyl CoA thiolase, len: 428 aa; similar to TR:O86361 (EMBL:AL021929) Mycobacterium tuberculosis FadA2, 440 aa; fasta scores: opt: 1585 z-score: 1791.9 E(): 0; 63.0% identity in 446 aa overlap and to SW:THIK_ECOLI (EMBL:M87049) Escherichia coli 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (fatty oxidation complex beta subunit) (beta-ketothiolase) (acetyl-CoA acyltransferase) FadA, 387 aa; fasta scores: opt: 453 z-score: 515.8 E(): 2.7e-21; 30.9% identity in 430 aa overlap. Contains Pfam match to entry PF00108 thiolase, Thiolase; Belongs to the thiolase-like superfamily. [...] (428 aa)
SCO4906Sensor kinase protein; Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. May activate AfsQ1 by phosphorylation. (535 aa)
SCO49472SCK31.07, narG3, nitrate reductase alpha chain, len: 1227 aa; highly similar to SW:NARG_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase alpha chain (EC 1.7.99.4)NarG, 1228 aa; fasta scores: opt: 4080 z-score: 4618.0 E(): 0; 49.5% identity in 1206 aa overlap and to TR:O86717 (EMBL:AL031515) Streptomyces coelicolor NarG, putative nitrate reductase alpha chain SC5C7.20, 1231 aa; fasta scores: opt: 5648 z-score: 5294.1 E(): 0; 66.6% identity in 1232 aa overlap. Contains Pfam matches to entries PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases and PF01568 Molydop_bin [...] (1227 aa)
SCO49482SCK31.08, narH3, nitrate reductase beta chain, len: 548 aa; highly similar to SW:NARH_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase beta chain NarH, 487 aa; fasta scores: opt: 2088 z-score: 2047.9 E(): 0; 58.2% identity in 483 aa overlap and to TR:O86716 (EMBL:AL031515) Streptomyces coelicolor NarH, putative nitrate reductase beta chain SC5C7.19, 531 aa; fasta scores: opt: 2542 z-score: 2343.2 E(): 0; 71.6% identity in 503 aa overlap. (548 aa)
SCO49492SCK31.09, narJ3, nitrate reductase delta chain, len: 237 aa; similar to SW:NARJ_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase delta chain (EC 1.7.99.4) NarJ, 184 aa; fasta scores: opt: 332 z-score: 411.9 E(): 2.1e-15; 35.0% identity in 163 aa overlap and to TR:Q9RI30 (EMBL:AL109989) Streptomyces coelicolor NarJ2 SCJ12.30, 267 aa; fasta scores: opt: 436 z-score: 447.2 E(): 3.3e-19; 41.7% identity in 204 aa overlap. (220 aa)
SCO49502SCK31.10, narI3, nitrate reductase gamma chain, len: 237 aa; highly similar to SW:NARI_BACSU (EMBL:Z49884) Bacillus subtilis nitrate reductase gamma chain (EC 1.7.99.4) NarI, 223 aa; fasta scores: opt: 792 z-score: 991.9 E(): 0; 49.6% identity in 234 aa overlap and to TR:Q9RI29 (EMBL:109989) Streptomyces coelicolor putative nitrate reductase delta chain NarI2 SCJ12.31, 256 aa; fasta scores: opt: 813 z-score: 891.7 E(): 0; 54.3% identity in 230 aa overlap. Contains possible hydrophobic membrane spanning regions. (237 aa)
SCO5131SC9E12.16, possible two-component system sensor kinase, len: 388 aa; similar to TR:CAB88185 (EMBL:AL352972) Streptomyces coelicolor putative two-component system sensor kinase SCC30.15, 409 aa; fasta scores: opt: 773 z-score: 840.8 E(): 0; 41.9% identity in 389 aa overlap. Contains possible hydrophobic membrane spanning regions at N-terminal domain. (388 aa)
SCO5132SC9E12.17, possible two-component system response regulator, len: 204 aa; similar to TR:CAB88186 (EMBL:AL352972) Streptomyces coelicolor putative two-component response regulator SCC30.16, 210 aa; fasta scores: opt: 822 z-score: 928.1 E(): 0; 63.0% identity in 200 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain and PF00196 GerE, Bacterial regulatory proteins, luxR family. Also contains possible helix-turn-helix motif at residues 159..180 (+5.28 SD). (204 aa)
SCO5149SCP8.12, possible protease, len: 542 aa; C-terminal region similar to TR:O53896 (EMBL:AL021999) Mycobacterium tuberculosis putative serine protease MTV044.11, 464 aa; fasta scores: opt: 803 z-score: 614.5 E(): 9.2e-27; 39.4% identity in 469 aa overlap and to TR:AAF61294 (EMBL:AF155705) Lactococcus lactis serine protease HtrA, 408 aa; fasta scores: opt: 536 z-score: 415.8 E(): 1.1e-15; 34.8% identity in 310 aa overlap. Contains Pfam matches to entries PF00089 trypsin, Trypsin and PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). (542 aa)
SCO52612SC7G11.23, probable malate oxidoreductase, len: 409 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38), 478 aa; fasta scores: opt: 1385 z-score: 1470.9 E(): 0; 55.0% identity in 391 aa overlap. Contains 2x Pfam matches to entry PF00390 malic, Malic enzyme. (409 aa)
SCO5363Hypothetical protein 2SC6G5.07; 2SC6G5.07, unknown, len: 166 aa. (166 aa)
SCO5399SC8F4.03, thiL, probable acetoacetyl-coA thiolase, len: 401aa; similar to many eg. SW:P14611 (THIL_ALCEU) acetoacetyl-coA thiolase from Alcaligenes eutrophus (393 aa) fasta scores; opt: 1272, z-score: 1344.2, E(): 0, 53.6% identity in 390 aa overlap. Also similar to TR:Q9XAM9 (EMBL:AL079355) beta-ketoadipyl-coA thiolase from Streptomyces coelicolor (cosmid 4C6) (400 aa) fasta scores; opt: 949, z-score: 919.8, E(): 0, 42.0% identity in 393 aa overlap. Contains Pfam match to entry PF00108 thiolase and Prosite matches to PS00098 Thiolases acyl-enzyme intermediate signature, PS00737 Thiola [...] (401 aa)
SCO5436SC6A11.12, possible sodium:dicarboxylate symporter, len: 466 aa; similar to many e.g. SW:P50334 (DCTA_SALTY) C4-dicarboxylate transport protein from Salmonella typhimurium (428 aa) fasta scores: opt: 1320, z-score: 1451.6, E(): 0, 48.9% identity in 419 aa overlap. Contains Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (466 aa)
SCO5584SC2E1.01, glnB, nitrogen regulatory protein P-II, partial CDS, len: >54 aa; highly similar to many e.g. GLNB_AZOBR (112 aa), fasta scores; opt: 198 z-score: 381.9 E(): 4.9e-14, 50.0% identity in 54 aa overlap; SC7A1.28, partial CDS, glnB, nitrogen regulatory protein P-II, len: 92aa; similar to many eg. SW:GLNB_RHIME nitrogen regulatory protein P-II from Rhizobium meliloti (112 aa) fasta scores; opt: 402, z-score: 776.2, E(): 0, (58.7% identity in 92 aa overlap). Contains PS00496 P-II protein urydylation site and Pfam match to entry PF00543 P-II, Nitrogen regulatory protein P-II, score [...] (112 aa)
SCO5585Putative protein pII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (835 aa)
SCO5621RNA polymerase sigma factor WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (280 aa)
SCO5784SC4H2.05, probable two-component sensor protein, len: 358 aa; similar to many e.g. DEGS_BACSU P13799 sensor protein DegS (ec 2.7.3.-), Bacillus subtilis (385 aa), fasta scores; opt: 317 z-score: 334.6 E(): 2e-11, 31.3% identity in 227 aa overlap. Contains possible hydrophobic membrane spanning regions. (358 aa)
SCO5871Putative turgor pressure sensor; SC2E9.12, kdpD, two-component sensor/protein kinase, len: 848 aa; similar to Escherichia coli turgor pressure sensor KDPD_ECOLI P21865 sensor protein kdpD (ec 2.7.3.-) (894 aa), fasta scores; opt: 997 z-score: 1347.4 E(): 0, 34.8% identity in 877 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry signal PF00512, Signal C terminal domain, score 184.57. Contains possible hydrophobic membrane spanning regions. (848 aa)
SCO5872Putative turgor pressure regulator; SC2E9.13, kdpE, two-component trascriptional regulator, len: 227, similar to E.coli turgor pressure regulator KDPE_ECOLI P21866 kdp operon transcriptional regulatory protein (225 aa), fasta scores; opt: 752 z-score: 1090.9 E(): 0, 51.1% identity in 225 aa overlap. Contains Pfam match to entry trans_reg_C PF00486, Transcriptional regulatory proteins, C terminal, score 96.22. (227 aa)
SCO6163SC1A9.27c, probable sensor kinase, len: 303aa; similar to a family of sensor kinases eg. TR:O69960 (EMBL:AL022268) probable two-component sensor protein from Streptomyces coelicolor (358 aa) fasta scores; opt:1037, z-score: 1477.8, E():0, (59.2% identity in 299 aa overlap) and TR:Q52558 (EMBL:U02041) two-component sensor regulating virulence genes of Pseudomonas solanacearum (502 aa) fasta scores; opt: 388, z-score: 475.5, E():3.3e-19, (31.5% identity in 270 aa overlap). Contains possible hydrophobic membrane spanning regions. (303 aa)
SCO6424SC1A6.13c, probable two-component system sensor protein, len: 331 aa; contains two potential transmembrane domains in the C-terminus; similar to e.g. DEGS_BACSU P13799 sensor protein DegS (EC 2.7.3.-) Bacillus subtilis (385 aa), fasta scores: opt: 316 z-score: 369.3 E(): 1.9e-13, 30.7% identity in 212 aa overlap and to TR:Q52558 (EMBL:U02041) Burkholderia solanacearum VrsA, 502 aa; fasta scores: opt: 398 Z-score: 416.9 E(): 1.4e-15; 31.724% identity in 290 aa overlap. Contains possible hydrophobic membrane spanning regions. (331 aa)
SCO6471SC9C7.07c, probable citratelyase, len: 339 aa; similar to many e.g. SW:CILB_KLEPN citrate lyase beta chain from Klebsiella pneumoniae (289 aa) fasta scores; opt: 187, z-score: 643.3, E(): 1.5e-28, (30.5% identity in 298 aa overlap); Belongs to the HpcH/HpaI aldolase family. (339 aa)
SCO6532SC5C7.17c, narI, probable nitrate reductase gamma chain; len: 240 aa; similar to many e.g. NARI_BACSU nitrate reductase gamma chain (EC 1.7.99.4) (223 aa), fasta scores; opt: 664 z-score: 1084.3 E(): 0, 41.5% identity in 217 aa overlap. Contains possible hydrophobic membrane spanning regions. (240 aa)
SCO6533SC5C7.18c, narJ, probable nitrate reductase delta chain, len: 164 aa; similar to many e.g. NARJ_BACSU nitrate reductase delta chain (EC 1.7.99.4) (184 aa), fasta scores; opt: 208 z-score: 429.0 E(): 1.2e-16, 30.1% identity in 163 aa overlap. (164 aa)
SCO6534SC5C7.19c, narH, probable nitrate reductase beta chain, len: 531 aa; highly similar to many e.g. NARH_BACSU nitrate reductase beta chain (EC 1.7.99.4) (487 aa), fasta scores; opt: 2099 z-score: 2179.2 E(): 0, 58.0% identity in 495 aa overlap. Contains PS00190 Cytochrome c family heme-binding site signature and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains, score 61.10, E-value 1.8e-16. (531 aa)
SCO6535SC5C7.20c, narG, probable nitrate reductase alpha chain, len: 1231 aa; highly similar to many e.g. NARG_BACSU nitrate reductase alpha chain (EC 1.7.99.4) (1228 aa), fasta scores; opt: 4306 z-score: 3216.7 E(): 0, 51.5% identity in 1235 aa overlap. Contains PS00551 and PS00490 Prokaryotic molybdopterin oxidoreductases signatures 1 and 2 and Pfam match to entry PF00384 molybdopterin, Prokaryotic molybdopterin oxidoreductases, score 79.90, E-value 1e-24; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1231 aa)
SCO6548SC5C7.33, probable secreted cellulase, len: 579 aa; similar to many, e.g. TR:Q60029 (EMBL:U18978) beta-1,4-exocellulase precursor (596 aa), fasta scores; opt: 2131 z-score: 2323.9 E(): 0, 62.1% identity in 585 aa overlap. Contains possible N-terminal signal sequence, PS00655 Glycosyl hydrolases family 6 signature 1 and Pfam match to entry PF00553 CBD_1, Cellulose binding domain, score 161.20, E-value 9.8e-46 near C-terminus. (579 aa)
SCO6731SC5F2A.14, probable thiolase, len: 404aa; similar to many egs. TR:O53871 (EMBL:AL022004) putative beta-ketoadypyl coA tiolase from Mycobacterium tuberculosis (403 aa) fasta scores; opt: 1842, z-score: 1989.2, E(): 0, (67.6% identity in 404 aa overlap) and TR:O53017 (EMBL:X97452) acetyl coA thiolase from Escherichia coli (401 aa) fasta scores; opt: 819, z-score: 887.9, E(): 0, (41.7% identity in 424 aa overlap). Also similar to SC6A5.37 (EMBL:AL049485) probable acetyl coA acetyltransferase from Streptomyces coelicolor (404 aa) fasta scores; opt: 2480, z-score: 2352.6, E(): 0, (95.0% ide [...] (404 aa)
SCO6772Conserved hypothetical protein; SC6A5.21c, unknown, len: 287aa; similar to TR:P96830 (EMBL:Z92770) hypothetical protein from Mycobacterium tuberculosis (276 aa) fasta scores; opt: 189, z-score: 220.4, E(): 5.6e-05, (32.3% identity in 279 aa overlap). (287 aa)
SCO6788SC6A5.37, probable acetyl coA acetyltransferase (thiolase), len: 404aa; similar to many eg. TR:O53017 (EMBL:X97452) acetyl coA acetyltransferase (thiolase) from Escherichia coli (401 aa) fasta scores; opt: 831, z-score: 891.0, E(): 0, (41.9% identity in 422 aa overlap). Contains Pfam match to entry PF00108 thiolase, Thiolase and Prosite matches to PS00737 Thiolases signature 2 and PS00099 Thiolases active site; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
SCO6816SC1A2.25c, possible ABC transporter binding lipoprotein, len: 290 aa. Similar to several including: Escherichia coli SW:PSTS_ECOLI (EMBL:K01992) phosphate-binding protein precursor (346 aa), fasta scores opt: 158 z-score: 176.7 E(): 0.019 25.9% identity in 259 aa overlap and Methanobacterium thermoautotrophicum TR:O27760 (EMBL:AE000929) phosphate-binding protein, PstS (271 aa), fasta scores opt: 510 z-score: 554.5 E(): 1.8e-23 34.9% identity in 281 aa overlap. Contains an appropriately positioned Prosite hit to PS00013 Prokaryotic membrane lipoprotein lipid attachment site, a Pfam matc [...] (290 aa)
SCO6929Hypothetical protein; SC1G8.01c, unknown, partial CDS,len: >270 aa. Weakly similar to Bacillus subtilis SW:SPAC_BACSU (EMBL:M86869) subtilin biosynthetic protein, possibly involved in export, SpaC (441 aa), fasta scores opt: 319 z-score: 378.0 E(): 1.4e-13 29.0% identity in 245 aa overlap; SC1B2.35c, unknown, partial CDS, len: >181 aa. Similar to Streptomyces coelicolor TR:CAB55532 (EMBL:AL117322) hypothetical 49.0 kd protein, SCF1.12 (466 aa), fasta scores opt: 238 z-score: 283.2 E(): 2.6e-08 31.1% identity in 180 aa overlap. (419 aa)
SCO6930SC1G8.02c, unknown, len: 1032 aa. Similar to a number of proteins involved in the posttranslational modification of the lantibiotics e.g. Bacillus subtilis SW:SPAB_BACSU (EMBL:L24075) subtilin biosynthesis protein, SpaB (1030 aa), fasta scores opt: 516 z-score: 571.0 E(): 2.4e-24 22.1% identity in 988 aa overlap. Also similar to Streptomyces coelicolor TR:CAB55531 (EMBL:AL117322) hypothetical 114.5 kd protein, SCF1.11 (1053 aa), fasta scores opt: 884 z-score: 982.0 E(): 0 30.6% identity in 1081 aa overlap. Contains a TTA leucine codon, possible target for bldA regulation. (1032 aa)
SCO6962Putative glutamine synthetase; SC6F7.15c, possible glutamine synthetase (EC 6.3.1.2), len: 466 aa. Similar to many glutamine synthetases e.g. Bacillus subtilis SW:GLNA_BACSU(EMBL:M22811) GlnA (443 aa), fasta scores opt: 540 z-score: 593.0 E(): 1.4e-25 28.5% identity in 421 aa overlap. Contains a Pfam match to entry PF00120 gln-synt, Glutamine synthetase. (466 aa)
SCO7049SC4G1.15, probable glutaminase, len: 307 aa; similar to TR:O87405 (EMBL:AF057158) Rhizobium etli glutaminase A, 309 aa; fasta scores: opt: 990 z-score: 1158.2 E(): 0; 52.3% identity in 304 aa overlap and to middle part of SW:GLSK_RAT (EMBL:M65150) Rattus norvegicus glutaminase, kidney isoform precursor (EC 3.5.1.2) GlsK, 647 aa; fasta scores: opt: 577 z-score: 672.7 E(): 5.3e-30; 35.2% identity in 293 aa overlap; Belongs to the glutaminase family. (307 aa)
SCO7076SC3A4.02, putative two-component histidine kinase, len: 483 aa. Similar in parts to Agrobacterium tumefaciens SW:CHVG_AGRTU(EMBL:L18860) putative two-component histidine kinase required for virulence (690 aa), fasta scores, opt:399 z-score: 426.8 E(): 2.6e-16 33.1% identity in 357 aa overlap. Also similar to Streptomyces coelicolor SCD84.23c (481 aa), fasta scores opt: 874 z-score: 748.4 E():0 39.8% identity in 480 aa overlap. Contains a Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins and a Pfam match to entry PF00512 signal, Histidine kinase. Contains proba [...] (483 aa)
SCO7231SC2H12.30, possible two-component system sensor kinase, len: 503 aa. Highly similar to many other sensor kinases e.g. Streptomyces coelicolor SW:AFQ2_STRCO (EMBL:D10654) sensor protein, AfsQ2, a putative regulator of secondary metabolism (EC 2.7.3.-) (535 aa), fasta scores opt: 1112 z-score: 1254.8 E():0 42.0% identity in 519 aa overlap. Contains Pfam matches to entries PF00672 DUF5, Domain found in bacterial signal proteins and PF00512 signal, Histidine kinase. Contains possible membrane spanning hydrophobic domains. (503 aa)
SCO7534SC8G12.10, possible two component system histidine kinase, len: 504 aa. Highly similar to several e.g. Streptomyces coelicolor SW:AFQ2_STRCO(EMBL:D10654) sensor protein AfsQ2 (EC 2.7.3.-) (535 aa), fasta scores opt: 1060 z-score: 1143.7 E(): 0 41.3% identity in 506 aa overlap. Contains Pfam matches to entries PF00672 DUF5, Domain found in bacterial signal proteins and PF00512 signal, Histidine kinase domain, as well as a possible N-terminal hydrophobic membrane spanning region. (504 aa)
SCO7637SC10F4.10c, secreted endoglucanase, len: 486 aa; highly similar to SW:GUNA_STRLI (EMBL:M82807) Streptomyces lividans endoglucanase CelA precursor (EC 3.2.1.4) CelA, 459 aa; fasta scores: opt: 2977 z-score: 3136.1 E(): 0; 97.4% identity in 461 aa overlap. Contains Pfam matches to entries PF00553 CBD_2, Cellulose binding domain and PF00150 cellulase, Cellulase (glycosyl hydrolase family 5) and matches to Prosite entries PS00561 Cellulose-binding domain, bacterial type and PS00659 Glycosyl hydrolases family 5 signature. Also contains possible N-terminal region signal peptide sequence. (486 aa)
SCP1.52cSCP1.52c, possible lysase, len: 287aa; similar to many eg. SW:P17725 (CILB_KLEPN) citrate lyase beta chain (EC 4.1.3.6) (289 aa) fasta scores; opt: 392, z-score: 446.6, E(): 2.1e-17, 31.5% identity in 286 aa overlap; Belongs to the HpcH/HpaI aldolase family. (287 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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