STRINGSTRING
SCO7564 SCO7564 SCO0269 SCO0269 SCO0270 SCO0270 SCO0554 SCO0554 SCO0707 SCO0707 SCO0708 SCO0708 SCO0709 SCO0709 SCO0710 SCO0710 SCO1330 SCO1330 SCO1344 SCO1344 SCO1517 SCO1517 SCO1655 SCO1655 SCO1880 SCO1880 SCO1944 SCO1944 SCO2008 SCO2008 SCO2009 SCO2009 SCO2010 SCO2010 SCO2011 SCO2011 SCO2012 SCO2012 SCO2043 SCO2043 SCO2115 SCO2115 SCO2117 SCO2117 SCO2131 SCO2131 SCO2561 SCO2561 SCO2687 SCO2687 SCO2688 SCO2688 SCO2695 SCO2695 SCO2720 SCO2720 SCO2821 SCO2821 SCO2851 SCO2851 SCO3005 SCO3005 SCO3210 SCO3210 SCO3213 SCO3213 SCO3214 SCO3214 SCO3416 SCO3416 SCO3454 SCO3454 SCO3455 SCO3455 SCO3456 SCO3456 SCO3571 SCO3571 SCO3883 SCO3883 SCO4503 SCO4503 SCO4646 SCO4646 SCO4722 SCO4722 SCO5110 SCO5110 SCO5112 SCO5112 SCO5113 SCO5113 SCO5114 SCO5114 SCO5115 SCO5115 SCO5116 SCO5116 SCO5117 SCO5117 SCO5118 SCO5118 SCO5119 SCO5119 SCO5120 SCO5120 SCO5121 SCO5121 SCO5476 SCO5476 SCO5477 SCO5477 SCO5478 SCO5478 SCO5479 SCO5479 SCO5480 SCO5480 SCO5580 SCO5580 SCO5586 SCO5586 SCO5713 SCO5713 SCO5714 SCO5714 SCO5715 SCO5715 SCO5716 SCO5716 SCO5872 SCO5872 SCO6111 SCO6111 SCO6112 SCO6112 SCO6113 SCO6113 SCO6114 SCO6114 SCO6160 SCO6160 SCO6234 SCO6234 SCO6451 SCO6451 SCO6452 SCO6452 SCO6453 SCO6453 SCO6454 SCO6454 SCO6455 SCO6455 SCO6552 SCO6552 SCO6644 SCO6644 SCO6645 SCO6645 SCO6655 SCO6655 SCO6691 SCO6691 SCO6790 SCO6790 SCO6929 SCO6929 SCO6930 SCO6930 SCO6968 SCO6968 SCO7181 SCO7181 SCO7182 SCO7182 SCO7183 SCO7183 SCO7184 SCO7184 SCO7185 SCO7185 SCO7563 SCO7563 SCO7565 SCO7565 SCO7566 SCO7566 SCO7567 SCO7567 SCO7677 SCO7677 SCO7678 SCO7678 SCO7679 SCO7679 SCO7680 SCO7680
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO7564SC5F1.18, possible oligopeptide ABC transporter integral membrane protein, len: 330 aa; similar to TR:Q9KFX2 (EMBL:AP001508) Bacillus halodurans oligopeptide ABC transporter (permease) AppB, 305 aa; fasta scores: opt: 883 z-score: 1023.7 E(): 0; 44.8% identity in 299 aa overlap and to SW:OPPB_ECOLI (EMBL:AE000223) Escherichia coli oligopeptide transport system permease protein OppB, 306 aa; fasta scores: opt: 680 z-score: 790.0 E(): 0; 36.0% identity in 308 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component [...] (330 aa)
SCO0269Hypothetical protein; SCF1.11, unknown, len: 1053aa; similar to large proteins thought to be involved in the post-translational modification of lantibiotics eg. SW:SPAB_BACSU subtilin modification protein from Bacillus subtilis (1030 aa) fasta scores; opt: 346, z-score: 367.5, E(): 4.2e-13, (22.6% identity in 1041 aa overlap). (1053 aa)
SCO0270Conserved hypothetical protein; SCF1.12, unknown, len: 466 aa; similar to proteins predicted to be involved in lantibiotic biosynthesis eg. SW:SPAC_BACSU subtilin biosynthesis protein from Bacillus subtilis (441 aa) fasta scores; opt: 502, z-score: 549.2, E(): 3.2e-23, (28.9% identity in 405 aa overlap). (466 aa)
SCO0554SCF73.01c, manA, probable secreted beta-mannosidase, len: 327 aa; similar to many e.g. MANA_STRLI P51529 mannan endo-1,4-beta-mannosidase precursor (EC 3.2.1.78) (363 aa), fasta scores; opt: 1189 z-score: 1332.7 E(): 0, 61.1% identity in 288 aa overlap. Contains N-terminal signal sequence, and Pfam match to entry PF00150 cellulase, Cellulase (glycosyl hydrolase family 5). Also similar to SC2H4.16 (62.2% identity in 288 aa overlap); SCF11.34c, possible sugar hydrolase, partial CDS, len: >278 aa; C-teminus similar to SW:GUN4_THEFU (EMBL:L20093) Thermomonospora fusca endoglucanase E-4 pre [...] (565 aa)
SCO0707SCF42.17c, possible branched-chain amino acid ABC transport permease, len: 398 aa. Similar to many amino acid transporters including: Pseudomonas aeruginosa SW:BRAE_PSEAE (EMBL:D90223) high-affinity branched-chain amino acid transport protein BraE (417 aa), fasta scores opt: 327 z-score: 334.2 E(): 3.2e-11 28.3% identity in 336 aa overlap and Streptomyces coelicolor TR:CAB52066 (EMBL:AL109732) putative branched chain amino acid transport permease SC7H2.24 (608 aa), fasta scores opt: 403 z-score: 407.6 E(): 2.6e-15 31.0% identity in 342 aa overlap. Contains a possible N-terminal signal [...] (398 aa)
SCO0708SCF42.18c, possible branched-chain amino acid ABC transport protein, len: 299 aa. Similar to many other transport proteins including: Pseudomonas aeruginosa SW:BRAD_PSEAE(EMBL:D90223) high-affinity branched-chain amino acid transport protein, BraD (307 aa), fasta scores opt: 318 z-score: 364.2 E(): 6.8e-13 28.5% identity in 312 aa overlap and Deinococcus radiodurans TR:AAF09863(EMBL:AE001889) branched-chain amino acid ABC transporter, permease protein (285 aa), fasta scores opt: 432 z-score: 492.1 E(): 5.1e-20 34.6% identity in 295 aa overlap. Contains multiple possible membrane spanni [...] (299 aa)
SCO0709SCF42.19c, possible branched-chain amino acid transport ATP-binding protein, len: 266 aa. Similar to many including: Pseudomonas aeruginosa SW:BRAF_PSEAE(EMBL:D90223) high-affinity branched-chain amino acid transport ATP-binding protein, BraF (255 aa), fasta scores opt: 689 z-score: 786.7 E():0 41.3% identity in 252 aa overlap and Deinococcus radiodurans TR:AAF11669(EMBL:AE002047) branched-chain amino acid ABC transporter, ATP-binding protein (259 aa), fasta scores opt: 749 z-score: 854.2 E():0 46.9% identity in 256 aa overlap. Also similar to Streptomyces coelicolor TR:CAB52067(EMBL:A [...] (266 aa)
SCO0710SCF42.20c, possible branched-chain amino acid transport ATP-binding protein, len: 263 aa. Similar to many including: Pseudomonas aeruginosa SW:BRAG_PSEAE(EMBL:D90223) high-affinity branched-chain amino acid transport ATP-binding protein, BraG (233 aa), fasta scores opt: 642 z-score: 685.0 E(): 9.1e-31 46.7% identity in 240 aa overlap and Streptomyces coelicolor TR:CAB52068(EMBL:AL109732) putative branched chain amino acid transport ATP-binding protein, SC7H2.26 (238 aa), fasta scores opt: 724 z-score: 770.7 E():0 48.5% identity in 241 aa overlap. Also similar to the adjoining CDS on th [...] (263 aa)
SCO13302SCG61.12c, possible fatty acid CoA ligase, len: 360aa; region similar to many possible fatty acid coA ligases eg. TR:Q9ZIP5 (EMBL:AF117694) malonyl CoA synthetase from Rhizobium trifolii (504 aa) fasta scores; opt: 198, z-score: 230.9, E(): 2.2e-05, 28.6% identity in 203 aa overlap. (360 aa)
SCO13442SCG61.26c, possible solute binding transport lipoprotein, len: 530aa; similar to many eg. TR:Q9RJ53 (EMBL:AL132648) putative lipoprotein oligopeptide binding protein (534 aa) fasta scores; opt: 1438, z-score: 1620.4, E(): 0, 43.4% identity in 539 aa overlap and SW:P76128 (YDDS_ECOLI) putative binding protein YddS precursor (516 aa) fasta scores; opt: 532, z-score: 600.2, E(): 5.9e-26, 25.7% identity in 517 aa overlap. Contains two Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5 and Prosite match to PS00013 Prokaryotic membrane lipoprote [...] (530 aa)
SCO1517SCL2.07c, possible secreted protein, len: 169 aa; similar to SW:YP88_MYCLE (EMBL:AL023591) Mycobacterium leprae hypothetical protein MCLB1259.04, 114 aa; fasta scores: opt: 205 z-score: 231.1 E(): 1.8e-05; 36.7% identity in 120 aa overlap. Contains possible N-terminal region signal peptide sequence. (169 aa)
SCO1655SCI41.38c, probable lipoprotein oligopeptide binding protein, len: 534 aa. Similar to TR:O54107 (EMBL:AL021529) Streptomyces coelicolor SC10A5.16C periplasmic oligopeptide binding protein, 521 aa; fasta scores: opt: 1101 z-score: 1218.9 E(): 0; 36.0% identity in 528 aa overlap. Contains two Pfam matches to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (534 aa)
SCO1880SCI39.27c, probable secreted pectate lyase, len: 444 aa; similar to SW:PEL_BACS (EMBL:X74880) Bacillus subtilis pectate lyase precursor (EC 4.2.2.2) Pel, 420 aa; fasta scores: opt: 1127 Z-score: 1249.8 bits: 240.3 E(): 5e-62; 42.431% identity in 436 aa overlap. Contains 2x Pfam matches to entry PF00544 pec_lyase, Pectate lyase. Contains also possible N-terminal region signal peptide sequence. (444 aa)
SCO1944Protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. (102 aa)
SCO2008SC7H2.22, possible branched chain amino acid binding protein, len: 481aa; similar to many eg. SW:LIVK_ECOLI leucine-specific binding protein from Escherichia coli (369 aa) fasta scores; opt: 360, z-score: 374.0, E(): 1.6e-13, (28.4% identity in 352 aa overlap). Contains possible N-terminal signal sequence. (418 aa)
SCO2009SC7H2.23, probable branched chain amino acid transport permease, len: 310aa; similar to many eg. SW:LIVH_SALTY high affinity branched chain amino acid transport permease from Salmonella typhimurium (308 aa) fasta scores; opt: 711, z-score: 782.4, E(): 0, (43.5% identity in 306 aa overlap). Contains possible membrane spanning hydrophobic regions; Belongs to the binding-protein-dependent transport system permease family. (310 aa)
SCO2010SC7H2.24, probable branched chain amino acid transport permease, len: 310aa; region from 200-608aa similar to many eg. SW:LIVM_SALTY high affinity branched chain amino acid transport permease from Salmonella typhimurium (425 aa) fasta scores; opt: 633, z-score: 702.7, E(): 8.1e-32, (36.8% identity in 400 aa overlap); Belongs to the binding-protein-dependent transport system permease family. (608 aa)
SCO2011SC7H2.25, probable branched chain amino acid transport ATP-binding protein, len: 309aa; similar to many eg. SW:LIVG_ECOLI branched chain amino acid transport ATP-binding protein from Escherichia coli (255 aa) fasta scores; opt: 770, z-score: 837.9, E(): 0, (46.8% identity in 250 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and Prosite match to PS00017 ATP/GTP-binding site motif A (P-loop). (309 aa)
SCO2012SC7H2.26, probable branched chain amino acid transport ATP-binding protein, len: 238aa; similar to many eg. SW:LIVF_ECOLI branched chain amino acid transport ATP-binding protein from Escherichia coli (237 aa) fasta scores; opt: 774, z-score: 860.8, E(): 0, (52.4% identity in 233 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and Prosite matches to PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. (238 aa)
SCO2043Putative anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (502 aa)
SCO2115SC6E10.09c, aroH, probable 2-dehydro-3-deoxyphosphoheptonate aldolase, len: 450 aa; highly similar to many, especially those from plants e.g. SW:AROF_ARATH (EMBL:M74819), Dhs1, Arabidopsis thaliana phospho-2-dehydro-3-deoxyheptonate aldolase 1 precursor (525 aa), fasta scores; opt: 1633 z-score: 1839.4 E(): 0, 53.8% identity in 437 aa overlap. The N-terminus is similar (but not identical) to the SW:AROF_STRCO, AroH, Streptomyces coelicolor 2-dehydro-3-deoxyphosphoheptonate aldolase N-terminal sequence determined from purified protein (TVNAKTSPSA GNTDDPLQAP S). Similar to TR:O52308 (EMB [...] (450 aa)
SCO2117SC6E10.11, trpE1, probable anthranilate synthase, len: 634 aa; highly similar to many anthranilate synthases e.g. TR:O30589 (EMBL:AF012627), TrpE, Streptomyces venezuelae anthranilate synthase (623 aa), fasta scores; opt: 3108 z-score: 3257.7 E(): 0, 80.0% identity in 620 aa overlap. Anthranilate synthases may have one or two components. This protein is similar at the C-terminus to TR:Q9Z4W8 (EMBL:AL035654), TrpG, S.coelicolor probable anthranilate synthase component II (200 aa) (32.7% identity in 202 aa overlap) and centrally to TR:Q9Z4W7 (EMBL:AL035654), trpE2, S.coelicolor probable [...] (634 aa)
SCO2131SC6G10.04, probable long chain fatty acid CoA ligase, len: 598 aa; similar to many e.g. TR:E1359128 (EMBL:AL034443) putative long chain fatty acid CoA ligase from Streptomyces coelicolor (608 aa) fasta scores; opt: 1347, z-score: 1506.7, E(): 0, (51.3% identity in 608 aa overlap) and SW:LCFB_RAT long chain fatty acid CoA ligase from Rattus norvegicus (Rat) (699 aa) fasta scores; opt: 568, z-score: 634.7, E(): 4.7e-28, (30.2% identity in 589 aa overlap). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme and Prosite match to PS00455 Putative AMP-binding domain signature. (598 aa)
SCO2561SCC77.28c, possible long-chain fatty-acid CoA ligase, len: 647 aa. Similar to many from eukaryotes and prokaryotes including: Homo sapiens (Human) SW:LCFB_HUMAN(EMBL:D10040) long-chain-fatty-acid-CoA ligase 2 (EC 6.2.1.3) (698 aa), fasta scores opt: 698 z-score: 755.0 E(): 0 29.6% identity in 612 aa overlap and Streptomyces coelicolor TR:Q9X7Z0(EMBL:AL049497) putative long chain fatty acid CoA ligase SC6G10.04 (598 aa), fasta scores opt: 1056 z-score: 1142.9 E():0 40.5% identity in 583 aa overlap. Contains a Pfam match to entry PF00501 AMP-binding and a Prosite hit to PS00455 Putative [...] (647 aa)
SCO2687GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (214 aa)
SCO2688Riboflavin-specific deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (381 aa)
SCO2695Hypothetical protein; SCC61A.16, unknown, len: 256 aa; region similar to others eg. TR:O69671 (EMBL:AL022121) hypothetical protein from Mycobacterium tuberculosis (425 aa) fasta scores; opt: 266, z-score: 305.4, E(): 1.5e-09, 32.3% identity in 248 aa overlap. (256 aa)
SCO2720SCC46.05c, possible long-chain fatty acid ligase, len: 642 aa; similar to TR:Q9ZBW6 (EMBL:AL034443) Streptomyces coelicolor putative long-chain-fatty-acid-CoA ligase SC4B5.02c, 608 aa; fasta scores: opt: 2039 z-score: 2214.0 E(): 0; 51.4% identity in 607 aa overlap and to SW:LCFB_HUMAN (EMBL:D10040) Homo sapiens long-chain-fatty-acid-CoA ligase 2 (EC 6.2.1.3) FacL2, 698 aa; fasta scores: opt: 471 z-score: 511.5 E(): 4.5e-21; 27.8% identity in 615 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme and match to Prosite entry PS00455 Putative AMP-binding doma [...] (642 aa)
SCO2821SCBAC17F8.12c, possible secreted pectate lyase, len: 521 aa: similar to many e.g. TR:Q9KGY6 (EMBL:AF278705) pectate lyase B from Alteromonas haloplanktis (658 aa) fasta scores; opt: 1744, Z-score: 1590.1, 63.301% identity (65.859% ungapped) in 515 aa overlap and SW:P04959 (PELB_ERWCH) pectate lyase B from Erwinia chrysanthemi (375 aa) fasta scores; opt: 413, Z-score: 386.2, 29.167% identity (32.464% ungapped) in 384 aa overlap. Contains Pfam match to entry PF00544 pec_lyase, Pectate lyase and a probable N-terminal signal sequence. (521 aa)
SCO2851Putative membrane protein; SCE20.25c, possible membrane protein, len: 237 aa. Similar in parts to many bacterial inner membrane proteins e.g. Streptomyces coelicolor TR:O54569(EMBL:Y16311) inner membrane protein, STH24.05 (431 aa), fasta scores opt: 240 z-score: 285.1 E(): 1.7e-08 25.0% identity in 232 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. (237 aa)
SCO3005Preprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (947 aa)
SCO3210SCE8.03c, aro, probable 2-dehydro-3-deoxyheptonate aldolase, len: 484 aa; similar to many e.g. TR:O52308 (EMBL:AF035756) 2-dehydro-3-deoxyheptonate aldolase from Streptomyces sp. fasta scores; opt: 1619, z-score: 1722.0, E(): 0, (54.5% identity in 440 aa overlap) and SW:AROF_ARATH phospho-2-dehydro-3-deoxyheptonate aldolase 1 from Arabidopsis thaliana (525 aa) fasta scores; opt: 1457, z-score: 1549.2, E(): 0, (48.4% identity in 457 aa overlap); Belongs to the class-II DAHP synthase family. (484 aa)
SCO3213SCE8.06c, trpG, anthranilate synthase component II, len: 200aa; similar to many eg. TR:G4185545 (EMBL:AF108766) TrpG, anthranilate synthase component II, from Rhodobacter sphaeroides (195 aa) fasta scores; opt: 728, z-score: 825.0, E(): 0, (60.2% identity in 186 aa overlap). Contains matches to Pfam entry PF00117 GATase, Glutamine amidotransferases class-I, score 332.60, E-value 4.3e-96 and Prosite PS00442 Glutamine amidotransferases class-I active site. (200 aa)
SCO3214Probable anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (511 aa)
SCO3416SCE9.23, gad, probable glutamate decarboxylase, len: 475 aa; similar to many e.g. SW:DCEA_ECOLI (EMBL:M84024), gadA, Escherichia coli glutamate decarboxylase alpha (466 aa), fasta scores; opt: 1433 z-score: 1665.2 E(): 0, 50.0% identity in 426 aa overlap. Contains Pfam match to entry PF00282 pyridoxal_deC, Pyridoxal-dependent decarboxylase conserved domain, score 276.70, E-value 1.1e-79; Belongs to the group II decarboxylase family. (475 aa)
SCO3454SCE46.11c, possible ABC-transporter membrane protein, len: 280 aa; similar to TR:Q44381 (EMBL:U60011) Agrobacterium tumefaciens inner membrane protein MotD, 273 aa; fasta scores: opt: 360 z-score: 418.0 E(): 6.1e-16; 29.3% identity in 256 aa overlap and to SW:POTC_ECOLI (EMBL:M64519) Escherichia coli spermidine/putrescine transport system permease protein PotC, 264 aa; fasta scores: opt: 309 z-score: 360.4 E(): 1e-12; 25.8% identity in 260 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and Prosite match [...] (280 aa)
SCO3455SCE46.12c, possible ABC-transporter transport protein, len: 285 aa; similar to TR:O57756 (EMBL:AP000001) Pyrococcus horikoshii 284 aa long hypothetical sugar transport membrane protein, 284 aa; fasta scores: opt: 281 z-score: 329.5 E(): 5.2e-11; 26.6% identity in 278 aa overlap and to SW:UGPA_ECOLI (EMBL:X13141) Escherichia coli SN-glycerol-3-phosphate transport system permease protein UgpA, 295 aa; fasta scores: opt: 233 z-score: 274.6 E(): 6e-08; 28.7% identity in 279 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membra [...] (285 aa)
SCO3456SCE46.13c, possible secreted protein, len: 135 aa; similar to TR:CAC41457 (EMBL:AL591782) Rhizobium meliloti conserved hypothetical protein SMC02589, 408 aa; fasta scores: opt: 927 Z-score: 1029.9 E(): 9.8e-50; 37.198% identity in 414 aa overlap. Contains possible N-terminal region signal peptide sequence. (417 aa)
SCO3571SCH17.05, probable transcriptional regulator, len: 224 aa; similar to many, especially cAMP-binding receptors, e.g. TR:O34015 (EMBL:U87623), Crp, Vibrio cholerae cyclic AMP receptor protein (210 aa), fasta scores; opt: 314 z-score: 381.1 E(): 6.7e-14, 30.6% identity in 180 aa overlap. Highly similar to TR:O69644 (EMBL:AL022121) Mycobacterium tuberculosis putative transcriptional regulator (224 aa) (54.5% identity in 224 aa overlap). Contains probable helix-turn-helix motif at aa 176-197 (Score 1923, +5.74 SD). Contains Pfam matches to entry PF00027 cNMP_binding, Cyclic nucleotide-bindi [...] (224 aa)
SCO3883Putative membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity). (431 aa)
SCO4503SCD35.10, probable long-chain-fatty acid CoA ligase, len: 642 aa; similar to TR:Q9ZBW6 (EMBL:AL034443) Streptomyces coelicolor putative long-chain-fatty acid CoA ligase SC4B5.02c, 608 aa; fasta scores: opt: 2125 z-score: 2339.4 E(): 0; 53.0% identity in 610 aa overlap and to SW:LCFE_RAT (EMBL:AB012933) Rattus norvegicus long-chain-fatty acid CoA ligase 5 (EC 6.2.1.3) FacL5, 683 aa; fasta scores: opt: 488 z-score: 536.4 E(): 1.9e-22; 27.3% identity in 607 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme and match to Prosite entry PS00455 Putative AMP-bind [...] (642 aa)
SCO4646Preprotein translocase SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (94 aa)
SCO4722Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (437 aa)
SCO5110SCBAC31E11.06, possible lipoprotein, len: 771 aa; similar to SW:YC80_MYCTU (EMBL:Z77137) Mycobacterium tuberculosis hypothetical 63.5 kDa protein MTCY50.02, 591 aa; fasta scores: opt: 565 Z-score: 501.6 bits: 103.2 E(): 2.5e-20; 26.190% identity in 756 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. (771 aa)
SCO5112SCBAC31E11.08, bldKA, possible ABC transport system integral membrane protein, len: 343 aa; identical to previously sequenced TR:P72406 (EMBL:U68036) Streptomyces coelicolor BldKA, 335 aa. Methionine start codon 9 amino acids upstream from the previous sequence start; possible frameshift from frame 2 into frame 1 in the previously sequenced DNA. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possibl [...] (343 aa)
SCO5113SCBAC31E11.09, bldKB, possible ABC transport system lipoprotein, len: 600 aa; almost identical to TR:P72407 (EMBL:U68036) Streptomyces coelicolor BldKB, 602 aa. Contains 4x Pfam matches to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence. (600 aa)
SCO5114SCBAC31E11.10, bldKC, possible ABC transport system integral membrane protein, len: 325 aa; almost identical to previously sequenced TR:P72408 (EMBL:U68036) Streptomyces coelicolor BldKC, 323 aa. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Also contains possible hydrophobic membrane spanning regions. (325 aa)
SCO5115SCBAC31E11.11, bldKD, putative ABC transporter intracellular ATPase subunit, len: 353 aa; almost identical to previously sequenced TR:P72409 (EMBL:U680360) Streptomyces coelicolor BldKD putative ABC transporter intracellular ATPase subunit, 353 aa and similar to TR:O86574 (EMBL:AL031184) Streptomyces coelicolor SC2A11.13, 366 aa; fasta scores: opt: 1427 Z-score: 1344.1 bits: 257.3 E(): 3.8e-69; 60.340% identity in 353 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transp [...] (353 aa)
SCO5116SC9E12.01, probable peptide transport system ATP-binding protein (fragment), len: >142 aa; similar to SW:OPPF_ECOLI (EMBL:AE000223) Escherichia coli oligopeptide transport protein ATP-binding protein OppF, 334 aa; fasta scores: opt: 344 z-score: 423.0 E(): 4.3e-16; 56.5% identity in 92 aa overlap and to TR:O86575 (EMBL:AL031184) Streptomyces coelicolor oligopeptide ABC transporter ATP-binding protein SC2A11.14, 496 aa; fasta scores: opt: 488 z-score: 576.6 E(): 1.7e-26; 56.6% identity in 136 aa overlap; SCBAC31E11.12, bldKE, putative ABC transporter intracellular ATPase subunit (fragme [...] (381 aa)
SCO5117SC9E12.02, possible peptide transport system secreted peptide-binding protein, len: 544 aa; similar to SW:OPPA_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide-binding protein OppA precursor, 545 aa; fasta scores: opt: 648 z-score: 642.6 E(): 2.5e-28; 26.1% identity in 552 aa overlap and to TR:P72407 (EMBL:U68036) Streptomyces coelicolor SpoOKA homologue BldKB, 602 aa; blastp scores: Score = 165 (58.1 bits), Expect = 2.9e-10, Sum P(2) = 2.9e-10; Identities = 116/502 (23%), Positives = 202/502 (40%). Contains 2x Pfam matches to entry PF00496 SBP_bac_5, Bacterial extracellular solute-b [...] (544 aa)
SCO5118SC9E12.03, probable peptide transport system integral membrane protein, len: 307 aa; similar to TR: SW:OPPB_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport system permease protein OppB, 311 aa; fasta scores: opt: 688 z-score: 788.7 E(): 0; 36.0% identity in 308 aa overlap and to TR:P72408 (EMBL:U68036) Streptomyces coelicolor SpoOKC homologue BldKC, 323 aa; blastp scores: Score = 354 (124.6 bits), Expect = 1.9e-32, P = 1.9e-32; Identities = 82/235 (34%), Positives = 138/235 (58%). Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems [...] (307 aa)
SCO5119SC9E12.04, probable peptide transport system integral membrane protein, len: 305 aa; similar to SW:OPPC_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport system permease protein OppC, 305 aa; fasta scores: opt: 670 z-score: 745.0 E(): 0; 35.5% identity in 296 aa overlap and to TR:P72406 (EMBL:U68036) Streptomyces coelicolor SpoOKB homologue BldKA, 335 aa; blastp scores: Score = 382 (134.5 bits), Expect = 9.1e-41, Sum P(2) = 9.1e-41; Identities = 88/231 (38%), Positives = 134/231 (58%). Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport syste [...] (305 aa)
SCO5120SC9E12.05, probable peptide transport system ATP-binding protein, len: 327 aa; similar to SW:OPPD_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport system ATP-binding protein OppD, 358 aa; fasta scores: opt: 1126 z-score: 1167.7 E(): 0; 53.9% identity in 310 aa overlap, to TR:P72409 (EMBL:U68036) Streptomyces coelicolor putative ABC transporter intracellular ATPase subunit BldKD, 353 aa; fasta scores: opt: 1035 z-score: 1074.2 E(): 0; 51.5% identity in 326 aa overlap and to TR:O86574 (EMBL:AL031184) Streptomyces coelicolor oligopeptide ABC transporter ATP-binding protein SC2 [...] (327 aa)
SCO5121SC9E12.06, probable peptide transport system ATP-binding protein, len: 356 aa; similar to SW:APPF_BACSU (EMBL:U20909) Bacillus subtilis oligopeptide transport ATP-binding protein AppF, 329 aa; fasta scores: opt: 1255 z-score: 1332.6 E(): 0; 57.3% identity in 335 aa overlap, to TR:P72410 (EMBL:U68036) Streptomyces coelicolor putative ABC transporter intracellular ATPase subunit BldKE (fragment), 284 aa; fasta scores: opt: 999 z-score: 1063.6 E(): 0; 58.1% identity in 260 aa overlap and to TR:O86575 (EMBL:AL031184) Streptomyces coelicolor oligopeptide ABC transporter ATP-binding protein [...] (356 aa)
SCO5476SC2A11.10, probable oligopeptide transport integral membrane protein, len: 335 aa; similar to mnay e.g. APPC_BACSU oligopeptide transport permease protein appC (303 aa), fasta scores; opt: 465 z-score: 1038.5 E(): 0, 41.4% identity in 309 aa overlap. Also similar to S. coelicolor TR:P72406 (EMBL:U68036) bldKA (335 aa), fasta scores; opt: 912 z-score: 1192.3 E(): 0, 42.1% identity in 330 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature and Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membr [...] (335 aa)
SCO5477SC2A11.11, probable oligopeptide-binding lipoprotein, len: 600 aa; similar to e.g. OPPA_BACSU oligopeptide-binding protein oppA precursor (545 aa), fasta scores; opt: 401 z-score: 242.5 E(): 3e-06, 25.5% identity in 554 aa overlap Also similar to S. coelicolor TR:P72407 (EMBL:U68036) bldKB (602 aa), fasta scores; opt: 702 z-score: 583.5 E(): 3e-25, 29.3% identity in 614 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site, and Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-bind [...] (600 aa)
SCO5478SC2A11.12, probable oligopeptide transport system integral membrane protein, len: 332 aa; similar to many e.g. OPPB_ECOLI oligopeptide transport system permease protein (306 aa), fasta scores; opt: 568 z-score: 807.4 E(): 0, 35.0% identity in 337 aa overlap Also similar to S. coelicolor TR:P72408 (EMBL:U68036) bldKC (323 aa), fasta scores; opt: 875 z-score: 1186.1 E(): 0 42.4% identity in 337 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature and Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner [...] (332 aa)
SCO5479SC2A11.13, probable oligopeptide ABC transporter ATP-binding protein, len: 365 aa; similar to many e.g. OPPD_BACSU oligopeptide transport ATP-binding protein (336 aa), fasta scores; opt: 1089 z-score: 1413.1 E(): 0, 52.3% identity in 323 aa overlap Also similar to S. coelicolor TR:P72409 (EMBL:U68036) bldKD (353 aa), fasta scores; opt: 1396 z-score: 1731.9 E(): 0, 58.4% identity in 365 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran, ABC transporters, score 203.50, E-value 3.3e-57. (365 aa)
SCO5480SC2A11.14, probable oligopeptide ABC transporter ATP-binding protein, len: 496 aa; similar to many e.g. APPF_BACSU oligopeptide transport ATP-binding protein (329 aa), fasta scores; opt: 1284 z-score: 1056.3 E(): 0, 56.4% identity in 326 aa overlap Also similar to S. coelicolor TR:P72410 (EMBL:U68036) bldKE (284 aa), fasta scores; opt: 1114 z-score: 1091.6 E(): 0, 59.3% identity in 280 aa overlap. Contains PS00017 ATP /GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature and Pfam match to entry PF00005 ABC_tran, ABC transporters, score 202.90, E-value 4.8e-57. C [...] (496 aa)
SCO5580Putative prokaryotic docking protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (412 aa)
SCO5586Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (550 aa)
SCO5713SC9F2.03, possible peptide transport ATP-binding protein, len: 393aa; similar to many (confirmed and proposed) eg. SW:OPPD_ECOLI oligopeptide transport ATP-binding protein from Escherichia coli (337 aa) fasta scores; opt: 870, z-score: 693.2, E(): 2.7e-31, (44.1% identity in 311 aa overlap).Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. Also similar to the gene immediately downstream (SC9F2.04) suggesting a local duplication event fasta scores; opt: 722, z-score: 477.4, E(): 9.4e-22, (42.8% identity in 327 aa overlap). Also contain [...] (398 aa)
SCO5714SC9F2.02, possible peptide transport permease, len: 317aa; similar to many (confirmed and proposed) eg. SW:APPC_BACSU oligopeptide transport permease, AppC, from Bacillus subtilis (303 aa) fasta scores; opt: 638, z-score: 718.2, E(): 1.1e-32, (36.5% identity in 277 aa overlap). Contains probable membrane spanning hydrophobic regions. Also contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 42.30, E-value 1.1e-08. (317 aa)
SCO5715SC3C3.01c, probable peptide transport system integral membrane protein, partial CDS, len: >229 aa; similar to many e.g. DPPB_ECOLI dipeptide transport system permease protein (339 aa), fasta scores; opt: 359 z-score: 654.6 E(): 3.3e-29, 35.3% identity in 238 aa overlap. Also similar to S. coelicolor SC2A11.12 (E(): 5.6e-12, 30.7% identity in 244 aa overlap); SC9F2.01, partial CDS, possible peptide transport system permease, len:>140aa; constitutes the C-terminal half of a CDS whose N-terminal region (TR:O86635) lies on Streptomyces coelicolor cosmid SC3C3 (EMBL:AL031231). Similar to ma [...] (318 aa)
SCO5716SC3C3.02c, probable peptide transport system secreted peptide binding protein, len: 621 aa; similar to e.g. DPPA_ECOLI periplasmic dipeptide transport protein precursor (535 aa), fasta scores; opt: 195 z-score: 391.5 E(): 1.5e-14, 26.4% identity in 550 aa overlap. Contains N-terminals signal sequence, possible membrane anchor at C-terminus and Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 48.60, E-value 1.1e-11. (621 aa)
SCO5872Putative turgor pressure regulator; SC2E9.13, kdpE, two-component trascriptional regulator, len: 227, similar to E.coli turgor pressure regulator KDPE_ECOLI P21866 kdp operon transcriptional regulatory protein (225 aa), fasta scores; opt: 752 z-score: 1090.9 E(): 0, 51.1% identity in 225 aa overlap. Contains Pfam match to entry trans_reg_C PF00486, Transcriptional regulatory proteins, C terminal, score 96.22. (227 aa)
SCO6111SCBAC1A6.35c, probable oligopeptide ABC transporter ATP-binding protein, len: 585 aa; similar to SW:YLIA_ECOLI (EMBL:AE000185) Escherichia coli hypothetical ABC transporter ATP-binding protein YliA, 629 aa; fasta scores: opt: 1480 z-score: 1352.7 E(): 0; 44.5% identity in 580 aa overlap and N- and C-terminal regions both similar to SW:OPPD_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport ATP-binding protein OppD, 358 aa; fasta scores: opt: 864 z-score: 796.4 E(): 0; 49.6% identity in 274 aa overlap. Contains 2x Pfam matches to entry PF00005 ABC_tran, ABC transporter and mat [...] (585 aa)
SCO6112SCBAC1A6.36c, probable oligopeptide ABC transporter integral membrane protein, len: 297 aa; similar to SW:APPC_BACSU (EMBL:U20909) Bacillus subtilis oligopeptide transport system permease protein AppC, 303 aa; fasta scores: opt: 725 z-score: 842.9 E(): 0; 39.4% identity in 287 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Also contains possible hydrophobic membrane spanning regions. (297 aa)
SCO6113SCBAC33E8.01c, possible peptide ABC transporter integral membrane protein (fragment), len: >47 aa. Similar to the N-terminal part of TR:Q9KGM9 (EMBL:AP001507) Bacillus halodurans oligopeptide ABC transporter (permease) BH0029, 314 aa; fasta scores: opt: 136 Z-score: 200.4 bits: 42.5 E(): 0.0014; 47.826% identity in 46 aa overlap; SCBAC1A6.37c, probable oligopeptide ABC transporter integral membrane protein (fragment), len: >312 aa; similar to SW:APPB_BACSU (EMBL:U20909) Bacillus subtilis oligopeptide transport system permease protein AppB, 317 aa; fasta scores: opt: 763 z-score: 895.6 [...] (319 aa)
SCO6114SC9B2.01c, partial CDS, possible secreted peptide binding /transport protein, len: 223aa; similar to many eg. SW:OPPA_BACSU oligopeptide-binding protein OppA from Bacillus subtilis (545 aa) fasta scores; opt: 117, z-score: 142.4, E(): 1.2, (25.9% identity in 139 aa overlap). Contains probable N-terminal signal sequence; SCBAC33E8.02c, possible peptide-binding transport protein (fragment), len: >411 aa. Similar to C-terminal region of TR:Q9K6T2 (EMBL:AP001519) Bacillus halodurans dipeptide ABC transporter (dipeptide-binding protein) BH3644, 557 aa; fasta scores: opt: 199 Z-score: 227.0 [...] (602 aa)
SCO6160Putative SecDF protein-export membrane protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. (795 aa)
SCO6234SC2H4.16, manA, probable secreted beta-mannosidase, len: 384 aa; 94.5% identical to MANA_STRLI mannan endo-1,4-beta-mannosidase precursor (363 aa). Contains PS00659 Glycosyl hydrolases family 5 signature and Pfam match to entry PF00150 cellulase, Cellulase (glycosyl hydrolase family 5), score 104.70, E-value 1.8e-27. (384 aa)
SCO6451SC9B5.18, probable substrate binding protein, len: 467aa; First of a five gene operon probably involved in peptide uptake. Very similar to SW:XP55_STRLI protein precursor of XP55, a major secreted protein from Streptomyces lividans (542 aa) fasta scores: opt: 3353, z-score: 2613.8, E(): 0, (95.9% identity in 532 aa overlap). Also similar to many substrate binding. (542 aa)
SCO6452SC9B5.19, probable transport permease protein, len: 334aa; second of a five gene operon probably involved in peptide uptake, similar to many transport permeases eg. SW:DPPB_ECOLI DppB, dipeptide transport system permease protein from Escherichia coli (339 aa) fasta scores: opt: 362, z-score: 742.8, E(): 0, (32.9% identity in 340 aa overlap). (334 aa)
SCO6453SC9B5.20, probable transport permease protein, len: 312aa; third of a five gene operon probably involved in peptide uptake, similar to many transport permeases eg. SW:APPC_BACSU oligopeptide transport permease protein, AppC from Bacillus subtilis (303 aa) fasta scores: opt: 643, z-score: 780.7, E(): 0, (36.6% identity in 295 aa overlap). Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. (312 aa)
SCO6454SC9B5.21, probable ABC transporter ATP-binding protein, len: 335aa; fourth of a five gene operon probably involved in peptide uptake, similar to many eg. SW:DPPD_BACSU dipeptide transport ATP-binding protein, DppD, from Bacillus subtilis (335 aa) fasta scores: opt: 486, z-score: 654.6, E(): 3.6e-29, (37.6% identity in 348 aa overlap). Contains PS00017 ATP /GTP-binding site motif A (P-loop). Also contains Pfam match to entry PF00005 ABC_tran, ABC transporters. (335 aa)
SCO6455SC9B5.22, probable ABC transporter ATP-binding protein, len: 222aa; fifth of a five gene operon probably involved in peptide uptake, similar to many eg. SW:OPPF_SALTY oligopeptide transport ATP-binding protein, OppF, from Salmonella typhimurium (334 aa) fasta scores: opt: 412, z-score: 569.7, E(): 1.9e-24, (35.1% identity in 194 aa overlap). Contains PS00017 ATP /GTP-binding site motif A (P-loop). Also contains Pfam match to entry PF00005 ABC_tran, ABC transporters. (222 aa)
SCO6552SC4B5.02c, probable long-chain-fatty-acid-CoA ligase, len: 608aa, similar to many eg. TR:O53521 (EMBL:AL021957) putative long-chain-fatty-acid-CoA ligase from Mycobacterium tuberculosis (600 aa), fasta scores; opt: 1177, z-score: 1838.1, E(): 0, (44.8% identity in 612 aa overlap). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score -73.00, E-value 7.8e-11 and PS00455 Putative AMP-binding domain signature. (608 aa)
SCO6644SC4G2.18, probable solute-binding lipoprotein, len: 503 aa; similar to many members of the bacterial extracellular solute-binding protein family 5YLIB_ECOLI putative binding protein YLIB precursor (512 aa), fasta scores; opt: 364 z-score: 328.6 E(): 4.6e-11, 27.8% identity in 467 aa overlap. Contains N-terminal signal sequence with appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site and Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 36.60, E-value 2.2e-08. (503 aa)
SCO6645SC4G2.19, probable transport system permease protein, len: 601 aa; similar to many members of the oppBC family e.g. NIKB_ECOLI nickel transport system permease protein (314 aa), fasta scores; opt: 405 z-score: 322.1 E(): 1.1e-10, 33.4% identity in 290 aa overlap. (601 aa)
SCO6655GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (221 aa)
SCO6691SC4C6.01, probable phospholipase C, partial CDS, len: >501 aa; similar to e.g. SW:PHLN_PSEAE (EMBL:M59304), plcN, Pseudomonas aeruginosa non-hemolytic phospholipase C precursor (692 aa), fasta scores; opt: 1073 z-score: 1149.1 E(): 0, 44.7% identity in 524 aa overlap; SC6G3.07, probable phospholipase C, partial CDS, len: >221 aa; similar to e.g. SW:PHLN_PSEAE (EMBL:M59304), plcN, Pseudomonas aeruginosa non-hemolytic phospholipase C precursor (692 aa), fasta scores; opt: 853 z-score: 1021.1 E(): 0, 51.3% identity in 232 aa overlap. Continues in cosmid 4C6 (EMBL:AL079355) as SC4C6.01. (687 aa)
SCO6790SC6A5.39, probable long chain fatty acid coA ligase, len: aa; similar to many eg. TR:E1359128 putative long chain fatty acid coA ligase from Streptomyces coelicolor (608 aa) fasta scores; opt: 943, z-score: 1037.6, E(): 0, (34.8% identity in 621 aa overlap) and SW:LCFX_RAT long chain fatty acid coA ligase from Rattus norvegicus (Rat) (697 aa) fasta scores; opt: 532, z-score: 584.9, E(): 2.8e-25, (28.0% identity in 626 aa overlap). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme and Prosite match to PS00455 Putative AMP-binding domain signature. (612 aa)
SCO6929Hypothetical protein; SC1G8.01c, unknown, partial CDS,len: >270 aa. Weakly similar to Bacillus subtilis SW:SPAC_BACSU (EMBL:M86869) subtilin biosynthetic protein, possibly involved in export, SpaC (441 aa), fasta scores opt: 319 z-score: 378.0 E(): 1.4e-13 29.0% identity in 245 aa overlap; SC1B2.35c, unknown, partial CDS, len: >181 aa. Similar to Streptomyces coelicolor TR:CAB55532 (EMBL:AL117322) hypothetical 49.0 kd protein, SCF1.12 (466 aa), fasta scores opt: 238 z-score: 283.2 E(): 2.6e-08 31.1% identity in 180 aa overlap. (419 aa)
SCO6930SC1G8.02c, unknown, len: 1032 aa. Similar to a number of proteins involved in the posttranslational modification of the lantibiotics e.g. Bacillus subtilis SW:SPAB_BACSU (EMBL:L24075) subtilin biosynthesis protein, SpaB (1030 aa), fasta scores opt: 516 z-score: 571.0 E(): 2.4e-24 22.1% identity in 988 aa overlap. Also similar to Streptomyces coelicolor TR:CAB55531 (EMBL:AL117322) hypothetical 114.5 kd protein, SCF1.11 (1053 aa), fasta scores opt: 884 z-score: 982.0 E(): 0 30.6% identity in 1081 aa overlap. Contains a TTA leucine codon, possible target for bldA regulation. (1032 aa)
SCO6968SC6F7.21, probable long-chain-fatty-acid-CoA ligase, len: 511 aa. Similar to several including: Bacillus subtilis SW:LCFA_BACSU (EMBL:Z75208) long-chain-fatty-acid-CoA ligase (EC 6.2.1.3) (560 aa), fasta scores opt: 877 z-score: 981.0 E():0 35.4% identity in 534 aa overlap and Archaeoglobus fulgidus TR:O28502 (EMBL:AE000980) long-chain-fatty-acid-CoA ligase (569 aa), fasta scores opt: 971 z-score: 1085.9 E():0 38.1% identity in 525 aa overlap. Contains a Prosite hit to PS00455 Putative AMP-binding domain signature and a Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. (511 aa)
SCO7181SC8A11.09, probable branched amino acid transport system ATP-binding protein, len: 261 aa; similar to SW:LIVG_ECOLI (EMBL:J05516) Escherichia coli high-affinity branched-chain amino acid transport ATP-binding protein LivG, 255 aa; fasta scores: opt: 586 z-score: 615.7 E(): 7.9e-27; 41.6% identity in 250 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop). (261 aa)
SCO7182SC8A11.10, probable branched amino acid transport system ATP-binding protein, len: 237 aa; similar to SW:LIVF_ECOLI (EMBL:J05516) Escherichia coli high-affinity branched-chain amino acid transport ATP-binding protein LivF, 237 aa; fasta scores: opt: 687 z-score: 739.1 E(): 0; 50.7% identity in 223 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. (237 aa)
SCO7183SC8A11.11, probable branched amino acid transport system permease, len: 290 aa; similar to SW:LIVH_ECOLI (EMBL:J05516) Escherichia coli high-affinity branched-chain amino acid transport system permease LivH, 308 aa; fasta scores: opt: 427 z-score: 471.1 E(): 9e-19; 34.4% identity in 305 aa overlap. Contains possible hydrophobic membrane spanning regions. (290 aa)
SCO7184SC8A11.12, probable branched amino acid transport system permease, len: 349 aa; similar to SW:LIVM_ECOLI (EMBL:J05516) Escherichia coli high-affinity branched-chain amino acid transport system permease, LivM, 425 aa; fasta scores: opt: 254 z-score: 285.7 E(): 1.9e-08; 28.1% identity in 360 aa overlap. Contains possible hydrophobic membrane spanning regions. (349 aa)
SCO7185SC8A11.13, probable branched amino acid binding secreted protein, len: 396 aa; similar to SW:LIVK_ECOLI (EMBL:M29378) Escherichia coli leucine-specific binding protein precursor LivK, 369 aa; fasta scores: opt: 233 z-score: 262.9 E(): 3.6e-07; 24.7% identity in 360 aa overlap. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence. (396 aa)
SCO7563SC5F1.17, possible ABC transporter solute binding lipoprotein, len: 516 aa; similar to TR:Q9KFX3 (EMBL:AP001508) Bacillus halodurans oligopeptide ABC transporter AppA, 516 aa; fasta scores: opt: 708 z-score: 807.2 E(): 0; 29.7% identity in 482 aa overlap. Contains 2x Pfam matches to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5 and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal signal peptide sequence. (516 aa)
SCO7565SC5F1.19, probable oligopeptide ABC transporter integral membrane protein, len: 301 aa; similar to SW:DPPC_ECOLI (EMBL:L08399) Escherichia coli dipeptide transport system permease protein DppC, 300 aa; fasta scores: opt: 805 z-score: 912.6 E(): 0; 45.2% identity in 270 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. Also contains possible hydrophobic membrane spanning regions. (301 aa)
SCO7566SC5F1.20, probable oligopeptide ABC transporter ATP-binding protein, len: 288 aa; similar to SW:OPPD_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport ATP-binding protein OppD, 358 aa; fasta scores: opt: 934 z-score: 1022.9 E(): 0; 54.2% identity in 262 aa overlap and to TR:CAC05750 (EMBL:AL391751) Streptomyces coelicolor putative peptide transport system ATP-binding protein SC9E12.05, 327 aa; fasta scores: opt: 905 z-score: 714.2 E(): 4e-34; 53.5% identity in 260 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and match to Prosite entry PS00017 AT [...] (288 aa)
SCO7567SC5F1.21, probable oligopeptide ABC transporter ATP-binding protein, len: 316 aa; similar to SW:OPPF_BACSU (EMBL:X56347) Bacillus subtilis oligopeptide transport ATP-binding protein OppF, 308 aa; fasta scores: opt: 811 z-score: 836.7 E(): 0; 46.9% identity in 273 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature. (316 aa)
SCO7677SC4C2.12, possible secreted solute-binding protein, len: 528 aa; similar to TR:P96429 (EMBL:Z79692) Sinorhizobium meliloti periplasmic binding protein ORF23, 537 aa; fasta scores: opt: 644 z-score: 679.5 E(): 2.6e-30; 28.8% identity in 525 aa overlap. Contains Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5 and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence. (528 aa)
SCO7678SC4C2.13, possible metal transport integral membrane protein, len: 316 aa; similar to SW:NIKB_ECOLI (EMBL:X73143) Escherichia coli nickel transport system permease protein NikB, 314 aa; fasta scores: opt: 490 z-score: 547.6 E(): 5.8e-23; 30.4% identity in 313 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Also contains possible hydrophobic membrane spanning regions and possible N-terminal signal peptide sequence. (316 aa)
SCO7679SC4C2.14, possible transport system integral membrane protein, len: 284 aa; similar to SW:Y4TQ_RHISN (EMBL:Z68203) Rhizobium sp. probable peptide ABC transporter permease protein Y4tQ, 291 aa; fasta scores: opt: 433 z-score: 466.4 E(): 1.9e-18; 33.2% identity in 277 aa overlap. Contains possible hydrophobic membrane spanning regions. (284 aa)
SCO7680SC4C2.15, possible ABC transporter ATP-binding protein, len: 541 aa; similar to TR:AAG05449 (EMBL:AE004632) Pseudomonas aeruginosa probable ATP-binding component of ABC transporter PA2061, 536 aa; fasta scores: opt: 861 z-score: 716.8 E(): 2.2e-32; 37.4% identity in 522 aa overlap. Contains 2x Pfam matches to entry PF00005 ABC_tran, ABC transporter and 2x matches to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop) and 2x to PS00211 ABC transporters family signature. (541 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.