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SCO0945 SCO0945 SCO1114 SCO1114 SCO1202 SCO1202 SCO1255 SCO1255 SCO1343 SCO1343 SCO1792 SCO1792 SCO1990 SCO1990 SCO2003 SCO2003 SCO2111 SCO2111 SCO2626 SCO2626 SCO3174 SCO3174 SCO3355 SCO3355 SCO3434 SCO3434 SCO3569 SCO3569 SCO4495 SCO4495 SCO5143 SCO5143 SCO5494 SCO5494 SCO5573 SCO5573 SCO5760 SCO5760 SCO6150 SCO6150 SCO6341 SCO6341 SCO6461 SCO6461 SCO7522 SCO7522
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCO0945SCM10.34c, probable formamidopyrimidine-DNA glycosylase len: 287 aa; similar to TR:P71565 (EMBL:Z79700) Mycobacterium tuberculosis hypothetical 16.5k kD protein MTYC10D7.30c, 158 aa; fasta scores: opt: 608 z-score: 707.4 E(): 5.2e-32; 59.0% identity in 156 aa overlap and to SW:FPG_SYNEN (EMBL:Y10290) Synechococcus elongatus naegeli formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) MutM, 284 aa; fasta scores: opt: 426 z-score: 495.1 E(): 3.4e-20; 33.6% identity in 283 aa overlap. Contains Pfam match to entry PF01149 Fapy_DNA_glyco, Formamidopyrimidine-DNA glycosylase. (287 aa)
SCO1114Uracil DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (225 aa)
SCO1202Putative DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (512 aa)
SCO12552SCG18.02, mug, G/U mismatch-specific DNA glycosylase, len: 160 aa; highly similar to SW:MUG_ECOLI (EMBL:U28379) Escherichia coli mismatch-specific DNA glycosylase (EC 3.2.2.-) Mug, 168 aa; fasta scores: opt: 448 z-score: 564.7 E(): 5.7e-24; 44.7% identity in 152 aa overlap. (160 aa)
SCO1343uracil-DNA glycosylase (EC 3.2.2.-); Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (227 aa)
SCO1792Putative DNA glycosylase; SCI51.32c, possible 3-methyladenine DNA glycosylase, len: 213 aa; similar to several eukaryotic 3-methyladenine DNA glycosylases, but shorter at the N-terminus e.g. SW:3MG_HUMAN (EMBL:M74905) Homo sapiens (Human) DNA-3-methyladenine glycosylase (298 aa), fasta scores; opt: 410 z-score: 485.1 E(): 1.1e-19, 38.6% identity in 207 aa overlap. Also similar putative 3-methyladenine DNA glycosylases from mycobacteria e.g. SW:3MGH_MYCTU (EMBL:Z98268) Mycobacterium tuberculosis possible 3-methyladenine DNA glycosylase (203 aa) (43.0% identity in 193 aa overlap). (213 aa)
SCO1990Conserved hypothetical protein; SC7H2.04c, unknown, len: 237aa; similar to SW:Y08N_MYCTU hypothetical protein from Mycobacterium tuberculosis (350 aa) fasta scores; opt: 870, z-score: 990.4, E(): 0, (57.1% identity in 231 aa overlap). (237 aa)
SCO2003DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (907 aa)
SCO2111Putative endonuclease; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (294 aa)
SCO2626SCC80.11c, probable DNA repair hydrolase (fragment), len: >306 aa; similar to SW:FPG_ECOLI (EMBL:M86305) Escherichia coli formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) MutM, 269 aa; fasta scores: opt: 347 z-score: 395.3 E(): 1.7e-14; 31.6% identity in 209 aa overlap. Contains Pfam match to entry PF01149 Fapy_DNA_glyco, Formamidopyrimidine-DNA glycosylase and match to Prosite entry; Belongs to the FPG family. (280 aa)
SCO3174SCE87.25c, possible exodeoxyribonuclease (EC 3.1.11.2) (putative secreted protein), len: 274 aa. Highly similar to several e.g. Bacillus subtilis SW:EXOA_BACSU (EMBL:D26185) exodeoxyribonuclease (EC 3.1.11.2) (252 aa), fasta scores opt: 592 z-score: 694.3 E(): 2.7e-31 38.6% identity in 267 aa overlap and Methanobacterium thermoautotrophicum TR:O26314 (EMBL:AE000808) exodeoxyribonuclease (257 aa), fasta scores opt: 674 z-score: 789.1 E():0 41.6% identity in 262 aa overlap. Also similar to Pseudomonas aeruginosa TR:Q51380 (EMBL:U38241) catabolite repression control protein (259 aa), fast [...] (274 aa)
SCO3355SCE94.06, mutY, putative adenine glycosylase, len: 308 aa; previously partially sequenced therefore partially identical to TR:E1358524 (EMBL:AJ131213) MutY, putative adenine glycosylase from Streptomyces coelicolor (183 aa) fasta scores; opt: 1220, z-score: 1357.4, E(): 0, (100.0% identity in 183 aa overlap). Also similar to many others e.g. SW:MUTY_SALTY MutY, adenine glycosylase from Salmonella typhimurium (350 aa) fasta scores; opt: 500, z-score: 558.7, E(): 8.3e-24, (39.4% identity in 231 aa overlap). Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III. (308 aa)
SCO3434SCE36.01, partial CDS, possible DNA polymerase I, len: >328 aa; similar to the C-terminal region many e.g. SW:DPO1_CHLAU DNA polymerase I from Chloroflexus aurantiacus (942 aa) fasta scores; opt: 287, z-score: 322.2, E(): 1.3e-10, (28.9% identity in 305 aa overlap). Contains two Pfam matches to entry PF00476 DNA_pol_A, DNA polymerase family A; SCE9.41, hypothetical protein, partial CDS, len: >268 aa; unknown function, probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. (563 aa)
SCO3569Putative endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (250 aa)
SCO4495SCD35.02, possible DNA polymerase related protein, len: 212 aa; similar to TR:AAF11304 (EMBL:AE002016) Deinococcus radiodurans DNA polymerase-related protein DR1751, 237 aa; fasta scores: opt: 380 z-score: 451.4 E(): 1e-1; 41.5% identity in 188 aa overlap and to N-terminal region of SW:DPOL_BPSP1 (EMBL:M84415) Bacteriophage SP01 DNA polymerase (EC 2.7.7.7) 31, 924 aa; fasta scores: opt: 191 z-score: 223.4 E(): 5.2e-05; 33.7% identity in 169 aa overlap. (212 aa)
SCO5143SCP8.06, tag, DNA-3-methyladenine glycosylase I, len: 194 aa; highly similar to SW:3MG1_ECOLI (EMBL:J02606) Escherichia coli DNA-3-methyladenine glycosylase I (EC 3.2.2.20) Tag, 187 aa; fasta scores: opt: 529 z-score: 636.5 E(): 5.5e-28; 45.2% identity in 177 aa overlap. (194 aa)
SCO5494Putative DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (735 aa)
SCO5573formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). (286 aa)
SCO5760DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (276 aa)
SCO6150SC1A9.14, possible ADA-like regulatory protein, len: 477 aa; similar to ADA_MYCTU (EMBL:Z73902) putative ADA regulatory protein from Mycobacterium tuberculosis (496 aa) fasta scores; opt: 1135, z-score: 1376.3, E(): 0, (51.6% identity in 486 aa overlap). Also note N-terminal region similar to N-terminal region of ADA_ECOLI (EMBL:M10211) ADA regulatory protein from Escherichia coli (354 aa) fasta scores; opt: 302, z-score: 255.8, E(): 5.7e-07, (34.5% identity in 171 aa overlap) and C-terminal region similar to 3MG2_ECOLI AlkA, 3-methyladenine DNA glycosylase II involved in DNA repair (2 [...] (477 aa)
SCO6341SC3A7.09, probable exonuclease, len: 259 aa; similar to exonuclease III from many organisms e.g. EX3_ECOLI exodeoxyribonuclease III (EC 3.1.11.2) (268 aa), fasta scores; opt: 302 z-score: 443.2 E(): 2e-17, 33.5% identity in 266 aa overlap. (259 aa)
SCO6461SC9B5.28, possible ADA-like regulatory protein, len: 490 aa; similar to SC1A9.14 (EMBL:AL034446) possible ADA-like regulatory protein from Streptomyces coelicolor (477 aa) fasta scores: opt: 1192, z-score: 937.1, E(): 0, (53.3% identity in 501 aa overlap). Also similar to ADA_MYCTU putative ADA regulatory protein from Mycobacterium tuberculosis (496 aa) fasta scores; opt: 2185, z-score: 2395.4, E(): 0, (66.7% identity in 490 aa overlap). Also note N-terminal region similar to N-terminal region of ADA_ECOLI ADA regulatory protein from Escherichia coli (354 aa) fasta scores; opt: 257, z- [...] (490 aa)
SCO7522Putative DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (723 aa)
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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