STRINGSTRING
SSIL_0051 SSIL_0051 dnaX dnaX dnaN dnaN SSIL_0131 SSIL_0131 radA radA sbcD sbcD SSIL_0610 SSIL_0610 recX recX SSIL_0812 SSIL_0812 SSIL_0815 SSIL_0815 SSIL_0945 SSIL_0945 SSIL_1022 SSIL_1022 SSIL_1177 SSIL_1177 polA polA SSIL_1199 SSIL_1199 coaE coaE nrdR nrdR SSIL_1203 SSIL_1203 SSIL_1204 SSIL_1204 SSIL_1231 SSIL_1231 uvrC uvrC SSIL_1493 SSIL_1493 recD2 recD2 SSIL_1529 SSIL_1529 SSIL_1531 SSIL_1531 mutS mutS mutL mutL lexA lexA SSIL_2118 SSIL_2118 SSIL_2586 SSIL_2586 dinG dinG SSIL_2741 SSIL_2741 recO recO recA recA polC polC SSIL_3008 SSIL_3008 recG recG uvrA uvrA uvrB uvrB topB topB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SSIL_0051ATPase. (340 aa)
dnaXDNA polymerase III, gamma/tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (583 aa)
dnaNDNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...] (378 aa)
SSIL_0131Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (450 aa)
radAPredicted ATP-dependent serine protease; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (457 aa)
sbcDDNA repair exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (387 aa)
SSIL_0610ATPase. (1017 aa)
recXUncharacterized protein; Modulates RecA activity; Belongs to the RecX family. (271 aa)
SSIL_0812Replicative DNA helicase. (423 aa)
SSIL_0815Superfamily II DNA helicase. (1097 aa)
SSIL_0945DNA polymerase III, alpha subunit. (251 aa)
SSIL_10225'-3' exonuclease. (292 aa)
SSIL_1177DNA polymerase III, alpha subunit. (1024 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (876 aa)
SSIL_1199formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (290 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa)
nrdRPredicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (155 aa)
SSIL_1203Replication initiation/membrane attachment protein. (915 aa)
SSIL_1204DNA replication protein. (319 aa)
SSIL_1231Predicted nucleoside-diphosphate sugar epimerase. (158 aa)
uvrCNuclease subunit of the excinuclease complex; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (596 aa)
SSIL_1493Single-stranded DNA-specific exonuclease. (773 aa)
recD2ATP-dependent exoDNAse alpha subunit; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (833 aa)
SSIL_1529Predicted membrane metal-binding protein. (191 aa)
SSIL_1531DNA polymerase III, delta subunit. (336 aa)
mutSMismatch repair ATPase; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (871 aa)
mutLDNA mismatch repair enzyme; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (629 aa)
lexASOS-response transcriptional repressors; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (207 aa)
SSIL_2118Superfamily II DNA helicase. (587 aa)
SSIL_2586Topoisomerase IA. (724 aa)
dinGRad3-related DNA helicase; 3'-5' exonuclease. (926 aa)
SSIL_2741Superfamily II DNA helicase. (481 aa)
recORecombinational DNA repair protein; Involved in DNA repair and RecF pathway recombination. (257 aa)
recARecA/RadA recombinase; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (358 aa)
polCDNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1443 aa)
SSIL_3008Predicted Rossmann fold nucleotide-binding protein. (297 aa)
recGRecG-like helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (679 aa)
uvrAExcinuclease ATPase subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (955 aa)
uvrBHelicase subunit of the DNA excision repair complex; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the [...] (660 aa)
topBTopoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superco [...] (732 aa)
Your Current Organism:
Solibacillus silvestris
NCBI taxonomy Id: 1002809
Other names: S. silvestris StLB046, Solibacillus silvestris StLB046, Solibacillus silvestris str. StLB046, Solibacillus silvestris strain StLB046
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