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scpB scpB cshB cshB SSIL_2869 SSIL_2869 era era infB infB flhF flhF fliI fliI hslU hslU ffh ffh ftsY ftsY smc smc recG recG rsgA-2 rsgA-2 ftsZ ftsZ ftsA ftsA typA typA prfC prfC SSIL_3240 SSIL_3240 SSIL_3241 SSIL_3241 addA addA SSIL_3249 SSIL_3249 uvrA uvrA uvrB uvrB icmF icmF SSIL_3482 SSIL_3482 SSIL_3499 SSIL_3499 SSIL_3543 SSIL_3543 SSIL_3767 SSIL_3767 SSIL_3768 SSIL_3768 ftsH ftsH mnmE mnmE SSIL_0113 SSIL_0113 engD engD SSIL_0131 SSIL_0131 SSIL_0185 SSIL_0185 fusA fusA tuf tuf SSIL_0259 SSIL_0259 SSIL_0262 SSIL_0262 hflX hflX cshA cshA SSIL_0457 SSIL_0457 SSIL_0486 SSIL_0486 SSIL_0493 SSIL_0493 yfmL yfmL SSIL_0630 SSIL_0630 SSIL_0735 SSIL_0735 SSIL_0801 SSIL_0801 SSIL_0812 SSIL_0812 SSIL_0817 SSIL_0817 SSIL_1132 SSIL_1132 SSIL_1140 SSIL_1140 deaD deaD mutS2 mutS2 SSIL_1268 SSIL_1268 clpX clpX lon lon SSIL_1432 SSIL_1432 minD minD obgE obgE ruvA ruvA ruvB ruvB recD2 recD2 lepA lepA mutL mutL SSIL_1719 SSIL_1719 SSIL_1727 SSIL_1727 cadA cadA rsgA rsgA SSIL_2225 SSIL_2225 SSIL_2228 SSIL_2228 SSIL_2437 SSIL_2437 tetP tetP SSIL_2493 SSIL_2493 SSIL_2657 SSIL_2657
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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scpBPredicted transcriptional regulator containing the HTH domain; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (196 aa)
cshBSuperfamily II DNA and RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (436 aa)
SSIL_2869Hypothetical protein. (268 aa)
eraGTPase; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (304 aa)
infBTranslation initiation factor 2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (790 aa)
flhFFlagellar GTP-binding protein. (396 aa)
fliIFlagellar biosynthesis/type III secretory pathway ATPase. (441 aa)
hslUATP-dependent protease HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (463 aa)
ffhSignal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (452 aa)
ftsYSignal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (414 aa)
smcChromosome segregation ATPase; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1193 aa)
recGRecG-like helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (679 aa)
rsgA-2Predicted GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (293 aa)
ftsZCell division GTPase; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (387 aa)
ftsAActin-like ATPase; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (431 aa)
typAPredicted membrane GTPase. (616 aa)
prfCPeptide chain release factor RF-3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (523 aa)
SSIL_3240ATPase with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. (709 aa)
SSIL_3241Predicted metal-sulfur cluster biosynthetic enzyme. (104 aa)
addAATP-dependent exoDNAse beta subunit; ATP-dependent DNA helicase. (1239 aa)
SSIL_3249ATP-dependent nuclease, subunit B; ATP-dependent DNA helicase. (1213 aa)
uvrAExcinuclease ATPase subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (955 aa)
uvrBHelicase subunit of the DNA excision repair complex; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the [...] (660 aa)
icmFmethylmalonyl-CoA mutase, N-terminal domain/subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1080 aa)
SSIL_3482Superfamily I DNA and RNA helicase. (786 aa)
SSIL_3499Superfamily I DNA and RNA helicase. (730 aa)
SSIL_3543Superfamily I DNA and RNA helicase. (740 aa)
SSIL_3767Predicted nucleotide kinase. (331 aa)
SSIL_3768Cation transport ATPase. (865 aa)
ftsHATP-dependent Zn protease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (679 aa)
mnmEPredicted GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (461 aa)
SSIL_0113ATPase. (253 aa)
engDPredicted GTPase; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (366 aa)
SSIL_0131Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (450 aa)
SSIL_0185ATPase with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. (814 aa)
fusATranslation elongation factor; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 sub [...] (692 aa)
tufTranslation elongation factor; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (395 aa)
SSIL_0259ATPase; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (351 aa)
SSIL_0262Uncharacterized protein. (214 aa)
hflXGTPase; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (426 aa)
cshASuperfamily II DNA and RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (517 aa)
SSIL_0457MoxR-like ATPase. (313 aa)
SSIL_0486ABC-type multidrug transport system, ATPase component. (258 aa)
SSIL_0493Superfamily I DNA and RNA helicase. (752 aa)
yfmLSuperfamily II DNA and RNA helicase. (410 aa)
SSIL_0630Cation transport ATPase. (634 aa)
SSIL_0735Superfamily I DNA and RNA helicase. (671 aa)
SSIL_0801DNA mismatch repair enzyme. (498 aa)
SSIL_0812Replicative DNA helicase. (423 aa)
SSIL_0817Superfamily I DNA and RNA helicase. (374 aa)
SSIL_1132Uncharacterized conserved protein. (204 aa)
SSIL_1140Actin-like ATPase. (718 aa)
deaDSuperfamily II DNA and RNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. (481 aa)
mutS2Mismatch repair ATPase; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (788 aa)
SSIL_1268Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
clpXATP-dependent protease Clp, ATPase subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (423 aa)
lonATP-dependent Lon protease, bacterial type; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (774 aa)
SSIL_1432Phage-related minor tail protein. (427 aa)
minDSeptum formation inhibitor-activating ATPase. (294 aa)
obgEPredicted GTPase; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (429 aa)
ruvAHolliday junction resolvasome, DNA-binding subunit; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (251 aa)
ruvBHolliday junction resolvasome, helicase subunit; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
recD2ATP-dependent exoDNAse alpha subunit; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (833 aa)
lepAMembrane GTPase LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (609 aa)
mutLDNA mismatch repair enzyme; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (629 aa)
SSIL_1719Putative periplasmic protein kinase ArgK. (361 aa)
SSIL_1727Predicted ATPase. (246 aa)
cadACation transport ATPase. (821 aa)
rsgAPredicted GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (353 aa)
SSIL_2225MoxR-like ATPase. (372 aa)
SSIL_2228Predicted GTPase. (605 aa)
SSIL_2437Cation transport ATPase. (797 aa)
tetPTranslation elongation factor. (646 aa)
SSIL_2493ATP-dependent Lon protease. (295 aa)
SSIL_2657Predicted GTPase. (1203 aa)
Your Current Organism:
Solibacillus silvestris
NCBI taxonomy Id: 1002809
Other names: S. silvestris StLB046, Solibacillus silvestris StLB046, Solibacillus silvestris str. StLB046, Solibacillus silvestris strain StLB046
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