STRINGSTRING
ytnP ytnP ipk ipk SSIL_0069 SSIL_0069 SSIL_0083 SSIL_0083 SSIL_0085 SSIL_0085 SSIL_0088 SSIL_0088 SSIL_0089 SSIL_0089 SSIL_0090 SSIL_0090 SSIL_0178 SSIL_0178 ispF ispF glcB glcB SSIL_0346 SSIL_0346 SSIL_0398 SSIL_0398 acpS acpS SSIL_0449 SSIL_0449 SSIL_0510 SSIL_0510 SSIL_0533 SSIL_0533 yoaI yoaI SSIL_0570 SSIL_0570 uxuA uxuA SSIL_0604 SSIL_0604 SSIL_0605 SSIL_0605 SSIL_0674 SSIL_0674 SSIL_0694 SSIL_0694 SSIL_0726 SSIL_0726 SSIL_0757 SSIL_0757 pgk pgk tpiA tpiA gpmI gpmI eno eno SSIL_0858 SSIL_0858 SSIL_0947 SSIL_0947 cypC cypC SSIL_0960 SSIL_0960 SSIL_0989 SSIL_0989 SSIL_0995 SSIL_0995 hutH hutH SSIL_1032 SSIL_1032 SSIL_1033 SSIL_1033 SSIL_1034 SSIL_1034 lipA lipA SSIL_1095 SSIL_1095 SSIL_1120 SSIL_1120 SSIL_3809 SSIL_3809 SSIL_3793 SSIL_3793 SSIL_3792 SSIL_3792 yvfV yvfV SSIL_3715 SSIL_3715 SSIL_3703 SSIL_3703 SSIL_3700 SSIL_3700 SSIL_3695 SSIL_3695 SSIL_3686 SSIL_3686 hutU hutU hutI hutI SSIL_3668 SSIL_3668 SSIL_3629 SSIL_3629 SSIL_3618 SSIL_3618 mdcA mdcA SSIL_3615 SSIL_3615 SSIL_3614 SSIL_3614 SSIL_3588 SSIL_3588 SSIL_3577 SSIL_3577 SSIL_3507 SSIL_3507 SSIL_3469 SSIL_3469 SSIL_3468 SSIL_3468 lipL lipL SSIL_3413 SSIL_3413 SSIL_3407 SSIL_3407 SSIL_3406 SSIL_3406 mmgC mmgC SSIL_3404 SSIL_3404 SSIL_3397 SSIL_3397 fabZ fabZ SSIL_3305 SSIL_3305 SSIL_3246 SSIL_3246 fabH fabH SSIL_3237 SSIL_3237 SSIL_3134 SSIL_3134 SSIL_3112 SSIL_3112 SSIL_3108 SSIL_3108 SSIL_3061 SSIL_3061 coaBC coaBC fapR fapR plsX plsX SSIL_3035 SSIL_3035 acpP acpP uxaC uxaC uxaA uxaA dxr dxr SSIL_2870 SSIL_2870 SSIL_2867 SSIL_2867 SSIL_2865 SSIL_2865 SSIL_2853 SSIL_2853 ispH ispH SSIL_2798 SSIL_2798 SSIL_2744 SSIL_2744 panB panB panC panC panD panD SSIL_2650 SSIL_2650 SSIL_2633 SSIL_2633 SSIL_2632 SSIL_2632 SSIL_2631 SSIL_2631 SSIL_2630 SSIL_2630 SSIL_2628 SSIL_2628 SSIL_2627 SSIL_2627 SSIL_2626 SSIL_2626 SSIL_2625 SSIL_2625 SSIL_2619 SSIL_2619 SSIL_2604 SSIL_2604 SSIL_2523 SSIL_2523 SSIL_2521 SSIL_2521 SSIL_2427 SSIL_2427 SSIL_2298 SSIL_2298 SSIL_2196 SSIL_2196 SSIL_2178 SSIL_2178 SSIL_2133 SSIL_2133 SSIL_2126 SSIL_2126 SSIL_2106 SSIL_2106 SSIL_2032 SSIL_2032 SSIL_2021 SSIL_2021 SSIL_1990 SSIL_1990 bioB bioB bioA bioA bioD bioD SSIL_1843 SSIL_1843 SSIL_1842 SSIL_1842 SSIL_1841 SSIL_1841 SSIL_1832 SSIL_1832 SSIL_1759 SSIL_1759 SSIL_1758 SSIL_1758 SSIL_1756 SSIL_1756 SSIL_1752 SSIL_1752 SSIL_1740 SSIL_1740 SSIL_1684 SSIL_1684 SSIL_1683 SSIL_1683 kynU kynU ispG ispG aroE aroE SSIL_1355 SSIL_1355 SSIL_1253 SSIL_1253 ysiA ysiA SSIL_1239 SSIL_1239 SSIL_1186 SSIL_1186 pykA pykA pfkA pfkA accA accA accD accD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ytnPZn-dependent hydrolase, including glyoxylase. (286 aa)
ipk4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (288 aa)
SSIL_0069acyl-CoA dehydrogenase. (401 aa)
SSIL_0083Zn-dependent hydrolase. (277 aa)
SSIL_0085Uncharacterized protein. (454 aa)
SSIL_0088acyl-CoA dehydrogenase. (388 aa)
SSIL_0089enoyl-CoA hydratase/carnithine racemase. (258 aa)
SSIL_0090Acyl dehydratase. (175 aa)
SSIL_0178acyl-CoA hydrolase. (162 aa)
ispF2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
SSIL_0346Predicted metal-dependent hydrolase with the TIM-barrel fold. (526 aa)
SSIL_0398acetyl-CoA hydrolase. (506 aa)
acpSPhosphopantetheinyl transferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (117 aa)
SSIL_0449Fatty acid desaturase. (343 aa)
SSIL_0510Threonine dehydrogenase. (324 aa)
SSIL_0533Putative intracellular protease/amidase. (228 aa)
yoaIAromatic ring hydroxylase. (480 aa)
SSIL_0570Hypothetical protein. (332 aa)
uxuAD-mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (356 aa)
SSIL_0604acyl-CoA dehydrogenase. (380 aa)
SSIL_0605acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
SSIL_0674Aldo/keto reductase. (276 aa)
SSIL_0694enoyl-CoA hydratase/carnithine racemase. (260 aa)
SSIL_0726enoyl-CoA hydratase/carnithine racemase. (258 aa)
SSIL_0757Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)
pgk3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
SSIL_0858Predicted membrane protein. (219 aa)
SSIL_0947Isochorismate synthase. (400 aa)
cypCCytochrome P450. (418 aa)
SSIL_0960Amidohydrolase 2. (248 aa)
SSIL_0989acyl-CoA dehydrogenase. (550 aa)
SSIL_0995FAD/FMN-containing dehydrogenase. (468 aa)
hutHHistidine ammonia-lyase. (494 aa)
SSIL_10323-hydroxyacyl-CoA dehydrogenase. (794 aa)
SSIL_1033acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
SSIL_1034acyl-CoA dehydrogenase. (594 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (303 aa)
SSIL_1095Isochorismate synthase. (460 aa)
SSIL_1120Predicted flavoprotein. (431 aa)
SSIL_3809Isocitrate lyase. (427 aa)
SSIL_3793Uncharacterized conserved protein. (226 aa)
SSIL_3792Uncharacterized conserved protein containing a ferredoxin-like domain. (475 aa)
yvfVFe-S oxidoreductase. (238 aa)
SSIL_37152-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase. (316 aa)
SSIL_37032-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase. (320 aa)
SSIL_3700acyl-CoA dehydrogenase. (399 aa)
SSIL_3695acyl-CoA dehydrogenase. (402 aa)
SSIL_3686PEP phosphonomutase. (287 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (553 aa)
hutIImidazolonepropionase. (422 aa)
SSIL_3668NADPH:quinone reductase. (325 aa)
SSIL_36293-oxoacyl-[acyl-carrier-protein] synthase III. (334 aa)
SSIL_3618(acyl-carrier-protein) S-malonyltransferase. (308 aa)
mdcAMalonate decarboxylase subunit alpha. (549 aa)
SSIL_3615Hypothetical protein. (98 aa)
SSIL_3614Hypothetical protein. (562 aa)
SSIL_3588Hypothetical protein. (76 aa)
SSIL_3577acyl-CoA dehydrogenase. (396 aa)
SSIL_3507Transcriptional regulator. (188 aa)
SSIL_3469Predicted membrane protein. (205 aa)
SSIL_34687-keto-8-aminopelargonate synthetase. (396 aa)
lipLLipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (275 aa)
SSIL_3413acyl-CoA dehydrogenase. (384 aa)
SSIL_3407acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
SSIL_34063-hydroxyacyl-CoA dehydrogenase. (284 aa)
mmgCacyl-CoA dehydrogenase. (378 aa)
SSIL_3404acyl-CoA dehydrogenase. (378 aa)
SSIL_3397Fructose/tagatose bisphosphate aldolase. (284 aa)
fabZ3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (145 aa)
SSIL_3305Transcriptional regulator. (195 aa)
SSIL_32462-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase. (300 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (311 aa)
SSIL_32373-oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa)
SSIL_3134Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1144 aa)
SSIL_3112enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (254 aa)
SSIL_3108Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (297 aa)
SSIL_3061acetyl-CoA hydrolase. (72 aa)
coaBCPhosphopantothenoylcysteine synthetase/decarboxylase. (187 aa)
fapRUncharacterized protein; Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism. (190 aa)
plsXFatty acid/phospholipid biosynthesis enzyme; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (331 aa)
SSIL_3035(acyl-carrier-protein) S-malonyltransferase. (317 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa)
uxaCGlucuronate isomerase. (464 aa)
uxaAAltronate dehydratase. (497 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (381 aa)
SSIL_2870Zn-dependent hydrolase, including glyoxylase. (266 aa)
SSIL_2867acyl-CoA dehydrogenase. (380 aa)
SSIL_2865enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (268 aa)
SSIL_2853acyl-CoA dehydrogenase. (378 aa)
ispHPenicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (322 aa)
SSIL_2798acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
SSIL_2744Enoyl-[acyl-carrier-protein] reductase. (258 aa)
panBKetopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (278 aa)
panCPanthothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (287 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa)
SSIL_2650Malic enzyme. (404 aa)
SSIL_2633acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (372 aa)
SSIL_2632acyl-CoA dehydrogenase. (391 aa)
SSIL_2631acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
SSIL_2630acetyl-CoA hydrolase. (428 aa)
SSIL_2628acyl-CoA dehydrogenase. (314 aa)
SSIL_2627acyl-CoA dehydrogenase. (73 aa)
SSIL_2626Hypothetical protein. (135 aa)
SSIL_2625Acyl dehydratase. (126 aa)
SSIL_2619enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (264 aa)
SSIL_2604Phosphopantothenoylcysteine synthetase/decarboxylase. (220 aa)
SSIL_2523enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
SSIL_2521NADPH:quinone reductase. (325 aa)
SSIL_2427Aldo/keto reductase. (268 aa)
SSIL_2298NADPH:quinone reductase. (322 aa)
SSIL_2196acetyl-CoA hydrolase. (506 aa)
SSIL_2178Predicted membrane protein. (210 aa)
SSIL_2133enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (267 aa)
SSIL_2126FAD/FMN-containing dehydrogenase. (454 aa)
SSIL_21062-oxoglutarate dehydrogenase complex, dehydrogenase component. (935 aa)
SSIL_20323-hydroxyacyl-CoA dehydrogenase. (297 aa)
SSIL_2021acyl-CoA dehydrogenase. (379 aa)
SSIL_1990Aldo/keto reductase. (279 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (332 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (455 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (235 aa)
SSIL_1843acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
SSIL_1842Acyl dehydratase. (132 aa)
SSIL_1841Acyl dehydratase. (149 aa)
SSIL_1832acyl-CoA dehydrogenase. (388 aa)
SSIL_1759acyl-CoA dehydrogenase. (390 aa)
SSIL_1758acyl-CoA dehydrogenase. (398 aa)
SSIL_1756acetyl-CoA acetyltransferase. (387 aa)
SSIL_1752NADPH:quinone reductase. (328 aa)
SSIL_1740Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
SSIL_1684Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa)
SSIL_1683Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (166 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (419 aa)
ispGEnzyme; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (369 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa)
SSIL_1355acyl-CoA dehydrogenase. (347 aa)
SSIL_1253enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa)
ysiATranscriptional regulator. (193 aa)
SSIL_1239Uncharacterized conserved protein. (396 aa)
SSIL_1186Isocitrate dehydrogenase. (420 aa)
pykAPyruvate kinase. (157 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
accAacetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa)
accDacetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa)
Your Current Organism:
Solibacillus silvestris
NCBI taxonomy Id: 1002809
Other names: S. silvestris StLB046, Solibacillus silvestris StLB046, Solibacillus silvestris str. StLB046, Solibacillus silvestris strain StLB046
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